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Journal Articles

Structural Basis of Vitamin K Antagonism

Weikai Li, PhD, Shixuan Liu, Shuang Li

Blood (2019) 134 (Supplement_1): 482.

https://doi.org/10.1182/blood-2019-127324

Published: 2019

Journal Articles

Detection of Multiple Recurrent Novel BCL2 Mutations Co-Occurring with BCL2 Gly101Val in Patients with Chronic Lymphocytic Leukemia on Long Term Venetoclax

Piers Blombery, MBBS, Ella Thompson, PhD BSc, Tamia Nguyen, Xiangting Chen, PhD, Michelle McBean, Richard W Birkinshaw, PhD, Peter E Czabotar, PhD, Rachel Thijssen, Mary Ann Anderson, MBBS, PhD FRACP, FRCPA, John F. Seymour, MBBS, PhD FRACP, David Alan Westerman, MBBS, FRCPA, FRACP, David C.S. Huang, MBBS MRCP PhD, Andrew W. Roberts, MBBS, PhD

Blood (2019) 134 (Supplement_1): 171.

https://doi.org/10.1182/blood-2019-125457

Published: 2019

Journal Articles

Identification of Tractable Drug-like eIF4Al Inhibitors with Potent Anti-Tumor Activity

Tyler A. Cunningham, BS, Derek Essegian, BS, MS, Stephan Schürer, PhD, Jonathan H. Schatz, MD

Blood (2019) 134 (Supplement_1): 5760.

https://doi.org/10.1182/blood-2019-130494

Published: 2019

Journal Articles

A Small Molecule Inhibitor of Protein Tyrosine Phosphatase-Sigma (PTPσ) Promotes Hematopoietic Stem Cell (HSC) Regeneration

Yurun Zhang, Mamle Quarmyne, PhD, Heather A Himburg, PhD, Xiao Yan, William McBride, PhD, Michael Jung, PhD, John P. Chute, MD

Blood (2016) 128 (22): 822.

https://doi.org/10.1182/blood.V128.22.822.822

Published: 2016

Journal Articles

The JAK1/2 Inhibitor Momelotinib Does Not Inhibit Thiamine Uptake in Vitro

Marilyn Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, Andy Whitney, Irene Lepist, Adrian Ray

Blood (2015) 126 (23): 4099.

https://doi.org/10.1182/blood.V126.23.4099.4099

Published: 2015

Journal Articles

Identification of a First in Class GSK3-Alpha Selective Inhibitor As a New Differentiation Therapy for AML

Lina Benajiba, Florence Wagner, PhD, Linda Ross, PhD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Jennifer Gale, Jen Pan, PhD, Yan-Lin Zhang, PhD, Joshua Sacher, PhD, Michel Weiwer, PhD, Richard M. Stone, MD, Edward Holson, PhD, Kimberly Stegmaier, MD

Blood (2015) 126 (23): 870.

https://doi.org/10.1182/blood.V126.23.870.870

Published: 2015

Journal Articles

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

Osheiza Abdulmalik, DVM, MS, Tanvi Deshpande, MS, Mohini Ghatge, PhD, Yan Zhang, PhD, Jurgen Venitz, MDPhD, Apurvasena Parikh, PhD, Martin K. Safo, PhD

Blood (2014) 124 (21): 218.

https://doi.org/10.1182/blood.V124.21.218.218

Published: 2014

Journal Articles

Liganded Hb ζ 2 β S 2 Exhibits Antipolymer Activity Despite a T-like Quaternary Structure

Martin K. Safo, PhD, J. Eric Russell, MD

Blood (2014) 124 (21): 4062.

https://doi.org/10.1182/blood.V124.21.4062.4062

Published: 2014

Journal Articles

Mutation in Retinoic X Receptor-γ Is a Possible Mechanism of All-Trans Retinoic Acid Resistance in Acute Promyelocytic Leukemia(APL): Identifying Genetic Changes Related to Drug Resistance in APL Using Whole Exome Sequencing

Jeonghwan Youk, MD, Youngil Koh, MD, Hyunkyung Park, Dae-Yoon Kim, Chan-Soo Lee, Junglim Lee, MD, Hyo Jung Kim, MD PhD, Hwi-Joong Yoon, MD PhD, Kwang-Sung Ahn, PhD, Jong-Sun Jung, PhD, Inho Kim, MD PhD, Seonyang Park, MD PhD, Sung-Soo Yoon, MD PhD

Blood (2014) 124 (21): 2358.

https://doi.org/10.1182/blood.V124.21.2358.2358

Published: 2014

Journal Articles

NS-018, a Selective JAK2V617F Inhibitor, Improves JAK2V617F-Induced Murine Myelofibrosis Without Decreasing The Erythrocyte Or Platelet Count

Yohei Nakaya, Kotaro Shide, MD, PhD, Haruna Naito, PhD, Tomoko Niwa, PhD, Tatsuya Horio, Jun Miyake, PhD, Kazuya Shimoda, MD, PhD

Blood (2013) 122 (21): 3847.

https://doi.org/10.1182/blood.V122.21.3847.3847

Published: 2013

Journal Articles

The Proteasomal Inhibitor Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity.

Biyin Cao, MD, PhD, Mingyun Shen, Mr., Depei Wu, Jianhong Du, MD, Jingyu Zhu, Suning Chen, Aining Sun, Xiaowen Tang, MD, PhD, Zhuan Xu, Yan Kong, MD. PhD, Xinliang Mao, MD, PhD

Blood (2012) 120 (21): 2449.

https://doi.org/10.1182/blood.V120.21.2449.2449

Published: 2012

Journal Articles

Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity

Marc N. Offman, Marcin Krol, Naina Patel, Shekhar Krishnan, JiZhong Liu, Vaskar Saha, Paul A. Bates

Blood (2011) 117 (5): 1614–1621.

https://doi.org/10.1182/blood-2010-07-298422

Published: 2011

Includes: Supplemental data

Journal Articles

Increased Platelet Binding of NN1731, a Factor VIIa Variant with Enhanced Tissue Factor-Independent Activity.

Maureane R. Hoffman, MD, PhD, Egon Persson, PhD, Mirella Ezban, Dougald M. Monroe, III, PhD

Blood (2010) 116 (21): 1133.

https://doi.org/10.1182/blood.V116.21.1133.1133

Published: 2010

Journal Articles

Enhanced SH3:Linker Interaction Suppresses Activating Mutations of the c-Abl Protein-Tyrosine Kinase.

Shoghag Panjarian, Shugui Chen, John Engen, Thomas Smithgall

Blood (2010) 116 (21): 1208.

https://doi.org/10.1182/blood.V116.21.1208.1208

Published: 2010

Journal Articles

Virtual and Physical Analysis of the Proximal T Cell Signalosome Reveals PP2A Inhibition Is Important for Co-Stimulatory Function of Immunomodulatory (IMiD) Drugs

Jessica M. McDaniel, BS, Kenyon G. Daniel, PhD, Fred Luhder, PhD, Sheng Wei, MD, Richard Tanner, MPH, Danielle Grams, Alan F. List, MD, P.K. Epling-Burnette, PharmD, PhD

Blood (2010) 116 (21): 281.

https://doi.org/10.1182/blood.V116.21.281.281

Published: 2010

Journal Articles

Identification of Two Novel Mutations in the CYB5R3 Gene in Five Cases of Type I Methemoglobinemia

Felipe R. Lorenzo, V, MD, PhD, Roberto H Nussenzveig, PhD, John D Phillips, PhD, Stanley L. Schrier, MD, Josef T. Prchal, MD

Blood (2008) 112 (11): 3854.

https://doi.org/10.1182/blood.V112.11.3854.3854

Published: 2008

Journal Articles

Molecular Basis Explanation of Imatinib Resistance of Bcr-Abl Due to T315I and P-Loop Mutations from Molecular Dynamics Simulations.

Tai-Sung Lee, Steven Potts, Hagop Kantarjian, M.D., Jorge Cortes, M.D., Francis Giles, M.D., Maher Albitar, M.D.

Blood (2007) 110 (11): 2917.

https://doi.org/10.1182/blood.V110.11.2917.2917

Published: 2007

Journal Articles

Inhibition of Nitric Oxide Synthase (NOS) 1, NOS2, and NOS3 Enzymatic Activities by Vitamin B 12 and Related Corrins: Biochemical and Molecular Modeling Studies.

J. Brice Weinberg, MD, Youwei Chen, MD, John C. Salerno, PhD, Dipak K. Ghosh, PhD

Blood (2007) 110 (11): 2663.

https://doi.org/10.1182/blood.V110.11.2663.2663

Published: 2007

Journal Articles

Variants of Recombinant Factor IX with Enhanced Functional Properties.

Rudolf Hartmann, PhD, Michael Dockal, PhD, Willibald Kammlander, Erwin Panholzer, Friedrich Scheiflinger, PhD

Blood (2007) 110 (11): 2694.

https://doi.org/10.1182/blood.V110.11.2694.2694

Published: 2007

Journal Articles

A Novel In-Frame Deletion in Domain C1 of Factor V Gene Results in Profound Decrease in Factor V Activity.

Jaewoo Song, MD, Hyun-Sook Kim, MD, PhD, Singyoung Kim, Jong-Rak Choi, MD, PhD, Yoo-Hong Min, MD, PhD, Ki-Yung Kwon, MD, PhD, Jong-Ha Yoo, MD

Blood (2007) 110 (11): 2151.

https://doi.org/10.1182/blood.V110.11.2151.2151

Published: 2007

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Structural Basis of Vitamin K Antagonism

Detection of Multiple Recurrent Novel BCL2 Mutations Co-Occurring with BCL2 Gly101Val in Patients with Chronic Lymphocytic Leukemia on Long Term Venetoclax

Identification of Tractable Drug-like eIF4Al Inhibitors with Potent Anti-Tumor Activity

A Small Molecule Inhibitor of Protein Tyrosine Phosphatase-Sigma (PTPσ) Promotes Hematopoietic Stem Cell (HSC) Regeneration

The JAK1/2 Inhibitor Momelotinib Does Not Inhibit Thiamine Uptake in Vitro

Identification of a First in Class GSK3-Alpha Selective Inhibitor As a New Differentiation Therapy for AML

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

Liganded Hb ζ 2 β S 2 Exhibits Antipolymer Activity Despite a T-like Quaternary Structure

Mutation in Retinoic X Receptor-γ Is a Possible Mechanism of All-Trans Retinoic Acid Resistance in Acute Promyelocytic Leukemia(APL): Identifying Genetic Changes Related to Drug Resistance in APL Using Whole Exome Sequencing

NS-018, a Selective JAK2V617F Inhibitor, Improves JAK2V617F-Induced Murine Myelofibrosis Without Decreasing The Erythrocyte Or Platelet Count

The Proteasomal Inhibitor Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity.

Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity

Increased Platelet Binding of NN1731, a Factor VIIa Variant with Enhanced Tissue Factor-Independent Activity.

Enhanced SH3:Linker Interaction Suppresses Activating Mutations of the c-Abl Protein-Tyrosine Kinase.

Virtual and Physical Analysis of the Proximal T Cell Signalosome Reveals PP2A Inhibition Is Important for Co-Stimulatory Function of Immunomodulatory (IMiD) Drugs

Identification of Two Novel Mutations in the CYB5R3 Gene in Five Cases of Type I Methemoglobinemia

Molecular Basis Explanation of Imatinib Resistance of Bcr-Abl Due to T315I and P-Loop Mutations from Molecular Dynamics Simulations.

Inhibition of Nitric Oxide Synthase (NOS) 1, NOS2, and NOS3 Enzymatic Activities by Vitamin B 12 and Related Corrins: Biochemical and Molecular Modeling Studies.

Variants of Recombinant Factor IX with Enhanced Functional Properties.

A Novel In-Frame Deletion in Domain C1 of Factor V Gene Results in Profound Decrease in Factor V Activity.

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