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Journal Articles

Combinatorial Genetics Uncovers Novel Targets for the Treatment of Npm1/Cohesin Mutated AML

Alison E Meyer, PhD, Cary Stelloh, Joseph B Fisher, PhD, Kirthi Pulakanti, George S. Vassiliou, FRCPath, MRCP, PhD, Aaron D Viny, MDMS, Ross L. Levine, MD, Sridhar Rao, MD PhD

Blood (2019) 134 (Supplement_1): 2515.

https://doi.org/10.1182/blood-2019-126042

Published: 2019

Journal Articles

VAV1 Mutations Contributes to the Development of T-Cell Malignancies in Mice

Kota Fukumoto, MD, Mamiko Sakata-Yanagimoto, MD PhD, Manabu Fujisawa, MD, Tatsuhiro Sakamoto, MD PhD, Tran B. Nguyen, Sakurako Suma, MD, Hiroaki Miyoshi, MD PhD, Koichi Ohshima, MD PhD, Keisuke Kataoka, MD PhD, Seishi Ogawa, MD PhD, Shigeru Chiba, MD PhD

Blood (2019) 134 (Supplement_1): 300.

https://doi.org/10.1182/blood-2019-124591

Published: 2019

Journal Articles

DOCK2 Expression Affects Leukemogenesis and Disease Progression in a Murine Model of FLT3/ITD Acute Myeloid Leukemia

Min Wu, PhD, Li Li, MD PhD, Donald Small, MD PhD, Amy S. Duffield, MD PhD

Blood (2019) 134 (Supplement_1): 2534.

https://doi.org/10.1182/blood-2019-129157

Published: 2019

Journal Articles

Role of Vav1 Genomic Alterations in T-Cell Differentiation and Transformation in Peripheral T-Cell Lymphoma

Jose Rodriguez Cortes, PhD, Anisha R. Cooke, Aidan Quinn, Ioan Filip, PhD, Juan Angel Patino, PhD, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD, Teresa Palomero, PhD

Blood (2019) 134 (Supplement_1): 1482.

https://doi.org/10.1182/blood-2019-129438

Published: 2019

Journal Articles

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Nicolas Nassar, PhD, Shailaja N Hegde, PhD, Anjelika Gasilina, Mark Wunderlich, MS, Gurdat Premnauth, Edward Merino, PhD, Yuan Lin, PhD, Reza Ahmadian, PhD, Yi Zheng, PhD, Benjamin Mizukawa, Lisa Privette Vinnedge, PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 4647.

https://doi.org/10.1182/blood-2019-130250

Published: 2019

Journal Articles

Unique dependence on Sos1 in Kras G12D -induced leukemogenesis

Xiaona You, Guangyao Kong, Erik A. Ranheim, David Yang, Yun Zhou, Jing Zhang

Blood (2018) 132 (24): 2575–2579.

https://doi.org/10.1182/blood-2018-09-874107

Published: 2018

Includes: Supplemental data

Journal Articles

UTX and MBD3 Epistasis Regulates Rac Gtpase Activation and Sensitizes Human Acute Myeloid Leukemia Cells to Dock Inhibition

Shankha Subhra Chatterjee, MSc, Mayukh Biswas, MSc, Liberalis Debraj Boila, MSc, Sayan Chakraborty, MSc, Sayantani Sinha, MSc, Debasis Banerjee, MD, Amitava Sengupta, PhD

Blood (2018) 132 (Supplement 1): 3880.

https://doi.org/10.1182/blood-2018-99-113843

Published: 2018

Journal Articles

Identifying ARHGEF12 As an Important Regulator of Erythropoiesis By Calculating Red Blood Cell Transfusion for Chemotherapy Induced Anemia and By Conditional Knockout Mouse Model

Yangyang Xie, Ruichi Wu, Li Gao, MD, Xiaoxiao Chen, Xiao-Jian Sun, PhD, Shuhong Shen, MD PhD

Blood (2018) 132 (Supplement 1): 3606.

https://doi.org/10.1182/blood-2018-99-117724

Published: 2018

Journal Articles

RGL4 over Expression Correlates with Variation in Midostaurin Response in FLT3-ITD Mutant AML Samples

Mara Rosenberg, BS, Cristina E. Tognon, PhD, Kevin M Watanabe-Smith, PhD, Uma Borate, MD

Blood (2018) 132 (Supplement 1): 1365.

https://doi.org/10.1182/blood-2018-99-120296

Published: 2018

Journal Articles

Downstream Pathway of AML1-ETO Targeted ARHGEF12 Might be Targetable for Rock Inhibitor to Improve Therapy Outcome

Yangyang Xie, Ruichi Wu, Xiaoxiao Chen, Xiao-Jian Sun, PhD, Shuhong Shen, MD PhD

Blood (2018) 132 (Supplement 1): 3914.

https://doi.org/10.1182/blood-2018-99-117845

Published: 2018

Journal Articles

DOCK2 Knockdown Mitigates Disease Progression in Murine Models Harboring a FLT3/ITD Mutation

Min Wu, PhD, Li Li, MD PhD, Bao Nguyen, MS, Donald Small, MD PhD, Amy S. Duffield, MD PhD

Blood (2017) 130 (Supplement 1): 1216.

https://doi.org/10.1182/blood.V130.Suppl_1.1216.1216

Published: 2017

Journal Articles

Calcium-Induced Conformational Changes in EF hands and Autoinhibitory Linker Region are Critical for Catalytic Activity of CalDAG-GEFI Towards the Small GTPase Rap1

Aaron Cook, Wei Deng, PhD, Renhao Li, PhD, John Sondek, PhD, Wolfgang Bergmeier, PhD

Blood (2017) 130 (Supplement 1): 3614.

https://doi.org/10.1182/blood.V130.Suppl_1.3614.3614

Published: 2017

Journal Articles

Prognostic Importance of DOCK1 Transcript Levels, and Biologic Insights from DOCK1 -Associated Gene and Microrna Expression Signatures in De Novo acute Myeloid Leukemia

Ya Zhang, MD, Ying Li, MD, Lingyan Zhang, MD, Xiaosheng Fang, MD, Changqing Zhen, MD, Xin Wang, MD PhD

Blood (2017) 130 (Supplement 1): 3952.

https://doi.org/10.1182/blood.V130.Suppl_1.3952.3952

Published: 2017

Journal Articles

RGL2 Deficiency Impairs Human Erythropoiesis By Altering Terminal Erythroid Differentiation and Apoptosis

Harry Lesmana, MD, Georgios E Christakopoulos, MD, Mary Risinger, Haripriya Sakthivel, Omar Niss, MD, Theodosia A. Kalfa, MD PhD

Blood (2017) 130 (Supplement 1): 8.

https://doi.org/10.1182/blood.V130.Suppl_1.8.8

Published: 2017

Journal Articles

Murine Studies to Test the Efficacy of Platelet Transfusions in the Management of Platelet Function Disorders

Raymond Piatt, BS, Robert Hugh Lee, PhD, David Paul, PhD, Wolfgang Bergmeier, PhD

Blood (2017) 130 (Supplement 1): 1123.

https://doi.org/10.1182/blood.V130.Suppl_1.1123.1123

Published: 2017

Journal Articles

Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding

Blood (2017) 130 (8): 1026–1030.

https://doi.org/10.1182/blood-2017-03-776773

Published: 2017

Includes: Supplemental data

Journal Articles

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Hisashi Kato, Yozo Nakazawa, Yumi Kurokawa, Hirokazu Kashiwagi, Yoichiro Morikawa, Daisuke Morita, Fumiaki Banno, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2016) 128 (23): 2729–2733.

https://doi.org/10.1182/blood-2016-03-704825

Published: 2016

Includes: Supplemental data

Journal Articles

Recurrent VAV1 Abnormalities in Angioimmunoblastic T Cell Lymphoma

Daisuke Komori, MS, Mamiko Sakata-Yanagimoto, MD PhD, Sharna Tanzima Nuhat, Doctor, Kota Fukumoto, MD, Manabu Fujisawa, MD, Shoko Nishizawa, MS, Kosei Matsue, MD PhD, Koji Izutsu, MD PhD, Naoya Nakamura, Kenichi Yoshida, MD PhD, Seishi Ogawa, MD PhD, Shigeru Chiba, MD, PhD

Blood (2016) 128 (22): 4104.

https://doi.org/10.1182/blood.V128.22.4104.4104

Published: 2016

Journal Articles

Comprehensive Analysis of the Structural, Biochemical and Signaling Differences of the p210 and p185 Isoforms of Bcr-Abl in CML and B-ALL

Oliver Hantschel, PhD, Sina Reckel, Hamelin Romain, Florence Armand, Delphine Harduin, Shohei Koide, Volker Dötsch, Marc Moniatte

Blood (2016) 128 (22): 4238.

https://doi.org/10.1182/blood.V128.22.4238.4238

Published: 2016

Journal Articles

Targeted Depletion of Amino Acids As a Novel Therapy for Acute Leukemia and Other Cancers: Mechanisms and Countermechanisms

Aysenur Esen, MD, Anwar A Khan, PhD, Jason Chan, Nadim Mahmud, MD PhD, John G. Quigley, MD

Blood (2016) 128 (22): 4716.

https://doi.org/10.1182/blood.V128.22.4716.4716

Published: 2016

NARROW

Combinatorial Genetics Uncovers Novel Targets for the Treatment of Npm1/Cohesin Mutated AML

VAV1 Mutations Contributes to the Development of T-Cell Malignancies in Mice

DOCK2 Expression Affects Leukemogenesis and Disease Progression in a Murine Model of FLT3/ITD Acute Myeloid Leukemia

Role of Vav1 Genomic Alterations in T-Cell Differentiation and Transformation in Peripheral T-Cell Lymphoma

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Unique dependence on Sos1 in Kras G12D -induced leukemogenesis

UTX and MBD3 Epistasis Regulates Rac Gtpase Activation and Sensitizes Human Acute Myeloid Leukemia Cells to Dock Inhibition

Identifying ARHGEF12 As an Important Regulator of Erythropoiesis By Calculating Red Blood Cell Transfusion for Chemotherapy Induced Anemia and By Conditional Knockout Mouse Model

RGL4 over Expression Correlates with Variation in Midostaurin Response in FLT3-ITD Mutant AML Samples

Downstream Pathway of AML1-ETO Targeted ARHGEF12 Might be Targetable for Rock Inhibitor to Improve Therapy Outcome

DOCK2 Knockdown Mitigates Disease Progression in Murine Models Harboring a FLT3/ITD Mutation

Calcium-Induced Conformational Changes in EF hands and Autoinhibitory Linker Region are Critical for Catalytic Activity of CalDAG-GEFI Towards the Small GTPase Rap1

Prognostic Importance of DOCK1 Transcript Levels, and Biologic Insights from DOCK1 -Associated Gene and Microrna Expression Signatures in De Novo acute Myeloid Leukemia

RGL2 Deficiency Impairs Human Erythropoiesis By Altering Terminal Erythroid Differentiation and Apoptosis

Murine Studies to Test the Efficacy of Platelet Transfusions in the Management of Platelet Function Disorders

Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Recurrent VAV1 Abnormalities in Angioimmunoblastic T Cell Lymphoma

Comprehensive Analysis of the Structural, Biochemical and Signaling Differences of the p210 and p185 Isoforms of Bcr-Abl in CML and B-ALL

Targeted Depletion of Amino Acids As a Novel Therapy for Acute Leukemia and Other Cancers: Mechanisms and Countermechanisms

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American Society of Hematology

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ASH Publications

American Society of Hematology

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