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Tiffany Hylkema
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Journal Articles

Potent Target-Specific Efficacy of CAR T Cells Directed Toward the AML and KMT2A-Rearranged Specific Antigen CLEC2A

Danielle C. Kirkey, Grace Hawkins, Melia Blankenfeld, Isabel Lira, Nika Panahi, Margaret G Hines, Seungmin Shin, Tiffany Hylkema, Cyd McKay, Christina Root, Logan K. Wallace, Jack H. Peplinski, Rhonda E. Ries, Concetta Quintarelli, Franco Locatelli, Wei Li, Soheil Meshinchi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2050.
https://doi.org/10.1182/blood-2024-212075
Published: 2024
Journal Articles

Preclinical Efficacy of CD276 (B7-H3) CAR T in Acute Myeloid Leukemia

Isabel Lira, Danielle C. Kirkey, Marilena Nicolaidou, Henrike Muller, Marta Barisa, Melia Blankenfeld, Grace Hawkins, Cyd McKay, Christina Root, Laura Pardo, Michael R. Loken, Tiffany Hylkema, Concetta Quintarelli, Franco Locatelli, John Anderson, Soheil Meshinchi
Journal: Blood
Blood (2024) 144 (Supplement 1): 4793.
https://doi.org/10.1182/blood-2024-206227
Published: 2024
Journal Articles

Discovery and Immunotherapeutic Targeting of the Tumor-Specific Target LAMP5 in Acute Myeloid Leukemia

Grace Hawkins, Danielle Kirkey, Nika Panahi, Melia Blankenfeld, Isabel Lira, Tiffany Hylkema, Cyd McKay, Christina Root, Jack H. Peplinski, Logan K. Wallace, Rhonda E. Ries, Laura Pardo, Michael R. Loken, Soheil Meshinchi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3413.
https://doi.org/10.1182/blood-2024-204043
Published: 2024
Journal Articles

DNMT3A Mutants Are Enriched in NPMc+ AML and Associated with Adverse Outcome in Childhood AML

Rhonda E Ries, Xiaotu Ma, Claudia Tregnago, Todd A. Alonzo, Jim Wang, Tiffany Hylkema, Benjamin J Huang, Alireza Torabi, Jack H Peplinski, Logan K Wallace, Richard Aplenc, Alan S Gamis, Katherine Tarlock, Franco Locatelli, Martina Pigazzi, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4306.
https://doi.org/10.1182/blood-2023-181060
Published: 2023
Journal Articles

CLEC2A Is a Novel AML-Restricted Immunotherapeutic Target Enriched in KMT2A-Rearranged Acute Myeloid Leukemia

Danielle C Kirkey, Leila Robinson, Derek Janssens, Margaret G Hines, Tiffany Hylkema, Makia K Manselle, Rhonda E Ries, Jack H Peplinski, Logan K Wallace, Dominik Otto, Katherine Tarlock, Steven Henikoff, Wei Li, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 290.
https://doi.org/10.1182/blood-2023-188439
Published: 2023
Journal Articles

LAMP5 Is an AML-Restricted Immunotherapeutic Target Enriched in High-Risk Acute Myeloid Leukemia

Nika Panahi, Tiffany Hylkema, Grace Hawkins, Makia K Manselle, Jack H Peplinski, Logan K Wallace, Rhonda E Ries, Soheil Meshinchi, Danielle C Kirkey
Journal: Blood
Blood (2023) 142 (Supplement 1): 1585.
https://doi.org/10.1182/blood-2023-188352
Published: 2023
Journal Articles

CD276 (B7-H3) Is an Immunotherapeutic Target in Acute Myeloid Leukemia with Preclinical Efficacy of Vobramitamab Duocarmazine, an Investigational CD276 Antibody-Drug Conjugate

Danielle C Kirkey, Melia Blankenfeld, Tiffany Hylkema, Deryk Loo, Ashley Ward, Leila Robinson, Jack H Peplinski, Logan K Wallace, Laura Pardo, Andrew J. Menssen, Rhonda E Ries, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 5958.
https://doi.org/10.1182/blood-2023-187450
Published: 2023
Journal Articles

Potent and Target Specific Cytotoxicity of PRAME TCR Mimic CAR T Cells in KMT2A-Rearranged AML Patient-Derived Xenograft Model

Danielle C Kirkey, Leila Robinson, Tiffany Hylkema, Anisha Loeb, Rhonda E Ries, Cyd McKay, Christina Root, Laura Pardo, Keith R. Loeb, Quy Le, David A. Scheinberg, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4821.
https://doi.org/10.1182/blood-2023-188391
Published: 2023
Journal Articles

Disease Monitoring in Acute Myeloid Leukemia with CLEC2A qRT-PCR

Makia K Manselle, Danielle Kirkey, Rhonda E Ries, Tiffany Hylkema, Nika Panahi, Leila Robinson, Logan K Wallace, Jack H Peplinski, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6021.
https://doi.org/10.1182/blood-2023-190133
Published: 2023
Journal Articles

Prognostic impact of CSF3R mutations in favorable risk childhood acute myeloid leukemia

Clinical Trials & Observations
Katherine Tarlock, Todd Alonzo, Yi-Cheng Wang, Robert B. Gerbing, Rhonda E. Ries, Tiffany Hylkema, Jenny L. Smith, Julia E. Maxson, Soheil Meshinchi
Journal: Blood
Blood (2020) 135 (18): 1603–1606.
https://doi.org/10.1182/blood.2019004179
Published: 2020
Includes: Supplemental data
Journal Articles

CD33 SNP Genotype and Splice Variation Are Associated with CD33 Cell Surface Expression and SGN-CD33A Pharmacokinetics

Katherine Tarlock, MD, Zixing Wang, Rory Rohm, Travis Biechele, Rhonda E. Ries, MA, Tiffany Hylkema, BS, Jatinder K Lamba, PhD, Gary D Means, PhD, Robert Thurman, Bill Arthur, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3942.
https://doi.org/10.1182/blood-2018-99-113932
Published: 2018
Journal Articles

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options — a COG and Target Pediatric AML Study

Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Marianne T. Santaguida, BSc, PhD, Christos Gekas, PhD, Todd A Alonzo, PhD, Robert B Gerbing, MA, Alan S Gamis, MD MPH, Richard Aplenc, MD PhD, E. Anders Kolb, MD, Tiffany Hylkema, BS, Lisa Eidenschink Brodersen, PhD, Michael R. Loken, PhD, Hamid Bolouri, PhD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 881.
https://doi.org/10.1182/blood-2018-99-115544
Published: 2018
Journal Articles

Functional Properties of Exon 17 KIT Mutations in Pediatric CBF AML Predict for Inferior Outcome and Enhanced Response to Tyrosine Kinase Inhibition: A Report from the Children's Oncology Group

Katherine Tarlock, MD, Todd A Alonzo, PhD, Robert B Gerbing, Yi-Cheng Wang, Rhonda E. Ries, MA, Tiffany Hylkema, BS, Jason Joaquin, Susana C. Raimondi, PhD, Betsy A Hirsch, PhD, Edward A Kolb, MD, Alan S Gamis, MD MPH, Soheil Meshinchi, MD PhD, Jessica A. Pollard, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 25.
https://doi.org/10.1182/blood.V130.Suppl_1.25.25
Published: 2017
Journal Articles

Functional Evaluation and Clinical Implications of FLT3 J uxtamembrane Domain Short Variants in Pediatric AML

Katherine Tarlock, MD, Todd A Alonzo, PhD, Yi-Cheng Wang, Robert B Gerbing, Tiffany Hylkema, BS, Rhonda E. Ries, MA, M. Eva Hansen, Edward A Kolb, MD, Alan S Gamis, MD MPH, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2664.
https://doi.org/10.1182/blood.V130.Suppl_1.2664.2664
Published: 2017
Journal Articles

Discovery and Functional Validation of Novel Pediatric Specific FLT3 Activating Mutations in Acute Myeloid Leukemia: Results from the COG/NCI Target Initiative

Katherine Tarlock, MD, M. Eva Hansen, Tiffany Hylkema, Rhonda Ries, MA, Jason E. Farrar, MD, Jaime Guidry Auvil, Daniela S. Gerhard, PhD, Malcolm A. Smith, MD PhD, Tanja M. Davidsen, PhD, Patee Gesuwan, Leandro C. Hermida, Marco A Marra, PhD, Andrew J. Mungall, PhD, Karen Mungall, PhD, Yussanne Ma, Stuart Zong, William Long, PhD, Titus Boggon, PhD, Todd A. Alonzo, PhD, E. Anders Kolb, MD, Alan S. Gamis, MD MPH, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2015) 126 (23): 87.
https://doi.org/10.1182/blood.V126.23.87.87
Published: 2015