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Journal Articles

Resistance to Bruton tyrosine kinase inhibitors: the Achilles heel of their success story in lymphoid malignancies

Deborah M. Stephens, John C. Byrd

Blood (2021) 138 (13): 1099–1109.

https://doi.org/10.1182/blood.2020006783

Published: 2021

Journal Articles

Tyrosine Kinase Inhibitors (TKIs) Targeting Syk and BTK Signaling Differentially Affect PI3K Signalosome Organization and Platelet Function

Tony Zheng, Elizabeth R Lofurno, Sarah Elgamal, Alexander R Melrose, Jiaqing Pang, Joseph J Shatzel, MD, Owen J T McCarty, PhD, Joseph Aslan, PhD

Blood (2019) 134 (Supplement_1): 2074.

https://doi.org/10.1182/blood-2019-129066

Published: 2019

Journal Articles

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, Xiang-ming Zha, PhD, Stephanie Halene, MD, Jing Fang, MD PhD

Blood (2019) 134 (Supplement_1): 2661.

https://doi.org/10.1182/blood-2019-125455

Published: 2019

Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Blood (2019) 134 (Supplement_1): 531.

https://doi.org/10.1182/blood-2019-121996

Published: 2019

Journal Articles

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Tanabe Mikoto, MD, Nguyen Hoang Maianh, MD, Kohei Hosokawa, MD PhD, Noriharu Nakagawa, MD, Luis Espinoza, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 3736.

https://doi.org/10.1182/blood-2019-126677

Published: 2019

Journal Articles

Loss of Gpr68 Enhances Hematopoietic Stem Cell Function during Aging

Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Yan Xu, PhD, Xiang-ming Zha, PhD, Jing Fang, MD PhD

Blood (2019) 134 (Supplement_1): 3719.

https://doi.org/10.1182/blood-2019-125168

Published: 2019

Journal Articles

The Fully Human Anti-CD47 Antibody SRF231 Has Dual-Mechanism Antitumor Activity Against Chronic Lymphocytic Leukemia (CLL) Cells and Increases the Activity of Both Rituximab and Venetoclax

Rebecca Valentin, MD, Marisa O. Peluso, MS, Timothy Z. Lehmberg, BA, Ammar Adam, DVM, Li Zhang, MA, Caroline M. Armet, BS, Jennifer L. Guerriero, PhD, Benjamin H. Lee, MD PhD, Vito J. Palombella, PhD, Pamela M. Holland, PhD, Alison M. Paterson, PhD, Matthew S. Davids, MD

Blood (2018) 132 (Supplement 1): 4393.

https://doi.org/10.1182/blood-2018-99-110181

Published: 2018

Journal Articles

Overexpression of Phospholipase C Beta 2 Is Associated with Favorable Prognosis in Normal Karyotype Acute Myeloid Leukemia

Jun Hyung Lee, MD MS, Hyun-Jung Choi, MD PhD, Soo-Hyun Kim, MD PhD, Jong-Hee Shin, MD PhD, Soon-Pal Suh, MD PhD, Myung-Geun Shin, MD PhD

Blood (2017) 130 (Supplement 1): 2677.

https://doi.org/10.1182/blood.V130.Suppl_1.2677.2677

Published: 2017

Journal Articles

Linear and Branching Progression of Chronic Lymphocytic Leukemia (CLL) Under PI3K Inhibition (PI3Ki)

Julio Delgado, MD, Silvia Bea, Rafael Valdes-Mas, Blanca Gonzalez-Farre, Jesus Gutierrez-Abril, Monica Lopez-Guerra, Alba Navarro, Marta Aymerich, Neus Villamor, Magda Pinyol, Armando Lopez-Guillermo, Carlos Lopez-Otin, Xose Puente, Elias Campo, MD PhD

Blood (2017) 130 (Supplement 1): 3000.

https://doi.org/10.1182/blood.V130.Suppl_1.3000.3000

Published: 2017

Journal Articles

Myeloid Leukemia Stem Cells Depend on Phospholipase C Gamma 1 (Plcg1) Signaling

Tina M. Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, BS, Juliane Mohr, PhD, Soenke Weinert, PhD, Stephanie Frey, Anja Sammt, Lars Bullinger, MD, Florian H. Heidel, MD

Blood (2016) 128 (22): 1202.

https://doi.org/10.1182/blood.V128.22.1202.1202

Published: 2016

Journal Articles

Role of Nuclear Inositide Signalling and microRNA Signature in Myelodysplastic Syndromes during Azacitidine and Lenalidomide Therapy

Matilde Follo, PhD, Sara Mongiorgi, PhD, Cristina Clissa, MD, Annalisa Astolfi, PhD, Domenico Russo, MD, Marco Gobbi, MD, Costanza Bosi, MD, Monica Crugnola, MD, Marta Stanzani, MD, Stefano Ratti, MD, Sarah Parisi, MD, Marilena Barraco, PhD, Lucia Manzoli, MD, Andrea Pession, MD, Lucio Cocco, MD, PhD, Carlo Finelli, MD

Blood (2016) 128 (22): 5091.

https://doi.org/10.1182/blood.V128.22.5091.5091

Published: 2016

Journal Articles

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Mateusz Adamiak, MS, Ahmed Abdelbaset Ismail, PhD, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3342.

https://doi.org/10.1182/blood.V128.22.3342.3342

Published: 2016

Journal Articles

Idelalisib Impairs TREM-1 and TLR Mediated Neutrophil Activation

Astrid Hasibeder, Nicole Stadler, Pamela Aranda Lopez, Alexander Desuki, Oliver Kriege, Alexander N.R. Weber, Christian Michel, Daniel Teschner, Georg Hess, MD, Matthias Theobald, MD, Markus Radsak, MD

Blood (2016) 128 (22): 2510.

https://doi.org/10.1182/blood.V128.22.2510.2510

Published: 2016

Journal Articles

Frequent Activating Somatic Alterations in T-Cell Receptor / NF-κb Signaling in Adult T-Cell Leukemia/Lymphoma

Keisuke Kataoka, MD PhD, Yasunobu Nagata, MDPhD, Akira Kitanaka, MD PhD, Yuichi Shiraishi, MD PhD, Jun-ichirou Yasunaga, MDPhD, Yasushi Totoki, Kenichi Chiba, BA, Aiko Sato-Otsubo, PhD, Shinichi Kotani, Masashi Sanada, MD PhD, Hiroko Tanaka, BA, Hiromichi Suzuki, MD PhD, Yusuke Sato, MD PhD, Yusuke Shiozawa, MD, Tetsuichi Yoshizato, MD, Kenichi Yoshida, MD PhD, Hideki Makishima, MD PhD, Guangyong Ma, Kisato Nosaka, MD PhD, Masakatsu Hishizawa, MD PhD, Hidehiro Itonaga, MD PhD, Yoshitaka Imaizumi, MD PhD, Wataru Munakata, MD, Nakamura Hiromi, Natsuko Hama, Kotaro Shide, MD PhD, Yoko Kubuki, Tomonori Hidaka, Takuro Kameda, Tsuyoshi Nakamaki, MD, Ken Ishiyama, MD PhD, Shuichi Miyawaki, MD, Kensei Tobinai, MD PhD, Yasushi Miyazaki, MD PhD, Akifumi Takaori-Kondo, MD PhD, Toshiki Watanabe, MD, PhD, Tatsuhiro Shibata, Masao Matsuoka, MD PhD, Satoru Miyano, MD PhD, Kazuya Shimoda, MD PhD, Seishi Ogawa, MD PhD

Blood (2015) 126 (23): 113.

https://doi.org/10.1182/blood.V126.23.113.113

Published: 2015

Journal Articles

Novel Evidence That a Lipolytic Enzyme - Hematopoietic-Specific Phospholipase C Beta 2 - Promotes Mobilization of Hematopoietic Stem Cells By Decreasing Their Lipid Raft-Mediated Bone Marrow Retention and Increasing the Pro-Mobilizing Effects of Granulocytes

Mateusz Adamiak, MS, Agata Poniewierska-Baran, PhD, Gabriela Schneider, PhD, Ahmed Abdelbaset-Ismail, PhD, Malwina Suszynska, PhD, Ahmed Abdel-Latif, MD PhD, Magdalena Kucia, PhD, Janina Ratajczak, MD PhD, Mariusz Z Ratajczak, MD PhD

Blood (2015) 126 (23): 1896.

https://doi.org/10.1182/blood.V126.23.1896.1896

Published: 2015

Journal Articles

Reduced PLCG1 expression Is Associated with Inferior Survival in Myelodysplastic Syndromes

Masayuki Shiseki, MD PhD, Mayuko Ishii, Mari Ohwashi, Kentaro Yoshinaga, MDPhD, Naoki Mori, MD PhD, Junji Tanaka, MD, PhD

Blood (2015) 126 (23): 1700.

https://doi.org/10.1182/blood.V126.23.1700.1700

Published: 2015

Journal Articles

Association of Azacitidine and Lenalidomide (Combined vs Sequential Treatment) in High-Risk Myelodysplastic Syndromes. Final Results of a Randomized Phase II Multicenter Study

Blood (2015) 126 (23): 2871.

https://doi.org/10.1182/blood.V126.23.2871.2871

Published: 2015

Journal Articles

Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation

Ta-Ming Liu, Jennifer A. Woyach, Yiming Zhong, Arletta Lozanski, Gerard Lozanski, Shuai Dong, Ethan Strattan, Amy Lehman, Xiaoli Zhang, Jeffrey A. Jones, Joseph Flynn, Leslie A. Andritsos, Kami Maddocks, Samantha M. Jaglowski, Kristie A. Blum, John C. Byrd, Jason A. Dubovsky, Amy J. Johnson

Blood (2015) 126 (1): 61–68.

https://doi.org/10.1182/blood-2015-02-626846

Published: 2015

Includes: Supplemental data

Journal Articles

Novel Evidence That, in Addition to Proteolytic Enzymes, Lipolytic Enzymes Are Involved in Mobilization of Hematopoietic Stem/Progenitor Cells (HSPCs) - an Important Pro-Mobilizing Role Identified for Hematopoietic-Specific Phospholipase C (PLCβ2)

Sylwia Borkowska, MS, Agata Poniewierska-Baran, MS, Gabriela Schneider, PhD, Daniel Pedziwiatr, MS, Malwina Suszynska, MS, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2014) 124 (21): 2448.

https://doi.org/10.1182/blood.V124.21.2448.2448

Published: 2014

Journal Articles

Gβ1 a Component Of The Heterotrimeric G Protein Is a New Protein Phosphatase 1c Interacting Protein That Regulates Platelet Activation

Subhashree Pradhan, Ph.D., Tanvir Khatlani, Ph.D, Satya P. Kunapuli, PhD, K. Vinod Vijayan, PhD

Blood (2013) 122 (21): 3508.

https://doi.org/10.1182/blood.V122.21.3508.3508

Published: 2013

NARROW

Resistance to Bruton tyrosine kinase inhibitors: the Achilles heel of their success story in lymphoid malignancies

Tyrosine Kinase Inhibitors (TKIs) Targeting Syk and BTK Signaling Differentially Affect PI3K Signalosome Organization and Platelet Function

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Loss of Gpr68 Enhances Hematopoietic Stem Cell Function during Aging

The Fully Human Anti-CD47 Antibody SRF231 Has Dual-Mechanism Antitumor Activity Against Chronic Lymphocytic Leukemia (CLL) Cells and Increases the Activity of Both Rituximab and Venetoclax

Overexpression of Phospholipase C Beta 2 Is Associated with Favorable Prognosis in Normal Karyotype Acute Myeloid Leukemia

Linear and Branching Progression of Chronic Lymphocytic Leukemia (CLL) Under PI3K Inhibition (PI3Ki)

Myeloid Leukemia Stem Cells Depend on Phospholipase C Gamma 1 (Plcg1) Signaling

Role of Nuclear Inositide Signalling and microRNA Signature in Myelodysplastic Syndromes during Azacitidine and Lenalidomide Therapy

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Idelalisib Impairs TREM-1 and TLR Mediated Neutrophil Activation

Frequent Activating Somatic Alterations in T-Cell Receptor / NF-κb Signaling in Adult T-Cell Leukemia/Lymphoma

Novel Evidence That a Lipolytic Enzyme - Hematopoietic-Specific Phospholipase C Beta 2 - Promotes Mobilization of Hematopoietic Stem Cells By Decreasing Their Lipid Raft-Mediated Bone Marrow Retention and Increasing the Pro-Mobilizing Effects of Granulocytes

Reduced PLCG1 expression Is Associated with Inferior Survival in Myelodysplastic Syndromes

Association of Azacitidine and Lenalidomide (Combined vs Sequential Treatment) in High-Risk Myelodysplastic Syndromes. Final Results of a Randomized Phase II Multicenter Study

Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation

Novel Evidence That, in Addition to Proteolytic Enzymes, Lipolytic Enzymes Are Involved in Mobilization of Hematopoietic Stem/Progenitor Cells (HSPCs) - an Important Pro-Mobilizing Role Identified for Hematopoietic-Specific Phospholipase C (PLCβ2)

Gβ1 a Component Of The Heterotrimeric G Protein Is a New Protein Phosphatase 1c Interacting Protein That Regulates Platelet Activation

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American Society of Hematology

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American Society of Hematology

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