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Journal Articles

Pre-Clinical Efficacy of the Novel Kinase Inhibitor Nintedanib on PAX5 Fusion Genes in Pediatric Ph-like B-Cell Precursor Acute Lymphoblastic Leukemia

Grazia Fazio, Silvia Bresolin, Claudia Saitta, Daniela Silvestri, Elena Vendramini, Chiara Palmi, Silvia Rigamonti, Marta Galbiati, Manuel Quadri, Stefano Mecca, Angela Maria Savino, Michela Bardini, Andrea Grioni, Maria Grazia Valsecchi, PhD, Geertruy te Kronnie, Andrea Biondi, MD, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 745.
https://doi.org/10.1182/blood-2019-128509
Published: 2019
Journal Articles

Oxphos Inhibition Induces Formation of Tunneling Nanotubes in AML Cells and Facilitates Mitochondrial Transfer from BM Stroma to AML That Contributes to Microenvironment-Mediated Drug-Resistance of AML

Haeun Yang, Yoko Tabe, MD PhD, Kaori Saito, Kotoko Yamatani, MD, Rodrigo Jacamo, PhD, Helen Ma, MS, Vivian Ruvolo, MS, Qi Zhang, PhD, Vinitha Mary Kuruvilla, MSc, Natalia Baran, PhDMD, Junichi Imoto, Kazuho Ikeo, PhD, Kaori Moriya, Yuko Murakami-Tonami, MD PhD, Koya Suzuki, PhD, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Christopher P Vellano, Joseph Marszalek, Marina Y Konopleva, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 911.
https://doi.org/10.1182/blood-2019-125007
Published: 2019
Journal Articles

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Mario Scarpa, PhD, Prerna Singh, MS, Shivani Kapoor, MS, Jonelle K. Lee, MS, Sandrine Niyongere, MD, Goutham Narla, MD PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1276.
https://doi.org/10.1182/blood-2019-129011
Published: 2019
Journal Articles

Astragalus Polysaccharide Promotes Hematopoiesis in an Irradiated Mouse Model and Reduces Apoptosis of Hematopoietic Cells

Wan-huang Xu, Liang Li, PhD, Liuming Yang, Hongwu Xin, Beng H Chong, MBBS, PhD, Mo Yang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4903.
https://doi.org/10.1182/blood-2019-131631
Published: 2019
Journal Articles

Targeting Nicotinamide Adenine Dinucleotide (NAD) Glycohydrase Activity of CD38 Exerts Anti-Myeloma Effect Accompanying Intracellular NAD Elevation

Saki Kushima, Takayuki Sasano, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1810.
https://doi.org/10.1182/blood-2019-123624
Published: 2019
Journal Articles

Onset of Regulatory B Cells Occurs at Initial Stage of B Cell Dysfunction in Multiple Myeloma

Zhongqing Zou, Tingting Guo, Jian Cui, Li Zhang, Ling Pan
Journal: Blood
Blood (2019) 134 (Supplement_1): 1780.
https://doi.org/10.1182/blood-2019-128703
Published: 2019
Journal Articles

JX06, a Novel PDK1 Inhibitor, Induces Myeloma Cell Apoptosis By Metabolic Reprogramming and Works Synergistically with Bortezomib

Takayuki Sasano, Saki Kushima, Matsushita Yutaka, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1814.
https://doi.org/10.1182/blood-2019-123619
Published: 2019
Journal Articles

Highly Differentiated Anti-CD47 Antibody, AO-176, Potently Inhibits Hematologic Malignancies Alone and in Combination

John Richards, PhD, Myriam N Bouchlaka, BS,PhD, Robyn J Puro, PhD, Ben J Capoccia, PhD, Ronald R Hiebsch, BS, Michael J Donio, BS, W. Casey Wilson, PhD, Prabir Chakraborty, PhD, Victoria Sung, PhD, Daniel S Pereira, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1844.
https://doi.org/10.1182/blood-2019-126298
Published: 2019
Journal Articles

Next Generation CRISPR Gene-Edited and Off-the-Shelf Virus-Specific T-Cells for the Immunocompromised Patient

Rafet Basar, MD, May Daher, MD, Nadima Uprety, MS, Elif Gokdemir, BS, Abdullah Saleh Alsuliman, PhD, Mayela Carolina Mendt, PhD, Lucila Kerbauy, MD, Mayra Shanley, PhD, Gonca Ozcan, MD, Emily Ensley, BS, Ana Karen Nunez Cortes, MD, Li Li, MD, Junjun Lu, Mecit Kaplan, MS, Vandana Nandivada, BS, MS, Mustafa Bdaiwi, MD, Ye Li, Luciana Melo Garcia, MD, Enli Liu, MD, Sonny Ang, PhD, Pinaki P Banerjee, PhD, Richard E. Champlin, MD, Elizabeth J. Shpall, MD, Katayoun Rezvani, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1944.
https://doi.org/10.1182/blood-2019-125276
Published: 2019
Journal Articles

CELL-Derived Microparticles and Sickle CELL Disease Chronic Vasculopathy in Sub-Saharan Africa

Abdoul Karim Dembele, MD, Claudine Lapoumeroulie, PhD, Mor Diaw, PhD, Oumar Tessougué, MD, Lucile Offredo, MS, Dapa Aly Diallo, MD, Saliou Diop, MD MSc, Jacques Elion, MD PhD, Yves Colin Aronovicz, Pierre Louis Tharaux, MD PhD, Xavier Jouven, MD PhD, Marc Romana, PhD, Brigitte Ranque, MD PhD, Caroline Le Van Kim, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3568.
https://doi.org/10.1182/blood-2019-121334
Published: 2019
Journal Articles

Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells

Uri Rozovski, MD, David M. Harris, PhD, Ping Li, PhD, Zhiming Liu, BS, Taghi Manshouri, PhD, Ivo Veletic, MD, Preetesh Jain, MBBS,MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, Srdan Verstovsek, MD PhD, William G. Wierda, MD PhD, Michael J Keating, MBBS, Zeev E. Estrov, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3018.
https://doi.org/10.1182/blood-2019-124014
Published: 2019
Journal Articles

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

Tiziana Vaisitti, PhD, Katti Jessen, PhD, Thanh-Trang Vo, PhD, Mira Ko, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Esteban Braggio, PhD, Arianna Di Napoli, Amy Chadburn, MD, John N. Allan, MD, Richard R. Furman, MD, Langdon L. Miller, Brian J Lanutti, PhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2856.
https://doi.org/10.1182/blood-2019-126827
Published: 2019
Journal Articles

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Yawara Kawano, MD PhD, Takayuki Sasano, Saki Kushima, Yuki Inada, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3097.
https://doi.org/10.1182/blood-2019-125756
Published: 2019
Journal Articles

In Vitro and in Vivo Activity of Melflufen in Amyloidosis

Ken Flanagan, PhD, Muntasir M Majumder, MSc, BPharm, Romika Kumari, PhD, Juho Miettinen, PhD, Ana Slipicevic, PhD, Sarah A. Holstein, MD PhD, Michelle L. Varney, MS, Minna Suvela, MSC, Fredrik Lehmann, PhD, Nina N. Nupponen, PhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3100.
https://doi.org/10.1182/blood-2019-125952
Published: 2019
Journal Articles

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Ipsita Pal, PhD, Sohani Das Sharma, PhD, Andre M. Grilo, PhD, Prabhjot S. Mundi, MD, Luigi Scotto, PhD, Abdullah Mahmood Ali, PhD, Luke E Berchowitz, PhD, Siddhartha Mukherjee, MD PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2864.
https://doi.org/10.1182/blood-2019-129528
Published: 2019
Journal Articles

Variable Response to BCL2 Inhibition in MDS Is Enhanced across MDS Subtypes with Synergistic Combination of BCL2+MCL1 Inhibition

Melissa A. Fischer, MSc, PhD, Maria Arrate, MSc, Merrida A Childress, PhD, Brianna N Smith, MD MS, Yuanbin Song, MD, Rana Gbyli, MS, Thomas Stricker, MD PhD, Stephanie Halene, MD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2982.
https://doi.org/10.1182/blood-2019-126578
Published: 2019
Journal Articles

Mn Porphyrin-Based Redox Active Drugs Improve Anemia and Reduce Organ Damage in a Murine Model of Sickle Cell Disease

Madhan Thamilarasan, PhD, Rodolfo Estupinan, Rahima Zennadi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2255.
https://doi.org/10.1182/blood-2019-131140
Published: 2019
Journal Articles

Modeling the Behavior of Hematopoietic Compartments from Stem to Red Cells in Murine Steady State and Stress Hematopoiesis

Celine Bonnet, BSc, Panhong Gou, BSc, Vincent Bensaye, PhD Associate Professor, Catherine Lacout, Ingeneer, Karine Bailly, Ingeneer, Marie-helene Schlagetter, MD PhD, Evelyne Lauret, PhD, Sylvie Meleard, PhD Professor, Stephane Giraudier, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2224.
https://doi.org/10.1182/blood-2019-123704
Published: 2019
Journal Articles

Dose-Dependent Iron Chelating Effects of Eltrombopag on in Vitro Human Megakaryopoiesis

Zhi-Jian Liu, PhD, Emoke Deschmann, MD, Haley E. Ramsey, PhDMSc, Henry Feldman, Bethan Psaila, MD PhD, Nichola Cooper, MD MRCP, Evangelia Vlachodimtropoulou Koumoutsea, MBBS,PhDBSc, John B. Porter, MA MDFRCP FRCPath, James B. Bussel, MD, Michael Georgieff, MD, Martha Sola-Visner, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2475.
https://doi.org/10.1182/blood-2019-131895
Published: 2019
Journal Articles

DNA Cytosine-Demethylating Agent 5-Aza-2'-Deoxycytidine Targets Leukemia Cells through Reducing DNA N 6 -Methyladenine

Xiaochang Liu, PhD, Jiuxia Pang, Christopher Seiler, Ryan Kempen, Hao Liu, Aref Al-Kali, MD, Y. Natalia Tretyakova, Mark Litzow, MD, Shujun Liu
Journal: Blood
Blood (2019) 134 (Supplement_1): 2513.
https://doi.org/10.1182/blood-2019-130490
Published: 2019