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Journal Articles

In Human Visualization of Ibrutinib-Induced CLL Compartment Shift

Marius E Mayerhoefer, Alexander Haug, Ulrich Jaeger, MD, Lukas Kazianka, MD, Verena Pichler, Sarah Pfaff, Hans-Jürgen Wester, PhD, Marcus Hacker, Philipp Bernhard Staber, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1750.
https://doi.org/10.1182/blood-2019-131469
Published: 2019
Journal Articles

Patient Preferences Regarding Anticoagulation Therapy in Patients with Cancer Having a VTE Event - a Discrete Choice Experiment in the Cosimo Study

Nils Picker, MSc, Alexander T Cohen, MBBS, MSc, MD, Anthony Maraveyas, MD PhD, Jan Beyer-Westendorf, MD, Agnes Yuet Ying Lee, MD MSc, FRCPC, Lorenzo G Mantovani, Yoriko De Sanctis, MS, Khaled Abdelgawwad, Samuel Fatoba, Miriam Bach, Thomas Wilke, Prof. Dr. rer. oec.
Journal: Blood
Blood (2019) 134 (Supplement_1): 2159.
https://doi.org/10.1182/blood-2019-128095
Published: 2019
Journal Articles

A Meta-Analysis Evaluating the Risk of Bleeding-Related Adverse Events with Defibrotide Treatment

William Tappe, Saurabh Aggarwal, Ozlem Topaloglu, Massimo Iacobelli
Journal: Blood
Blood (2019) 134 (Supplement_1): 2016.
https://doi.org/10.1182/blood-2019-123686
Published: 2019
Journal Articles

Response to Bcma CAR-T Cells Correlates with Pretreatment Target Antigen Density and Is Improved By Small Molecule Inhibition of Gamma Secretase

Damian J. Green, MD, Margot Pont, PhD, Andrew J. Cowan, MD, Gabriel O Cole, Blythe Duke Sather, PhD, Anne M Nagengast, RN, Xaoling Song, Sushma Thomas, Brent L Wood, MD PhD, Michelle L Blake, PhD, Melissa G Works, PhD, Ted A Gooley, PhD, David G. Maloney, MD PhD, Stanley R. Riddell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1856.
https://doi.org/10.1182/blood-2019-129582
Published: 2019
Journal Articles

Comparative Studies on the Interaction of Unfractionated Heparin and Sulodexide with Functional Anti-Heparin Platelet Factor 4 Antibodies

Ambar Farooqui, Debra Hoppensteadt, PhD, Omer Iqbal, MD, Cassie Bacher, Jeanine Walenga, PhD, Ahmed Kouta, Walter Jeske, PhD, Bruce Lewis, Jawed Fareed, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2446.
https://doi.org/10.1182/blood-2019-131825
Published: 2019
Journal Articles

Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells

Satoshi Kitazawa, PhD, Yukiko Ishii, PhD, Keiko Makita-Suzuki, Koichi Saito, PhD, Kensuke Takayanagi, Hiromi Sugihara, Shun Matsuda, PhD, Takayuki Yamakawa, PhD, Yasuhiro Tsutsui, Tadashi Tanaka, Tomohisa Hatta, PhD, Tohru Natsume, PhD, Toru Kondo, PhD, Yuichi Ishikawa, MD PhD, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2663.
https://doi.org/10.1182/blood-2019-121869
Published: 2019
Journal Articles

A Phase Ia/Ib Study Exploring the Synthetic Lethality of the Orally Administered Novel BTK Inhibitor, Dtrmwxhs-12 (DTRM-12), in Combination with Everolimus and Pomalidomide in Patients with Relapsed/Refractory CLL, DLBCL or Other B-Cell Lymphomas

Anthony R. Mato, MDMSCE, Stephen J Schuster, MD, Francine M. Foss, MD, Iris Isufi, MD, Wei Ding, MD PhD, Danielle M. Brander, MD, Andrea Sitlinger, MD, Han W. Tun, MD, Muhamad Alhaj Moustafa, MD, Kaitlin Kennard, RN, BSN, Cara M King, MPH, Amber Koehler, PA-C, MS, Casey Aitken, Wei He, PhD, Albert Kearney, PhD, Min Gui, PhD, Barry Douglas Anderson, MD PhD, Allison C. Rosenthal, DO, Lindsey E. Roeker, MD, Scott F. Huntington, MD MPH
Journal: Blood
Blood (2019) 134 (Supplement_1): 810.
https://doi.org/10.1182/blood-2019-126192
Published: 2019
Journal Articles

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Guang Yang, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Amanda Kofides, Lian Xu, MS, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael Gray, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 394.
https://doi.org/10.1182/blood-2019-130636
Published: 2019
Journal Articles

Discovery of DWP213388, a Potent ITK and BTK Selective Dual Inhibitor with Excellent Efficacy and Safety, for Treating Gvhd

Deokki Eom, BS, Jae Hun Jung, Eun Kyung KIM, PhD, Wolyoung Kim, Qingri Li, Jaehyun Jung, Sohee Im, Yong Dae Shin, Hyaejung Hyun, Joon Seok Park
Journal: Blood
Blood (2019) 134 (Supplement_1): 4426.
https://doi.org/10.1182/blood-2019-126839
Published: 2019
Journal Articles

Targeted Protein Degradation of BTK As a Unique Therapeutic Approach for B Cell Malignancies

Aileen Kelly, PhD, Daniel W Robbins, May Tan, Austin Tenn-McClellan, Joel McIntosh, Jeffrey Wu, Zef Konst, Daisuke Kato, Luz Perez, Jennifer Tung, Anna Kolobova, Timothy Ingallinera, Jenny McKinnell, Dahlia Weiss, Mark Noviski, Jordan Ye, Ge Peng, Mario Cardozo, Jeff Mihalic, Steve Basham, Ryan Rountree, Dane E Karr, Neil Bence, Christoph W Zapf, Arthur T Sands
Journal: Blood
Blood (2019) 134 (Supplement_1): 3805.
https://doi.org/10.1182/blood-2019-129262
Published: 2019
Journal Articles

Serotonin Targeting Using Common Antidepressants Induces Rapid Recovery of Cytopenia

Tereza Coman, MD PhD, Guillemette Fouquet, Julien Rossignol, MD PhD, Jean-Henri Bourhis, Olivier Hermine, Francine Côté, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3715.
https://doi.org/10.1182/blood-2019-122658
Published: 2019
Journal Articles

A Phase I/II Study of NMS-03592088, a FLT3, KIT and CSF1R Inhibitor, in Patients with Relapsed or Refractory AML or CMML

Marina Ciomei, Lucia Zanetta, Federico Lussana, MD, Erika Ravelli, MD, Francesco Fiorentini, Roberta Bosotti, Elena Ardini, Andrea Lombardi Borgia, Romana Pulci, Rosalinda Gatto, Alessandro Di Sanzo, Elena Colajori, MD, Cristina Davite, Arturo Galvani, Frank Xiaodong Gan, Giuseppe Rossi, Matteo Giovanni Della Porta, MD, Roberto Cairoli, MD, Alessandro Rambaldi, MD, Antonella Isacchi
Journal: Blood
Blood (2019) 134 (Supplement_1): 3855.
https://doi.org/10.1182/blood-2019-121954
Published: 2019
Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Yurie Nagai, MD, Naoya Mimura, MD PhD, Ola Rizq, MD PhD, Yusuke Isshiki, MD PhD, Motohiko Oshima, PhD, Mohamed Rizk, BSc, MSc, Atsunori Saraya, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Makiko Miyota, Nagisa Oshima-Hasegawa, MD PhD, Shokichi Tsukamoto, MD PhD, Shio Mitsukawa, MD PhD, Yusuke Takeda, MD PhD, Chikako Ohwada, MD PhD, Masahiro Takeuchi, MD PhD, Tohru Iseki, MD PhD, Chiaki Nakaseko, MD PhD, Josephine Sheedy, BS, MSc, Marla Weetall, PhD, Atsushi Iwama, MD PhD, Emiko Sakaida, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4414.
https://doi.org/10.1182/blood-2019-122350
Published: 2019
Journal Articles

Efficacy of OR21, a Novel Oral Demethylating Agent in Chronic Myeloid Leukemia

Kazuharu Kamachi, MD, Hiroshi Ureshino, MD, Nao Yoshida, MD, Yuki Kurahashi, Tatsuro Watanabe, PhD, Seiji Okada, MD PhD, Shinya Kimura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5365.
https://doi.org/10.1182/blood-2019-125460
Published: 2019
Journal Articles

An Updated Safety and Efficacy Results of Phase 1 Study of HQP1351, a Novel 3 rd Generation of BCR-ABL Tyrosine Kinase Inhibitor (TKI), in Patients with TKI Resistant Chronic Myeloid Leukemia

Qian Jiang, MD, Xiaojun Huang, MD, Zi Chen, MD, Qian Niu, Lichuang Men, Hengbang Wang, PhD, Jiao JI, PhD MD, Bo Huang, Dayu Shi, Ting Zhao, Yue Hou, Dajun Yang, MD PhD, Yifan Zhai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 493.
https://doi.org/10.1182/blood-2019-124295
Published: 2019
Journal Articles

Dynamic Evolution of Ponatinib Resistant BCR-ABL1 T315 and Compound Mutations

Jiaqi Chen, PhD, Hongxing Liu, Fang Wang, MD, Yang Zhang, MD, Xue Chen, MD, Daijing Nie, MD, Yu Li, Yincheng Tan, Yuanli Xu, Xiaoli Ma
Journal: Blood
Blood (2019) 134 (Supplement_1): 3796.
https://doi.org/10.1182/blood-2019-129579
Published: 2019
Journal Articles

The Efficacy of a Novel Oral Proteasome Inhibitor NNU546 in Multiple Myeloma

Ye Yang, PhD, Yongqiang Zhu, Chunyan Gu
Journal: Blood
Blood (2019) 134 (Supplement_1): 5586.
https://doi.org/10.1182/blood-2019-127927
Published: 2019
Journal Articles

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity Selectively Targets Human Acute Myeloid Leukemia Stem Cells

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Jean Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3932.
https://doi.org/10.1182/blood-2018-99-120258
Published: 2018
Journal Articles

Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition

Natalia Baran, PhDMD, Alessia Lodi, PhD, Shannon Renee Sweeney, MS, Pandey Renu, PhD, Vinitha Mary Kuruvilla, Antonio Cavazos, MSc, Daniel Herranz, PharmD, Anna Skwarska, PhD, Marc Warmoes, PhD, R. Eric Davis, MD, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason P Gay, MS, Sergej Naumovich Konoplev, MD PhD, Marcin Kaminski, PhD, Jeffrey J Kovacs, PhD, Di Du, PhD, Elias J. Jabbour, MD, Adolfo A. Ferrando, MD PhD, Maria E Di Francesco, PhD, Philip L Lorenzi, PhD, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y. Konopleva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4020.
https://doi.org/10.1182/blood-2018-99-117310
Published: 2018
Journal Articles

Multi-Modal Mechanisms and Anti-Sickling of Novel Sulfated Non-Anticoagulant Low Molecular Weight Heparin in Sickle Cell Disease

Shaker A Mousa, PhD BPharm, MBA, MSc, Noureldien Hassan Elsayed Darwish, MDPhDBS, Vandhana Muralidharan-Chari, PhD, Mohamed Qari, MD, Chen Qiukan, J Eric Russell, MD, Osheiza Abdulmalik, DVM
Journal: Blood
Blood (2018) 132 (Supplement 1): 265.
https://doi.org/10.1182/blood-2018-99-115121
Published: 2018