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Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Blood (2019) 134 (Supplement_1): 1692.

https://doi.org/10.1182/blood-2019-128573

Published: 2019

Journal Articles

S100A9 Contributes to T Cell Dysfunction through Its Interaction with RAGE in MDS

Wendy Kandell, BS, Thu Le Trinh, PhD, Xianghong Chen, PhD, Pingyan Cheng, MD, Danielle Gilvary, BS, Yin-Kai Chen, MD, Alexandra Calescibetta, Erika Adriana Eksioglu, MS PhD, Alan F. List, MD, Sheng Wei, MD

Blood (2019) 134 (Supplement_1): 4228.

https://doi.org/10.1182/blood-2019-128717

Published: 2019

Journal Articles

Dysregulation of Splicing Patterns in MDS Induced By the S100A9/Fto Axis

Erika Adriana Eksioglu, MS PhD, Ling Cen, PhD, Xianghong Chen, PhD, Pingyan Cheng, MD, Kenneth Wright, PhD, Thu Le Trinh, PhD, Danielle Gilvary, BS, Wendy Kandell, BS, Jinhong Liu, MD, Yin-Kai Chen, MD, Amy F McLemore, M.S., Alexandra Calescibetta, John Cleveland, PhD, Alan F. List, MD, Sheng Wei, MD

Blood (2019) 134 (Supplement_1): 4215.

https://doi.org/10.1182/blood-2019-128434

Published: 2019

Journal Articles

Genomic-DNA Exposed By Somatic Gene Mutations Engages the cGAS/STING Axis to License the NLRP3 Inflammasome in Myelodysplastic Syndromes

Amy F McLemore, M.S., Kathy L McGraw, PhD, Hsin-An Hou, MD PhD, Grace A Ward, BS, Alexis H Onimus, BS, Nicole D. Vincelette, PhD, Matthew A. Rodrigues, PhD, Neelkamal Chaudhary, PhD, Ling Zhang, MD, Benjamin S. Meyer, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3075.

https://doi.org/10.1182/blood-2018-99-116929

Published: 2018

Journal Articles

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy L McGraw, PhD, Amy F McLemore, M.S., Farnoosh Abbas-Aghababazadeh, PhD, Hsin-An Hou, MD PhD, Thu Le Trinh, PhD, Nicole D. Vincelette, PhD, Benjamin S. Meyer, Alexis H Onimus, BS, Alexandra Calescibetta, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3076.

https://doi.org/10.1182/blood-2018-99-118493

Published: 2018

Journal Articles

Immune Checkpoint Profiling of TP53 Mutant and Wild-Type Myeloid Malignancies: TP53 Mutations Direct Immune Tolerance Via an Immunosuppressive Phenotype

David A Sallman, MD, McLemore Amy, Rami S. Komrokji, MD, Kathy McGraw, PhD, Susan M. Geyer, PhD, Erika Eksioglu, PhD MS, Najla Al Ali, M.Sc, Jeffrey E. Lancet, MD, Sheng Wei, MD, Eric Padron, MD, Alan F. List, MD

Blood (2017) 130 (Supplement 1): 423.

https://doi.org/10.1182/blood.V130.Suppl_1.423.423

Published: 2017

Journal Articles

Immunodepletion of MDSC By AMV564, a Novel Tetravalent Bispecific CD33/CD3 T Cell Engager Restores Immune Homeostasis in MDS in Vitro

Pingyan Cheng, MD, Erika Eksioglu, PhD MS, Xianghong Chen, PhD, Max Wei, Jeanmarie Guenot, Judy Fox, Alan F List, MD, Sheng Wei, MD

Blood (2017) 130 (Supplement 1): 51.

https://doi.org/10.1182/blood.V130.Suppl_1.51.51

Published: 2017

Journal Articles

The S100A9/Fto Axis Induces Formation of RNA:DNA Hybrids That Serve As Damps Initiating Myeloid Skewing & Genetic Injury in MDS

Erika Eksioglu, PhD MS, Xianghong Chen, PhD, Pingyan Cheng, MD, Jinhong Liu, MD, Kathy McGraw, PhD, David A Sallman, MD, Eric Padron, MD, Alan F List, MD, Sheng Wei, MD

Blood (2017) 130 (Supplement 1): 52.

https://doi.org/10.1182/blood.V130.Suppl_1.52.52

Published: 2017

Journal Articles

Molecular Characterization of SRSF2 Mutation Identifies a Clinically Relevant Lncrna (MALAT1) in Chronic Myelomonocytic Leukemia (CMML)

Maria E. Balasis, Jane Merelvede, Sateesh Kunigal, Xiaoyi Ren, Yan Ma, Qing Zhang, PhD, Jeff Painter, Nathalie M. Droin, PhD, Joseph Johnson, Sean Yoder, M.S, Rami S. Komrokji, MD, Ling Zhang, MD, Sheng Wei, MD, Torsten Haferlach, Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD Prof, P.K. Epling-Burnette, PhD, Eric Padron, MD

Blood (2015) 126 (23): 1641.

https://doi.org/10.1182/blood.V126.23.1641.1641

Published: 2015

Journal Articles

Mesenchymal Cell Associated Fibrosis in Experimental mpl W515L Mouse Model of Myelofibrosis

Lanzhu Yue, PhD, Ying Han, MD, Ling Zhang, MD, Sheng Wei, MD, Xiubao Ren, MD, Zonghong Shao, Pearlie K Epling-Burnette, PhD

Blood (2015) 126 (23): 604.

https://doi.org/10.1182/blood.V126.23.604.604

Published: 2015

Journal Articles

The Proinflammatory Protein S100A9 Suppresses Erythropoietin Elaboration in Patients with Myelodysplastic Syndromes

Thomas Cluzeau, MDPhD, Kathy L McGraw, PhD, Brittany Irvine, Erico Masala, Lionel Ades, MD PhD, Ashley A Basiorka, Ghulam J Mufti, FRCP, FRCPath, Jaroslaw P. Maciejewski, MD PhD, Sheng Wei, MD, Pierre Fenaux, MD PhD, Valeria Santini, MD, Alan F. List, MD

Blood (2015) 126 (23): 355.

https://doi.org/10.1182/blood.V126.23.355.355

Published: 2015

Journal Articles

Inflammaging-Associated Metabolic Alterations Foster Development of the MDS Genotype

Sheng Wei, MD, Erika Adriana Eksioglu, PhD MS, Xianghong Chen, PhD, Thomas Cluzeau, MDPhD, Ashley Basiorka, Alexis Burnette, Max Wei, Kathy L McGraw, PhD, Eric Padron, MD, Alan F. List, MD

Blood (2015) 126 (23): 144.

https://doi.org/10.1182/blood.V126.23.144.144

Published: 2015

Journal Articles

A Phase II Study to Determine the Safety and Efficacy of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase (IDO) Enzyme INCB024360 in Patients with Myelodysplastic Syndromes

Rami S Komrokji, MD, Sheng Wei, MD, Adam W Mailloux, PhD, Ling Zhang, MD, Eric Padron, MD, Jeffrey E. Lancet, MD, Sara Tinsley, ARNP, Lisa A Nardelli, BS, CCRP, Cynthia Benoit, RN, Javier Pinilla-Ibarz, MD PhD, Pearlie K Epling-Burnette, PhD, Alan F List, MD

Blood (2014) 124 (21): 4653.

https://doi.org/10.1182/blood.V124.21.4653.4653

Published: 2014

Journal Articles

Lenalidomide Induces Lipid Raft Assembly to Enhance Erythropoietin Receptor Signaling in Myelodysplastic Syndrome Progenitors

Kathy L McGraw, PhD, Ashley A Basiorka, Joseph Johnson, Justine Clark, Gisela Caceres, Eric Padron, MD, Ruth Heaton, Yukiyasu Ozawa, MD PhD, Sheng Wei, MD, Lubomir Sokol, MD PhD, Alan F List, MD

Blood (2014) 124 (21): 4623.

https://doi.org/10.1182/blood.V124.21.4623.4623

Published: 2014

Journal Articles

Novel Therapeutic Approach to Improve Hematopoiesis By Targeting Myeloid Derived Suppressor Cells with a Humanized Anti-CD33 Antibody

Erika A Eksioglu, PhD, Karl-Heinz Heider, PhD, Bjoern Rueter, MD, Alexis Burnette, Max Wei, Kathy McGraw, Ashley A Basiorka, Parthik Patel, Jeffrey Lancet, Rami Komrokji, MD, Alan F. List, MD, Sheng Wei, MD

Blood (2014) 124 (21): 4597.

https://doi.org/10.1182/blood.V124.21.4597.4597

Published: 2014

Journal Articles

A Novel Role For Histone Deacetylase 11 (HDAC11) As a Regulator Of Neutrophil Function and Differentiation In Normal and Malignant Hematopoesis

Eva Sahakian, Ph.D, John Powers, B.S., Jie Chen, M.A., Allison Distler, B.S., Jennifer Rock-Klotz, B.S., Susan Deng, B.S., Sheng Wei, MD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, M.D. Ph.D., Pedro Horna, M.D.

Blood (2013) 122 (21): 2267.

https://doi.org/10.1182/blood.V122.21.2267.2267

Published: 2013

Journal Articles

Pluripotent Fibrosis Initiating Mesenchymal Stromal Cell Linked To Cytopenias In LGL Leukemia Through Genetic Reprogramming

Pearlie K. Epling-Burnette, PhD, Adam W. Mailloux, PhD, Ling Zhang, MD, Lynn C. Moscinski, MD, Sheng Wei, MD, Sean J Yoder, MS, Lubomir Sokol, MD, Ph.D, Loughran P Thomas, MD

Blood (2013) 122 (21): 1218.

https://doi.org/10.1182/blood.V122.21.1218.1218

Published: 2013

Journal Articles

Novel Predictor Of Lenalidomide Response In Non-del5q MDS Reveals Linkage To Molecular Mechanism: First Characterization Of T-Cell Function In Cereblon Homozygous Deficient Mice

Pearlie K Epling-Burnette, PhD, Ying Han, MD, Adam W Mailloux, PhD, Ling Zhang, MD, Jessica M. McDaniel, PhD, Rajadhyaksha Anjali, PhD, Sheng Wei, MD, Ritchie David, PhD, Paul Neeson, PhD, Rami S. Komrokji, MD, Alan List, MD

Blood (2013) 122 (21): 748.

https://doi.org/10.1182/blood.V122.21.748.748

Published: 2013

Journal Articles

Lenalidomide Upregulates Erythropoietin Receptor Expression Through Inhibition of the E3-Ubiquitin Ligase Ring Finger Protein 41 (RNF41)

Ashley A. Basiorka, Kathy L. McGraw, Lori N. Griner, Ling Zhang, MD, Leentje De Ceuninck, Gisela Caceres, Lubomir Sokol, MD, Ph.D, Rami S. Komrokji, MD, Sheng Wei, MD, Jan Tavernier, Ph.D., Alan F. List, MD

Blood (2012) 120 (21): 3455.

https://doi.org/10.1182/blood.V120.21.3455.3455

Published: 2012

Journal Articles

Targeted Repression of TP53 Promotes Erythropoiesis in Del(5q) MDS and Overcomes Clinical Resistance to Lenalidomide

Gisela Caceres, Joe Johnson, Kathy L. McGraw, Ashley A. Basiorka, Kenian Liu, Ph.D., Larry J Smith, Ph.D., F. Joseph Daugherty, MD, Sheng Wei, MD, Rami S. Komrokji, MD, Ling Zhang, MD, Neil Littleton, MD, Richard A. Wells, MD, DPhil, Lubomir Sokol, MD, Ph.D, Alan F List, MD

Blood (2012) 120 (21): 920.

https://doi.org/10.1182/blood.V120.21.920.920

Published: 2012

NARROW

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

S100A9 Contributes to T Cell Dysfunction through Its Interaction with RAGE in MDS

Dysregulation of Splicing Patterns in MDS Induced By the S100A9/Fto Axis

Genomic-DNA Exposed By Somatic Gene Mutations Engages the cGAS/STING Axis to License the NLRP3 Inflammasome in Myelodysplastic Syndromes

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Immune Checkpoint Profiling of TP53 Mutant and Wild-Type Myeloid Malignancies: TP53 Mutations Direct Immune Tolerance Via an Immunosuppressive Phenotype

Immunodepletion of MDSC By AMV564, a Novel Tetravalent Bispecific CD33/CD3 T Cell Engager Restores Immune Homeostasis in MDS in Vitro

The S100A9/Fto Axis Induces Formation of RNA:DNA Hybrids That Serve As Damps Initiating Myeloid Skewing & Genetic Injury in MDS

Molecular Characterization of SRSF2 Mutation Identifies a Clinically Relevant Lncrna (MALAT1) in Chronic Myelomonocytic Leukemia (CMML)

Mesenchymal Cell Associated Fibrosis in Experimental mpl W515L Mouse Model of Myelofibrosis

The Proinflammatory Protein S100A9 Suppresses Erythropoietin Elaboration in Patients with Myelodysplastic Syndromes

Inflammaging-Associated Metabolic Alterations Foster Development of the MDS Genotype

A Phase II Study to Determine the Safety and Efficacy of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase (IDO) Enzyme INCB024360 in Patients with Myelodysplastic Syndromes

Lenalidomide Induces Lipid Raft Assembly to Enhance Erythropoietin Receptor Signaling in Myelodysplastic Syndrome Progenitors

Novel Therapeutic Approach to Improve Hematopoiesis By Targeting Myeloid Derived Suppressor Cells with a Humanized Anti-CD33 Antibody

A Novel Role For Histone Deacetylase 11 (HDAC11) As a Regulator Of Neutrophil Function and Differentiation In Normal and Malignant Hematopoesis

Pluripotent Fibrosis Initiating Mesenchymal Stromal Cell Linked To Cytopenias In LGL Leukemia Through Genetic Reprogramming

Novel Predictor Of Lenalidomide Response In Non-del5q MDS Reveals Linkage To Molecular Mechanism: First Characterization Of T-Cell Function In Cereblon Homozygous Deficient Mice

Lenalidomide Upregulates Erythropoietin Receptor Expression Through Inhibition of the E3-Ubiquitin Ligase Ring Finger Protein 41 (RNF41)

Targeted Repression of TP53 Promotes Erythropoiesis in Del(5q) MDS and Overcomes Clinical Resistance to Lenalidomide

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American Society of Hematology

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American Society of Hematology

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