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Wendy Béguelin
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Journal Articles

Follicular Dendritic Cells Represent a Therapeutic Vulnerability in Early Follicular Lymphoma

Caitlin Gribbin, Dylan McNally, Ioannis Karagiannidis, Henna S. Nam, Hiranmayi Ravichandran, Baptiste Brauge, Karin Tarte, Amy Chadburn, Madhu M Ouseph, Sebastian Carrasco, Christian Steidl, David W. Scott, Ari M Melnick, Wendy Béguelin
Journal: Blood
Blood (2024) 144 (Supplement 1): 739.
https://doi.org/10.1182/blood-2024-198542
Published: 2024
Journal Articles

DTX1 Controls Germinal Center B-Cell Development and Lymphomagenesis

Atish Kizhakeyil, Sreejoyee Ghosh, Estela Rojas-Neira, Qing Deng, Jared Henderson, Jordan Showell, Ari Melnick, Wendy Beguelin, Francisco Vega, Loretta J. Nastoupil, Michael R Green
Journal: Blood
Blood (2022) 140 (Supplement 1): 1700–1701.
https://doi.org/10.1182/blood-2022-167086
Published: 2022
Journal Articles

Evolution of the Tumor Microenvironment throughout Progression and Transformation of EZH2 Mutant Follicular Lymphoma

Yusuke Isshiki, Dylan McNally, Ari M. Melnick, Wendy Béguelin
Journal: Blood
Blood (2021) 138 (Supplement 1): 446.
https://doi.org/10.1182/blood-2021-148996
Published: 2021
Journal Articles

Aging-Associated Epigenetic Reprogramming Alters the Germinal Center Reaction and Targets Pathways Related to Lymphomagenesis

Rossella Marullo, Maria Victoria Revuelta, Wendy Béguelin, Juan Lara-Garcia, Leandro Cerchietti
Journal: Blood
Blood (2021) 138 (Supplement 1): 676.
https://doi.org/10.1182/blood-2021-152684
Published: 2021
Journal Articles

The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma

Katsuyoshi Takata, MD PhD, Lauren C. Chong, MSc, Daisuke Ennishi, MD PhD, Avinash Thakur, PhD, Shannon Healy, PhD, Elena Viganò, PhD, Tao Dao, MD PhD, Julie S Nielsen, Susana Ben-Neriah, BSc, Tomohiro Aoki, MD PhD, Ethan Tse, Stacy Hung, Michael Y. Li, BS, Merrill Boyle, BSc, Sung Soo Mun, Christopher Bourne, Bruce W Woolcock, Adele Telenius, Allen Zhang, Ali Bashashati, Saeed Saberi, Gianluca D' Antonio, Brad H Nelson, Sohrab P Shah, Pamela Hoodless, Ari Melnick, MD, Randy D. Gascoyne, MD, Joseph M Connors, MD, David A. Scheinberg, MD PhD, Wendy Béguelin, PhD, David W. Scott, MBChB, PhD, Christian Steidl, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-141168
Published: 2020
Journal Articles

EZH2 Gain-of-Function Mutations Generate a Lymphoma-Permissive Immune Niche

Wendy Béguelin, PhD, Matthew R Teater, PhD, Cem Meydan, PhD, Jude M Phillip, PhD, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2768.
https://doi.org/10.1182/blood-2019-132263
Published: 2019
Journal Articles

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 As a Therapeutic Target for Restoring MHC Expression in Diffuse Large B-Cell Lymphoma

Daisuke Ennishi, MDPhD, Katsuyoshi Takata, MD PhD, Wendy Béguelin, PhD, Gerben Duns, PhD, Anja Mottok, Pedro Farinha, MD PhD, Ali Bashashati, David Scott, Merrill Boyle, BSc, Barbara Meissner, PhD, Susana Ben-Neriah, BSc, Bruce W Woolcock, Adele Telenius, Daniel Lai, Matthew R Teater, PhD, Robert Kridel, PhD MD, Kerry J Savage, BSc, MD MSc, Laurie H Sehn, MD MPH, Ryan D. Morin, PhD BSc MSc, Marco A. Marra, PhD, Sohrab P Shah, Joseph M. Connors, MD, Randy D. Gascoyne, MD, David W. Scott, PhD MD FRACP FRCPA, Ari M Melnick, MD, Christian Steidl, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2018-99-112010
Published: 2018
Journal Articles

EZH2 Enables the Proliferation of Germinal Center B Cells and DLBCL through a Rb-E2F1 Positive Feedback Loop Involving Repression of CDKN1A

Wendy Béguelin, PhD, Martin A Rivas, PhD, María Teresa Calvo Fernández, Ari Melnick, MD
Journal: Blood
Blood (2016) 128 (22): 734.
https://doi.org/10.1182/blood.V128.22.734.734
Published: 2016
Journal Articles

A Chromatin Reader That Acts As a Key to Lock in and Coordinate Recruitment of Transcription Factors and a Novel Polycomb Complex to Bivalent Chromatin Thus Driving Formation of Germinal Centers and B-Cell Lymphomas

Wendy Béguelin, Matt Teater, Connie Corcoran, Michelle Hamline, Randy D. Gascoyne, Ross L. Levine, MD, Omar Abdel-Wahab, Rita Shaknovich, Olivier Elemento, Vivian J. Bardwell, Ari Melnick, MD
Journal: Blood
Blood (2015) 126 (23): 434.
https://doi.org/10.1182/blood.V126.23.434.434
Published: 2015
Journal Articles

BAP1 Loss Results in EZH2-Dependent Transformation in Myelodysplastic Syndromes

Lindsay M LaFave, PhD, Wendy Béguelin, PhD, Richard Koche, PhD, Matt Teater, Efthymia Papalexi, Barbara Spitzer, MD, Sarah Knutson, PhD, John Campbell, PhD, Heike Keilhack, PhD, Paul M Thomas, PhD, Neil L Kelleher, PhD, Omar Abdel-Wahab, Ari M. Melnick, MD, Scott A. Armstrong, MD PhD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 713.
https://doi.org/10.1182/blood.V126.23.713.713
Published: 2015
Journal Articles

EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains

Wendy Béguelin, PhD, Matt R. Teater, MS, Katerina Hatzi, PhD, Relja Popovich, PhD, Yanwen Jiang, PhD, Karen L. Bunting, PhD, Monica Rosen, Hao Shen, MD, Shao Ning Yang, Young Rock Chung, MSc, Rita Shaknovich, MD/PhD, Caretha Creasy, Randy D. Gascoyne, MD, Leandro Cerchietti, MD, Ross L. Levine, MD, Omar Abdel-Wahab, MD, Jonathan D. Licht, MD, Olivier Elemento, PhD, Ari M. Melnick, MD
Journal: Blood
Blood (2013) 122 (21): 1.
https://doi.org/10.1182/blood.V122.21.1.1
Published: 2013
Journal Articles

IL10 Receptor a Is a Novel Therapeutic Target That Is Epigenetically Disregulated in Low Grade Lymphomas with Plasmacytic Differentiation.

Wendy Beguelin, Ph.D., Alisa Chalmers, Lucas Tsikitas, Wayne Tam, MD, PhD, Govind Bhagat, MD, Rita Shaknovich, MD/PhD
Journal: Blood
Blood (2012) 120 (21): 2383.
https://doi.org/10.1182/blood.V120.21.2383.2383
Published: 2012