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Journal Articles

Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI Treatment

Ling Li, PhD, Tereza Osdal, MSc, YinWei Ho, MA, Tinisha McDonald, Sookhee Chun, Su Chu, MD, Allen Lin, Cedric Dos Santos, Ph.D, Mihaela Lucia Popa, VMD, Bjorn T Gjertsen, MD PhD, Wenyong Chen, PhD, Sonia Lain, Emmet McCormack, PhD, Ravi Bhatia, MD
Journal: Blood
Blood (2013) 122 (21): 2685.
https://doi.org/10.1182/blood.V122.21.2685.2685
Published: 2013
Journal Articles

Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining

Sujata Chakraborty, Jeremy M. Stark, Can-Lan Sun, Hardik Modi, WenYong Chen, Timothy R. O'Connor, Stephen J. Forman, Smita Bhatia, Ravi Bhatia
Journal: Blood
Blood (2012) 119 (26): 6187–6197.
https://doi.org/10.1182/blood-2011-05-352252
Published: 2012
Includes: Supplemental data
Journal Articles

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

Hongfeng Yuan, Zhiqiang Wang, Ling Li, Hao Zhang, Hardik Modi, David Horne, Ravi Bhatia, WenYong Chen
Journal: Blood
Blood (2012) 119 (8): 1904–1914.
https://doi.org/10.1182/blood-2011-06-361691
Published: 2012
Includes: Supplemental data
Journal Articles

Pharmacological Inhibition of the Stress-Related Deacetylase SIRT1 Enhances Eradication of CML stem Cells

Ling Li, PhD, Lisheng Wang, PhD, Liang Li, PhD, Tinisha McDonald, Yin Wei Ho, Tessa L. Holyoake, PhD, FRCP, FRCPath, Wenyong Chen, PhD, Ravi Bhatia, MD
Journal: Blood
Blood (2011) 118 (21): 448.
https://doi.org/10.1182/blood.V118.21.448.448
Published: 2011
Journal Articles

SIRT1 Inhibition Induces Apoptosis In Human CML Progenitors by Enhancing p53 Acetylation and Activation

Ling Li, PhD, Lisheng Wang, PhD, Tinisha McDonald, BS, Aswani Bolla, MS, Tessa L. Holyoake, PhD, FRCP, FRCPath, Wenyong Chen, PhD, Ravi Bhatia, MD
Journal: Blood
Blood (2010) 116 (21): 200.
https://doi.org/10.1182/blood.V116.21.200.200
Published: 2010
Journal Articles

Role of the SIRT1 Deacetylase in Survival and Imatinib Resistance of CML CD34+ Progenitors.

Ling Li, PhD, Liang Li, MD, PhD, Hongfeng Yuan, PhD, Wenyong Chen, PhD, Ravi Bhatia, MD
Journal: Blood
Blood (2009) 114 (22): 189.
https://doi.org/10.1182/blood.V114.22.189.189
Published: 2009