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Stanley Chun-Wei Lee, PhD
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Journal Articles

Oncogenic Mutations in XPO1 Promote Lymphoid Transformation By Altering Nuclear/Cytoplasmic Localization of NFκB Signaling Intermediates

Justin Taylor, MD, Xiao Jing Zhang, Stella V Paffenholz, Alexander V Penson, PhD, Matthew Chang, Christina Marcelus, Lillian E Bitner, Young Rock Chung, MS, Akihide Yoshimi, MD, Stanley Chun-Wei Lee, PhD, Myriam Boukhali, MS, Rajesh K Soni, PhD, Ronald C Hendrickson, PhD, Barry S Taylor, PhD, Jose A Rodríguez, PhD, Wilhelm Haas, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 879.
https://doi.org/10.1182/blood.V130.Suppl_1.879.879
Published: 2017
Journal Articles

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Akihide Yoshimi, Kuan-Ting Lin, PhD, Daniel Wiseman, MB, ChB, Andrew M Intlekofer, MD PhD, Bo Wang, Alessandro Pastore, MD, Mohammad Rahman, Stanley Chun-Wei Lee, PhD, Bo Liu, PhD, Jean-Baptiste Micol, MD PhD, Stephane De Botton, Virginie Penard-Lacronique, PhD, Alan H. Shih, MD PhD, Eytan M. Stein, MD, Benjamin H Durham, MD BS, Daichi Inoue, MD PhD, Xiao Jing Zhang, Todd Albrecht, Young Rock Chung, MS, Shouyong Peng, Silvia Buonamici, PhD, James Palacino, PhD, Peter Smith, PhD, Craig B. Thompson, MD, Ross L. Levine, MD, Eric Wagner, PhD, Adrian R. Krainer, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 473.
https://doi.org/10.1182/blood.V130.Suppl_1.473.473
Published: 2017
Journal Articles

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Franco Izzo, PhD, Asaf Poran, Stanley Chun-Wei Lee, PhD, Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Rafael Schulman, BS, Michelle Ki, Kenigsberg Ephraim, PhD, Omar Abdel-Wahab, MD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 559.
https://doi.org/10.1182/blood.V130.Suppl_1.559.559
Published: 2017
Journal Articles

Integrated Molecular Analysis Identifies Replicative Stress As Sensitizer to Imetelstat Therapy in AML

Claudia Bruedigam, Amy H Porter, Brad Wackrow, Jasmin Straube, PhD, Leanne T Cooper, Axia Song, Stanley Chun-Wei Lee, PhD, Omar Abdel-Wahab, MD, Geoffrey R Hill, MD, Steven W. Lane, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 798.
https://doi.org/10.1182/blood.V130.Suppl_1.798.798
Published: 2017
Journal Articles

Serine/Arginine-Rich Splicing Factor 1 (SRSF1) Is Required for Adult and Embryonic Hematopoiesis and Has Non-Overlapping Roles with SRSF2 in Hematopoiesis

Young Rock Chung, MS, Hana Cho, Young Joon Kim, Eunhee Kim, PhD, Stanley Chun-Wei Lee, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2016) 128 (22): 1478.
https://doi.org/10.1182/blood.V128.22.1478.1478
Published: 2016
Journal Articles

Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity

Stanley Chun-Wei Lee, PhD, Khrystyna Dilai, Esther A. Obeng, MDPhD, Eunhee Kim, PhD, Jean-Baptiste Micol, MD PhD, Akihide Yoshimi, MD PhD, Christophe Willekens, MD, Daichi Inoue, Véronique Saada, PharmD, Hana Cho, Young Rock Chung, MS, James Palacino, PhD, Michael Seiler, PhD, Silvia Buonamici, PhD, Peter Smith, Benjamin L. Ebert, MD PhD, Robert Bradley, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2016) 128 (22): 961.
https://doi.org/10.1182/blood.V128.22.961.961
Published: 2016
Journal Articles

The Preclinical Efficacy of a Novel Telomerase Inhibitor, Imetelstat, in AML - a Randomized Trial in Patient-Derived Xenografts

Claudia Bruedigam, PhD, Brad Wackrow, Axia Song, Amy H Porter, Stanley Chun-Wei Lee, PhD, Andrew S. Moore, MBBS FRACP PhD, Omar Abdel-Wahab, MD, Steven W Lane, PhD
Journal: Blood
Blood (2016) 128 (22): 578.
https://doi.org/10.1182/blood.V128.22.578.578
Published: 2016
Journal Articles

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Silvia Buonamici, PhD, Akihide Yoshimi, MD PhD, Michael Thomas, Michael Seiler, PhD, Betty Chan, PhD, Benjamin Caleb, Rachel Darman, PhD, Peter Fekkes, PhD, Craig Karr, PhD, Gregg F. Keaney, PhD, Virginia M. Klimek, MD, Kaiko Kunii, Linda Lee, Stanley Chun-Wei Lee, PhD, Xiang Liu, PhD, Carol Meeske, Yoshiharu Mizui, PhD, Eric Padron, MD, Eunice Park, PhD, Ermira Pazolli, PhD, Sudeep Prajapati, PhD, Justin Taylor, MD, John Wang, PhD, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, MD, Omar Abdel-Wahab, MD, Peter G Smith, PhD
Journal: Blood
Blood (2016) 128 (22): 966.
https://doi.org/10.1182/blood.V128.22.966.966
Published: 2016
Journal Articles

Therapeutic Targeting of Spliceosomal Mutant Myeloid Leukemias through Modulation of Splicing Catalysis

Stanley Chun-Wei Lee, PhD, Heidi Dvinge, Eunhee Kim, PhD, Hana Cho, Young Rock Chung, MS, Jean-Baptiste Micol, MD, Benjamin Durham, MD PhD, Young Joon Kim, Michael Thomas, Camille Lobry, PhD, Silvia Buonamici, PhD, Peter Smith, Robert K. Bradley, PhD, Omar Abdel-Wahab
Journal: Blood
Blood (2015) 126 (23): 4.
https://doi.org/10.1182/blood.V126.23.4.4
Published: 2015