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Journal Articles

Phase 1 Study of UCN-01 in Combination with Perifosine in Patients with Relapsed and Refractory Acute Leukemias and High Risk Myelodysplastic Syndromes (MDS)

Kelly J. Norsworthy, MD, Alexander E Perl, MD, Martin Carroll, MD, Selina M. Luger, MD, Kenneth S. Bauer, PharmD, PhD, Michael L. Tidwell, CRNP, Dina Ioffe, BA, Maria R. Baer, MD, Edward A. Sausville, MD, PhD, Ivana Gojo, MD

Blood (2011) 118 (21): 1557.

https://doi.org/10.1182/blood.V118.21.1557.1557

Published: 2011

Journal Articles

Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo

Yun Dai, Shuang Chen, Rena Shah, Xin-Yan Pei, Li Wang, Jorge A. Almenara, Lora B. Kramer, Paul Dent, Steven Grant

Blood (2011) 117 (6): 1947–1957.

https://doi.org/10.1182/blood-2010-06-291146

Published: 2011

Includes: Supplemental data

Journal Articles

Hypomethylating Agents Correct Subcellular Localization of FOXO3a and (re)Establish Expression of Its Transcriptional Targets In AML and MDS- Cells

Sylvain Thepot, Elodie Lainey, Marie Sebert, Lionel Ades, Claude Gardin, Pierre Fenaux, MD, PhD, Guido Kroemer, Simone Boehrer

Blood (2010) 116 (21): 2173.

https://doi.org/10.1182/blood.V116.21.2173.2173

Published: 2010

Journal Articles

G2/M Arrest Sensitizes Chronic Myelogenous Leukemia Cells to TRAIL-Induced Apoptosis

David Devlin, Medical, Student, Eva Szegezdi, Post-Doctoral, Researcher, Paavilainen Tanja, Student, Orsolya Orosz, Student, Michael O'Dwyer, MD, FRCPath, Michael Carty, Senior, Lecturer, Afshin Samali, PhD, Séverine Cruet Hennequart, PhD

Blood (2010) 116 (21): 4465.

https://doi.org/10.1182/blood.V116.21.4465.4465

Published: 2010

Journal Articles

CRLF2/JAK Signaling Confers Susceptibility to JAK Inhibitors and Small Molecule Inhibitors of Protein Kinase C.

Nathan West, Akinori Yoda, Ph.D., Sabina Chiaretti, Kartik Mani, Robin Foà, James Bradner, David M Weinstock, MD

Blood (2009) 114 (22): 3767.

https://doi.org/10.1182/blood.V114.22.3767.3767

Published: 2009

Journal Articles

Antiproliferative Effects of Lenalidomide in Combination with Chemotherapeutic Agents in Lymphoma Cell Lines

Anita K Gandhi, Jian Kang, Lori Capone, Ling-Hua Zhang, Blake Bartlett, Dennis Pietronegro, Annette Ervin-Haynes, Peter H Schafer

Blood (2008) 112 (11): 4990.

https://doi.org/10.1182/blood.V112.11.4990.4990

Published: 2008

Journal Articles

The Capacity of the Hypomethylating Agents Azacytidine and Decitabine to Induce Apoptosis and Cell Cycle Arrest Depends on the Activation of the DNA-Damage Response Pathway.

Simone Boehrer, Lionel Ades, Nicolas Tajeddine, Lorenzo Galluzzi, Stephane de Botton, Pierre Fenaux, Guido Kroemer

Blood (2008) 112 (11): 1655.

https://doi.org/10.1182/blood.V112.11.1655.1655

Published: 2008

Journal Articles

Selective Suppression of the DNA Damage Response in Acute Myeloid Leukemia Versus Myelodysplastic Syndrome.

Simone Boehrer, Lionel Ades, Nicolas Tajeddine, Lorenzo Galluzzi, Wolf-Karsten Hofmann, Pierre Fenaux, Guido Kroemer

Blood (2008) 112 (11): 1656.

https://doi.org/10.1182/blood.V112.11.1656.1656

Published: 2008

Journal Articles

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

Yun Dai, Shuang Chen, Xin-Yan Pei, Jorge A. Almenara, Lora B. Kramer, Charis A. Venditti, Paul Dent, Steven Grant

Blood (2008) 112 (6): 2439–2449.

https://doi.org/10.1182/blood-2008-05-159392

Published: 2008

Includes: Supplemental data

Journal Articles

Further Evidence That MDS and AML Cells Exhibit a Differential Capacity To Activate the DNA-Damage Response (DDR) Pathways.

Simone Boehrer, MD, Lionel Ades, MD, Lorenzo Galluzzi, Ken Olaussen, PhD, Thorsten Braun, MD, Jennifer Grosjean, PhD, Claire Fabre, MD, Stephane de Botton, MD, Pierre Fenaux, MD, PhD, Guido Kroemer, MD, PhD

Blood (2007) 110 (11): 2438.

https://doi.org/10.1182/blood.V110.11.2438.2438

Published: 2007

Journal Articles

Lenalidomide Displays Anti-Proliferative Activity and Combination Effects with Chemotherapeutic Agents Against a Burkitt’s Lymphoma Cell Line.

Anita K. Gandhi, PhD, Jian Kang, BS, Ling-Hua Zhang, PhD, Blake Bartlett, PhD, Peter H. Schafer, PhD, David I. Stirling, PhD

Blood (2007) 110 (11): 4516.

https://doi.org/10.1182/blood.V110.11.4516.4516

Published: 2007

Journal Articles

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism

Xin-Yan Pei, Yun Dai, Sarah Tenorio, Jianghua Lu, Hisashi Harada, Paul Dent, Steven Grant

Blood (2007) 110 (6): 2092–2101.

https://doi.org/10.1182/blood-2007-04-083204

Published: 2007

Journal Articles

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

Yun Dai, Payal Khanna, Shuang Chen, Xin-Yan Pei, Paul Dent, Steven Grant

Blood (2007) 109 (10): 4415–4423.

https://doi.org/10.1182/blood-2006-09-047076

Published: 2007

Journal Articles

Abrogation of the DNA-Damage Response in De Novo AML Versus MDS Cell Lines.

Simone Boehrer, MD, PhD, Lionel Ades, MD, Claire Fabre, MD, Pierre Fenaux, MD, PhD, Guido Kroemer, MD, PhD

Blood (2006) 108 (11): 2649.

https://doi.org/10.1182/blood.V108.11.2649.2649

Published: 2006

Journal Articles

DNA Repair Genes Are Upregulated in Multiple Myeloma (MM) Patients Relapsing after Tandem Transplantation.

Guido Tricot, MD, PhD, Fenghuang Zhan, MD, PhD, Yongsheng Huang, PhD, Bart Barlogie, MD, PhD, John Shaughnessy, PhD

Blood (2006) 108 (11): 3392.

https://doi.org/10.1182/blood.V108.11.3392.3392

Published: 2006

Journal Articles

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

Deepa Sampath, Jorge Cortes, Zeev Estrov, Min Du, Zheng Shi, Michael Andreeff, Varsha Gandhi, William Plunkett

Blood (2006) 107 (6): 2517–2524.

https://doi.org/10.1182/blood-2005-08-3351

Published: 2006

Journal Articles

Tachpyridine, a metal chelator, induces G 2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation

JoLyn Turner, Constantinos Koumenis, Timothy E. Kute, Roy P. Planalp, Martin W. Brechbiel, Dillon Beardsley, Brooke Cody, Kevin D. Brown, Frank M. Torti, Suzy V. Torti

Blood (2005) 106 (9): 3191–3199.

https://doi.org/10.1182/blood-2005-03-1263

Published: 2005

Journal Articles

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK

Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Payal Khanna, Song Iy Han, Clint Mitchell, Paul Dent, Steven Grant

Blood (2005) 105 (4): 1706–1716.

https://doi.org/10.1182/blood-2004-07-2767

Published: 2005

Journal Articles

Highly Synergistic Interaction between Farnesyltransferase Inhibitors and the Chk1 Inhibitor UCN-01 to Induce Apoptosis in Human Leukemia Cells through Interruption of Both Akt and MEK/ERK Pathways and Activation of SEK1/JNK.

Yun Dai, Ph.D., Mohamed Rahmani, Ph.D., Xin-Yan Pei, M.D., Payal Khanna, Paul Dent, Ph.D., Steven Grant, M.D.

Blood (2004) 104 (11): 3403.

https://doi.org/10.1182/blood.V104.11.3403.3403

Published: 2004

Journal Articles

Interruption of the NF-κB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

Yun Dai, Xin-Yan Pei, Mohamed Rahmani, Daniel H. Conrad, Paul Dent, Steven Grant

Blood (2004) 103 (7): 2761–2770.

https://doi.org/10.1182/blood-2003-09-3037

Published: 2004

NARROW

Phase 1 Study of UCN-01 in Combination with Perifosine in Patients with Relapsed and Refractory Acute Leukemias and High Risk Myelodysplastic Syndromes (MDS)

Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo

Hypomethylating Agents Correct Subcellular Localization of FOXO3a and (re)Establish Expression of Its Transcriptional Targets In AML and MDS- Cells

G2/M Arrest Sensitizes Chronic Myelogenous Leukemia Cells to TRAIL-Induced Apoptosis

CRLF2/JAK Signaling Confers Susceptibility to JAK Inhibitors and Small Molecule Inhibitors of Protein Kinase C.

Antiproliferative Effects of Lenalidomide in Combination with Chemotherapeutic Agents in Lymphoma Cell Lines

The Capacity of the Hypomethylating Agents Azacytidine and Decitabine to Induce Apoptosis and Cell Cycle Arrest Depends on the Activation of the DNA-Damage Response Pathway.

Selective Suppression of the DNA Damage Response in Acute Myeloid Leukemia Versus Myelodysplastic Syndrome.

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

Further Evidence That MDS and AML Cells Exhibit a Differential Capacity To Activate the DNA-Damage Response (DDR) Pathways.

Lenalidomide Displays Anti-Proliferative Activity and Combination Effects with Chemotherapeutic Agents Against a Burkitt’s Lymphoma Cell Line.

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

Abrogation of the DNA-Damage Response in De Novo AML Versus MDS Cell Lines.

DNA Repair Genes Are Upregulated in Multiple Myeloma (MM) Patients Relapsing after Tandem Transplantation.

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

Tachpyridine, a metal chelator, induces G 2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK

Highly Synergistic Interaction between Farnesyltransferase Inhibitors and the Chk1 Inhibitor UCN-01 to Induce Apoptosis in Human Leukemia Cells through Interruption of Both Akt and MEK/ERK Pathways and Activation of SEK1/JNK.

Interruption of the NF-κB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

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American Society of Hematology

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American Society of Hematology

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