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Acalabrutinib Monotherapy in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia: 42-Month Follow-up of a Phase 2 Study

Richard R. Furman, MD, William G. Wierda, MD PhD, Anna Schuh, Stephen Devereux, PhD, Jorge M. Chaves, MD, Jennifer R. Brown, MD PhD, Peter Hillmen, MD PhD, Peter Martin, FRCPC, MD MS, Farrukh T Awan, MD, Deborah M. Stephens, DO, Paolo Ghia, MD PhD, Jacqueline C. Barrientos, MD MS, John M. Pagel, MD PhD DSc, Jennifer Woyach, MD, Kathleen Burke, PhD, Todd Covey, Michael Gulrajani, Ahmed Hamdy, MD, Raquel Izumi, PhD, Melanie M. Frigault, PhD, Priti Patel, MD, Wayne Rothbaum, Min Hui Wang, PhD, Susan M. O'Brien, MD, John C. Byrd, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3039.
https://doi.org/10.1182/blood-2019-128706
Published: 2019
Journal Articles

Comprehensive Sequencing Identifies High Frequency of Copy Number Changes in Korean Patients with Acute Lymphoblastic Leukemia

Sang-Yong Shin, MD, Borahm Kim, Seung-Tae Lee, Jong Rak Choi, MD PhD, Sun-Hee Kim, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5166.
https://doi.org/10.1182/blood-2018-99-112027
Published: 2018
Journal Articles

Highly Efficient Editing of the Beta-Globin Gene in Patient Derived Hematopoietic Stem and Progenitor Cells to Treat Sickle Cell Disease

So Hyun Park, BS, Ciaran M Lee, PhD, Daniel P. Dever, PhD, Timothy H Davis, BS, Joab Camarena, BS, Yankai Zhang, PhD, Matthew Porteus, MD PhD, Vivian A Sheehan, MD PhD, Gang Bao, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2192.
https://doi.org/10.1182/blood-2018-99-117371
Published: 2018
Journal Articles

Addition of Ixazomib to an Rd Backbone Improves Clinical Benefit in Relapsed/Refractory Multiple Myeloma (RRMM) Patients (Pts) with Non-Canonical NF-KB Activation — Results from the Tourmaline-MM1 Study

Ajeeta B Dash, PhD, Jacob Zhang, PhD, Lei Shen, PhD, Bin Li, PhD, Deborah Berg, RN, MSN, Jianchang Lin, PhD, Hervé Avet-Loiseau, MDPhD, Nizar Bahlis, MD, Philippe Moreau, Paul Richardson, Alessandra Di Bacco, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 473.
https://doi.org/10.1182/blood-2018-99-114614
Published: 2018
Journal Articles

Activation of CRLF2/IL7RA Signaling in Normal Human Cord Blood Hematopoietic Progenitors Induces Philadelphia-like B-Cell Precursor Pre-Leukemia and Leukemia In Vivo

Ifat Geron, PhD, Angela Maria Savino, PhD, Noa Tal, MD PhD, John Brown, PhD, Virginia A Turati, DPhil, Yu Nee Lee, PhD, Chela James, PhD, Avigail Rein Gil, MD, Yehudit Birger, PhD, Inna Muler, Michal Hameiri, PhD, Victoria Marcu-Malina, PhD, Ute Fischer, PhD, Arndt Borkhardt, MD, Ilan M. Kirsch, MD, Arnon Nagler, MD, Tariq Enver, PhD, Shai Izraeli, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 566.
https://doi.org/10.1182/blood-2018-99-115913
Published: 2018
Journal Articles

The Genomic Landscape of Multiple Myeloma Complex Structural Variations

Francesco Maura, Niccolò Bolli, Kevin J Dawson, Nicos Angelopoulos, PhD, Stephane Minvielle, Inigo Martincorena, Thomas J Mitchell, Anthony Fullam, Santiago Gonzalez, Dominik Glodzik, Raphael Szalat, MD, Mehmet Kemal Samur, PhD, Mariateresa Fulciniti, PhD, Yu-Tzu Tai, PhD, Florence Magrangeas, Philippe Moreau, MDPhD, Paolo Corradini, MD, Kenneth C Anderson, MD, David Wedge, PhD, Moritz Gerstung, PhD, Hervé Avet-Loiseau, MD PhD, Nikhil Munshi, MD, Peter J Campbell, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 330.
https://doi.org/10.1182/blood.V130.Suppl_1.330.330
Published: 2017
Journal Articles

Impact on Quality of Life (QoL) of Patients with Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma Under Ibrutinib Treatment: Preliminary Data from a Real World Prospective Project (pilot study)

Maria J. Mela Osorio, MD, Carolina Pavlovsky, MD, Mariana Juni, Ms, Isolda I. Fernandez, MD, Luciana C. Ferrari, MD, Esteban Ciliberti, MD, Miguel A. Pavlovsky, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5343.
https://doi.org/10.1182/blood.V130.Suppl_1.5343.5343
Published: 2017
Journal Articles

Concurrent Treatment with Pim Kinase Inhibitor Downregulates Alternative Non-Homologous End-Joining Repair and Decreases Genomic Instability in FLT3-ITD Cells Treated with Topoisomerase 2 Inhibitor Chemotherapy Drugs

Kshama A. Doshi, PhD, Shivani Kapoor, MS, Ying Zou, MD PhD, Xiang Li, PhD, Mario Scarpa, MS, Nidal Muvarak, PhD, Pratik Nagaria, PhD, Olga Goloubeva, PhD MSc, Adriana E. Tron, PhD, Charles J. Bieberich, PhD, Feyruz V. Rassool, BSc, PhD, Maria R. Baer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1243.
https://doi.org/10.1182/blood.V130.Suppl_1.1243.1243
Published: 2017
Journal Articles

Integrated Genetic/Epigenetic Analysis Revealed High Heterogeneity of Acute Lymphoblastic Leukemia in Down Syndrome

Yasuo Kubota, MD, Kumiko Uryu, MD PhD, Tatsuya Ito, MD, Tomoko Kawai, PhD, Masafumi Seki, MD,PhD, Tomoya Isobe, Tsutomu Toki, PhD, Kenichi Yoshida, MD PhD, Keisuke Kataoka, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, B.A., Hiroko Tanaka, B.A., Satoru Miyano, PhD, Akira Oka, MD PhD, Yasuhide Hayashi, Seishi Ogawa, MD PhD, Kiminori Terui, MD PhD, Atsushi Sato, MD, Kenichiro Hata, MD PhD, Etsuro Ito, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3975.
https://doi.org/10.1182/blood.V130.Suppl_1.3975.3975
Published: 2017
Journal Articles

Jarid2 Restricts Long-Term Repopulating Stem Cell Capacity in Multipotent Progenitors and Acts As Tumor Suppressor in Chronic Myeloid Neoplasms

Hamza Celik, PhD, Won Kyun Koh, MS, Elizabeth Leigh Ostrander, BS, Ashley C. Kramer, BS, William C Wilson, PhD, Greg Fishberger, BS, Cates Mallaney, MS, BS, Alok Kothari, MD, Grant Anthony Challen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 488.
https://doi.org/10.1182/blood.V130.Suppl_1.488.488
Published: 2017
Journal Articles

FAT1 Mutations Influence Time to First Treatment in Untreated CLL

Chris D. Jakubowski, MD, Joshua Felsenfeld, MD, Erica B. Bhavsar, Jacquelyn R. Holjencin, PA, Emilee A. Thomas, PA, Richard R Furman, MD, John N. Allan, MD
Journal: Blood
Blood (2016) 128 (22): 4349.
https://doi.org/10.1182/blood.V128.22.4349.4349
Published: 2016
Journal Articles

Cytogenetics in Hairy Cell Leukemia at Diagnosis and Relapse: The Rate of Therapy-Related Myeloid Malignancies Is Low

Bartlomiej Getta, MBBS,, Omar Abdel-Wahab, Jae H. Park, MD, Martin S Tallman, MD
Journal: Blood
Blood (2015) 126 (23): 2644.
https://doi.org/10.1182/blood.V126.23.2644.2644
Published: 2015
Journal Articles

The Influence of FLI1 Expression Levels on Megakaryopoiesis: Studies Using iPSCs

Karen K Vo, BS, Danuta Jadwiga Jarocha, PhD, Randolph B Lyde, Jr., BS, Spencer Sullivan, MD, Deborah French, PhD, Mortimer Poncz, MD
Journal: Blood
Blood (2015) 126 (23): 2352.
https://doi.org/10.1182/blood.V126.23.2352.2352
Published: 2015
Journal Articles

Large Cohort Analysis of Targeted NGS Mutations and Cytogenetic Abnormalities in Hematologic Malignancies

Mohammad Omar Hussaini, MD, Haipeng Shao, MD, PhD, Lynn C. Moscinski, MD, Jinming Song, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1406.
https://doi.org/10.1182/blood.V126.23.1406.1406
Published: 2015
Journal Articles

Application of a Short Tandem Repeat Based PCR Assay for Chronological Monitoring of Myelodysplastic Syndrome (MDS) Patients with Deletion of Chromosome 5q Following Lenalidomide Treatment

Johann-Christoph Jann, Daniel Nowak, MD, Florian Nolte, Stephanie Fey, Verena Nowak, Julia Oblaender, Jovita Pressler, Alice Charlotte Fabarius, PhD, Uwe Platzbecker, MD, Aristoteles Giagounidis, MD, Katharina Goetze, MD, Anne Letsch, Detlef Haase, MD, Richard F. Schlenk, MD, Gesine Bug, MD, Michael Luebbert, MD, Arnold Ganser, MD, Ulrich Germing, MD, Claudia Haferlach, MD, Wolf-Karsten Hofmann, MD, Maximilian Mossner
Journal: Blood
Blood (2015) 126 (23): 2891.
https://doi.org/10.1182/blood.V126.23.2891.2891
Published: 2015
Journal Articles

The Mutational Landscape of CTCL and Sezary Syndrome

Teresa Palomero, PhD, Ana Carolina da Silva Almeida, PhD, Francesco Abate, PhD, Hossein Khiabanian, PhD, Estela Martinez-Escala, MD, Joan Guitart, MD, Cornelis P Tensen, MD, Maarten H. Vermeer, MD PhD, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD
Journal: Blood
Blood (2015) 126 (23): 573.
https://doi.org/10.1182/blood.V126.23.573.573
Published: 2015
Journal Articles

Prognostic Impact of Rare Single Abnormalities in Myelodysplastic Syndromes

Julie Schanz, MD PhD, Heinz Tüchler, Francesc Sole, PhD, Guillermo Sanz, MD PhD, Guillermo Garcia-Manero, MD, Michelle M. Le Beau, John M. Bennett, MD, Marilyn L. Slovak, PhD, Pierre Fenaux, MD PhD, Luca Malcovati, MD, Mario Cazzola, MD, Peter Valent, MD, Kazuma Ohyashiki, MD PhD, Alessandro Levis, Mikkael A. Sekeres, MD MS, Sudhir Tauro, PhD, Silvia Magalhaes, A. A van de Loosdrecht, Jaroslav Cermak, MD PhD, Michael Luebbert, MD, Reinhard Stauder, MD MSc, Eva Hellstrom-Lindberg, MD PhD, Tatjana Gindina, MD, Ulrich Germing, MD, Peter Greenberg, MD, Detlef Haase, MD
Journal: Blood
Blood (2015) 126 (23): 2879.
https://doi.org/10.1182/blood.V126.23.2879.2879
Published: 2015
Journal Articles

Comprehensive Genetic Characterization of 17p Deleted CLL Identifies Predictors of Overall Survival

Lijian Yu, Haesook T. Kim, PhD, Siddha Kasar, PhD, Parul Benien, Wei Du, Kevin Hoang, Reina Improgo, PhD, Stacey M. Fernandes, Josephine L. Klitgaard, MSc,PhD, Charles Lee, PhD, Gady Getz, Sunita R Setlur, Jennifer R. Brown, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2907.
https://doi.org/10.1182/blood.V126.23.2907.2907
Published: 2015
Journal Articles

Development of a DNA-Based Targeted Assay Suitable for Accurate Quantification of Chromosomal Deletions in Myelodysplastic Syndromes with Deletion (5q) and Other Clonal Diseases

Johann-Christoph Jann, Daniel Nowak, Florian Nolte, Stephanie Fey, Verena Nowak, Julia Obländer, Jovita Pressler, Alice Fabarius, PhD, Claudia Haferlach, MD, Hind Medyouf, PhD, Wolf-Karsten Hofmann, Maximilian Mossner
Journal: Blood
Blood (2014) 124 (21): 1925.
https://doi.org/10.1182/blood.V124.21.1925.1925
Published: 2014
Journal Articles

R.I.S.C.L: A Holistic Molecular Diagnostic Tool for Myeloid Malignancies

Thomas D McKerrell, MD, Ignacio Varela, PhD, Nicolo Bolli, MD PhD, Postingl Hannes, PhD, Zemin Ning, PhD, German Tischler, PhD, Anthony Bench, PhD, Bridget Manasse, PhD, Joanna Baxter, PhD, Jorge Sierra, MD PhD, Dora Foukaneli, MD PhD, Allan Warren, MD PhD, Vincenza Colona, PhD, Chris Tyler-Smith, PhD, Brian Huntly, MD PhD, Josep F. Nomdedeu, MD, Mike Scott, PhD, George Vassiliou, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2342.
https://doi.org/10.1182/blood.V124.21.2342.2342
Published: 2014