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Journal Articles

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

Blood (2017) 130 (2): 146–155.

https://doi.org/10.1182/blood-2016-08-731505

Published: 2017

Includes: Supplemental data

Journal Articles

MYC Regulation Via the LIN28B/Let-7 Axis in Multiple Myeloma

Salomon Manier, MD, John Powers, PhD, Antonio Sacco, BS, Siobhan Glavey, MD, Daisy Huynh, BS, MS, Michaela R. Reagan, PhD, Karma Salem, MD, Michele Moschetta, MD, Yuji Mishima, PhD, Xavier Leleu, MD PhD, Aldo M Roccaro, MD PhD, George Q. Daley, MD PhD, Irene M. Ghobrial, MD

Blood (2015) 126 (23): 1755.

https://doi.org/10.1182/blood.V126.23.1755.1755

Published: 2015

Journal Articles

A Novel Role for Histone Deacetylase 11 (HDAC11) in B Cell Lymphopoiesis and Plasma Cell Survival in Multiple Myeloma

Jason B. Brayer, MDPhD, Eva Sahakian, PhD, John Powers, M.S., Mark B Meads, PhD, Susan Deng, Allison Distler, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Alejandro Villagra, PhD, Javier Pinilla-Ibarz, MD PhD, Eduardo M. Sotomayor, MD, Kenneth H. Shain, MD PhD

Blood (2014) 124 (21): 4715.

https://doi.org/10.1182/blood.V124.21.4715.4715

Published: 2014

Journal Articles

Histone Deacetylase 11 (HDAC11) Is a Novel Regulator In The Expansion Of MDSCs Via The Transcription Factor C/EBP-β

Jie Chen, M.A., John Powers, B.S., Jennifer Rock-Klotz, B.S., Susan Deng, B.S., Allison Distler, B.S., Fengdong Cheng, MD, Alejandro Villagra, PhD, Eduardo M. Sotomayor, MD, Eva Sahakian, Ph.D, Javier Pinilla-Ibarz, MD, PhD

Blood (2013) 122 (21): 4887.

https://doi.org/10.1182/blood.V122.21.4887.4887

Published: 2013

Journal Articles

A Novel Role For Histone Deacetylase 11 (HDAC11) As a Regulator Of Neutrophil Function and Differentiation In Normal and Malignant Hematopoesis

Eva Sahakian, Ph.D, John Powers, B.S., Jie Chen, M.A., Allison Distler, B.S., Jennifer Rock-Klotz, B.S., Susan Deng, B.S., Sheng Wei, MD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, M.D. Ph.D., Pedro Horna, M.D.

Blood (2013) 122 (21): 2267.

https://doi.org/10.1182/blood.V122.21.2267.2267

Published: 2013

Journal Articles

A Novel Role For Histone Deacetylase 11 (HDAC11) In Plasma Cell Differentation and Survival

Eva Sahakian, Ph.D, Jason B. Brayer, MD, PhD, John Powers, B.S., Mark Meads, PhD, Allison Distler, Susan Deng, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Javier Pinilla-Ibarz, MD, PhD, Eduardo M. Sotomayor, MD, Kenneth Shain, MD, PhD

Blood (2013) 122 (21): 1907.

https://doi.org/10.1182/blood.V122.21.1907.1907

Published: 2013

Journal Articles

Combination of ACY1215, a Selective Histone Deacetylase 6 (HDAC6) Inhibitor with the Bruton Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, Represents a Novel Therapeutic Strategy in Mantle Cell Lymphoma (MCL)

Eva Sahakian, Ph.D, Jennifer Rock-Klotz, B.S., Bijal D. Shah, MD, John Powers, B.S., Jennifer L. Cultrera, MD, Susan Deng, David M Woods, M.S., Michael Nguyen, Fengdong Cheng, MD, Hongwei Wang, Patricio Perez-Villarroel, B.S., Maritza Lienlaf, B.S., Tesa Knox, M.S., Selina Chen-Kiang, PhD, Alejandro Villagra, PhD, Jianguo Tao, MD, PhD, Javier Pinilla-Ibarz, MD, PhD, Simon S Jones, Eduardo M. Sotomayor, MD

Blood (2012) 120 (21): 1660.

https://doi.org/10.1182/blood.V120.21.1660.1660

Published: 2012

Journal Articles

Novel Role of Histone Deacetylase 11 (HDAC11) in Hematopoiesis

Eva Sahakian, Ph.D, John Powers, B.S., Pedro Horna, M.D., Jennifer Rock-Klotz, B.S., Susan Deng, David M Woods, M.S., Michael Nguyen, Karrune V. Woan, PhD, Fengdong Cheng, MD, Alejandro Villagra, PhD, Dmitry Gabrilovich, MD, PhD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD, PhD

Blood (2012) 120 (21): 4728.

https://doi.org/10.1182/blood.V120.21.4728.4728

Published: 2012

Journal Articles

Physical Interaction of Histone Deacetylase 6 (HDAC6) with STAT3 Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Blood (2012) 120 (21): 829.

https://doi.org/10.1182/blood.V120.21.829.829

Published: 2012

Journal Articles

Inducible Expression of Cancer Testis Antigens in Myelodysplastic Syndrome (MDS) Patients Following Treatment with an Oral 5-Azacytidine

John Powers, B.S., Eva Sahakian, Ph.D, Jason A Dubovsky, Ph.D, Tyler Farnum, Emmanuel Berchmans, B.S., Douglas G McNeel, MD, Barry S. Skikne, MD, Kyle J MacBeth, Rami S. Komrokji, MD, Javier Pinilla-Ibarz, MD, PhD

Blood (2012) 120 (21): 3828.

https://doi.org/10.1182/blood.V120.21.3828.3828

Published: 2012

Journal Articles

Histone Deacetylase 11 (HDAC11) Regulates Cytotoxic T-Cell Function and Memory Phenotype

David M Woods, M.S., Karrune V. Woan, PhD, Eva Sahakian, Ph.D, John Powers, B.S., Fengdong Cheng, MD, Hongwei Wang, Jennifer Rock-Klotz, B.S., Jeffrey S. Weber, MD, PhD, Alejandro Villagra, PhD, Javier Pinilla-Ibarz, MD, PhD, Eduardo M. Sotomayor, MD

Blood (2012) 120 (21): 840.

https://doi.org/10.1182/blood.V120.21.840.840

Published: 2012

Journal Articles

A Novel Role of Histone Deacetylase 11 (HDAC11) in Regulation of Myeloid-Derived Suppressor Cell (MDSC) Expansion

Eva Sahakian, Ph.D, John Powers, B.S., Jennifer Rock-Klotz, B.S., Marsilio Adriani, Ph.D, Karrune V. Woan, Oscar Merino, Ajaypal S. Gill, Susan Deng, Fengdong Cheng, MD, Alejandro Villagra, Noreen Luetteke, Edward Seto, Eduardo M. Sotomayor, Ivan M. Borrello, MD, Javier Pinilla-Ibarz, MD, PhD

Blood (2011) 118 (21): 2439.

https://doi.org/10.1182/blood.V118.21.2439.2439

Published: 2011

Journal Articles

Epigenetic Modulation of STAT3 by Histone Deacetylase 6 (HDAC6) Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Fengdong Cheng, Zi Wang, Hongwei Wang, Karrune V. Woan, Eva Sahakian, Ph.D, Jennifer Rock Klotz, Liqing Wang, Rongxiang Han, Oscar Merino, Susan Deng, Lianet Vazquez, Ajaypal S. Gill, Danay Marante, John Powers, B.S., Wayne W. Hancock, Javier Pinilla, Edward Seto, Eduardo M. Sotomayor, Alejandro Villagra

Blood (2011) 118 (21): 519.

https://doi.org/10.1182/blood.V118.21.519.519

Published: 2011

Journal Articles

Tubastatin A, a Selective HDAC6 Inhibitor, Enhances Antigen-Presenting Cell (APC) Function and Restores the Responsiveness of Anergic CD4+ T Cells

Hongwei Wang, Zi Wang, Fengdong Cheng, Karrune V. Woan, Jennifer Rock-Klotz, Eva Sahakian, Ph.D, John Powers, B.S., Pinilla Javier, Joel Bergman, Alejandro Villagra, Alan Kozikowski, Eduardo M. Sotomayor

Blood (2011) 118 (21): 520.

https://doi.org/10.1182/blood.V118.21.520.520

Published: 2011

Journal Articles

The Opposing Role of Histone Deacetylase 10 (HDAC10) and HDAC11 in Proliferation/Survival of Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL)

Eva Sahakian, Ph.D, Bijal D. Shah, MD, John Powers, B.S., Susan Deng, Oscar Merino, Ajaypal S. Gill, Jennifer Rock-Klotz, B.S., Karrune V. Woan, Lianet Vazquez, Hongwei Wang, MD, Selina Chen-Kiang, PhD, Jianguo Tao, MD, PhD, Alejandro Villagra, Javier Pinilla-Ibarz, MD, PhD, Eduardo M. Sotomayor

Blood (2011) 118 (21): 1363.

https://doi.org/10.1182/blood.V118.21.1363.1363

Published: 2011

Journal Articles

Enhanced Immunological Responses Following K562/GM-CSF/CD40L Vaccine Plus Lenalidomide in High-Risk Myelodysplastic Syndrome

John Powers, B.S., Eric Padron, MD, Jason Dubovsky, Ph.D, Emmanuel Berchmans, B.S., Tyler Farnum, Fanqi Bai, MD, Eva Sahakian, Ph.D, Jamil Ahmed, Rami S. Komrokji, MD, Jeffrey E. Lancet, MD, Alan F. List, MD, Douglas G McNeel, MD, Sophie Dessureault, MD, Scott Antonia, MD, Eduardo M. Sotomayor, P.K. Epling-Burnette, PharmD, PhD, Javier Pinilla-Ibarz, MD, PhD

Blood (2011) 118 (21): 1725.

https://doi.org/10.1182/blood.V118.21.1725.1725

Published: 2011

Journal Articles

A Phase I Pilot Study of Bystander Vaccine and Lenalidomide Immune Augmentation In Patients with Myelodysplastic Syndrome (MDS)

Eric Padron, MD, Rami S. Komrokji, MD, Jeffrey E. Lancet, MD, Alan F. List, MD, Sophie Dessureault, Scott Antonia, Jamil Ahmed, Shiddhi Patel, John Powers, Fanqi Bai, Eduardo M. Sotomayor, MD, P.K. Epling-Burnette, PharmD, PhD, Javier Pinilla-Ibarz, MD

Blood (2010) 116 (21): 2925.

https://doi.org/10.1182/blood.V116.21.2925.2925

Published: 2010

Journal Articles

Correlative Analysis of T Cell Subpopulations and CD20 Expression In a Phase II Study of Lenalidomide In Combination with Rituximab In Patients with Relapsed or Refractory CLL/SLL

Marays Veliz, M.D., John Powers, Ling Zhang, MD, Enrique Santana, RN, Jeffrey E. Lancet, MD, Rami S. Komrokji, MD, Mohamed Kharfan-Dabaja, MD, Sara Tinsley, ARNP, Darcie Deaver, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD

Blood (2010) 116 (21): 4630.

https://doi.org/10.1182/blood.V116.21.4630.4630

Published: 2010

Journal Articles

Molecular, Epigenetic, and Phenotypic Repolarization of T Lymphocytes From Chronic Lymphocytic Leukemia Patients Using 5-Aza-2′-Deoxycytidine

Jason A Dubovsky, John Powers, Yang Gao, Luis F Mariusso, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD

Blood (2010) 116 (21): 4651.

https://doi.org/10.1182/blood.V116.21.4651.4651

Published: 2010

NARROW

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

MYC Regulation Via the LIN28B/Let-7 Axis in Multiple Myeloma

A Novel Role for Histone Deacetylase 11 (HDAC11) in B Cell Lymphopoiesis and Plasma Cell Survival in Multiple Myeloma

Histone Deacetylase 11 (HDAC11) Is a Novel Regulator In The Expansion Of MDSCs Via The Transcription Factor C/EBP-β

A Novel Role For Histone Deacetylase 11 (HDAC11) As a Regulator Of Neutrophil Function and Differentiation In Normal and Malignant Hematopoesis

A Novel Role For Histone Deacetylase 11 (HDAC11) In Plasma Cell Differentation and Survival

Combination of ACY1215, a Selective Histone Deacetylase 6 (HDAC6) Inhibitor with the Bruton Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, Represents a Novel Therapeutic Strategy in Mantle Cell Lymphoma (MCL)

Novel Role of Histone Deacetylase 11 (HDAC11) in Hematopoiesis

Physical Interaction of Histone Deacetylase 6 (HDAC6) with STAT3 Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Inducible Expression of Cancer Testis Antigens in Myelodysplastic Syndrome (MDS) Patients Following Treatment with an Oral 5-Azacytidine

Histone Deacetylase 11 (HDAC11) Regulates Cytotoxic T-Cell Function and Memory Phenotype

A Novel Role of Histone Deacetylase 11 (HDAC11) in Regulation of Myeloid-Derived Suppressor Cell (MDSC) Expansion

Epigenetic Modulation of STAT3 by Histone Deacetylase 6 (HDAC6) Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Tubastatin A, a Selective HDAC6 Inhibitor, Enhances Antigen-Presenting Cell (APC) Function and Restores the Responsiveness of Anergic CD4+ T Cells

The Opposing Role of Histone Deacetylase 10 (HDAC10) and HDAC11 in Proliferation/Survival of Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL)

Enhanced Immunological Responses Following K562/GM-CSF/CD40L Vaccine Plus Lenalidomide in High-Risk Myelodysplastic Syndrome

A Phase I Pilot Study of Bystander Vaccine and Lenalidomide Immune Augmentation In Patients with Myelodysplastic Syndrome (MDS)

Correlative Analysis of T Cell Subpopulations and CD20 Expression In a Phase II Study of Lenalidomide In Combination with Rituximab In Patients with Relapsed or Refractory CLL/SLL

Molecular, Epigenetic, and Phenotypic Repolarization of T Lymphocytes From Chronic Lymphocytic Leukemia Patients Using 5-Aza-2′-Deoxycytidine

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