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Journal Articles

RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug

Martin Wermke, Aylin Camgoz, Maciej Paszkowski-Rogacz, Sebastian Thieme, Malte von Bonin, Andreas Dahl, Uwe Platzbecker, Mirko Theis, Gerhard Ehninger, Sebastian Brenner, Martin Bornhäuser, Frank Buchholz

Blood (2015) 125 (24): 3760–3768.

https://doi.org/10.1182/blood-2014-07-590646

Published: 2015

Includes: Supplemental data

Journal Articles

A Genome Wide shRNA Screen In Primary Human AML Cells Identifies ROCK1 As a Novel Therapeutic Target

Martin Wermke, MD, Aylin Camgoz, Maciej Paszkowski-Rogacz, PhD, Sebastian Thieme, PhD, Malte von Bonin, MD, Andreas Dahl, PhD, Mirko Theis, PhD, Gerhard Ehninger, MD, Sebastian Brenner, MD, Martin Bornhäuser, MD, Frank Buchholz, PhD

Blood (2013) 122 (21): 170.

https://doi.org/10.1182/blood.V122.21.170.170

Published: 2013

Journal Articles

The histone demethylase UTX regulates stem cell migration and hematopoiesis

Sebastian Thieme, Tobias Gyárfás, Cornelia Richter, Günes Özhan, Jun Fu, Dimitra Alexopoulou, Michael H. Muders, Irene Michalk, Christiane Jakob, Andreas Dahl, Barbara Klink, Joanna Bandoła, Michael Bachmann, Evelin Schröck, Frank Buchholz, A. Francis Stewart, Gilbert Weidinger, Konstantinos Anastassiadis, Sebastian Brenner

Blood (2013) 121 (13): 2462–2473.

https://doi.org/10.1182/blood-2012-08-452003

Published: 2013

Includes: Supplemental data

Journal Articles

Aberrant Intracellular Retention of Mutated Receptor Tyrosine Kinase FLT3 in Human Leukemic Cells as a Potential Mechanism Supporting the Pathogenesis of Acute Myeloid Leukaemia.

Sina Koch, Martin Ryser, Angela Jacobi, Sebastian Brenner, Martin Bornhaeuser, Gerhard Ehninger, Christian Thiede

Blood (2008) 112 (11): 2245.

https://doi.org/10.1182/blood.V112.11.2245.2245

Published: 2008

Journal Articles

Expression and Functional Analysis of Autotaxin, a Relevant Motility and Survival Factor, in FLT3-ITD Positive Acute Myeloid Leukemia and Primary Hematopoietic Stem Cells.

Claudia Ortlepp, Christine Steudel, Sina Koch, Angela Jacobi, Satu Kyttaelae, Martin Ryser, Sebastian Brenner, Martin Bornhaeuser, Gerhard Ehninger, Christian Thiede

Blood (2008) 112 (11): 1206.

https://doi.org/10.1182/blood.V112.11.1206.1206

Published: 2008

Journal Articles

Role of Jagged/Notch Signaling in the Cell Fate Determination of Bone Marrow Human Mesenchymal Stem Cells.

Fernando Ugarte, Martin F. Ryser, MD, Sebastian Thieme, PhD, Martin Bornhaeuser, MD, PhD, Sebastian Brenner, MD

Blood (2007) 110 (11): 1923.

https://doi.org/10.1182/blood.V110.11.1923.1923

Published: 2007

Journal Articles

Interplay of CXCR4 and FLT3-ITD in the Regulation of Stem Cell Migration and Proliferation.

Angela Jacobi, Martin F. Ryser, MD, Sina Koch, Romy Lehmann, Martin Bornhaeuser, MD, PhD, Sebastian Brenner, MD

Blood (2007) 110 (11): 1818.

https://doi.org/10.1182/blood.V110.11.1818.1818

Published: 2007

Journal Articles

Electroporation of CXCR4 mRNA into Primary Mesenchymal Stem Cells Enables SDF-1 Dependent Migration.

Martin F. Ryser, MD, Fernando Ugarte, Sebastian Thieme, Marcus Gentsch, PhD, Martin Herber, DVM, Sebastian Brenner, MD

Blood (2006) 108 (11): 2574.

https://doi.org/10.1182/blood.V108.11.2574.2574

Published: 2006

Journal Articles

FLT3-ITD Mediated Growth Advantage of Human CD34+ PBPCs Is Dependent on Stromal Cells.

Angela Jacobi, Martin F. Ryser, MD, Sina Koch, Sebastian Brenner, MD

Blood (2006) 108 (11): 2546.

https://doi.org/10.1182/blood.V108.11.2546.2546

Published: 2006

Journal Articles

Physiological Gradients of Serum Albumin Regulate SDF-1/CXCR4 Dependent Migration.

Martin F. Ryser, MD, Joachim Roesler, MD, PhD, Harry L. Malech, MD, Angela Roesen-Wolff, MD, PhD, Sebastian Brenner, MD

Blood (2005) 106 (11): 2308.

https://doi.org/10.1182/blood.V106.11.2308.2308

Published: 2005

Journal Articles

S1P 1 Overexpression Inhibits SDF1/CXCR4 Dependent Migration and In Vivo Homing of Hematopoietic Stem Cells.

Martin F. Ryser, MD, Fernando A. Ugarte, BSc, Romy Lehmann, Harry L. Malech, MD, Joachim Roesler, MD, PhD, Angela Roesen-Wolff, MD, PhD, Sebastian Brenner, MD

Blood (2005) 106 (11): 2188.

https://doi.org/10.1182/blood.V106.11.2188.2188

Published: 2005

Journal Articles

Cloning and Functional Analysis of the Rhesus Macaque ABCG2 Gene: Forced Expression Confers an SP Phenotype among Hematopoietic Stem Cell Progeny in Vivo.

Takahiro Ueda, M.D., Sebastian Brenner, M.D., Harry Malech, M.D., Saskia Langemeijer, Martha Kirby, Oswald Phang, Allen Krouse, Robert E. Donahue, D.V.M., Elizabeth M. Kang, M.D., John F. Tisdale, M.D.

Blood (2004) 104 (11): 3219.

https://doi.org/10.1182/blood.V104.11.3219.3219

Published: 2004

Journal Articles

Concentrated RD114-pseudotyped MFGS-gp91 phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/β2-microglobulin –/– repopulating mobilized human peripheral blood CD34 + cells

Sebastian Brenner, Narda L. Whiting-Theobald, Gilda F. Linton, Kevin L. Holmes, Mindy Anderson-Cohen, Patrick F. Kelly, Elio F. Vanin, André M. Pilon, David M. Bodine, Mitchell E. Horwitz, Harry L. Malech

Blood (2003) 102 (8): 2789–2797.

https://doi.org/10.1182/blood-2002-05-1482

Published: 2003

Journal Articles

Third-generation, self-inactivating gp91 phox lentivector corrects the oxidase defect in NOD/SCID mouse–repopulating peripheral blood–mobilized CD34 + cells from patients with X-linked chronic granulomatous disease

Joachim Roesler, Sebastian Brenner, Anatoly A. Bukovsky, Narda Whiting-Theobald, Thomas Dull, Michael Kelly, Curt I. Civin, Harry L. Malech

Blood (2002) 100 (13): 4381–4390.

https://doi.org/10.1182/blood-2001-12-0165

Published: 2002

NARROW

RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug

A Genome Wide shRNA Screen In Primary Human AML Cells Identifies ROCK1 As a Novel Therapeutic Target

The histone demethylase UTX regulates stem cell migration and hematopoiesis

Aberrant Intracellular Retention of Mutated Receptor Tyrosine Kinase FLT3 in Human Leukemic Cells as a Potential Mechanism Supporting the Pathogenesis of Acute Myeloid Leukaemia.

Expression and Functional Analysis of Autotaxin, a Relevant Motility and Survival Factor, in FLT3-ITD Positive Acute Myeloid Leukemia and Primary Hematopoietic Stem Cells.

Role of Jagged/Notch Signaling in the Cell Fate Determination of Bone Marrow Human Mesenchymal Stem Cells.

Interplay of CXCR4 and FLT3-ITD in the Regulation of Stem Cell Migration and Proliferation.

Electroporation of CXCR4 mRNA into Primary Mesenchymal Stem Cells Enables SDF-1 Dependent Migration.

FLT3-ITD Mediated Growth Advantage of Human CD34+ PBPCs Is Dependent on Stromal Cells.

Physiological Gradients of Serum Albumin Regulate SDF-1/CXCR4 Dependent Migration.

S1P 1 Overexpression Inhibits SDF1/CXCR4 Dependent Migration and In Vivo Homing of Hematopoietic Stem Cells.

Cloning and Functional Analysis of the Rhesus Macaque ABCG2 Gene: Forced Expression Confers an SP Phenotype among Hematopoietic Stem Cell Progeny in Vivo.

Concentrated RD114-pseudotyped MFGS-gp91 phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/β2-microglobulin –/– repopulating mobilized human peripheral blood CD34 + cells

Third-generation, self-inactivating gp91 phox lentivector corrects the oxidase defect in NOD/SCID mouse–repopulating peripheral blood–mobilized CD34 + cells from patients with X-linked chronic granulomatous disease

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American Society of Hematology

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ASH Publications

American Society of Hematology

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