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Journal Articles

C-Myc Driven Tolerogenic Tumor Microenvironment (TME) in Mantle Cell Lymphoma (MCL) Is Overcome By Bromodomain Inhibition

Fengdong Cheng, MD, Yuan Ren, PhD, Jie Chen, PhD, Zi Wang, B.S., Tao Li, MD, Kieron Dunleavy, MD, Jianqing Lin, MD, James Bradner, MD, Mitchell R. Smith, MDPhD, Bijal D. Shah, MD, Eduardo Sotomayor, MD, Jianguo Tao, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 777.
https://doi.org/10.1182/blood-2018-99-116865
Published: 2018
Journal Articles

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

David M. Woods, Karrune V. Woan, Fengdong Cheng, Andressa L. Sodré, Dapeng Wang, Yongxia Wu, Zi Wang, Jie Chen, John Powers, Javier Pinilla-Ibarz, Yu Yu, Ya Zhang, Xuefeng Wu, Xiaoyan Zheng, Jeffrey Weber, Wayne W. Hancock, Edward Seto, Alejandro Villagra, Xue-Zhong Yu, Eduardo M. Sotomayor
Journal: Blood
Blood (2017) 130 (2): 146–155.
https://doi.org/10.1182/blood-2016-08-731505
Published: 2017
Includes: Supplemental data
Journal Articles

Inhibition of Histone Deacetylase 6 (HDAC6) Disrupts the Tolerogenic STAT3 Signaling Pathway and Augments Antitumor Immune Responses in Mantle Cell Lymphoma (MCL)

Hongwei Wang, MD, Fengdong Cheng, MD, Zi Wang, Maritza Lienlaf, BS., Patricio Perez-Villarroel, Tessa Knox, MS, Eva Sahakian, Ph.D, Javier Pinilla-Ibarz, MD, PhD, Pedro Horna, M.D., Selina Chen-Kiang, PhD, Peter Martin, MD, Joel Bergman, Alan Kozikowski, Alejandro Villagra, PhD, Jianguo Tao, MD, PhD, Bijal D. Shah, MD, Eduardo M. Sotomayor, MD
Journal: Blood
Blood (2012) 120 (21): 3724.
https://doi.org/10.1182/blood.V120.21.3724.3724
Published: 2012
Journal Articles

Physical Interaction of Histone Deacetylase 6 (HDAC6) with STAT3 Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Fengdong Cheng, M.D., Zi Wang, Hongwei Wang, Maritza Lienlaf, BS., Karrune V. Woan, PhD, Patricio Perez-Villarroel, BS., Jennifer Rock-Klotz, B.S., Eva Sahakian, Ph.D, Tessa Knox, MS, David M Woods, M.S., John Powers, B.S., Rongxiang Han, Oscar Merino, Susan Deng, Danay Marante, MS, Wayne W. Hancock, Alan Kozikowski, Joel Bergman, Javier Pinilla, Edward Seto, PhD, Eduardo M. Sotomayor, MD, Alejandro Villagra, PhD
Journal: Blood
Blood (2012) 120 (21): 829.
https://doi.org/10.1182/blood.V120.21.829.829
Published: 2012
Journal Articles

Histone Deacetylase 11 (HDAC11) Is a Regulatory Checkpoint of T-Cell Function: Implications for T-Cell Adoptive Immunotherapy

Karrune V. Woan, Dapeng Wang, Ph.D, Zi Wang, Fengdong Cheng, MD, Lianet Vazquez, David Woods, Yu Yu, Ph.D, Eva Sahakian, Ph.D, Hongwei Wang, Elphine Telles, Lirong Peng, Liqing Wang, Wayne W. Hancock, MD, PhD, Bruce R. Blazar, MD, Noreen Luetteke, Edward Seto, Javier Pinilla, Alejandro Villagra, Xue-Zhong Yu, M.D., M.S., Eduardo M. Sotomayor
Journal: Blood
Blood (2011) 118 (21): 359.
https://doi.org/10.1182/blood.V118.21.359.359
Published: 2011
Journal Articles

Lycorine Modulates the Expression of p21 Via a p53-Independent Pathway in HL-60 Cells

Jing Liu, Shu-Ling Wang, Lin Fang, Mao Ye, Zhi-Wei Sun, Lv Li, Zi Wang, Hui-Wen Yan, Sai-Qun Luo, Hui-Yong Chen, Xiuli An, MD, PhD, Wei-Xin Hu
Journal: Blood
Blood (2011) 118 (21): 4297.
https://doi.org/10.1182/blood.V118.21.4297.4297
Published: 2011
Journal Articles

Epigenetic Modulation of STAT3 by Histone Deacetylase 6 (HDAC6) Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Fengdong Cheng, Zi Wang, Hongwei Wang, Karrune V. Woan, Eva Sahakian, Ph.D, Jennifer Rock Klotz, Liqing Wang, Rongxiang Han, Oscar Merino, Susan Deng, Lianet Vazquez, Ajaypal S. Gill, Danay Marante, John Powers, B.S., Wayne W. Hancock, Javier Pinilla, Edward Seto, Eduardo M. Sotomayor, Alejandro Villagra
Journal: Blood
Blood (2011) 118 (21): 519.
https://doi.org/10.1182/blood.V118.21.519.519
Published: 2011
Journal Articles

Tubastatin A, a Selective HDAC6 Inhibitor, Enhances Antigen-Presenting Cell (APC) Function and Restores the Responsiveness of Anergic CD4+ T Cells

Hongwei Wang, Zi Wang, Fengdong Cheng, Karrune V. Woan, Jennifer Rock-Klotz, Eva Sahakian, Ph.D, John Powers, B.S., Pinilla Javier, Joel Bergman, Alejandro Villagra, Alan Kozikowski, Eduardo M. Sotomayor
Journal: Blood
Blood (2011) 118 (21): 520.
https://doi.org/10.1182/blood.V118.21.520.520
Published: 2011
Journal Articles

Identification of a Discrete Subpopulation of T-Cells Over-Expressing HDAC11 with a TH17 Phenotype

Karrune Woan, Fengdong Cheng, Hongwei Wang, Jennifer Rock-Klotz, Zi Wang, Yu Yu, Edward Seto, Noreen Luetteke, Xue-Zhong Yu, Alejandro Villagra, Eduardo M. Sotomayor, MD
Journal: Blood
Blood (2010) 116 (21): 588.
https://doi.org/10.1182/blood.V116.21.588.588
Published: 2010
Journal Articles

Targeting Histone Deacetylase 6 (HDAC6) as a Novel Approach to Overcome T-Cell Anergy.

Fengdong Cheng, Hongwei Wang, Karrune Woan, Jennifer Rock-Klotz, Zi Wang, Oscar Merino, Ajay Gill, Danay Marante, Lianet Vazquez, Edward Seto, Javier Pinilla-Ibarz, MD, Eduardo M. Sotomayor, MD, Alejandro Villagra
Journal: Blood
Blood (2010) 116 (21): 1483.
https://doi.org/10.1182/blood.V116.21.1483.1483
Published: 2010