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Journal Articles

Hexokinase-2 Regulates Hypoxia-Inducible Autophagy, Leading to Enhance Anti-Apoptotic Capability of Refractory Multiple Myeloma

Sho Ikeda, MD PhD, Fumito Abe, MD PhD, Matsuda Yuka, Akihiro Kitadate, MD PhD, Takahiro Kobayashi, MD PhD, Naoto Takahashi, MD PhD, Hiroyuki Tagawa, MD PhD

Blood (2019) 134 (Supplement_1): 1787.

https://doi.org/10.1182/blood-2019-123360

Published: 2019

Journal Articles

Acute Inflammation Induces Lactate Release By Bone Marrow Neutrophils That Promotes Their Mobilization Via Endothelial GPR81 Signaling

Eman Khatib-Massalha, MSc, Suditi Bhattacharya, MSc, Hassan Massalha, PhD, Karin Golan, PhD, Orit Kollet, PhD, Anju Kumari, PhD, Francesca Avemaria, PhD, Tomer Itkin, PhD, Shiri Gur-Cohen, PhD, Abraham Avigdor, MD, Shalev Itzkovitz, PhD, Stefan Offermanns, MD PhD, Amiram Ariel, PhD, Ronen Alon, PhD, Tsvee Lapidot, PhD

Blood (2019) 134 (Supplement_1): 3582.

https://doi.org/10.1182/blood-2019-123248

Published: 2019

Journal Articles

Decreased Activity and Stability of Pyruvate Kinase in Hereditary Hemolytic Anemia: A Potential Target for Therapy By AG-348 (Mitapivat), an Allosteric Activator of Red Blood Cell Pyruvate Kinase

Minke A.E. Rab, MD, Brigitte A. van Oirschot, Stephanie van Straaten, MD PhD, Bart J. Biemond, MD PhD, Jennifer Bos, Penelope A. Kosinski, MS, Charles Kung, PhD, Eduard J. van Beers, MD PhD, Richard van Wijk, PhD

Blood (2019) 134 (Supplement_1): 3506.

https://doi.org/10.1182/blood-2019-129996

Published: 2019

Journal Articles

Pyruvate Kinase (PK) Protein and Enzyme Levels in the Diagnosis and Clinical Phenotype of PK Deficiency

Kathryn Addonizio, BA, Hanny Al-Samkari, MD, Bertil Glader, MD PhD, D Holmes Morton, MD, Satheesh Chonat, MD, Alexis A. Thompson, MD MPH, Kevin H. M. Kuo, MDMSc,FRCPC, Yaddanapudi Ravindranath, MBBS, Heng Wang, MD PhD, Jennifer A. Rothman, MD, Janet L. Kwiatkowski, MD MSCE, Charles Kung, PhD, Penelope A. Kosinski, MS, Hasan Al-Sayegh, MS, Wendy B. London, PhD, Rachael F. Grace, MD

Blood (2019) 134 (Supplement_1): 3515.

https://doi.org/10.1182/blood-2019-125248

Published: 2019

Journal Articles

Activated but Not Quiescent Hematopoietic Stem Cells Rely Readily on Glycolysis As Their Main Source of Energy

Tasleem Arif, PhD, Raymond Liang, PhD, Maio Lin, Msc, Svetlana Kalmikova, Msc, Artem Kasianov, PhD, Vijay Menon, PhD, Dmitri Papatsenko, PhD, Saghi Ghaffari, PhD MD

Blood (2019) 134 (Supplement_1): 271.

https://doi.org/10.1182/blood-2019-129099

Published: 2019

Journal Articles

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Cheuk-Him Man, David T. Scadden, MD, Francois Mercier, MD FRCPC, Nian Liu, Wentao Dong, Gregory Stephanopoulos, PhD, Li Jiang, PhD, Yookyung Jung, PhD, Charles Lin, PhD, Anskar Y.-H. Leung, MD PhD

Blood (2019) 134 (Supplement_1): 3765.

https://doi.org/10.1182/blood-2019-123604

Published: 2019

Journal Articles

Hexokinase II Expression As a Prognosis Marker in Diffuse Large B-Cell Lymphoma (DLBCL) Pre- and Post- the Incorporation of Rituximab to Standard CHOP Chemotherapy

Juan J. Gu, MD PhD, Yizhen Liu, MD PhD, Jia Jin, Ling Yang, Zuguang Xia, Xiaojian Liu, Fangfang Lv, MD, Francisco J. Hernandez-Ilizaliturri, MD, Xiaonan Hong, Junning Cao, MD, Qunling Zhang, MD PhD

Blood (2019) 134 (Supplement_1): 5233.

https://doi.org/10.1182/blood-2019-128878

Published: 2019

Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Geethu Emily Thomas, PhDMSc,BSc, Grace Egan, MD, Laura Garcia Prat, Boaz Nachmias, MD PhD, Jordan M Chin, Fieke W Hoff, BSc, Kerstin Kaufmann, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Neil MacLean, Xiaoming Wang, Veronique Voisin, PhD, Aaron Botham, Andrea Arruda, Mark D. Minden, MD PhD, Gary D Bader, Steven M. Kornblau, MD, John E. Dick, PhD, Aaron D Schimmer, MD PhD

Blood (2019) 134 (Supplement_1): 2532.

https://doi.org/10.1182/blood-2019-123121

Published: 2019

Journal Articles

B-Cell Receptor Signaling Drives Glycolysis in Chronic Lymphocytic Leukemia Cells

Andrew James Clear, BSc, Annalisa D'Avola, PhD, Samir G. Agrawal, BSc, PhD MBChB, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, John G. Gribben, John Riches, MD PhD

Blood (2018) 132 (Supplement 1): 3121.

https://doi.org/10.1182/blood-2018-99-112860

Published: 2018

Journal Articles

Pirna-30473 Contributes to Tumorigenesis By Regulating RNA m6A Methylation in DLBCL

Bingzong Li, MD PhD, Huiying Han, Sha Song, Gao Fan, Nengjun Yi, Chen'ao Qian, Wenzhuo Zhuang, MD PhD

Blood (2018) 132 (Supplement 1): 2835.

https://doi.org/10.1182/blood-2018-99-114292

Published: 2018

Journal Articles

Hexokinase Proteins Impart Distinct Functions in Myeloid Development and Cell Death

Kristina Seiler, MD, Petra Minder, PhD, Iris Mashimo, Magali Humbert, PhD, Elizabeth Simpson, Mario P. Tschan, PhD, Bruce E. Torbett, PhD

Blood (2018) 132 (Supplement 1): 5088.

https://doi.org/10.1182/blood-2018-99-112145

Published: 2018

Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Geethu Thomas, PhD MSc, BSc, Laura Garcia Prat, Marcela Gronda, MSc, Rose Hurren, BSc, Neil MacLean, Xiaoming Wang, Botham Aaron, John E. Dick, Aaron D Schimmer, MD PhD

Blood (2018) 132 (Supplement 1): 2795.

https://doi.org/10.1182/blood-2018-99-110021

Published: 2018

Journal Articles

Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1

Kei Nakajima, Keita Kirito, MD, Ichiro Kawashima, Megumi Koshiishi, Takuma Kumagai, Toru Mitsumori

Blood (2017) 130 (Supplement 1): 4025.

https://doi.org/10.1182/blood.V130.Suppl_1.4025.4025

Published: 2017

Journal Articles

Low expression of hexokinase-2 is associated with false-negative FDG–positron emission tomography in multiple myeloma

Blood (2017) 130 (1): 30–34.

https://doi.org/10.1182/blood-2017-03-774422

Published: 2017

Includes: Supplemental data

Journal Articles

Two Novel Mutations in Ribosomal Proteins in the Czech National Diamond-Blackfan Anemia Registry

Zuzana Maceckova, MSc, Pavla Koralkova, MSc, Jana Volejnikova, MD PhD, Petr Vojta, MSc, Alexandra Jungova, MD, Zuzana Saxova, MSc, Renata Mojzikova, MSc, PhD, Marie Jarosova, MSc PhD, Ivana Hadacova, MD, Marian Hajduch, MD PhD, Monika Horvathova, MSc, PhD, Dagmar Pospisilova, MD PhD

Blood (2016) 128 (22): 3903.

https://doi.org/10.1182/blood.V128.22.3903.3903

Published: 2016

Journal Articles

JQ1, a c-MYC Inhibitor Targets Hexokinase II and Enhances the Cytotoxic Effects of Chemotherapeutic Agents in Diffuse Large B-Cell Lymphoma (DLBCL)

Juan J Gu, PhD, Matthew J. Barth, MD, Qunling Zhang, MD PhD, Cory Mavis, MSc, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2016) 128 (22): 5378.

https://doi.org/10.1182/blood.V128.22.5378.5378

Published: 2016

Journal Articles

Itraconazole, an Oral Antifungal Drug, Is Active in Chemotherapy Resistant B-Cell Non-Hodgkin Lymphoma and Enhances the Anti-Tumor Activity of Chemotherapy Agents

Juan J Gu, PhD, Lianjuan Yang, MD, Cory Mavis, MSc, Matthew J. Barth, MD, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2016) 128 (22): 5138.

https://doi.org/10.1182/blood.V128.22.5138.5138

Published: 2016

Journal Articles

Hyperbaric Oxygen Increases Sensitivity to Chemotherapy in Acute Leukemia

Tara L. Lin, MD, Amanda Wise, MS, Abigale Berry, Joseph Fontes, PhD, Partha Kasturi, PhD, Brea C. Lipe, MD, Omar S. Aljitawi, MD

Blood (2015) 126 (23): 1399.

https://doi.org/10.1182/blood.V126.23.1399.1399

Published: 2015

Journal Articles

Identification of CKMT1B As a New Target in EVI1-Positive AML

Alexandre Puissant, PhD, Nina Fenouille, PhD, Christopher F. Bassil, BA, Issam Ben-Sahra, PhD, Gabriela Alexe, PhD, Lina Benajiba, Azucena Ramos, Yana Pikman, MD, Michael R. Burgess, MD PhD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Richard M. Stone, MD, Kevin Shannon, MD, Michael T. Hemann, PhD, Kimberly Stegmaier, MD

Blood (2015) 126 (23): 3674.

https://doi.org/10.1182/blood.V126.23.3674.3674

Published: 2015

Journal Articles

Hypoxia-Inducible Factor (HIF)-1alpha Inhibitionin Myeloma Cells Significantly Increases the Anti-Myeloma Effect of Lenalidomide in Vivo

Paola Storti, PhD, Valentina Marchica, Denise Toscani, PhD, Irma Airoldi, PhD, Sophie Maiga, PhD, Marina Bolzoni, PhD, Nicoletta Campanini, Eugenia Martella, MD, Cristina Mancini, MD, Valentina Ferri, Gaetano Donofrio, PhD, Martine Amiot, PhD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2015) 126 (23): 3012.

https://doi.org/10.1182/blood.V126.23.3012.3012

Published: 2015

NARROW

Hexokinase-2 Regulates Hypoxia-Inducible Autophagy, Leading to Enhance Anti-Apoptotic Capability of Refractory Multiple Myeloma

Acute Inflammation Induces Lactate Release By Bone Marrow Neutrophils That Promotes Their Mobilization Via Endothelial GPR81 Signaling

Decreased Activity and Stability of Pyruvate Kinase in Hereditary Hemolytic Anemia: A Potential Target for Therapy By AG-348 (Mitapivat), an Allosteric Activator of Red Blood Cell Pyruvate Kinase

Pyruvate Kinase (PK) Protein and Enzyme Levels in the Diagnosis and Clinical Phenotype of PK Deficiency

Activated but Not Quiescent Hematopoietic Stem Cells Rely Readily on Glycolysis As Their Main Source of Energy

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Hexokinase II Expression As a Prognosis Marker in Diffuse Large B-Cell Lymphoma (DLBCL) Pre- and Post- the Incorporation of Rituximab to Standard CHOP Chemotherapy

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

B-Cell Receptor Signaling Drives Glycolysis in Chronic Lymphocytic Leukemia Cells

Pirna-30473 Contributes to Tumorigenesis By Regulating RNA m6A Methylation in DLBCL

Hexokinase Proteins Impart Distinct Functions in Myeloid Development and Cell Death

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1

Low expression of hexokinase-2 is associated with false-negative FDG–positron emission tomography in multiple myeloma

Two Novel Mutations in Ribosomal Proteins in the Czech National Diamond-Blackfan Anemia Registry

JQ1, a c-MYC Inhibitor Targets Hexokinase II and Enhances the Cytotoxic Effects of Chemotherapeutic Agents in Diffuse Large B-Cell Lymphoma (DLBCL)

Itraconazole, an Oral Antifungal Drug, Is Active in Chemotherapy Resistant B-Cell Non-Hodgkin Lymphoma and Enhances the Anti-Tumor Activity of Chemotherapy Agents

Hyperbaric Oxygen Increases Sensitivity to Chemotherapy in Acute Leukemia

Identification of CKMT1B As a New Target in EVI1-Positive AML

Hypoxia-Inducible Factor (HIF)-1alpha Inhibitionin Myeloma Cells Significantly Increases the Anti-Myeloma Effect of Lenalidomide in Vivo

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American Society of Hematology

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American Society of Hematology

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