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Journal Articles

The Impact of Chemotherapeutic Agents on Signaling and Epigenetics in Vascular Endothelial Cells

Srila Gopal, MD, Amanda Creech, Adam Officer, Shawn Egri, Desiree Davison, Jacob D Jaffe, PhD, Iris Z Jaffe, MD PhD

Blood (2016) 128 (22): 1353.

https://doi.org/10.1182/blood.V128.22.1353.1353

Published: 2016

Journal Articles

Chemical Mutagenesis Screen Identifies Novel Drug Resistant JAK2 Variants in V617FJAK2 Mediated MPN and Predict HSP90 Inhibitors As Possible Agents to Overcome Drug Resistance

Sivahari Prasad Gorantla, PhD, Detlef Bentrop, PhD, Nikolas Bubnoff, MD, Anna Lena Illert, MD, Robert Zeiser, MD, Justus Duyster, MD

Blood (2015) 126 (23): 3687.

https://doi.org/10.1182/blood.V126.23.3687.3687

Published: 2015

Journal Articles

Heat Shock Protein 90 Inhibitor NVP-AUY922 Has Potent Anti-Tumor Activity With Adult T-Cell Leukemia-Lymphoma Cells

Hiroaki Taniguchi, MD, Hiroo Hasegawa, MD, PhD, Daisuke Sasaki, PhD, Koji Ando, MD, PhD, Yasushi Sawayama, MD, PhD, Yoshitaka Imaizumi, MD, PhD, Daisuke Imanishi, MD, PhD, Jun Taguchi, MD, PhD, Tomoko Hata, MD, PhD, Kunihiro Tsukasaki, MD, PhD, Katsunori Yanagihara, MD, PhD, Naoki Mori, MD, PhD, Yasushi Miyazaki, MD, PhD

Blood (2013) 122 (21): 1829.

https://doi.org/10.1182/blood.V122.21.1829.1829

Published: 2013

Journal Articles

Involvement Of S100 Proteins and Hsp90 In The Pathogenesis Of Graft-Versus-Host Disease After Allogeneic Hematopoetic Cell Transplantation

Katharina Reinhardt, Dirk Föll, MD, Thomas Vogl, PhD, Falko Fend, MD, Christian Gille, MD, Tobias Feuchtinger, MD, Peter Lang, MD, Rupert Handgretinger, Wolfgang A. Bethge, MD, Ursula Holzer, MD

Blood (2013) 122 (21): 2058.

https://doi.org/10.1182/blood.V122.21.2058.2058

Published: 2013

Journal Articles

Drug Screening Reveals That Ibrutinib (PCI-32765) Exhibits Synergy With BCL-2 and Proteasome Inhibitors In Models Of Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL)

L. Kyle Brett, MD, Mark Axelrod, PhD, Zhishuo Ou, MD, Liang Zhang, MD, PhD, Vicki Gordon, BS, Elyse R Lopez, Archito T. Tamayo, MS, Richard J. Ford, MD, PhD, Lan V Pham, PhD, Michael J. Weber, PhD, Michael E. Williams, MD, ScM, Michael Wang, MD

Blood (2013) 122 (21): 3080.

https://doi.org/10.1182/blood.V122.21.3080.3080

Published: 2013

Journal Articles

Synergistic Effect Of Nifurtimox and Inhibition Of Hsp70/Hsp90 In Treatment Of Neuroblastoma

Karin Melanie Rohrer, Gernot Bruchelt, PhD, Rupert Handgretinger, Ursula Holzer, MD

Blood (2013) 122 (21): 5567.

https://doi.org/10.1182/blood.V122.21.5567.5567

Published: 2013

Journal Articles

Combined Therapy With BRD4 Antagonist and FLT3 Inhibitor Exerts Synergistic Activity Against Cultured and Primary AML Blast Progenitors Expressing FLT-ITD

Melissa Rodriguez, M.D., Ph.D, Warren Fiskus, Ph.D, Sunil Sharma, MD, Jun Qi, PhD, John A Valenta, M.S., Leasha J Schaub, M.S., Bhavin Shah, Santhana Devaraj, Ph.D, Swaminathan Padmanabhan Iyer, MD, James E Bradner, MD, Kapil N. Bhalla, MD

Blood (2013) 122 (21): 3821.

https://doi.org/10.1182/blood.V122.21.3821.3821

Published: 2013

Journal Articles

A Phase I Trial of the Intravenous (IV) Hsp90 Inhibitor 17-DMAG (alvespimycin) in Patients (pts) with Relapsed Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Kami Maddocks, MD, Erin K Hertlein, PhD, Joseph M. Flynn, DO, MPH, Leslie A Andritsos, MD, Amy J. Wagner, Timothy L. Chen, Mitch A. Phelps, PhD, Michael R. Grever, MD, Amy J. Johnson, PhD, John C. Byrd, MD, Jeffrey A. Jones, MD, MPH

Blood (2012) 120 (21): 1800.

https://doi.org/10.1182/blood.V120.21.1800.1800

Published: 2012

Journal Articles

The Novel Anti-Myeloma Agent Chaetocin Enhances Tumor-Specific Dendritic Cell Response Via the Induction of Heat Shock Protein and Cancer Testis Antigens On Myeloma Cells

Thanh-Nhan Nguyen-Pham, Hyun Ju Lee, Huong Thi Thanh Tran, MD, PhD, Manh-cuong Vo, My-Dung Hoang, Nuri Choi, Hyeoung-Joon Kim, MD, PhD, Je-Jung Lee, MD, PhD

Blood (2012) 120 (21): 4066.

https://doi.org/10.1182/blood.V120.21.4066.4066

Published: 2012

Journal Articles

The Anti-Proliferative Effects of Hsp90 Inhibitor Tricyclic Coumarin GUT-70 and Geldanamycin Analog 17-DMAG in AML Cells in Hypoxia

Linhua Jin, PhD, Yoko Tabe, MD, PhD, Kensuke Kojima, MD, PhD, Vivian Ruvolo, Takashi Miida, MD, PhD, Michael Andreeff, M.D., Ph.D., Marina Konopleva, MD, PhD, Shinya Kimura, MD, PhD

Blood (2011) 118 (21): 2480.

https://doi.org/10.1182/blood.V118.21.2480.2480

Published: 2011

Journal Articles

Activity of Allosteric, Switch-Pocket, ABL/FLT3 Kinase Inhibitor DCC2036 Against Cultured and Primary AML Progenitors with FLT-ITD or FLT3 Kinase Domain Mutations

Warren Fiskus, BSc, PhD, Catherine C. Smith, MD, Jacqueline Smith, MS, Scott C. Wise, MS, Elisabeth Lasater, PhD, Lauren E. Damon, Sara Salerno, BS, Allan Fleming, MD, Ruben Reyes, MD, Siddhartha Ganguly, MD, Mark S. Berger, MD, Tom J. Rutkoski, Ph.D, Joseph McGuirk, DO, Neil Shah, MD, PhD, Kapil N. Bhalla, MD

Blood (2011) 118 (21): 2611.

https://doi.org/10.1182/blood.V118.21.2611.2611

Published: 2011

Journal Articles

The Anti-Proliferative Effects of Tricyclic Coumarin GUT-70 as An Hsp90 Inhibitor In Mantle Cell Lymphoma

Linhua Jin, PhD, Shinya Kimura, MD, PhD, Yixin Zhou, Junya Kuroda, MD, PhD, Hiroya Asou, MD, PhD, Toshiya Inaba, MD, PhD, Takashi Miida, MD, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Yoko Tabe, MD, PhD

Blood (2010) 116 (21): 3977.

https://doi.org/10.1182/blood.V116.21.3977.3977

Published: 2010

Journal Articles

Micro-RNA and Gene Expression In CLL: Network Analysis Elucidating the Complex Role of the NF-κB Signaling Pathway In Disease.

Erin K Hertlein, PhD, Lianbo Yu, Jianying Zhang, Amy J. Johnson, PhD, David Lucas, PhD, Guido Marcucci, MD, David Jarjoura, John C. Byrd, MD

Blood (2010) 116 (21): 3642.

https://doi.org/10.1182/blood.V116.21.3642.3642

Published: 2010

Journal Articles

High Pro-Apoptotic Effects of 17-Allylamino-17-Demethoxy Geldanamycin (17-AAG) In Philadelphia Acute Lymphoblastic Leukemia (Ph+ ALL)

Emmanuelle Tavernier-Tardy, Pascale Flandrin, Francoise Solly, Jérôme Cornillon, Karine Augeul-Meunier, Jean-Louis Stephan, Denis Guyotat, Lydia Campos, MD, PhD

Blood (2010) 116 (21): 3226.

https://doi.org/10.1182/blood.V116.21.3226.3226

Published: 2010

Journal Articles

Clinical and Biologic Activity of the Heat Shock Protein-90 (HSP-90) Inhibitor 17-AAG in Patients with Relapsed Lymphoma.

Anas Younes, MD, Amanda R Copeland, MS, Jorge Romaguera, MD, Luis Fayad, MD, Michelle Fanale, M.D., Silvana de Castro Faria, MD, PhD, L. Jeffrey Medeiros, MD, Ph.D, S. Percy Ivy, MD

Blood (2009) 114 (22): 3744.

https://doi.org/10.1182/blood.V114.22.3744.3744

Published: 2009

Journal Articles

Modulation of ER Stress/Unfolded Protein Response (UPR) Pathways in Multiple Myeloma Cells by Inhibition of Hsp90 and Serine-Threonine Kinase CK2.

Francesco Piazza, Sabrina Manni, Carmela Gurrieri, Anna Colpo, Laura Quotti Tubi, Anna Cabrelle, Livio Trentin, Gianpietro Semenzato

Blood (2009) 114 (22): 3840.

https://doi.org/10.1182/blood.V114.22.3840.3840

Published: 2009

Journal Articles

Kinome-Wide RNAi Studies in Human Multiple Myeloma Identify a Lymphoid Restricted Kinase GRK6 as a Selectively Vulnerable Target That Regulates STAT3/MCL1.

Rodger E. Tiedemann, MBChB, PhD, FRACP, FRCPA, Yuan Xiao Zhu, Jessica Schmidt, BS, Hongwei Yin, PhD, Quick Que, PhD, David Azorsa, PhD, Louise M. Perkins, PhD, Esteban Braggio, PhD, Craig B. Reeder, MD, Rafael Fonseca, MD, P. Leif Bergsagel, MD, Spyro Mousses, PhD, A. Keith Stewart, MD

Blood (2009) 114 (22): 601.

https://doi.org/10.1182/blood.V114.22.601.601

Published: 2009

Journal Articles

The HSP90 Inhibitor 17-DMAG Targets NF-κB to Induce Apoptosis in CLL and Prolongs Survival in a CLL Mouse Model.

Erin K Hertlein, PhD, Thomas S Lin, MD, PhD, Wagner J Amy, Towns H William, II, Virginia M Goettl, Xiaoli Zhang, David Jarjoura, Chelsey A Raymond, Derek A West, John C. Byrd, MD, Amy J. Johnson, PhD

Blood (2009) 114 (22): 732.

https://doi.org/10.1182/blood.V114.22.732.732

Published: 2009

Journal Articles

Synergistic Activity of Co-Treatment with PIM1 Kinase Inhibitor SGI-1776 and Histone Deacetylase Inhibitor Panobinostat or Heat Shock Protein 90 Inhibitor AUY922 against Human CML and Myeloproliferative Neoplasm (MPN) Cells.

Warren C. Fiskus, Kathleen M. Buckley, Rekha Rao, Yongchao Wang, Atul Joshi, Daniel G. Chong, Anand Jillella, Celalettin Ustun, Peter Atajada, Cornelia Quadt, Kapil N. Bhalla

Blood (2009) 114 (22): 2651.

https://doi.org/10.1182/blood.V114.22.2651.2651

Published: 2009

Journal Articles

Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia

Livio Trentin, Martina Frasson, Arianna Donella-Deana, Federica Frezzato, Mario A. Pagano, Elena Tibaldi, Cristina Gattazzo, Renato Zambello, Gianpietro Semenzato, Anna M. Brunati

Blood (2008) 112 (12): 4665–4674.

https://doi.org/10.1182/blood-2008-02-139139

Published: 2008

NARROW

The Impact of Chemotherapeutic Agents on Signaling and Epigenetics in Vascular Endothelial Cells

Chemical Mutagenesis Screen Identifies Novel Drug Resistant JAK2 Variants in V617FJAK2 Mediated MPN and Predict HSP90 Inhibitors As Possible Agents to Overcome Drug Resistance

Heat Shock Protein 90 Inhibitor NVP-AUY922 Has Potent Anti-Tumor Activity With Adult T-Cell Leukemia-Lymphoma Cells

Involvement Of S100 Proteins and Hsp90 In The Pathogenesis Of Graft-Versus-Host Disease After Allogeneic Hematopoetic Cell Transplantation

Drug Screening Reveals That Ibrutinib (PCI-32765) Exhibits Synergy With BCL-2 and Proteasome Inhibitors In Models Of Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL)

Synergistic Effect Of Nifurtimox and Inhibition Of Hsp70/Hsp90 In Treatment Of Neuroblastoma

Combined Therapy With BRD4 Antagonist and FLT3 Inhibitor Exerts Synergistic Activity Against Cultured and Primary AML Blast Progenitors Expressing FLT-ITD

A Phase I Trial of the Intravenous (IV) Hsp90 Inhibitor 17-DMAG (alvespimycin) in Patients (pts) with Relapsed Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

The Novel Anti-Myeloma Agent Chaetocin Enhances Tumor-Specific Dendritic Cell Response Via the Induction of Heat Shock Protein and Cancer Testis Antigens On Myeloma Cells

The Anti-Proliferative Effects of Hsp90 Inhibitor Tricyclic Coumarin GUT-70 and Geldanamycin Analog 17-DMAG in AML Cells in Hypoxia

Activity of Allosteric, Switch-Pocket, ABL/FLT3 Kinase Inhibitor DCC2036 Against Cultured and Primary AML Progenitors with FLT-ITD or FLT3 Kinase Domain Mutations

The Anti-Proliferative Effects of Tricyclic Coumarin GUT-70 as An Hsp90 Inhibitor In Mantle Cell Lymphoma

Micro-RNA and Gene Expression In CLL: Network Analysis Elucidating the Complex Role of the NF-κB Signaling Pathway In Disease.

High Pro-Apoptotic Effects of 17-Allylamino-17-Demethoxy Geldanamycin (17-AAG) In Philadelphia Acute Lymphoblastic Leukemia (Ph+ ALL)

Clinical and Biologic Activity of the Heat Shock Protein-90 (HSP-90) Inhibitor 17-AAG in Patients with Relapsed Lymphoma.

Modulation of ER Stress/Unfolded Protein Response (UPR) Pathways in Multiple Myeloma Cells by Inhibition of Hsp90 and Serine-Threonine Kinase CK2.

Kinome-Wide RNAi Studies in Human Multiple Myeloma Identify a Lymphoid Restricted Kinase GRK6 as a Selectively Vulnerable Target That Regulates STAT3/MCL1.

The HSP90 Inhibitor 17-DMAG Targets NF-κB to Induce Apoptosis in CLL and Prolongs Survival in a CLL Mouse Model.

Synergistic Activity of Co-Treatment with PIM1 Kinase Inhibitor SGI-1776 and Histone Deacetylase Inhibitor Panobinostat or Heat Shock Protein 90 Inhibitor AUY922 against Human CML and Myeloproliferative Neoplasm (MPN) Cells.

Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia

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American Society of Hematology

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American Society of Hematology

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