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Journal Articles

Functional Proteomic Profiling of Myelodysplastic Syndromes Reveals Distinct Protein Expression Signatures and Identifies Candidate Therapeutic Targets

Brittany Knick Ragon, MD, Fieke W Hoff, Chenyue W Hu, Yihua Qiu, MD, Suk-Young Yoo, Amina Qutub, Steven M. Kornblau, MD

Blood (2016) 128 (22): 1975.

https://doi.org/10.1182/blood.V128.22.1975.1975

Published: 2016

Journal Articles

Recognition of Recurrent Protein Expression Patterns in Pediatric Acute Myeloid Leukemia Suggests New Therapeutic Targets

Fieke W Hoff, Chenyue W Hu, Yihua Qiu, MD, Suk-Young Yoo, Amina Qutub, Eveline S. de Bont, Terzah M. Horton, MD PhD, Steven M. Kornblau, MD

Blood (2016) 128 (22): 1712.

https://doi.org/10.1182/blood.V128.22.1712.1712

Published: 2016

Journal Articles

Recurrent Patterns of Protein Expression Signatures in Pediatric Acute Lymphoblastic Leukemia: Recognition and Therapeutic Guidance

Fieke W Hoff, Chenyue W Hu, Yihua Qiu, MD, Suk-Young Yoo, Amina Qutub, Terzah M. Horton, MD PhD, Steven M. Kornblau, MD

Blood (2016) 128 (22): 4089.

https://doi.org/10.1182/blood.V128.22.4089.4089

Published: 2016

Journal Articles

Focal Adhesion Kinase As a Potential Target in AML and MDS

Bing Z Carter, Steven M. Kornblau, MD, Po Yee Mak, MPhil, Hui Yang, MD PhD, Yihua Qiu, MD, Xuejie Jiang, Kevin Coombes, PhD, Nianxiang Zhang, Guillermo Garcia-Manero, MD, Michael Andreeff, MD, PhD

Blood (2015) 126 (23): 3680.

https://doi.org/10.1182/blood.V126.23.3680.3680

Published: 2015

Journal Articles

Acute Myelogenous Leukemia (AML) Mesenchymal Stromal Cell (MSC) Have Distinct Protein Expression Patterns Compared to Normal MSC

Steven M. Kornblau, MD, Peter Ruvolo, PhD, Rui-Yu Wang, MD PhD, Vivian Ruvolo, MS, Yihua Qiu, MD, Venkata Lokesh Battula, PhD, Zhihong Zeng, MD, Teresa McQueen, Suk-Young Yoo, Marina Konopleva, MD PhD, Michael Andreeff, MD, PhD

Blood (2015) 126 (23): 3813.

https://doi.org/10.1182/blood.V126.23.3813.3813

Published: 2015

Journal Articles

Mapping Microenvironment-Mediated Signaling Dependency of Targeted Inhibitors: A Mechanism-Based Approach of Selecting Effective Therapy Targeting Drug Resistant AML

Zhihong Zeng, MD, Wenbin Liu, PhD, Twee Tsao, MS, Yihua Qiu, MD, Ismael Samudio, PhD, Keith Baggerly, PhD, Steven M. Kornblau, MD, Hagop M Kantarjian, MD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD

Blood (2015) 126 (23): 1398.

https://doi.org/10.1182/blood.V126.23.1398.1398

Published: 2015

Journal Articles

Role of Mesenchymal Stem Cell Galectin 3 in the AML Tumor Microenvironment

Peter Ruvolo, PhD, Yihua Qiu, MD, Vivian Ruvolo, MS, Rui-Yu Wang, MD PhD, Zhihong Zeng, MD, Jared Burks, PhD, Rongqing Pan, MS, Numsen Hail, Jr., PhD, Teresa McQueen, Suk-Young Yoo, Steven M. Kornblau, MD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 1198.

https://doi.org/10.1182/blood.V126.23.1198.1198

Published: 2015

Journal Articles

MLN0128, a Second-Generation mTOR Kinase Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML

Zhihong Zeng, MD, Rui-Yu Wang, MD PhD, Yuexi Shi, MD, Yihua Qiu, MD, Duncan H Mak, MS, Kevin Coombes, PhD, Suk Young Yoo, PhD, Katti Jessen, Yi Liu, PhD, Christian Rommel, PhD, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, David Fruman, PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 3613.

https://doi.org/10.1182/blood.V124.21.3613.3613

Published: 2014

Journal Articles

Heatshock Protein (HSP) Family Expression Is Dichotomous and Prognostic in Acute Myelogenous Leukemia (AML)

Steven M. Kornblau, MD, Chenyue W Hu, Yihua Qiu, MD, Suk Young Yoo, PhD, Trang T Nguyen, Tapan Kadia, MD, Gautam Borthakur, MD, Kevin Coombes, PhD, Amina A Qutub, PhD

Blood (2014) 124 (21): 1026.

https://doi.org/10.1182/blood.V124.21.1026.1026

Published: 2014

Journal Articles

Disrupting Wnt/ß-Catenin Signaling By a ß-Catenin/CBP Modulator C-82 Suppresses Cell Growth and Induces Apoptosis in AML Blasts and CD34 + 38 - AML Progenitor Cells

Po Yee Mak, Steven M. Kornblau, MD, Yihua Qiu, MD, Wei Wei, MS, Hiroyuki Kouji, Kevin Coombes, PhD, Jorge E. Cortes, MD, Michael Andreeff, MD PhD, Bing Z Carter, PhD

Blood (2014) 124 (21): 3600.

https://doi.org/10.1182/blood.V124.21.3600.3600

Published: 2014

Journal Articles

CREB/ATF Family Protein Expression States in AML: Active CREB1, but Not ATF Is an Adverse Prognostic Factor

Steven M. Kornblau, MD, Chenyue W Hu, Yihua Qiu, MD, Suk Young Yoo, PhD, Kavita Chauhan, Elias Jabbour, MD, Farhad Ravandi, MD, Kevin Coombes, PhD, Amina A Qutub, PhD

Blood (2014) 124 (21): 2344.

https://doi.org/10.1182/blood.V124.21.2344.2344

Published: 2014

Journal Articles

Expression of Ribosomal Protein S6 (R6SP) and Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) Is Correlated in Acute Myelogenous Leukemia (AML) and Is Highly Prognostic, Especially in NPM1 and FLT3 Wildtype Patients

Steven M. Kornblau, MD, Chenyue W Hu, Yihua Qiu, MD, Suk Young Yoo, PhD, Rebecca A Murray, Nitin Jain, MD, Yesid Alvarado, MD, Kevin Coombes, PhD, Amina A Qutub, PhD

Blood (2014) 124 (21): 2369.

https://doi.org/10.1182/blood.V124.21.2369.2369

Published: 2014

Journal Articles

Cathepsin G Is Broadly Expressed By AML and Is an Effective Immunotherapeutic Target Against AML in Vivo

Gheath Alatrash, DO, PhD, Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Yihua Qiu, MD, Amjad H. Talukder, PhD, Vladimir Senyukov, PhD, Lisa S. St. John, PhD, Hong He, MD, Anna Sergeeva, PhD, Jason Roszik, PhD, Karen Clise-Dwyer, PhD, Sijie Lu, PhD, Qing Ma, PhD, Elizabeth A. Mittendorf, MD PhD, Dean A. Lee, MD PhD, David H Hawke, PhD, Lizee Gregory, PhD, Jeffrey J. Molldrem, Steven M. Kornblau, MD

Blood (2014) 124 (21): 3761.

https://doi.org/10.1182/blood.V124.21.3761.3761

Published: 2014

Journal Articles

Protein Expression Clusters Can Differentiate Leukemia Subtypes in Pediatric Leukemia

Terzah M Horton, MDPhD, Yihua Qiu, MD, Gaye Jenkins, MS, Steven M. Kornblau, MD

Blood (2014) 124 (21): 3784.

https://doi.org/10.1182/blood.V124.21.3784.3784

Published: 2014

Journal Articles

Adhesion Signaling States in AML

Chenyue W Hu, Amina A Qutub, PhD, Yihua Qiu, MD, Suk Young Yoo, PhD, Nianxiang Zhang, PhD, Naval G. Daver, MD, Maro Ohanian, DO, Kevin Coombes, PhD, Steven M. Kornblau, MD

Blood (2014) 124 (21): 2386.

https://doi.org/10.1182/blood.V124.21.2386.2386

Published: 2014

Journal Articles

A Global Proteomic Pathway Map In Acute Myeloid Leukemia (AML)

Chenyu W Hu, Amina A Qutub, PhD, Yihua Qiu, MD, Suk Young Yoo, PhD, Nianxiang Zhang, PhD, Naveen Pammaraju, MD, Courtney D. DiNardo, MD, Kevin R. Coombes, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 1302.

https://doi.org/10.1182/blood.V122.21.1302.1302

Published: 2013

Journal Articles

Classification Of Acute Myelogenous Leukemia (AML) Based On Functionally Related Proteins Groups

Steven M. Kornblau, MD, Chenyu W Hu, Suk Young Yoo, PhD, Yihua Qiu, MD, Nianxiang Zhang, PhD, Gautam Borthakur, MD, Naval G. Daver, MD, Amina A Qutub, PhD, Kevin R. Coombes, PhD

Blood (2013) 122 (21): 492.

https://doi.org/10.1182/blood.V122.21.492.492

Published: 2013

Journal Articles

Recurrent Patterns Of Histone Methylation and Acetylation Regulating Protein Expression In Acute Myelogenous Leukemia (AML)

Steven M. Kornblau, MD, Chenyu W Hu, Yihua Qiu, MD, Suk Young Yoo, PhD, Nianxiang Zhang, PhD, Farhad Ravandi, MD, Guillermo Garcia-Manero, MD, Amina A Qutub, PhD, Kevin R. Coombes, PhD

Blood (2013) 122 (21): 3733.

https://doi.org/10.1182/blood.V122.21.3733.3733

Published: 2013

Journal Articles

Phosphorylation Of GSK3β Is Associated With Inferior Survival In Acute Myeloid Leukemia and Is An Indicator Of AKT Activation In AML Blasts and Bone Marrow Mesenchymal Stem Cells

Peter P. Ruvolo, PhD, Rui-yu Wang, MD, PhD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Teresa McQueen, BS, Gautam Borthakur, MD, Yihua Qiu, MD, Kevin R. Coombes, PhD, Nianxiang Zhang, Elizabeth J Shpall, MD, Richard E Champlin, MD, Ramiro Garzon, MD, Guido Marcucci, MD, Carlo M. Croce, MD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 2551.

https://doi.org/10.1182/blood.V122.21.2551.2551

Published: 2013

Journal Articles

Acute Lymphoblastic Leukemia Is a Bcl-2 Dependent Disease: Proteomic Profiling and Pre-Clinical Efficacy Of a Selective Bcl-2 Antagonist ABT-199

Blood (2013) 122 (21): 3919.

https://doi.org/10.1182/blood.V122.21.3919.3919

Published: 2013

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Functional Proteomic Profiling of Myelodysplastic Syndromes Reveals Distinct Protein Expression Signatures and Identifies Candidate Therapeutic Targets

Recognition of Recurrent Protein Expression Patterns in Pediatric Acute Myeloid Leukemia Suggests New Therapeutic Targets

Recurrent Patterns of Protein Expression Signatures in Pediatric Acute Lymphoblastic Leukemia: Recognition and Therapeutic Guidance

Focal Adhesion Kinase As a Potential Target in AML and MDS

Acute Myelogenous Leukemia (AML) Mesenchymal Stromal Cell (MSC) Have Distinct Protein Expression Patterns Compared to Normal MSC

Mapping Microenvironment-Mediated Signaling Dependency of Targeted Inhibitors: A Mechanism-Based Approach of Selecting Effective Therapy Targeting Drug Resistant AML

Role of Mesenchymal Stem Cell Galectin 3 in the AML Tumor Microenvironment

MLN0128, a Second-Generation mTOR Kinase Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML

Heatshock Protein (HSP) Family Expression Is Dichotomous and Prognostic in Acute Myelogenous Leukemia (AML)

Disrupting Wnt/ß-Catenin Signaling By a ß-Catenin/CBP Modulator C-82 Suppresses Cell Growth and Induces Apoptosis in AML Blasts and CD34 + 38 - AML Progenitor Cells

CREB/ATF Family Protein Expression States in AML: Active CREB1, but Not ATF Is an Adverse Prognostic Factor

Expression of Ribosomal Protein S6 (R6SP) and Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) Is Correlated in Acute Myelogenous Leukemia (AML) and Is Highly Prognostic, Especially in NPM1 and FLT3 Wildtype Patients

Cathepsin G Is Broadly Expressed By AML and Is an Effective Immunotherapeutic Target Against AML in Vivo

Protein Expression Clusters Can Differentiate Leukemia Subtypes in Pediatric Leukemia

Adhesion Signaling States in AML

A Global Proteomic Pathway Map In Acute Myeloid Leukemia (AML)

Classification Of Acute Myelogenous Leukemia (AML) Based On Functionally Related Proteins Groups

Recurrent Patterns Of Histone Methylation and Acetylation Regulating Protein Expression In Acute Myelogenous Leukemia (AML)

Phosphorylation Of GSK3β Is Associated With Inferior Survival In Acute Myeloid Leukemia and Is An Indicator Of AKT Activation In AML Blasts and Bone Marrow Mesenchymal Stem Cells

Acute Lymphoblastic Leukemia Is a Bcl-2 Dependent Disease: Proteomic Profiling and Pre-Clinical Efficacy Of a Selective Bcl-2 Antagonist ABT-199

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