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Journal Articles

A Novel Role for Histone Deacetylase 10 (HDAC10) in the Regulation of PD-L1 Expression and Immune Tolerance Mediated By Antigen Presenting Cells (APCs)

Michael Wang, Bachelor of Science, Fengdong Cheng, MD, Jie Chen, PhD, Yixuan Li, PhD, Alejandro Villagra, PhD, Mitchell R. Smith, MD PhD, Edward Seto, PhD, Eduardo Martin Sotomayor, MD

Blood (2017) 130 (Supplement 1): 3561.

https://doi.org/10.1182/blood.V130.Suppl_1.3561.3561

Published: 2017

Journal Articles

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

Blood (2017) 130 (2): 146–155.

https://doi.org/10.1182/blood-2016-08-731505

Published: 2017

Includes: Supplemental data

Journal Articles

Histone Deacetylase 11 (HDAC11) Interaction with Ikaros Represent a Novel Mechanism of Regulation of Essential Transcriptional Factors in CD4+ T Cells

Jie Chen, PhDCandidate, Fengdong Cheng, MD, David Michael Woods, PhD, Edward Seto, PhD, Alejandro Villagra, PhD, Eduardo M. Sotomayor, MD

Blood (2016) 128 (22): 864.

https://doi.org/10.1182/blood.V128.22.864.864

Published: 2016

Journal Articles

JQ1, a Selective Bromodomain Inhibitor, Augment the Immunogenicity of Mantle Cell Lymphoma By Influencing the Expression of PD-L1

Hongwei Wang, MD, Fengdong Cheng, MD, Jie Cheng, PhD, Alejandro Villagra, PhD, Jianguo Tao, MD PhD, James E. Bradner, MD, Eduardo M. Sotomayor, MD

Blood (2015) 126 (23): 822.

https://doi.org/10.1182/blood.V126.23.822.822

Published: 2015

Journal Articles

A Novel Role for Histone Deacetylase 11 (HDAC11) in B Cell Lymphopoiesis and Plasma Cell Survival in Multiple Myeloma

Jason B. Brayer, MDPhD, Eva Sahakian, PhD, John Powers, M.S., Mark B Meads, PhD, Susan Deng, Allison Distler, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Alejandro Villagra, PhD, Javier Pinilla-Ibarz, MD PhD, Eduardo M. Sotomayor, MD, Kenneth H. Shain, MD PhD

Blood (2014) 124 (21): 4715.

https://doi.org/10.1182/blood.V124.21.4715.4715

Published: 2014

Journal Articles

Histone Deacetylase 6 (HDAC6) As a Regulator of Immune Check-Point Molecules in Chronic Lymphocytic Leukemia (CLL)

John J. Powers, B.S., Kamira K. Maharaj, B.S., Eva Sahakian, PhD, Limin Xing, PhD, Patricio PerezVillarroel, BS, Tessa Knox, MS, Steven Quayle, Simon S Jones, PhD, Alejandro Villagra, PhD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD PhD

Blood (2014) 124 (21): 3311.

https://doi.org/10.1182/blood.V124.21.3311.3311

Published: 2014

Journal Articles

JQ 1, a Selective Bromodomain Inhibitor, Decreased the Expression of the Tolerogenic Molecule PDL1 in Antigen-Presenting Cells (APCs) and Restores the Responsiveness of Anergic CD4+ T Cells

Hongwei Wang, MD, Fengdong Cheng, MD, Limin Xing, MD, Xiaohong Zhao, PhD, Alejandro Villagra, PhD, Javier Pinilla-Ibarz, MD PhD, Jianguo Tao, MD PhD

Blood (2014) 124 (21): 2749.

https://doi.org/10.1182/blood.V124.21.2749.2749

Published: 2014

Journal Articles

Selective Inhibition of HDAC6 Decreases Viability of Cutaneous T-Cell Lymphoma and Improves Immune Recognition

Tessa Knox, MS, Maritza Lienlaf, MS, Patricio Perez-Villarroel, BS., Calvin Lee, MD, Eva Sahakian, PhD, John J. Powers, B.S., Fengdong Cheng, MD, Jorge Canales, MS, Danay Marante, MS, Ed Seto, PhD, Eduardo M. Sotomayor, MD, Alejandro Villagra, PhD, Pedro Horna, MD

Blood (2014) 124 (21): 5423.

https://doi.org/10.1182/blood.V124.21.5423.5423

Published: 2014

Journal Articles

Selective Inhibition of Histone Deacetylase 6 (HDAC6) and HDAC3 As a Novel Therapeutic Strategy in Mantle Cell Lymphoma (MCL)

Fengdong Cheng, MD, Bing Xia, MD, Eva Sahakian, PhD, Tint Lwin, MD PhD, Hongwei Wang, MD, Limin Xing, MD, Bijal D. Shah, MD, Patricio PerezVillarroel, BS, Maritza LienlafMoreno, BS, Yizhuo Zhang, MD, Steven N Quayle, PhD, Simon S Jones, PhD, Javier Pinilla-Ibarz, MD PhD, Alejandro Villagra, PhD, Eduardo M. Sotomayor, MD, Jianguo Tao, MD PhD

Blood (2014) 124 (21): 5397.

https://doi.org/10.1182/blood.V124.21.5397.5397

Published: 2014

Journal Articles

A Phase I/II Trial Evaluating the Use of a Histone Deacetylase Inhibitor Panobinostat (LBH589) in Addition to Glucocorticoids in Patients with Acute Graft-Versus-Host Disease

Lia Perez, MD, Teresa Field, MD PhD, Marcie L Riches, MD MS, Hugo F Fernandez, MD, Frederick L Locke, MD, Brian C Betts, MD, Joseph Pidala, MD PhD, Erika Elmer, CCRP, Francisca Beato, BS, Maritza Lienlaf, MS, Pedro Horna, MD, Alejandro Villagra, PhD, Claudio Anasetti, MD

Blood (2014) 124 (21): 1167.

https://doi.org/10.1182/blood.V124.21.1167.1167

Published: 2014

Journal Articles

Histone Deacetylase 11 (HDAC11) As a Novel Transcriptional Regulator of C/EBP-β, in Immature Myeloid Cell to Myeloid Derived Suppressor Cell Transition

Jie Chen, MA, Eva Sahakian, PhD, John J. Powers, B.S., Maritza LienlafMoreno, BS, Limin Xing, PhD, Susan Deng, Allison Distler, Fengdong Cheng, MD, Alejandro Villagra, PhD, Pedro Horna, MD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD PhD

Blood (2014) 124 (21): 225.

https://doi.org/10.1182/blood.V124.21.225.225

Published: 2014

Journal Articles

Histone Deacetylase 11 (HDAC11) Is a Novel Regulator In The Expansion Of MDSCs Via The Transcription Factor C/EBP-β

Jie Chen, M.A., John Powers, B.S., Jennifer Rock-Klotz, B.S., Susan Deng, B.S., Allison Distler, B.S., Fengdong Cheng, MD, Alejandro Villagra, PhD, Eduardo M. Sotomayor, MD, Eva Sahakian, Ph.D, Javier Pinilla-Ibarz, MD, PhD

Blood (2013) 122 (21): 4887.

https://doi.org/10.1182/blood.V122.21.4887.4887

Published: 2013

Journal Articles

A Phase I/II Trial Evaluating The Use Of a Histone Deacetylase Inhibitor Panobinostat (LBH589) In Addition To Glucocorticoids In Patients With Acute Graft-Versus-Host Disease

Lia Perez, MD, Hugo F Fernandez, MD, Marcie Tomblyn, MD, MS, Frederick L Locke, MD, Teresa Field, MD, PhD, Joseph Pidala, MD, MS, Erika Elmer, CCRP, Francisca Beato, BS, Alejandro Villagra, PhD, Claudio Anasetti, MD

Blood (2013) 122 (21): 3308.

https://doi.org/10.1182/blood.V122.21.3308.3308

Published: 2013

Journal Articles

Role Of Histone Deacetylase 6 (HDAC6) In The Modulation Of STAT Pathways and Immune Function Of APCs

Maritza Lienlaf, MS, Patricio Perez-Villarroel, BS., Fengdong Cheng, MD, Calvin K. Lee, MD, Jorge Canales, MS, Tessa Knox, MS, Danay Marante, MS, Sean J Yoder, MS, Karrune V. Woan, PhD, Javier Pinilla-Ibarz, MD, PhD, Edward Seto, PhD, Eduardo M. Sotomayor, MD, Alejandro Villagra, PhD

Blood (2013) 122 (21): 1032.

https://doi.org/10.1182/blood.V122.21.1032.1032

Published: 2013

Journal Articles

Critical Role for Histone Deacetylase 6 (HDAC6) in the Regulation of IL-6, and the JAK/STA3 Signaling Cascade in Macrophages

Maritza Lienlaf, BS., Patricio Perez-Villarroel, BS., Fengdong Cheng, M.D., Hongwei Wang, MD, Danay Marante, MS, Sean Yoder, MS, Woan Karrune V., PhD, Tessa Knox, MS, Stephen Lagor, Javier Pinilla-Ibarz, MD, PhD, Edward Seto, PhD, Eduardo M. Sotomayor, MD, Alejandro Villagra, PhD

Blood (2012) 120 (21): 1039.

https://doi.org/10.1182/blood.V120.21.1039.1039

Published: 2012

Journal Articles

Combination of ACY1215, a Selective Histone Deacetylase 6 (HDAC6) Inhibitor with the Bruton Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, Represents a Novel Therapeutic Strategy in Mantle Cell Lymphoma (MCL)

Eva Sahakian, Ph.D, Jennifer Rock-Klotz, B.S., Bijal D. Shah, MD, John Powers, B.S., Jennifer L. Cultrera, MD, Susan Deng, David M Woods, M.S., Michael Nguyen, Fengdong Cheng, MD, Hongwei Wang, Patricio Perez-Villarroel, B.S., Maritza Lienlaf, B.S., Tesa Knox, M.S., Selina Chen-Kiang, PhD, Alejandro Villagra, PhD, Jianguo Tao, MD, PhD, Javier Pinilla-Ibarz, MD, PhD, Simon S Jones, Eduardo M. Sotomayor, MD

Blood (2012) 120 (21): 1660.

https://doi.org/10.1182/blood.V120.21.1660.1660

Published: 2012

Journal Articles

Novel Role of Histone Deacetylase 11 (HDAC11) in Hematopoiesis

Eva Sahakian, Ph.D, John Powers, B.S., Pedro Horna, M.D., Jennifer Rock-Klotz, B.S., Susan Deng, David M Woods, M.S., Michael Nguyen, Karrune V. Woan, PhD, Fengdong Cheng, MD, Alejandro Villagra, PhD, Dmitry Gabrilovich, MD, PhD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD, PhD

Blood (2012) 120 (21): 4728.

https://doi.org/10.1182/blood.V120.21.4728.4728

Published: 2012

Journal Articles

Physical Interaction of Histone Deacetylase 6 (HDAC6) with STAT3 Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Blood (2012) 120 (21): 829.

https://doi.org/10.1182/blood.V120.21.829.829

Published: 2012

Journal Articles

Inhibition of Histone Deacetylase 6 (HDAC6) Disrupts the Tolerogenic STAT3 Signaling Pathway and Augments Antitumor Immune Responses in Mantle Cell Lymphoma (MCL)

Hongwei Wang, MD, Fengdong Cheng, MD, Zi Wang, Maritza Lienlaf, BS., Patricio Perez-Villarroel, Tessa Knox, MS, Eva Sahakian, Ph.D, Javier Pinilla-Ibarz, MD, PhD, Pedro Horna, M.D., Selina Chen-Kiang, PhD, Peter Martin, MD, Joel Bergman, Alan Kozikowski, Alejandro Villagra, PhD, Jianguo Tao, MD, PhD, Bijal D. Shah, MD, Eduardo M. Sotomayor, MD

Blood (2012) 120 (21): 3724.

https://doi.org/10.1182/blood.V120.21.3724.3724

Published: 2012

Journal Articles

Histone Deacetylase 11 (HDAC11) Regulates Cytotoxic T-Cell Function and Memory Phenotype

David M Woods, M.S., Karrune V. Woan, PhD, Eva Sahakian, Ph.D, John Powers, B.S., Fengdong Cheng, MD, Hongwei Wang, Jennifer Rock-Klotz, B.S., Jeffrey S. Weber, MD, PhD, Alejandro Villagra, PhD, Javier Pinilla-Ibarz, MD, PhD, Eduardo M. Sotomayor, MD

Blood (2012) 120 (21): 840.

https://doi.org/10.1182/blood.V120.21.840.840

Published: 2012

NARROW

A Novel Role for Histone Deacetylase 10 (HDAC10) in the Regulation of PD-L1 Expression and Immune Tolerance Mediated By Antigen Presenting Cells (APCs)

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

Histone Deacetylase 11 (HDAC11) Interaction with Ikaros Represent a Novel Mechanism of Regulation of Essential Transcriptional Factors in CD4+ T Cells

JQ1, a Selective Bromodomain Inhibitor, Augment the Immunogenicity of Mantle Cell Lymphoma By Influencing the Expression of PD-L1

A Novel Role for Histone Deacetylase 11 (HDAC11) in B Cell Lymphopoiesis and Plasma Cell Survival in Multiple Myeloma

Histone Deacetylase 6 (HDAC6) As a Regulator of Immune Check-Point Molecules in Chronic Lymphocytic Leukemia (CLL)

JQ 1, a Selective Bromodomain Inhibitor, Decreased the Expression of the Tolerogenic Molecule PDL1 in Antigen-Presenting Cells (APCs) and Restores the Responsiveness of Anergic CD4+ T Cells

Selective Inhibition of HDAC6 Decreases Viability of Cutaneous T-Cell Lymphoma and Improves Immune Recognition

Selective Inhibition of Histone Deacetylase 6 (HDAC6) and HDAC3 As a Novel Therapeutic Strategy in Mantle Cell Lymphoma (MCL)

A Phase I/II Trial Evaluating the Use of a Histone Deacetylase Inhibitor Panobinostat (LBH589) in Addition to Glucocorticoids in Patients with Acute Graft-Versus-Host Disease

Histone Deacetylase 11 (HDAC11) As a Novel Transcriptional Regulator of C/EBP-β, in Immature Myeloid Cell to Myeloid Derived Suppressor Cell Transition

Histone Deacetylase 11 (HDAC11) Is a Novel Regulator In The Expansion Of MDSCs Via The Transcription Factor C/EBP-β

A Phase I/II Trial Evaluating The Use Of a Histone Deacetylase Inhibitor Panobinostat (LBH589) In Addition To Glucocorticoids In Patients With Acute Graft-Versus-Host Disease

Role Of Histone Deacetylase 6 (HDAC6) In The Modulation Of STAT Pathways and Immune Function Of APCs

Critical Role for Histone Deacetylase 6 (HDAC6) in the Regulation of IL-6, and the JAK/STA3 Signaling Cascade in Macrophages

Combination of ACY1215, a Selective Histone Deacetylase 6 (HDAC6) Inhibitor with the Bruton Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, Represents a Novel Therapeutic Strategy in Mantle Cell Lymphoma (MCL)

Novel Role of Histone Deacetylase 11 (HDAC11) in Hematopoiesis

Physical Interaction of Histone Deacetylase 6 (HDAC6) with STAT3 Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Inhibition of Histone Deacetylase 6 (HDAC6) Disrupts the Tolerogenic STAT3 Signaling Pathway and Augments Antitumor Immune Responses in Mantle Cell Lymphoma (MCL)

Histone Deacetylase 11 (HDAC11) Regulates Cytotoxic T-Cell Function and Memory Phenotype

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American Society of Hematology

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American Society of Hematology

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