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William Sun, PhD
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Journal Articles

Effects of Long-Term Ruxolitinib (RUX) on Bone Marrow (BM) Morphology in Patients with Myelofibrosis (MF) Enrolled in the COMFORT-I Study

Hans Michael Kvasnicka, MD PhD, Juergen Thiele, MD PhD, Carlos E. Bueso-Ramos, MD PhD, William Sun, PhD, Ahmad Naim, MD, Smitha Svaraman, PhD, Jessy Gao, MA, Jason R. Gotlib, MD, Vikas Gupta, MD FRCP, FRCPath, Kim-Hien Dao, DO, PhD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1949.
https://doi.org/10.1182/blood.V128.22.1949.1949
Published: 2016
Journal Articles

A Pooled Overall Survival (OS) Analysis of 5-Year Data from the COMFORT-I and COMFORT-II Trials of Ruxolitinib for the Treatment of Myelofibrosis (MF)

Srdan Verstovsek, MD PhD, Vikas Gupta, MD FRCP, FRCPath, Jason R. Gotlib, MD, Ruben A. Mesa, MD, Alessandro M. Vannucchi, MD, Jean-Jacques Kiladjian, MD PhD, Francisco Cervantes, MD PhD, William Sun, PhD, Jessy Gao, MA, Touchuan Dong, Ahmad Naim, MD, Prashanth Gopalakrishna, MBBS, MRCS, Claire N. Harrison, DM, FRCP, FRCPath
Journal: Blood
Blood (2016) 128 (22): 3110.
https://doi.org/10.1182/blood.V128.22.3110.3110
Published: 2016
Journal Articles

Clinical Outcomes with Ruxolitinib (RUX) in Patients with Myelofibrosis (MF) Stratified By Transfusion Status: A Pooled Analysis of the COMFORT-I and -II Trials

Vikas Gupta, MD FRCP, FRCPath, Srdan Verstovsek, MD PhD, Ronald Paquette, MD, Jason R. Gotlib, MD, Alessandro M. Vannucchi, MD, Jean-Jacques Kiladjian, MD PhD, Francisco Cervantes, MD PhD, William Sun, PhD, Jessy Gao, MA, Peter Langmuir, MD, Prashanth Gopalakrishna, MBBS, MRCS, Claire N. Harrison, DM, FRCP, FRCPath
Journal: Blood
Blood (2016) 128 (22): 3118.
https://doi.org/10.1182/blood.V128.22.3118.3118
Published: 2016
Journal Articles

The Effect of Ruxolitinib on White Blood Cell Counts in Patients with Polycythemia Vera: Results from the RESPONSE Trial

Carole B. Miller, MD, Jean-Jacques Kiladjian, MD PhD, Martin Griesshammer, MD, Ahmad B. Naim, MD, William Sun, PhD, Brian Gadbaw, MD, Srdan Verstovsek, MD PhD, Alessandro M. Vannucchi
Journal: Blood
Blood (2015) 126 (23): 4070.
https://doi.org/10.1182/blood.V126.23.4070.4070
Published: 2015
Journal Articles

Practical Measures of Clinical Benefit with Ruxolitinib Therapy: An Exploratory Analysis of COMFORT-I

Carole B Miller, MD, Rami S Komrokji, MD, Ruben Mesa, MD, William Sun, PhD, Michael Montgomery, MD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3202.
https://doi.org/10.1182/blood.V124.21.3202.3202
Published: 2014
Journal Articles

Ruxolitinib-Induced Modulation of Bone Marrow Microenvironment in Patients with Myelofibrosis Is Associated with Inflammatory Cytokine Levels

Hans Michael Kvasnicka, MD PhD, Juergen Thiele, MD PhD, Carlos E. Bueso-Ramos, MD PhD, William Sun, PhD, Jorge E. Cortes, Hagop M. Kantarjian, MD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3182.
https://doi.org/10.1182/blood.V124.21.3182.3182
Published: 2014
Journal Articles

Effects Of Five-Years Of Ruxolitinib Therapy On Bone Marrow Morphology In Patients With Myelofibrosis and Comparison With Best Available Therapy

Hans Michael Kvasnicka, MD, PhD, Jürgen Thiele, MD, PhD, Carlos E. Bueso-Ramos, MD, PhD, William Sun, PhD, Jorge E. Cortes, MD, Hagop M. Kantarjian, MD, Srdan Verstovsek, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4055.
https://doi.org/10.1182/blood.V122.21.4055.4055
Published: 2013
Journal Articles

Long-Term Outcomes Of Ruxolitinib Therapy In Patients With Myelofibrosis: 3-Year Update From COMFORT-I

Srdan Verstovsek, MD, PhD, Ruben A. Mesa, MD, Jason Gotlib, MD, MS, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. Dipersio, MD, PhD, John V. Catalano, MD, Michael W. Deininger, MD, PhD, Carole B. Miller, MD, Richard T. Silver, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Murat O. Arcasoy, MD, Elizabeth Hexner, MD, Roger M. Lyons, MD, Ronald Paquette, MD, Azra Raza, MD, Kris Vaddi, PhD, William Sun, PhD, Wei Peng, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2013) 122 (21): 396.
https://doi.org/10.1182/blood.V122.21.396.396
Published: 2013
Journal Articles

Optimizing Dose Titration Of Ruxolitinib: The COMFORT-I Experience

Ruben A. Mesa, MD, Rami S. Komrokji, MD, William Sun, PhD, Victor A. Sandor, MD, CM, Srdan Verstovsek, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4062.
https://doi.org/10.1182/blood.V122.21.4062.4062
Published: 2013
Journal Articles

Clinical Benefits of Ruxolitinib Therapy in Myelofibrosis Patients with Varying Degrees of Splenomegaly and Symptoms

Ruben A. Mesa, Jason Gotlib, Hagop M. Kantarjian, MD, William Sun, PhD, Srdan Verstovsek, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1727.
https://doi.org/10.1182/blood.V120.21.1727.1727
Published: 2012
Journal Articles

Improvement in Weight and Total Cholesterol and Their Association with Survival in Ruxolitinib-Treated Patients with Myelofibrosis From COMFORT-I

Ruben A. Mesa, Srdan Verstovsek, MD, PhD, Vikas Gupta, MD, FRCP, FRCPath, John Mascarenhas, MD, Ehab Atallah, MD, William Sun, PhD, Victor A. Sandor, MD, CM, Jason Gotlib
Journal: Blood
Blood (2012) 120 (21): 1733.
https://doi.org/10.1182/blood.V120.21.1733.1733
Published: 2012
Journal Articles

Long-Term Outcome of Ruxolitinib Treatment in Patients with Myelofibrosis: Durable Reductions in Spleen Volume, Improvements in Quality of Life, and Overall Survival Advantage in COMFORT-I

Srdan Verstovsek, MD, PhD, Ruben A. Mesa, Jason Gotlib, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. DiPersio, MD, PhD, John V. Catalano, MD, Michael W.N. Deininger, MD, PhD, Carole B. Miller, MD, Richard T. Silver, MD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Murat O. Arcasoy, MD, Elizabeth O. Hexner, MD, Roger M. Lyons, MD, Ronald Paquette, MD, PhD, Azra Raza, MD, Kris Vaddi, PhD, Susan Erickson-Viitanen, PhD, William Sun, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2012) 120 (21): 800.
https://doi.org/10.1182/blood.V120.21.800.800
Published: 2012
Journal Articles

Associations Between Improvements in Myelofibrosis (MF) Symptoms and Quality of Life Measures with Splenomegaly Reduction in COMFORT-I: A Randomized, Double-Blind, Phase III Trial of the JAK1 and JAK2 Inhibitor Ruxolitinib Versus Placebo in Patients with MF,

Ruben A. Mesa, MD, Jason Gotlib, MD, MS, Vikas Gupta, MD, FRCP, FRCPath, John F. DiPersio, MD, PhD, John Catalano, MD, Michael W. Deininger, Alan Shields, PhD, Carole B. Miller, MD, Richard T. Silver, MD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Thomas Hare, PhD, Sue Erickson-Viitanen, PhD, William Sun, PhD, Victor A. Sandor, MD, CM, Richard S. Levy, MD, Hagop M. Kantarjian, Srdan Verstovsek, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3842.
https://doi.org/10.1182/blood.V118.21.3842.3842
Published: 2011
Journal Articles

Clinical Burden and Progression of Myelofibrosis in a Controlled Study Population of Placebo-Treated Patients (COMFORT-I)

Srdan Verstovsek, MD, PhD, Ruben A. Mesa, MD, Jason Gotlib, MD, MS, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. DiPersio, MD, PhD, John Catalano, MD, Michael W. Deininger, Carole B. Miller, MD, Richard T. Silver, MD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Murat O. Arcasoy, MD, Elizabeth Hexner, MD, Roger M. Lyons, MD, Ronald Paquette, MD, PhD, Azra Raza, MD, Kris Vaddi, PhD, Sue Erickson-Viitanen, PhD, William Sun, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian
Journal: Blood
Blood (2011) 118 (21): 5146.
https://doi.org/10.1182/blood.V118.21.5146.5146
Published: 2011
Journal Articles

Consistent Benefit of Ruxolitinib Over Placebo in Spleen Volume Reduction and Symptom Improvement Across Subgroups and Overall Survival Advantage: Results From COMFORT-I

Srdan Verstovsek, MD, PhD, Ruben A. Mesa, MD, Jason Gotlib, MD, MS, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. DiPersio, MD, PhD, John Catalano, MD, Michael W. Deininger, Carole B. Miller, MD, Richard T. Silver, MD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Murat O. Arcasoy, MD, Elizabeth Hexner, MD, Roger M. Lyons, MD, Ronald Paquette, MD, PhD, Azra Raza, MD, Kris Vaddi, PhD, Sue Erickson-Viitanen, PhD, William Sun, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian
Journal: Blood
Blood (2011) 118 (21): 278.
https://doi.org/10.1182/blood.V118.21.278.278
Published: 2011
Journal Articles

Comparison of the Efficacy of Placebo and Best Available Therapy for the Treatment of Myelofibrosis in the COMFORT Studies

Ruben A. Mesa, MD, Srdan Verstovsek, MD, PhD, Francisco Cervantes, MD, PhD, Roger J. Waltzman, MD, Estella T. Mendelson, BSRN, MBA, Nicolas Martin, MS, William Sun, PhD, Victor A. Sandor, MD, CM, Richard S. Levy, MD, Claire N. Harrison, DM, FRCP, FRCPath
Journal: Blood
Blood (2011) 118 (21): 1753.
https://doi.org/10.1182/blood.V118.21.1753.1753
Published: 2011
Journal Articles

Reduction of Prothrombin in Mice Carrying a Conditional Knockout Allele Attenuates the Development of Paralysis Associated with Experimental Encephalitis.

Eric S. Mullins, MD, Keith W. Kombrinck, MS, Matthew J. Flick, PhD, Maureen A. Shaw, BS, William Sun, PhD, Sandra J. Degen, PhD, Katerina Akassoglou, PhD, Jay L. Degen, PhD
Journal: Blood
Blood (2007) 110 (11): 407.
https://doi.org/10.1182/blood.V110.11.407.407
Published: 2007
Journal Articles

Conditional Disruption of the Murine Prothrombin Gene.

Eric S. Mullins, MD, Matthew J. Flick, PhD, Keith W. Kombrinck, Sandra J. Degen, PhD, William Sun, PhD, Jay L. Degen, PhD
Journal: Blood
Blood (2006) 108 (11): 1600.
https://doi.org/10.1182/blood.V108.11.1600.1600
Published: 2006