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Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu

Blood (2021) 138 (2): 178–189.

https://doi.org/10.1182/blood.2020009345

Published: 2021

Includes: Supplemental data

Journal Articles

FXII inhibition: multipronged benefits

Helen Philippou

Blood (2021) 138 (2): 107–109.

https://doi.org/10.1182/blood.2021011032

Published: 2021

Journal Articles

Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways

Denis F. Noubouossie, Michael W. Henderson, Micah Mooberry, Anton Ilich, Patrick Ellsworth, Mark Piegore, Sarah C. Skinner, Rafal Pawlinski, Ian Welsby, Thomas Renné, Maureane Hoffman, Dougald M. Monroe, Nigel S. Key

Blood (2020) 135 (10): 755–765.

https://doi.org/10.1182/blood.2019001643

Published: 2020

Includes: Supplemental data

Journal Articles

Protease activity in single-chain prekallikrein

Ivan Ivanov, Ingrid M. Verhamme, Mao-fu Sun, Bassem Mohammed, Qiufang Cheng, Anton Matafonov, S. Kent Dickeson, Kusumam Joseph, Allen P. Kaplan, David Gailani

Blood (2020) 135 (8): 558–567.

https://doi.org/10.1182/blood.2019002224

Published: 2020

Includes: Supplemental data

Journal Articles

High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice

Michael Wayne Henderson, MSc, Erica Sparkenbaugh, PhD BS, Denis Noubouossie, MD PhD, Reiner Mailer, Thomas Renne, MD PhD, Keith R McCrae, MD, Nigel S. Key, MBChB, FRCP, Rafal Pawlinski, PhD

Blood (2019) 134 (Supplement_1): 3621.

https://doi.org/10.1182/blood-2019-127206

Published: 2019

Journal Articles

Heavy chain of FXII: not an innocent bystander!

Helen Philippou

Blood (2019) 133 (10): 1008–1009.

https://doi.org/10.1182/blood-2019-01-895110

Published: 2019

Journal Articles

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivan Ivanov, Anton Matafonov, Mao-fu Sun, Bassem M. Mohammed, Qiufang Cheng, S. Kent Dickeson, Suman Kundu, Ingrid M. Verhamme, Andras Gruber, Keith McCrae, David Gailani

Blood (2019) 133 (10): 1152–1163.

https://doi.org/10.1182/blood-2018-06-860270

Published: 2019

Includes: Supplemental data

Journal Articles

High Molecular Weight Kininogen Contributes to End-Organ Damage and Mortality in a Mouse Model of Sickle Cell Disease

Erica Sparkenbaugh, PhD BS, Kathryn Wilson, BS, Malgorzata Kasztan, PhD, David M. Pollock, PhD, Keith R. McCrae, MD, Rafal Pawlinski, PhD

Blood (2018) 132 (Supplement 1): 268.

https://doi.org/10.1182/blood-2018-99-116526

Published: 2018

Journal Articles

Coagulation Factor XII Plays an Important Role in Procoagulant Activity of Apoptotic Cells

Aizhen Yang, Yi Wu, MD PhD

Blood (2018) 132 (Supplement 1): 2457.

https://doi.org/10.1182/blood-2018-99-118223

Published: 2018

Journal Articles

Interrogation of the Coagulation Cascade Acute Coronary Syndrome Using Novel Elisa-Based Assays for Single Protease Quantification

Jens Posma, MSc, Rene van Oerle, Diane Fens, Jose govers Riemslag, PhD, Julia Mueller, PhD, Stefan Heitmeier, PhD, Hugo ten Cate, MD PhD, Henri M.H. Spronk, PhD

Blood (2018) 132 (Supplement 1): 5013.

https://doi.org/10.1182/blood-2018-99-118353

Published: 2018

Journal Articles

Supra-Physiological Concentrations of C1 Esterase Inhibitor Enhance Thrombin Generation in the Presence of Thrombomodulin

Ivan Tarandovskiy, PhD, Paul Buehler, Ph. D., Elena Karnaukhova

Blood (2017) 130 (Supplement 1): 2353.

https://doi.org/10.1182/blood.V130.Suppl_1.2353.2353

Published: 2017

Journal Articles

Comparison of FXII Activation in Human Plasma By Extracellular Vesicles from Cancer Cells Versus Non-Transformed Cells

Dewen You, PhD, Victor Chatterjee, MD, Suman Kundu, MBA, Mohamed Samour, MBBS, Alvin H. Schmaier, MD, Alok A. Khorana, MD, Keith McCrae, MD

Blood (2017) 130 (Supplement 1): 3705.

https://doi.org/10.1182/blood.V130.Suppl_1.3705.3705

Published: 2017

Journal Articles

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

Ivan Ivanov, Anton Matafonov, Mao-fu Sun, Qiufang Cheng, S. Kent Dickeson, Ingrid M. Verhamme, Jonas Emsley, David Gailani

Blood (2017) 129 (11): 1527–1537.

https://doi.org/10.1182/blood-2016-10-744110

Published: 2017

Includes: Supplemental data

Journal Articles

FXIIa Differentially Regulates Thrombin Generation during Steady State and Vaso-Occlusive Crisis in Sickle Cell Mice

Erica M Sparkenbaugh, PhD, Camille Faes, PhD, Denis Noubouossie, MD PhD, Daniel K. Kirchhofer, PhD, András Gruber, MD, Nigel S. Key, MB, ChB, Rafal Pawlinski, PhD

Blood (2016) 128 (22): 162.

https://doi.org/10.1182/blood.V128.22.162.162

Published: 2016

Journal Articles

Proteolytic Inactivation of ADAMTS13 By Activated Factor XI

Kathleen Garland, MD, Owen J.T. McCarty, PhD, Cristina Puy, PhD

Blood (2016) 128 (22): 4955.

https://doi.org/10.1182/blood.V128.22.4955.4955

Published: 2016

Journal Articles

Histone H4-Induced Thrombin Generation in Fresh and "Reconstituted" Blood

Saulius Butenas, PhD, Shannon M Prior, BS, Kenneth G. Mann, PhD

Blood (2015) 126 (23): 3494.

https://doi.org/10.1182/blood.V126.23.3494.3494

Published: 2015

Journal Articles

Discovery and Characterization of a Highly Specific Antibody Inhibitor of Factor XIIa, and the Subsequent Generation of a Factor XIIa/Plasma Kallikrein Bispecific Antibody

Blood (2015) 126 (23): 2268.

https://doi.org/10.1182/blood.V126.23.2268.2268

Published: 2015

Journal Articles

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat ( Desmodus rotundus ) inhibits inflammation and thrombosis in vivo

Dongying Ma, Daniella M. Mizurini, Teresa C. F. Assumpção, Yuan Li, Yanwei Qi, Michail Kotsyfakis, José M. C. Ribeiro, Robson Q. Monteiro, Ivo M. B. Francischetti

Blood (2013) 122 (25): 4094–4106.

https://doi.org/10.1182/blood-2013-08-517474

Published: 2013

Includes: Supplemental data

Journal Articles

Development Of a Serum Biomarker Panel That Predicts Imminent Risk Of Multiple Myeloma (MM) Progression From Premalignancy

A Kate Sasser, PhD, Tineke Casneuf, PhD, Dhammika Amaratunga, PhD, Volha Tryputsen, PhD, Shaji K Kumar, MD, Vincent Rajkumar, MD, Brett Hall

Blood (2013) 122 (21): 3115.

https://doi.org/10.1182/blood.V122.21.3115.3115

Published: 2013

Journal Articles

Induction of Endothelial Cell Apoptosis by Cleaved High Molecular Weight Kininogen Is Mediated Through a Lck and p53-Dependent Pathway

Venkaiah Betapudi, Ph.D., Keith R. McCrae, MD

Blood (2012) 120 (21): 3305.

https://doi.org/10.1182/blood.V120.21.3305.3305

Published: 2012

NARROW

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

FXII inhibition: multipronged benefits

Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways

Protease activity in single-chain prekallikrein

High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice

Heavy chain of FXII: not an innocent bystander!

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

High Molecular Weight Kininogen Contributes to End-Organ Damage and Mortality in a Mouse Model of Sickle Cell Disease

Coagulation Factor XII Plays an Important Role in Procoagulant Activity of Apoptotic Cells

Interrogation of the Coagulation Cascade Acute Coronary Syndrome Using Novel Elisa-Based Assays for Single Protease Quantification

Supra-Physiological Concentrations of C1 Esterase Inhibitor Enhance Thrombin Generation in the Presence of Thrombomodulin

Comparison of FXII Activation in Human Plasma By Extracellular Vesicles from Cancer Cells Versus Non-Transformed Cells

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

FXIIa Differentially Regulates Thrombin Generation during Steady State and Vaso-Occlusive Crisis in Sickle Cell Mice

Proteolytic Inactivation of ADAMTS13 By Activated Factor XI

Histone H4-Induced Thrombin Generation in Fresh and "Reconstituted" Blood

Discovery and Characterization of a Highly Specific Antibody Inhibitor of Factor XIIa, and the Subsequent Generation of a Factor XIIa/Plasma Kallikrein Bispecific Antibody

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat ( Desmodus rotundus ) inhibits inflammation and thrombosis in vivo

Development Of a Serum Biomarker Panel That Predicts Imminent Risk Of Multiple Myeloma (MM) Progression From Premalignancy

Induction of Endothelial Cell Apoptosis by Cleaved High Molecular Weight Kininogen Is Mediated Through a Lck and p53-Dependent Pathway

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American Society of Hematology

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American Society of Hematology

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