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Journal Articles

Increased Mutagenesis during Fetal Hematopoietic Development in Down Syndrome

Karlijn Hasaart, MSc, Freek Manders, MSc, Susana Chuva de Sousa Lopes, PhD, Ruben Van Boxtel, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1186.
https://doi.org/10.1182/blood-2019-122855
Published: 2019
Journal Articles

The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies

Joseph L. Wiemels, PhD, Ivo S Muskens, Shaobo Li, Priyatama Pandey, Ritu Roy, PhD, Helen M Hansen, BSc, Kimberly D Siegmund, PhD, Beth A Mueller, PhD, Xiaomei Ma, PhD, Catherine Metayer, MD PhD, Adam J de Smith, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2510.
https://doi.org/10.1182/blood-2019-131455
Published: 2019
Journal Articles

Clinical and Cytogenomic Features of Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21 (iAMP21) in the Context of Constitutional Ring Chromosome 21

Tatiana Tvrdik, PhD MSc, Kristian T. Schafernak, MD MPH, Jeffrey R Jacobsen, MD, Reha Toydemir, MD PhD, Alexandra M Walsh, MD, Bo Hong, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5208.
https://doi.org/10.1182/blood-2019-123766
Published: 2019
Journal Articles

Chromosome 21 Gain Is Dispensable for Transient Myeloproliferative Disorder (TMD) Development

Julius Lukes, Jr., MD, Eliska Potuckova, Julia Starkova, Jan Stary, MD PhD, Jan Zuna, Jan Trka, MD PhD, Marketa Zaliova
Journal: Blood
Blood (2018) 132 (Supplement 1): 2764.
https://doi.org/10.1182/blood-2018-99-112078
Published: 2018
Journal Articles

The Chromosome 21 Kinase DYRK1A and Its Substrate FOXO1 Constitute a Novel Therapeutic Pathway in B-ALL

Rahul S. Bhansali, Malini Rammohan, MS, Ji Heon Paul Lee, MD PhD, Sebastien Malinge, PhD, Yi-Chien Tsai, Nobuko Hijiya, MD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Corinne Fruit, Thierry Besson, PhD, John D. Crispino, PhD MBA
Journal: Blood
Blood (2018) 132 (Supplement 1): 548.
https://doi.org/10.1182/blood-2018-99-119854
Published: 2018
Journal Articles

Differential Phosphoproteomics Provides New Insights into Role of DYRK1A in Lymphopoiesis

Rahul S. Bhansali, Malini Rammohan, BS, Ji Heon Paul Lee, MD PhD, John D. Crispino, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1152.
https://doi.org/10.1182/blood.V130.Suppl_1.1152.1152
Published: 2017
Journal Articles

Constitutional Ring Chromosome 21 Predisposes to Acute Lymphoblastic Leukaemia (ALL) with iAMP21

Claire Schwab, Eigil Kjeldsen, MD DMSc, Nyla A. Heerema, PhD, Andrew Carroll, PhD, Matthew Bashton, PhD, Sarra Ryan, PhD, Anthony V. Moorman, PhD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Henrik Hasle, MD PhD, Christine J Harrison, PhD FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 3978.
https://doi.org/10.1182/blood.V130.Suppl_1.3978.3978
Published: 2017
Journal Articles

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis

Andrew Volk, PhD, Kaiwei Liang, PhD, Jianyun Zhao, Xinyu Li, Marinka Bulic, Stacy Marshall, Jeffrey W. Taub, MD, Yubin Ge, PhD, Sebastien Malinge, PhD, Elizabeth Bartom, PhD, Ali Shilatifard, PhD, John D. Crispino, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 245.
https://doi.org/10.1182/blood.V130.Suppl_1.245.245
Published: 2017
Journal Articles

Outcomes of Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia Based on Blast Genotype at Diagnosis: A Report from the Children's Oncology Group

Mignon L. Loh, MD, Elizabeth Raetz, MD, Meenakshi Devidas, PhD, Yunfeng Dai, PhD, Michael J. Borowitz, MD PhD, Andrew J. Carroll, PhD, I-Ming Chen, DVM, MS, Julie M. Gastier-Foster, PhD, Alison M. Friedmann, MD MSC, Richard C. Harvey, PhD, Nyla A. Heerema, PhD, Eric Larsen, MD, Yongjin Li, PhD, Kelly W. Maloney, MD, Leonard A. Mattano, Jr., MD, Charles G. Mullighan, MBBS, MSc, PhD, Karen R. Rabin, MD PhD, Shalini C. Reshmi, PhD, Kathryn G. Roberts, PhD, Cheryl L. Willman, MD, Brent L. Wood, MD PhD, Patrick Zweidler-McKay, MD PhD, Jinghui Zhang, PhD, Naomi Winick, MD, Stephen Hunger, MD, William L. Carroll, MD
Journal: Blood
Blood (2016) 128 (22): 451.
https://doi.org/10.1182/blood.V128.22.451.451
Published: 2016
Journal Articles

Improved Diagnosis of Intrachromosomal Amplification of Chromosome 21 (iAMP21) By Copy Number Profiling

Claire Schwab, Paul Sinclair, PhD, Anthony V. Moorman, PhD, Stephen Hunger, MD, Mignon L. Loh, MD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Christine Harrison
Journal: Blood
Blood (2016) 128 (22): 1733.
https://doi.org/10.1182/blood.V128.22.1733.1733
Published: 2016
Journal Articles

Blood Spotlight on iAMP21 acute lymphoblastic leukemia (ALL), a high-risk pediatric disease

Christine J. Harrison
Journal: Blood
Blood (2015) 125 (9): 1383–1386.
https://doi.org/10.1182/blood-2014-08-569228
Published: 2015
Journal Articles

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome

Lital Shaham, Elena Vendramini, Yubin Ge, Yaron Goren, Yehudit Birger, Marloes R. Tijssen, Maureen McNulty, Ifat Geron, Omer Schwartzman, Liat Goldberg, Stella T. Chou, Holly Pitman, Mitchell J. Weiss, Shulamit Michaeli, Benjamin Sredni, Berthold Göttgens, John D. Crispino, Jeffrey W. Taub, Shai Izraeli
Journal: Blood
Blood (2015) 125 (8): 1292–1301.
https://doi.org/10.1182/blood-2014-06-581892
Published: 2015
Includes: Supplemental data
Journal Articles

Exploring the Pathogenesis of Down Syndrome-Related Myeloproliferative Disorders Using iPSCs

Nishinaka Yoko, PhD, Akira Niwa, MDPhD, Mitsujiro Osawa, PhD, Akira Watanabe, PhD, Tatsutoshi Nakahata, MD PhD, Megumu K Saito, MD PhD
Journal: Blood
Blood (2014) 124 (21): 868.
https://doi.org/10.1182/blood.V124.21.868.868
Published: 2014
Journal Articles

GATA1-Centered Genetic Network on Chromosome 21 Drives Down Syndrome Acute Megakaryoblastic Leukemia

Lena Stachorski, Dirk Heckl, PhD, Veera Raghavan Thangapandi, Aliaksandra Maroz, PhD, Dirk Reinhardt, MD PhD, Jan-Henning Klusmann, MD
Journal: Blood
Blood (2014) 124 (21): 4310.
https://doi.org/10.1182/blood.V124.21.4310.4310
Published: 2014
Journal Articles

Modeling the Multi-Step Pathogenesis of Acute Myeloid Leukemia of Down Syndrome

Eric R. Lechman, PhD, Karin G. Hermans, PhD, Stephanie M. Dobson, BSc, Olga I. Gan, PhD, James A. Kennedy, MDPhD, John Chen, PhD, Johann K. Hitzler, MD, John E. Dick, PhD
Journal: Blood
Blood (2014) 124 (21): 3579.
https://doi.org/10.1182/blood.V124.21.3579.3579
Published: 2014
Journal Articles

NRF2 Signaling Promotes Survival and Drug Resistance Of Acute Myeloid Leukaemia Through Induction Of Mir-125b-1

Niraj M Shah, BSc, Stuart A Rushworth, PhD, Lyubov Zaitseva, PhD, Kristian M Bowles, MB BS, PhD, David J Macewan, PhD
Journal: Blood
Blood (2013) 122 (21): 3741.
https://doi.org/10.1182/blood.V122.21.3741.3741
Published: 2013
Journal Articles

Characterization Of Oncogenes On Chromosome 21 Identified By shRNA-Based Viability Screening

Lena Stachorski, Veera Raghavan Thangapandi, Dirk Reinhardt, Jan-Henning Klusmann
Journal: Blood
Blood (2013) 122 (21): 1201.
https://doi.org/10.1182/blood.V122.21.1201.1201
Published: 2013
Journal Articles

The Chromosome 21 Kinase DYRK1A Controls Cell Cycle Exit and Survival During Lymphoid Development and Is a Novel Therapeutic Target In Acute Lymphoblastic Leukemia

Benjamin J. Thompson, MD, PhD, Lauren Diebold, Sebastien Malinge, PhD, Bertrand Leblond, Anne-Sophie Casagrande, Laurent Désiré, Alicia Foucourt, Thierry Besson, Nobuko Hijiya, MD, John D. Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 814.
https://doi.org/10.1182/blood.V122.21.814.814
Published: 2013
Journal Articles

RUNX1 Deletions Are a Novel Mechanism of Loss of Function in AML and Are Associated with Adverse Cytogenetics.

Claudia Haferlach, MD, Vera Grossmann, MSc, Melanie Zenger, Wolfgang Kern, MD, Torsten Haferlach, MD, Alexander Kohlmann, PhD, Susanne Schnittger, PhD
Journal: Blood
Blood (2012) 120 (21): 2517.
https://doi.org/10.1182/blood.V120.21.2517.2517
Published: 2012
Journal Articles

Imbalances of Chromosome 21 in MDS/AML Include Cryptic Deletions but NOT RUNX1 Amplifications.

Katya Gancheva, Diana Brazma, Dr, Nahid Zarein, Julie Howard-Reeves, Phaidra Partheniou, Colin Grace, PhD, Elisabeth P. Nacheva, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2561.
https://doi.org/10.1182/blood.V120.21.2561.2561
Published: 2012