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Journal Articles

Pre-Clinical Efficacy of the Novel Kinase Inhibitor Nintedanib on PAX5 Fusion Genes in Pediatric Ph-like B-Cell Precursor Acute Lymphoblastic Leukemia

Grazia Fazio, Silvia Bresolin, Claudia Saitta, Daniela Silvestri, Elena Vendramini, Chiara Palmi, Silvia Rigamonti, Marta Galbiati, Manuel Quadri, Stefano Mecca, Angela Maria Savino, Michela Bardini, Andrea Grioni, Maria Grazia Valsecchi, PhD, Geertruy te Kronnie, Andrea Biondi, MD, Giovanni Cazzaniga, PhD

Blood (2019) 134 (Supplement_1): 745.

https://doi.org/10.1182/blood-2019-128509

Published: 2019

Journal Articles

Mechanistic Characterization of Tafasitamab-Mediated Antibody-Dependent Cellular Phagocytosis Alone or in Combination with Lenalidomide

Dimitrios Mougiakakos, MD, Simon Voelkl, PhD, Christian Bach, Andrej Stoll, Katrin Bitterer, Fabian Beier, MD, Jan Endell, Rainer Boxhammer, Jörg Thomas Bittenbring, MD, Andreas Mackensen, MD, Heiko Bruns, PhD

Blood (2019) 134 (Supplement_1): 4064.

https://doi.org/10.1182/blood-2019-124886

Published: 2019

Journal Articles

Microenvironmental Triggers Induce a Chemoresistant, Differentiated Subset of S100A8/A9 high AML Cells Via the Jak/STAT3 Signaling Axis

Martin Boettcher, PhD, Konstantinos Panagiotidis, Kristin Mentz, Simon Voelkl, PhD, Heiko Bruns, PhD, Robert Slany, PhD, Andreas Mackensen, MD, Dimitrios Mougiakakos, MD

Blood (2019) 134 (Supplement_1): 2714.

https://doi.org/10.1182/blood-2019-129689

Published: 2019

Journal Articles

A Novel Combination Regimen of BET and FLT3 Inhibition for FLT3-ITD Acute Myeloid Leukemia

Lauren Lee, Yoshiyuki Hizukuri, Paul Severson, Ben Powell, PhD, Chao Zhang, PhD, Yan Ma, Maiko Narahara, Hiroyuki Sumi, PhD, Gideon Bollag, PhD, Mark J. Levis, MD

Blood (2019) 134 (Supplement_1): 1373.

https://doi.org/10.1182/blood-2019-124030

Published: 2019

Journal Articles

The Influence of the Bone Marrow Niche on Drug Response Phenotypes of Blood Cancers

Sophie Rabe, MSc, Eva Schitter, Tobias Roider, Peter-Martin Bruch, Carolin Kolb, Marta Stolarczyk, Jennifer Hüllein, Junyan Lu, Christof von Kalle, Christoph Lutz, Peter Dreger, Carsten Mueller-Tidow, Thorsten Zenz, MD, Wolfgang Huber, Sascha Dietrich, MD

Blood (2018) 132 (Supplement 1): 262.

https://doi.org/10.1182/blood-2018-99-116053

Published: 2018

Journal Articles

Final Analysis of the Dose Escalation, Expansion and Biomarker Correlations in the Ph I/II Trial BGBC003 with the Selective Oral AXL Inhibitor Bemcentinib (BGB324) in Relapsed/Refractory AML and MDS

Sonja Loges, MD, PhD, Michael Heuser, MD, Joerg Chromik, Carlos E Vigil, MD, Peter Paschka, MD, Isabel Ben-Batalla, PhD, Nuray Akyüz, David Micklem, Robert Holt, Anthony Brown, James Lorens, Murray Yule, Maxim Kebenko, MD, Melanie Janning, Mascha Binder, MD, Walter Fiedler, MD, Jorge E. Cortes, MD, Bjorn Gjertsen, MD PhD

Blood (2018) 132 (Supplement 1): 2672.

https://doi.org/10.1182/blood-2018-99-120380

Published: 2018

Journal Articles

The Role of Notch in Endothelial Cell-Mediated Protection of AML Precursors from Targeted Therapy

Quy Le, PhD, Brandon Hadland, MD PhD, Soheil Meshinchi, MD PhD, Irwin D. Bernstein, MD

Blood (2018) 132 (Supplement 1): 3947.

https://doi.org/10.1182/blood-2018-99-119735

Published: 2018

Journal Articles

Comparative Inflammasome Analysis of Bone Marrow Stroma in Aging and Myelofibrosis

Larissa Balaian, PhD, Leslie A Crews, PhD, Cayla Mayson, BS, Frida Holm, PhD, Raymond H Diep, Heather Leu, BS, Anna Kulidjian, MD, Edward D. Ball, MD, Catriona Jamieson, MD PhD

Blood (2018) 132 (Supplement 1): 4331.

https://doi.org/10.1182/blood-2018-99-118993

Published: 2018

Journal Articles

NOX2 Derived Superoxide Induces Pro-Tumoral p16INK4a Driven Senescence in the AML Bone Marrow Microenvironment

Charlotte Hellmich, MBBChir, BSc, MRCP, Amina Abdul-Aziz, MSc, Yu Sun, BSc, MSc, Christopher Richard Marlein, BSc, Eoghan Forde, Rachel E Piddock, BSc, Manar Shafat, MSc, Adam Morfakis, BSc, Mehta Tarang, Federica Di Palma, Christopher Ingham, Angela Collins, MBBS, Anna Haestier, Bsc, PgD MBBS, MRCOG, Judith Campisi, PhD, Kristian Bowles, MBBS, PhD, Stuart Rushworth, PhD BSc

Blood (2018) 132 (Supplement 1): 2770.

https://doi.org/10.1182/blood-2018-99-115274

Published: 2018

Journal Articles

Senescent Mesenchymal Stem Cells Present at the Early Post Allogeneic Hematopoietic Stem Cell Transplantation Period Are Associated with an Increased Incidence of Acute Graft-Versus Host Disease and Increased Plasma Levels of Fas Ligand

Daniel Rivera, MD, Lika Osugui, PhD, Sandra Muntion, PhD, Miguel Alcoceba, PhD, Concepcion Rodriguez, Rebeca Ortega, Natalia Espinosa, MD, Ana Gomez de la Torre, Ana Rico, Miriam López-Parra, MD, Alba Redondo, MD, Eva Villarón, Félix López Cadenas, MD, Silvia Preciado, Maria Díez-Campelo, Lucía López Corral, MD, Marcos González, MD PhD, Dolores Caballero, MD, Fermin Sanchez-Guijo, MD PhD

Blood (2018) 132 (Supplement 1): 2116.

https://doi.org/10.1182/blood-2018-99-115363

Published: 2018

Journal Articles

Proteomic and Biological Analysis of Myeloma Cell Derived Extracellular Vesicles

Dominique B Hoelzinger, PhD, Sophia J Quinton, Denise K Walters, PhD, Renee C Tschumper, Diane F Jelinek, PhD

Blood (2018) 132 (Supplement 1): 5605.

https://doi.org/10.1182/blood-2018-99-116926

Published: 2018

Journal Articles

The Age of the Hematopoietic Microenvironment Specifies Lineage Commitment in MLL-Rearranged Leukemia

Grant Rowe, MD PhD, Edroaldo Lummertz da Rocha, Patricia Sousa, Pavlos Missios, Michael Morse, Jessica Barragan, Ronald Mathieu, George Q Daley, MD PhD

Blood (2017) 130 (Supplement 1): 135.

https://doi.org/10.1182/blood.V130.Suppl_1.135.135

Published: 2017

Journal Articles

Bone Marrow Stroma Protects FLT3 Acute Myeloid Leukemia (AML) through CYP3A4-Mediated Drug Metabolization of FLT3 Tyrosine Kinase Inhibitors (TKIs)

Yu-Ting Chang, MS, Daniela Hernandez, MD, Gabriel Ghiaur, MD PhD, Mark J. Levis, MD, Richard J. Jones, MD

Blood (2017) 130 (Supplement 1): 2519.

https://doi.org/10.1182/blood.V130.Suppl_1.2519.2519

Published: 2017

Journal Articles

Identification and Clinical Exploration of Individualized Targeted Therapeutic Approaches in Acute Myeloid Leukemia Patients By Integrating Drug Response and Deep Molecular Profiles

Disha Malani, MRes, Ashwini Kumar, MRes, Bhagwan Yadav, PhD, Mika Kontro, MD, Swapnil Potdar, MSc, Samuli Eldfors, MSc, Jani Saarela, Bjørn Tore Gjertsen, Riikka Karjalainen, Tero Aittokallio, Astrid Murumagi, Maija Wolf, PhD, Simon Anders, PhD, Krister Wennerberg, Caroline A Heckman, PhD, Kimmo Porkka, MD PhD, Olli Kallioniemi, MD PhD

Blood (2017) 130 (Supplement 1): 854.

https://doi.org/10.1182/blood.V130.Suppl_1.854.854

Published: 2017

Journal Articles

Early Growth Response (EGR)-1 Is a Key Regulator of Human Primary Bone Marrow Stroma Cells with a Dual Role in Proliferation and Hematopoietic Stroma Support Function

Hongzhe Li, PhD, Roshanak Ghazanfari, PhD, Hooi Ching Lim, PhD, Jenny Hansson, PhD, Dimitra Zacharaki, Stefan Scheding, MD

Blood (2017) 130 (Supplement 1): 3777.

https://doi.org/10.1182/blood.V130.Suppl_1.3777.3777

Published: 2017

Journal Articles

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

Mark B. Meads, PhD, Paula Oliveira, Bin Fang, Praneeth Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Tuan Nguyen, Allison Distler, Salah-Eddin Komrokji, Aunshka Collins, Hongyue Dai, PhD, John M. Koomen, Ariosto Siqueira Silva, PhD, Kenneth H Shain, MD PhD

Blood (2017) 130 (Supplement 1): 4411.

https://doi.org/10.1182/blood.V130.Suppl_1.4411.4411

Published: 2017

Journal Articles

Warfarin Impairs the Bone Marrow Microenvironment and Hematopoiesis Via the Periostin/Integrin Î²3 Pathway

Divij Verma, MSc, Keertik Fulzele, Kumar Rahul, Christina Karantanou, Raquel Pereira, Kathrin Kunz, Soraya Hoelper, Eva Weissenberger, Paul K. Ziegler, Sara Zia- Chahabi, Michaela Fontenay, MD PhD, Paola Divieti Pajevic, Daniela S. Krause, MD

Blood (2017) 130 (Supplement 1): 2444.

https://doi.org/10.1182/blood.V130.Suppl_1.2444.2444

Published: 2017

Journal Articles

Marrow Stromal Cells Secrete FGF2 in Exosomes, Providing Paracrine Protection for Leukemia Cells from Kinase Inhibitors

Elie Traer, MD PhD, Brian J. Druker, MD, Jakki Martinez, Nathalie Javidi-Sharifi, Isabel English, BA, Anupriya Agarwal, PhD, Jennifer Dunlap, MD

Blood (2017) 130 (Supplement 1): 306.

https://doi.org/10.1182/blood.V130.Suppl_1.306.306

Published: 2017

Journal Articles

Glycomimetic Antagonist of E-Selectin, GMI-1271, Enhances Therapeutic Activity of the Hypomethylating Agent, 5-Azacitidine, in the KG1 Model of AML

William E Fogler, PhD, Theodore AG Smith, PhD, Ji-Won Lee, PhD, John L Magnani, PhD

Blood (2017) 130 (Supplement 1): 5065.

https://doi.org/10.1182/blood.V130.Suppl_1.5065.5065

Published: 2017

Journal Articles

Preliminary Data Show Heterogenous Patterns of 18 f-FDG PET/CT When Assessing the Inflammatory Component of Primary or Secondary Myelofibrosis

Mario Ojeda-Uribe, Christophe Schohn, MD, Olivier Morel, MD, Nathalie Mac Dougall, MD, Xavier Malezieux, MD, Atteka Chabanse, PharmD, Andrien Norosoa, MD, Laurent Mauvieux, MD PhD, Hatem Boulahdour, MD PhD, Edmond Rust, MD

Blood (2017) 130 (Supplement 1): 5280.

https://doi.org/10.1182/blood.V130.Suppl_1.5280.5280

Published: 2017

NARROW

Pre-Clinical Efficacy of the Novel Kinase Inhibitor Nintedanib on PAX5 Fusion Genes in Pediatric Ph-like B-Cell Precursor Acute Lymphoblastic Leukemia

Mechanistic Characterization of Tafasitamab-Mediated Antibody-Dependent Cellular Phagocytosis Alone or in Combination with Lenalidomide

Microenvironmental Triggers Induce a Chemoresistant, Differentiated Subset of S100A8/A9 high AML Cells Via the Jak/STAT3 Signaling Axis

A Novel Combination Regimen of BET and FLT3 Inhibition for FLT3-ITD Acute Myeloid Leukemia

The Influence of the Bone Marrow Niche on Drug Response Phenotypes of Blood Cancers

Final Analysis of the Dose Escalation, Expansion and Biomarker Correlations in the Ph I/II Trial BGBC003 with the Selective Oral AXL Inhibitor Bemcentinib (BGB324) in Relapsed/Refractory AML and MDS

The Role of Notch in Endothelial Cell-Mediated Protection of AML Precursors from Targeted Therapy

Comparative Inflammasome Analysis of Bone Marrow Stroma in Aging and Myelofibrosis

NOX2 Derived Superoxide Induces Pro-Tumoral p16INK4a Driven Senescence in the AML Bone Marrow Microenvironment

Senescent Mesenchymal Stem Cells Present at the Early Post Allogeneic Hematopoietic Stem Cell Transplantation Period Are Associated with an Increased Incidence of Acute Graft-Versus Host Disease and Increased Plasma Levels of Fas Ligand

Proteomic and Biological Analysis of Myeloma Cell Derived Extracellular Vesicles

The Age of the Hematopoietic Microenvironment Specifies Lineage Commitment in MLL-Rearranged Leukemia

Bone Marrow Stroma Protects FLT3 Acute Myeloid Leukemia (AML) through CYP3A4-Mediated Drug Metabolization of FLT3 Tyrosine Kinase Inhibitors (TKIs)

Identification and Clinical Exploration of Individualized Targeted Therapeutic Approaches in Acute Myeloid Leukemia Patients By Integrating Drug Response and Deep Molecular Profiles

Early Growth Response (EGR)-1 Is a Key Regulator of Human Primary Bone Marrow Stroma Cells with a Dual Role in Proliferation and Hematopoietic Stroma Support Function

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

Warfarin Impairs the Bone Marrow Microenvironment and Hematopoiesis Via the Periostin/Integrin Î²3 Pathway

Marrow Stromal Cells Secrete FGF2 in Exosomes, Providing Paracrine Protection for Leukemia Cells from Kinase Inhibitors

Glycomimetic Antagonist of E-Selectin, GMI-1271, Enhances Therapeutic Activity of the Hypomethylating Agent, 5-Azacitidine, in the KG1 Model of AML

Preliminary Data Show Heterogenous Patterns of 18 f-FDG PET/CT When Assessing the Inflammatory Component of Primary or Secondary Myelofibrosis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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