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Journal Articles

Clonal Hematopoiesis with Somatic Mutations in "AYA" Generation of Patients with Chronic Myeloid Leukemia

Jitka Koblihova, Vaclava Polivkova, Adela Benesova, Hana Zizkova, Nikola Curik, Monika Pepek, Tomasz Stoklosa, MD PhD, Marketa Markova Stastna, Hana Klamová, Dana Srbova, Katerina Machova

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-140725

Published: 2020

Journal Articles

Predictive Significance of Selected Gene Mutations Identified Using Next Generation Sequencing in Relapsed and Refractory Chronic Lymphocytic Leukemia Patients Treated with Ibrutinib

Marcin M Machnicki, MSc, Patryk Górniak, Monika Pepek, MSc, Agnieszka Szymczyk, Elżbieta Iskierka-Jażdżewska, Pawel Steckiewicz, Aleksandra Bluszcz, Malgorzata Rydzanicz, PhD, Marek Hus, Rafal Ploski, MD PhD, Przemyslaw Juszczynski, Prof., MD PhD, Tomasz Stoklosa, MD PhD, Krzysztof Jamroziak, MD PhD, Bartosz Pula

Blood (2019) 134 (Supplement_1): 5456.

https://doi.org/10.1182/blood-2019-124693

Published: 2019

Journal Articles

ASXL1 Mutations Detectable at Diagnosis May Predict Response to Imatinib in Patients with Chronic Myeloid Leukemia

Marcin M Machnicki, MSc, Monika Pepek, MSc, Iwona Solarska, PhD, Joanna Niesiobedzka-Krezel, MD PhD, Ilona Seferynska, MD PhD, Joanna Gora Tybor, MD PhD, Magdalena Zawada, PhD, Tomasz Sacha, MD PhD, Waldemar Sawicki, MD PhD, Ewa Wasilewska, MD PhD, Katarzyna Pruszczyk, MD, Malgorzata Rydzanicz, PhD, Rafal Ploski, MD PhD, Tomasz Skorski, MD PhD, Tomasz Stoklosa, MD PhD

Blood (2019) 134 (Supplement_1): 4148.

https://doi.org/10.1182/blood-2019-129834

Published: 2019

Journal Articles

The Role of Shelterin Complex and Post-Translational Non-Enzymatic Modification in Telomere Maintenance in Chronic Myeloid Leukemia

Anna Deregowska, MSc, Katarzyna Pruszczyk, MD, Iwona Solarska, PhD, Ilona Seferynska, MD PhD, Marek Dudzinski, MD, Maciej Wnuk, PhD, Tomasz Stoklosa, MD PhD

Blood (2018) 132 (Supplement 1): 5426.

https://doi.org/10.1182/blood-2018-99-112879

Published: 2018

Journal Articles

Role of Shelterin Complex and Alternative Telomere Lengthening in Genomic Instability and Disease Progression in Chronic Myeloid Leukemia

Tomasz Stoklosa, MD PhD, Anna Deregowska, Katarzyna Pruszczyk, Iwona Solarska, PhD, Marcin M Machnicki, Jagoda Adamczyk, Ilona Seferynska, Anna Lewinska, PhD, Maciej Wnuk, PhD

Blood (2016) 128 (22): 1880.

https://doi.org/10.1182/blood.V128.22.1880.1880

Published: 2016

Journal Articles

Detailed Clinical, Immunological and Molecular Analysis of NOTCH1 , SF3B1 and MYD88 mutations in Chronic Lymphocytic Leukemia Patients Reveals Accumulation of Negative Prognostic Features in NOTCH1 and SF3B1 mutated Individuals

Maciej Putowski, Marta Podgórniak, Marta Piróg, Joanna Knap, Jacek Zawislak, Joanna Zaleska, Ewelina Zakrzewska, PhD, Joanna Purkot, Agnieszka Karczmarczyk, PhD, Paulina Wlasiuk, PhD, Waldemar Tomczak, MD PhD, Edyta Cichocka, MD PhD, Edyta Subocz, MD, Janusz Halka, MD PhD, Daria Zawirska, MD PhD, Witold Jeleniewicz, Andrzej Stepulak, MD PhD, Tomasz Stoklosa, MD PhD, Krzysztof Giannopoulos, MD PhD

Blood (2016) 128 (22): 5570.

https://doi.org/10.1182/blood.V128.22.5570.5570

Published: 2016

Journal Articles

Somatic Mutations in Commonly Mutated Genes in Myeloid Malignancies May Preexist or Arise in the Course of Chronic Myeloid Leukemia - Different Scenarios of Progression Revealed By Targeted Next-Generation Sequencing

Marcin M Machnicki, Iwona Solarska, PhD, Rafal Ploski, MD PhD, Ilona Seferynska, MD PhD, Tomasz Stoklosa, MD PhD

Blood (2015) 126 (23): 2771.

https://doi.org/10.1182/blood.V126.23.2771.2771

Published: 2015

Journal Articles

HIF1-Alpha and MYC Transcription Factor Signatures in B-Cell Acute Lymphoblastic Leukemia Are Associated with Positive Minimal Residual Disease Status: Therapeutic Implications

Tomasz Sewastianik, MSc, Patryk Gorniak, PhD, Przemyslaw Kiliszek, MSc, Anna Polak, MSc, Emilia Bialopiotrowicz, PhD, Ewa Jablonska, PhD, Maciej Szydlowski, PhD, Ewa Lech-Maranda, MD PhD, Katarzyna Borg, PhD, Hanna Makuch-Lasica, MSc, Adam Zabek, MSc, Piotr Mlynarz, PhD, Tomasz Stoklosa, MD PhD, Sebastian Giebel, MD PhD, Krzysztof Warzocha, MD PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 1436.

https://doi.org/10.1182/blood.V126.23.1436.1436

Published: 2015

Journal Articles

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD PhD, Katherine Sullivan, Paulina Podszywalow-Bartnicka, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Artur Slupianek, PhD, Chun Zhou, PhD, Sabine Cerny-Reiterer, DVM, Tomasz Stoklosa, MD PhD, Stephen M. Sykes, PhD, Peter Valent, MD, Curt I. Civin, MD, Markus Muschen, MD PhD, Mark D. Minden, MD PhD, Kolja Eppert, PhD, Tomasz Skorski, MD PhD

Blood (2014) 124 (21): 480.

https://doi.org/10.1182/blood.V124.21.480.480

Published: 2014

Journal Articles

HDAC Inhibitors As Potential New Agents Improving the Efficacy of Monoclonal Antibodies

Malgorzata Bobrowicz, MSc, Michal Dwojak, DMD, Agata Malenda, MD PhD, Kamil Bojarczuk, MSc, Marta Siernicka, MSc, Beata Pyrzynska, PhD, Ewa Lech-Maranda, MD PhD, Tomasz Stoklosa, MD PhD, Magdalena Winiarska, PhD, Jakub Golab, MD PhD

Blood (2014) 124 (21): 3641.

https://doi.org/10.1182/blood.V124.21.3641.3641

Published: 2014

Journal Articles

Effects of First and Next-Generation Tyrosine Kinase Inhibitors on Telomere-Mediated Chromosomal Instability in Chronic Myeloid Leukemia Cells

Tomasz Stoklosa, MD PhD, Anna Deregowska, Joanna Drzewinska-Chanko, PhD, Joanna Barankiewicz, MD, Machnicki M Marcin, Pruszczyk Katarzyna, Maciej Wnuk, PhD

Blood (2014) 124 (21): 5510.

https://doi.org/10.1182/blood.V124.21.5510.5510

Published: 2014

Journal Articles

Differential Expression of BIRC Family Genes In The Course Of Chronic Myeloid Leukemia – BIRC3 and BIRC8 As Potential New Candidates To Identify Disease Progression

Eliza Glodkowska-Mrowka, MD, Iwona Solarska, PhD, Piotr Mrowka, PhD, Katarzyna Bajorek, MSc, Joanna Niesiobedzka-Krezel, MD, Ilona Seferynska, MD, PhD, Katarzyna Borg, PhD, Tomasz Stoklosa, MD, PhD

Blood (2013) 122 (21): 2718.

https://doi.org/10.1182/blood.V122.21.2718.2718

Published: 2013

Journal Articles

Normal ABL1 Is a Tumor Suppressor and Therapeutic Target In BCR-ABL1–positive Leukemias

Yashodhara Dasgupta, Mateusz Koptyra, PhD, Margaret Nieborowska-Skorska, MD, PhD, Elisabeth Bolton Gillespie, PhD, Tomasz Stoklosa, MD, PhD, Grazyna Hoser, PhD, Mariusz Wasik, MD, Markus Muschen, Christine Richardson, PhD, Tomasz Skorski, MD, PhD

Blood (2013) 122 (21): 1466.

https://doi.org/10.1182/blood.V122.21.1466.1466

Published: 2013

Journal Articles

BCR-ABL1 Kinase Inhibits DNA Glycosylases to Enhance Oxidative DNA Damage and Stimulate Genomic Instability

Artur Slupianek, PhD, Rafal Falinski, PhD, Pawel Znojek, Tomasz Stoklosa, MD, PhD, Sylwia Flis, Valentina Doneddu, Ewelina Synowiec, Janusz Blasiak, Alfonso Bellacosa, Tomasz Skorski, MD, PhD

Blood (2012) 120 (21): 520.

https://doi.org/10.1182/blood.V120.21.520.520

Published: 2012

Journal Articles

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Blood (2011) 118 (21): 2736.

https://doi.org/10.1182/blood.V118.21.2736.2736

Published: 2011

Journal Articles

Statins Increase Antileukemic Potency of Imatinib Through the Inhibition of MDR/ABCB1 and BCRP/ABCG2 Drug Transporters Activity

Eliza Glodkowska-Mrowka, MD, Piotr Mrowka, M.Sc., Magdalena Winiarska, PhD, Grzegorz Basak, MD, PhD, Joanna Niesiobedzka-Krezel, MD, Ilona Seferynska, MD, PhD, Pawel Krzysztof Wlodarski, MD, PhD, Marek Jakobisiak, MD, PhD, Tomasz Stoklosa, MD, PhD

Blood (2011) 118 (21): 2742.

https://doi.org/10.1182/blood.V118.21.2742.2742

Published: 2011

Journal Articles

Prenyl Transferases Are Involved in the Regulation of CD20 Levels and Influence Anti-CD20 Monoclonal Antibody-Mediated Activation of Complement-Dependent Cytotoxicity,

Dominika Nowis, MD, PhD, Magdalena Winiarska, PhD, Jacek Bil, MD, PhD, Angelika Muchowicz, MSc, Malgorzata Wanczyk, MSc, Eliza Glodkowska-Mrowka, MD, Kamil Bojarczuk, BSc, Malgorzata Firczuk, PhD, Ewa Wilczek, PhD, Malgorzata Wachowska, MSc, Justyna Chlebowska, MSc, Michal Dwojak, Marta Miaczynska, PhD, Tomasz Stoklosa, MD, PhD, Jakub Golab, MD, PhD

Blood (2011) 118 (21): 3722.

https://doi.org/10.1182/blood.V118.21.3722.3722

Published: 2011

Journal Articles

Sorafenib Affects Membrane Complement Inhibitors and Improves Antitumor Activity of Rituximab,

Jakub Golab, MD, PhD, Jacek Bil, MD, PhD, Kamil Bojarczuk, BSc, Dominika Nowis, MD, PhD, Marcin Okroj, Ph.D., Grzegorz Basak, MD, PhD, Tomasz Stoklosa, MD, PhD, Magdalena Winiarska, PhD

Blood (2011) 118 (21): 3723.

https://doi.org/10.1182/blood.V118.21.3723.3723

Published: 2011

Journal Articles

Src Family Tyrosine Kinases Are Involved in the Transcriptional Regulation of CD20 Levels

Magdalena Winiarska, PhD, Jacek Bil, MD, PhD, Kamil Bojarczuk, BSc, Dominika Nowis, MD, PhD, Malgorzata Wanczyk, MSc, Michal Dwojak, Grzegorz Basak, MD, PhD, Tomasz Stoklosa, MD, PhD, Jakub Golab, MD, PhD

Blood (2011) 118 (21): 1661.

https://doi.org/10.1182/blood.V118.21.1661.1661

Published: 2011

Journal Articles

Potentiation of the Antileukemic Effects of Imatinib through the Modulation of BCRP/ABCG2 Activity.

Eliza Glodkowska-Mrowka, MD, Magda Winiarska, PhD, Piotr Mrowka, M.Sc., Grzegorz Basak, MD, PhD, Joanna Niesiobedzka-Krezel, MD, Ilona Seferynska, MD, PhD, Tomasz Stoklosa, MD, PhD

Blood (2010) 116 (21): 3400.

https://doi.org/10.1182/blood.V116.21.3400.3400

Published: 2010

NARROW

Clonal Hematopoiesis with Somatic Mutations in "AYA" Generation of Patients with Chronic Myeloid Leukemia

Predictive Significance of Selected Gene Mutations Identified Using Next Generation Sequencing in Relapsed and Refractory Chronic Lymphocytic Leukemia Patients Treated with Ibrutinib

ASXL1 Mutations Detectable at Diagnosis May Predict Response to Imatinib in Patients with Chronic Myeloid Leukemia

The Role of Shelterin Complex and Post-Translational Non-Enzymatic Modification in Telomere Maintenance in Chronic Myeloid Leukemia

Role of Shelterin Complex and Alternative Telomere Lengthening in Genomic Instability and Disease Progression in Chronic Myeloid Leukemia

Detailed Clinical, Immunological and Molecular Analysis of NOTCH1 , SF3B1 and MYD88 mutations in Chronic Lymphocytic Leukemia Patients Reveals Accumulation of Negative Prognostic Features in NOTCH1 and SF3B1 mutated Individuals

Somatic Mutations in Commonly Mutated Genes in Myeloid Malignancies May Preexist or Arise in the Course of Chronic Myeloid Leukemia - Different Scenarios of Progression Revealed By Targeted Next-Generation Sequencing

HIF1-Alpha and MYC Transcription Factor Signatures in B-Cell Acute Lymphoblastic Leukemia Are Associated with Positive Minimal Residual Disease Status: Therapeutic Implications

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

HDAC Inhibitors As Potential New Agents Improving the Efficacy of Monoclonal Antibodies

Effects of First and Next-Generation Tyrosine Kinase Inhibitors on Telomere-Mediated Chromosomal Instability in Chronic Myeloid Leukemia Cells

Differential Expression of BIRC Family Genes In The Course Of Chronic Myeloid Leukemia – BIRC3 and BIRC8 As Potential New Candidates To Identify Disease Progression

Normal ABL1 Is a Tumor Suppressor and Therapeutic Target In BCR-ABL1–positive Leukemias

BCR-ABL1 Kinase Inhibits DNA Glycosylases to Enhance Oxidative DNA Damage and Stimulate Genomic Instability

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Statins Increase Antileukemic Potency of Imatinib Through the Inhibition of MDR/ABCB1 and BCRP/ABCG2 Drug Transporters Activity

Prenyl Transferases Are Involved in the Regulation of CD20 Levels and Influence Anti-CD20 Monoclonal Antibody-Mediated Activation of Complement-Dependent Cytotoxicity,

Sorafenib Affects Membrane Complement Inhibitors and Improves Antitumor Activity of Rituximab,

Src Family Tyrosine Kinases Are Involved in the Transcriptional Regulation of CD20 Levels

Potentiation of the Antileukemic Effects of Imatinib through the Modulation of BCRP/ABCG2 Activity.

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American Society of Hematology

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American Society of Hematology

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