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Journal Articles

Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism

Blood (2021) 137 (19): 2681–2693.

https://doi.org/10.1182/blood.2019004571

Published: 2021

Includes: Supplemental data

Journal Articles

Arginine for mitochondrial oxidative enzymopathy

Daniel B. Kim-Shapiro, Mark T. Gladwin

Blood (2020) 136 (12): 1376–1378.

https://doi.org/10.1182/blood.2020006732

Published: 2020

Journal Articles

Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain

Claudia R. Morris, Lou Ann S. Brown, Michael Reynolds, Carlton D. Dampier, Peter A. Lane, Amanda Watt, Polly Kumari, Frank Harris, Shaminy Manoranjithan, Reshika D. Mendis, Janet Figueroa, Sruti Shiva

Blood (2020) 136 (12): 1402–1406.

https://doi.org/10.1182/blood.2019003672

Published: 2020

Includes: Supplemental data

Journal Articles

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Livingstone Fultang, Sarah Booth, Orli Yogev, Barbara Martins da Costa, Vanessa Tubb, Silvia Panetti, Victoria Stavrou, Ugo Scarpa, Andris Jankevics, Gavin Lloyd, Andrew Southam, Steven P. Lee, Warwick B. Dunn, Louis Chesler, Francis Mussai, Carmela De Santo

Blood (2020) 136 (10): 1155–1160.

https://doi.org/10.1182/blood.2019004500

Published: 2020

Includes: Supplemental data

Journal Articles

Codanin-1 Mutations Engineered in Human Erythroid Cells Allow Investigation of Mechanisms Underlying Congenital Dyserythropoietic Anemia

Zachary C. Murphy, PhD, Michael Getman, MS, Jacquelyn Lillis, Laurie A. Steiner, MD

Blood (2019) 134 (Supplement_1): 3739.

https://doi.org/10.1182/blood-2019-127415

Published: 2019

Journal Articles

An Autosomal Dominant SCID Form Due to a Gain of Function Mutation in the RAC2 Gene

Chantal Lagresle-Peyrou, PhD, Aurélien Olichon, Hanem Sadek, Philippe Roche, Claudine Tardy, Cindy Da Silva, Alexandrine Garrigue, Alain Fischer, MD PhD, Despina Moshous, MD PhD, Yves Collette, Capucine Picard, MD PhD, Jean-Laurent Casanova, PhD MD, Isabelle André, PhD, Marina Cavazzana, MD PhD

Blood (2019) 134 (Supplement_1): 3742.

https://doi.org/10.1182/blood-2019-126855

Published: 2019

Journal Articles

Targeting PRMT5 to Circumvent Acquired Ibrutinib Resistance in Mantle Cell Lymphoma

Shelby Sloan, BS, Fiona Brown, BS, JI Hyun Chung, PhD, Alexander Prouty, BS, Esther Wheeler, BS, Bonnie K Harrington, DVM, PhD, Eric Brooks, BS, Ayse S Yilmaz, MS, Hatice G Ozer, PhD, John C. Byrd, MD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Rosa Lapalombella, PhD, Kris Vaddi, PhD, Peggy Scherle, PhD, Youssef Youssef, MD, Robert A Baiocchi, MD PhD, Lapo Alinari, MD PhD

Blood (2019) 134 (Supplement_1): 4065.

https://doi.org/10.1182/blood-2019-128998

Published: 2019

Journal Articles

SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Tumor Protein p53 (TP53)-Mutant Acute Myeloid Leukemia Models

Heekyung Chung, PhD, Emily Creger, Lauren Sitts, Kevin Chiu, Chi-Ching Mak, PhD, Sunil KC, PhD, Betty Tam, PhD, Gail Bucci, Josh Stewart, Timothy Phalen, PhD, Steven Cha, MD

Blood (2019) 134 (Supplement_1): 3913.

https://doi.org/10.1182/blood-2019-131209

Published: 2019

Journal Articles

SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Mantle Cell Lymphoma Models

Heekyung Chung, PhD, Emily Creger, Lauren Sitts, Kevin Chiu, Chi-Ching Mak, PhD, Sunil KC, PhD, Betty Tam, PhD, Gail Bucci, Josh Stewart, Timothy Phalen, PhD, Steven Cha, MD

Blood (2019) 134 (Supplement_1): 4059.

https://doi.org/10.1182/blood-2019-124812

Published: 2019

Journal Articles

A Phase II Trial of Topical Sodium Nitrite in Patients with Sickle Cell Disease and Leg Ulcers

Shuo You, MD, Andrew Crouch, Ugochi Olivia Ogu, MD, Clemencia Solorzano, PharmD, Gracy Sebastian, NP, Markenya Mirander, Giacomo Vinces, D.O., Gregory J Kato, MD, Caterina P. Minniti, MD

Blood (2019) 134 (Supplement_1): 2292.

https://doi.org/10.1182/blood-2019-124440

Published: 2019

Journal Articles

An Epigenetic Screen Identifies PRMT5 As a Target for Inhibition of FLT3-ITD AML Cell Growth in Combination with Tyrosine Kinase Inhibitors

Aditi Dhir, MD, Andrew J Paterson, PhD, Shaowei Qiu, MD, Amanda K Mullen, Nick R Anderson, BS, Ravi Bhatia, MD

Blood (2019) 134 (Supplement_1): 2524.

https://doi.org/10.1182/blood-2019-125178

Published: 2019

Journal Articles

PRMT5 Is a Key Epigenetic Regulator That Promotes Transcriptional Activation in Mantle Cell Lymphoma By Regulating the Lysine Methyltransferase SETD7 and MLL1 Activity

JI Hyun Chung, PhD, Shelby Sloan, BS, Peggy Scherle, PhD, Kris Vaddi, PhD, Said Sif, PhD, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD

Blood (2019) 134 (Supplement_1): 2777.

https://doi.org/10.1182/blood-2019-131020

Published: 2019

Journal Articles

A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Justin M. Watts, MD, Terrence J Bradley, MD, Amber Thomassen, Andrew M. Brunner, MD, Mark D. Minden, MD PhD, Nikolaos Papadantonakis, MDPhDMSc, Sameem Abedin, MD, Amanda J Baines, Olena Barbash, PhD, Shelby Gorman, Brandon E Kremer, MD PhD, Gautam M. Borthakur, MD

Blood (2019) 134 (Supplement_1): 2656.

https://doi.org/10.1182/blood-2019-130337

Published: 2019

Journal Articles

Untargeted Metabolomics on Dried Blood Spots for the Diagnosis and Clinical Follow up of Rare Hereditary Anemias

Birgit van Dooijeweert, MD, Melissa Broeks, Msc, Judith Jans, PhD, Eduard J. van Beers, MD PhD, Nanda Verhoeven, PhD, Richard van Wijk, PhD, Marije Bartels, MD PhD

Blood (2019) 134 (Supplement_1): 3376.

https://doi.org/10.1182/blood-2019-131693

Published: 2019

Journal Articles

Development of Exosome-Capturing Antibody-Conjugated Nucleic Acid Medicines Targeting Multiple Myeloma Cells

Emi Soma, Yuki Toda, PhD, Shigekuni Hosogi, MD PhD, Asako Yamayoshi, PhD, Eishi Ashihara, MD PhD

Blood (2019) 134 (Supplement_1): 3365.

https://doi.org/10.1182/blood-2019-121995

Published: 2019

Journal Articles

Mass Cytometry Identifies a Novel Signature for Myeloid-Derived Suppressor-Cells in Waldenstrom's Macroglobulinemia

Shahrzad Jalali, PhD, Jose Villasboas, MD, Jie Shi, MD PhD, Cole Bothun, Hyojin Kim, PhD, Zhi-Zhang Yang, MD, Stephen M Ansell, MD

Blood (2019) 134 (Supplement_1): 3976.

https://doi.org/10.1182/blood-2019-124850

Published: 2019

Journal Articles

Increase Expression of the Genes PADI4, MPO and ELANE in the Chronic Phase of DVT Patients

Isabella Macedo Toni, MSc, Kiara Zapponi, Bidossessi Wilfried Hounkpe, Beatriz Moraes Martinelli, BSc, Silmara Aparecida De Lima Montalvão, PhD, Erich V De Paula, MD PhD, Joyce Maria Annichino- Bizzacchi, MD PhD

Blood (2019) 134 (Supplement_1): 4921.

https://doi.org/10.1182/blood-2019-131916

Published: 2019

Journal Articles

A Novel Composition of Endogenous Metabolic Modulators, AXA4010, Impacts Adhesion, Inflammation and RBC Membrane Deformability in Preclinical Models of Sickle Cell Disease

Michael Hamill, PhD, Sean Carroll, PhD, Revati Wani, PhD, Matthew Russell, PhD, Zoe Steuert, Arianna Nitzel, Andrew Downey, PhD, Murat Cokol, PhD, Raffi Afeyan, PhD, Svetlana Marukian, PhD, Tony Tramontin, PhD

Blood (2019) 134 (Supplement_1): 978.

https://doi.org/10.1182/blood-2019-124224

Published: 2019

Journal Articles

Safety of Intravenous Arginine Therapy in Children with Sickle Cell Disease Hospitalized for Vaso-Occlusive Pain: A Randomized Placebo-Controlled Trial in Progress

Claudia R. Morris, MD, Janet Figueroa, MPH, Amanda Watt, Kirshma Khemani, MD, Polly Kumari, MBBS, Morgan Barnett, MPH, Nitya Bakshi, MBBS, MS, Peter A. Lane, MD, Carlton Dampier, MD

Blood (2019) 134 (Supplement_1): 995.

https://doi.org/10.1182/blood-2019-122983

Published: 2019

Journal Articles

Ivo-Nivo: A Phase II Study of the IDH1 Inhibitor Ivosidenib (AG-120) in Combination with the Checkpoint Blockade Inhibitor Nivolumab for Patients with IDH1 Mutated Relapsed/Refractory AML and High Risk MDS

Namrata S Chandhok, MD, Wei Wei, MD, Stephanie Halene, MD, Thomas Prebet, MD PhD

Blood (2019) 134 (Supplement_1): 1374.

https://doi.org/10.1182/blood-2019-130033

Published: 2019

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Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism

Arginine for mitochondrial oxidative enzymopathy

Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Codanin-1 Mutations Engineered in Human Erythroid Cells Allow Investigation of Mechanisms Underlying Congenital Dyserythropoietic Anemia

An Autosomal Dominant SCID Form Due to a Gain of Function Mutation in the RAC2 Gene

Targeting PRMT5 to Circumvent Acquired Ibrutinib Resistance in Mantle Cell Lymphoma

SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Tumor Protein p53 (TP53)-Mutant Acute Myeloid Leukemia Models

SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Mantle Cell Lymphoma Models

A Phase II Trial of Topical Sodium Nitrite in Patients with Sickle Cell Disease and Leg Ulcers

An Epigenetic Screen Identifies PRMT5 As a Target for Inhibition of FLT3-ITD AML Cell Growth in Combination with Tyrosine Kinase Inhibitors

PRMT5 Is a Key Epigenetic Regulator That Promotes Transcriptional Activation in Mantle Cell Lymphoma By Regulating the Lysine Methyltransferase SETD7 and MLL1 Activity

A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Untargeted Metabolomics on Dried Blood Spots for the Diagnosis and Clinical Follow up of Rare Hereditary Anemias

Development of Exosome-Capturing Antibody-Conjugated Nucleic Acid Medicines Targeting Multiple Myeloma Cells

Mass Cytometry Identifies a Novel Signature for Myeloid-Derived Suppressor-Cells in Waldenstrom's Macroglobulinemia

Increase Expression of the Genes PADI4, MPO and ELANE in the Chronic Phase of DVT Patients

A Novel Composition of Endogenous Metabolic Modulators, AXA4010, Impacts Adhesion, Inflammation and RBC Membrane Deformability in Preclinical Models of Sickle Cell Disease

Safety of Intravenous Arginine Therapy in Children with Sickle Cell Disease Hospitalized for Vaso-Occlusive Pain: A Randomized Placebo-Controlled Trial in Progress

Ivo-Nivo: A Phase II Study of the IDH1 Inhibitor Ivosidenib (AG-120) in Combination with the Checkpoint Blockade Inhibitor Nivolumab for Patients with IDH1 Mutated Relapsed/Refractory AML and High Risk MDS

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American Society of Hematology

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