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Journal Articles

Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Blood (2019) 134 (Supplement_1): 4196.

https://doi.org/10.1182/blood-2019-127903

Published: 2019

Journal Articles

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

Camélia Benlabiod, Maira da Costa Cacemiro, PhD, Thomas Balligand, MD, Barbara Panneau-Schmaltz, PhD, Delphine Muller, Laure Touchard, Patrick Gonin, DVM, Jean-Luc Villeval, PhD, Stefan N Constantinescu, MD PhD, Hana Raslova, PhD, William Vainchenker, MD PhD, Isabelle Plo, Caroline Marty, PhD

Blood (2019) 134 (Supplement_1): 311.

https://doi.org/10.1182/blood-2019-127918

Published: 2019

Journal Articles

Differential Impact of Interferon Alpha on JAK2 V617F and Calr Mutated Hematopoietic Stem and Progenitor Cells in Classical MPN

Matthieu Mosca, PhDstudent, Lamia Lamrani, PhD, Christophe Marzac, MD, Amandine Tisserand, Valérie Edmond, PhD, Tracy Dagher, PhDstudent, Mira El-Khoury, PhD, Caroline Marty, PhD, Hugo Campario, PharmD, Nicole Casadevall, MD, Eric Solary, MD PhD, Hana Raslova, PhD, Bruno Cassinat, PharmD, PhD, Stefan N Constantinescu, MD, Jean-Jacques Kiladjian, MD PhD, Francois Girodon, MD PhD, Jean-Luc Villeval, PhD, William Vainchenker, MD PhD, Isabelle Plo, PhD

Blood (2018) 132 (Supplement 1): 4333.

https://doi.org/10.1182/blood-2018-99-114744

Published: 2018

Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Blood (2018) 132 (Supplement 1): 4.

https://doi.org/10.1182/blood-2018-99-118348

Published: 2018

Journal Articles

Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms

Blood (2018) 132 (Supplement 1): 3842.

https://doi.org/10.1182/blood-2018-99-116015

Published: 2018

Journal Articles

ATG2B/Gskip in De Novo Acute Myeloid Leukemia (AML): High Prevalence of Germline Predisposition in French West Indies and Potential Role of Overexpression in Acquired AML

Blood (2018) 132 (Supplement 1): 1482.

https://doi.org/10.1182/blood-2018-99-110366

Published: 2018

Journal Articles

Mutations in SRP54 Gene Cause Severe Primary Neutropenia As Well As Shwachman-Diamond-like Syndrome

Blood (2017) 130 (Supplement 1): LBA-3.

https://doi.org/10.1182/blood.V130.Suppl_1.LBA-3.LBA-3

Published: 2017

Journal Articles

Rare Type 1-like and Type 2-like Calrecticulin Mutants Induce Similar Myeloproliferative Neoplasms Than Type 1 and Type 2 Mutants in Mice

Katte Rao Toppaldoddi, Maira da Costa Cacemiro, Olivier Bluteau, PhD, Amélie Pioch, Barbara Panneau-Schmaltz, PhD, Delphine Muller, Nicole Casadevall, MD, Hana Raslova, PhD, Stefan N. Constantinescu, MD PhD, Isabelle Plo, William Vainchenker, MD PhD, Caroline Marty, PhD

Blood (2017) 130 (Supplement 1): 1665.

https://doi.org/10.1182/blood.V130.Suppl_1.1665.1665

Published: 2017

Journal Articles

The ETO2-GLIS2 Fusion Oncogene Alters Early Human Hematopoiesis in an Induced Pluripotent Stem Cells-Derived Model of Pediatric Acute Megakaryoblastic Leukemia

Salvatore Nicola Bertuccio, Marie Cambot, Cécile K Lopez, Larissa Lordier, Alessandro Donada, Zakia Aid, Franco Locatelli, MD PhD, Riccardo Masetti, MDPhD, William Vainchenker, MD PhD, Hana Raslova, PhD, Andrea Pession, MD, Thomas Mercher, PhD

Blood (2017) 130 (Supplement 1): 2512.

https://doi.org/10.1182/blood.V130.Suppl_1.2512.2512

Published: 2017

Journal Articles

Calreticulin Mutants Induce an Early Clonal Dominance and a Megakaryocytic Phenotype through the Activation of MPL/JAK2 Pathway in Human Primary Cells

Mira EL Khoury, Gaelle Vertenoeil, Caroline Marty, Christophe Marzac, Matthieu Mosca, Christian Pecquet, PhD, Fabrizia Favale, Robert Kralovics, Najet Debili, Nicole Casadevall, MD, Hana Raslova, PhD, Stefan N. Constantinescu, MD PhD, Isabelle Plo, William Vainchenker, MD PhD

Blood (2016) 128 (22): 1959.

https://doi.org/10.1182/blood.V128.22.1959.1959

Published: 2016

Journal Articles

New Insights into Mechanisms of Erythropoietin Receptor Mutations in Primary Familial and Congenital Polycythemia

Florence Pasquier, MD PhD, Caroline Marty, PhD, Frédérique Verdier, PhD, Sarah Grosjean, MBiol, Claude Préhu, MD, Stefan N. Constantinescu, MD PhD, Hana Raslova, PhD, Nicole Casadevall, MD, William Vainchenker, MD PhD, Christine Bellanné-Chantelot, PharmD, PhD, Isabelle Plo, PhD

Blood (2016) 128 (22): 631.

https://doi.org/10.1182/blood.V128.22.631.631

Published: 2016

Journal Articles

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Blood (2016) 128 (22): 572.

https://doi.org/10.1182/blood.V128.22.572.572

Published: 2016

Journal Articles

Targeting Acute Myeloid Leukemia with a New CXCR4 Antagonist IgG1 Antibody (PF-06747143)in NOD/SCID Mice

Yanyan Zhang, PhD, Erika Saavedra, MD, Ruoping Tang, Shu-Hui Liu, Tod Smeal, Valeria Fantin, PhD, Stephane De Botton, MD PhD, Ollivier Legrand, MD PhD, William Vainchenker, MD PhD, Flavia Pernasetti, Fawzia Louache, PhD

Blood (2015) 126 (23): 1362.

https://doi.org/10.1182/blood.V126.23.1362.1362

Published: 2015

Journal Articles

HSP70, the Key to Account for Erythroid Tropism of Diamond-Blackfan Anemia?

Marc Gastou, Sarah Rio, Mickael Dussiot, Narjesse Karboul, Thierry Leblanc, Margaux Sevin, Olivier Bluteau, Narla Mohandas, D.Sc., William Vainchenker, MD PhD, Carmen Garrido, PhD, Eric Solary, MD Prof, Olivier Hermine, Lydie Da Costa, MD PhD

Blood (2015) 126 (23): 671.

https://doi.org/10.1182/blood.V126.23.671.671

Published: 2015

Journal Articles

Thrombopoietin Activates STAT2 Inducing Type I Interferon Effects and Gene Expression: Implications for in Vivo Tpo Treatment and for Myeloproliferative Neoplasms

Stefan N Constantinescu, MD PhD Prof., Jean-Philippe Defour, BPharm,, Celine Mouton, Isabelle Plo, William Vainchenker, MD PhD, Jean-Luc Villeval, PhD, Thomas Michiels, MD PhD, Judith Staerk, Christian Pecquet, PhD

Blood (2014) 124 (21): 820.

https://doi.org/10.1182/blood.V124.21.820.820

Published: 2014

Journal Articles

Differential Association of Calreticulin Type 1 and Type 2 Mutations with Myelofibrosis and Essential Thrombocytemia: Relevance for Disease Evolution

Blood (2014) 124 (21): 1823.

https://doi.org/10.1182/blood.V124.21.1823.1823

Published: 2014

Journal Articles

Calr Mutants Retroviral Mouse Models Lead to a Myeloproliferative Neoplasm Mimicking an Essential Thrombocythemia Progressing to a Myelofibrosis

Caroline Marty, PhD, Nivarthi Harini, Christian Pecquet, PhD, Ilyas Chachoua, Vitalina Gryshkova, PhD, Jean-Luc Villeval, PhD, Stefan N. Constantinescu, MD PhD, Robert Kralovics, PhD, William Vainchenker, MD, PhD, Isabelle Plo

Blood (2014) 124 (21): 157.

https://doi.org/10.1182/blood.V124.21.157.157

Published: 2014

Journal Articles

Defect in Ribosome Biogenesis Contributes to Impaired Megakaryopoiesis in Primary Myelofibrosis

Laure Gilles, PhD, Ahmet Dirim Arslan, PhD, Katerina Konstantinoff, Maureen McNulty, Lasho Terra, PhD, Animesh Pardanani, MBBS, PhD, Brady L Stein, MD, Isabelle Plo, William Vainchenker, MD PhD, Leonidas Platanias, Ayalew Tefferi, MD, John D Crispino, PhD

Blood (2014) 124 (21): 4585.

https://doi.org/10.1182/blood.V124.21.4585.4585

Published: 2014

Journal Articles

Use Of 46/1 Haplotype Permits To Follow JAK2 V617F Clonal Architecture In PV Patients: Clonal Evolution and Impact Of IFNα Treatment

Salma Hasan, PhD student, Bruno Cassinat, PharmD, PhD, Jean-Pierre Le Couédic, Fabrizia Favale, Barbara Monte-Mor, Catherine Lacout, Eric Solary, MD, PhD, Jean-Luc Villeval, PhD, Nicole Casadevall, MD, Jean-Jacques Kiladjian, MD, PhD, William Vainchenker, MD, PhD, Isabelle Plo, Ph.D

Blood (2013) 122 (21): 4109.

https://doi.org/10.1182/blood.V122.21.4109.4109

Published: 2013

Journal Articles

Germline JAK2 Mutations In The Kinase Domain Are Responsible For Hereditary Thrombocytosis and Are Resistant To JAK2 and HSP90 Inhibitors

Caroline Marty, Ph.D, Cecile Saint-martin, Christian Pecquet, PhD, Sarah Grosjean, Joseph Saliba, PhD Student, Celine Mouton, Leroy Emilie, Ashot S. Harutyunyan, Jean-François Abgrall, Remy Favier, Eric Solary, Robert Kralovics, PhD, Stefan N. Constantinescu, MD, PhD, Albert Najman, MD, William Vainchenker, MD, PhD, Isabelle Plo, Ph.D, Christine Bellanné-Chantelot

Blood (2013) 122 (21): 1603.

https://doi.org/10.1182/blood.V122.21.1603.1603

Published: 2013

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Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

Differential Impact of Interferon Alpha on JAK2 V617F and Calr Mutated Hematopoietic Stem and Progenitor Cells in Classical MPN

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms

ATG2B/Gskip in De Novo Acute Myeloid Leukemia (AML): High Prevalence of Germline Predisposition in French West Indies and Potential Role of Overexpression in Acquired AML

Mutations in SRP54 Gene Cause Severe Primary Neutropenia As Well As Shwachman-Diamond-like Syndrome

Rare Type 1-like and Type 2-like Calrecticulin Mutants Induce Similar Myeloproliferative Neoplasms Than Type 1 and Type 2 Mutants in Mice

The ETO2-GLIS2 Fusion Oncogene Alters Early Human Hematopoiesis in an Induced Pluripotent Stem Cells-Derived Model of Pediatric Acute Megakaryoblastic Leukemia

Calreticulin Mutants Induce an Early Clonal Dominance and a Megakaryocytic Phenotype through the Activation of MPL/JAK2 Pathway in Human Primary Cells

New Insights into Mechanisms of Erythropoietin Receptor Mutations in Primary Familial and Congenital Polycythemia

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Targeting Acute Myeloid Leukemia with a New CXCR4 Antagonist IgG1 Antibody (PF-06747143)in NOD/SCID Mice

HSP70, the Key to Account for Erythroid Tropism of Diamond-Blackfan Anemia?

Thrombopoietin Activates STAT2 Inducing Type I Interferon Effects and Gene Expression: Implications for in Vivo Tpo Treatment and for Myeloproliferative Neoplasms

Differential Association of Calreticulin Type 1 and Type 2 Mutations with Myelofibrosis and Essential Thrombocytemia: Relevance for Disease Evolution

Calr Mutants Retroviral Mouse Models Lead to a Myeloproliferative Neoplasm Mimicking an Essential Thrombocythemia Progressing to a Myelofibrosis

Defect in Ribosome Biogenesis Contributes to Impaired Megakaryopoiesis in Primary Myelofibrosis

Use Of 46/1 Haplotype Permits To Follow JAK2 V617F Clonal Architecture In PV Patients: Clonal Evolution and Impact Of IFNα Treatment

Germline JAK2 Mutations In The Kinase Domain Are Responsible For Hereditary Thrombocytosis and Are Resistant To JAK2 and HSP90 Inhibitors

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