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Journal Articles

FT538, iPSC-Derived NK Cells Are Potent Inducers of Apoptosis in AML Cells and Their Effect Is Synergistic in Combination with Approved Therapeutic Strategies

Amanda Eckstrom, Anudishi Tyagi, Maryam Siddiqui, Sajid Mahmood, Lilly Wong, Bahram Bob Valamehr, Naval Daver, Venkata Lokesh Battula
Journal: Blood
Blood (2023) 142 (Supplement 1): 4817.
https://doi.org/10.1182/blood-2023-187192
Published: 2023
Journal Articles

Dual antigen–targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia

Frank Cichocki, Jodie P. Goodridge, Ryan Bjordahl, Sajid Mahmood, Zachary B. Davis, Svetlana Gaidarova, Ramzey Abujarour, Brian Groff, Alec Witty, Hongbo Wang, Katie Tuininga, Behiye Kodal, Martin Felices, Greg Bonello, Janel Huffman, Thomas Dailey, Tom T. Lee, Bruce Walcheck, Bahram Valamehr, Jeffrey S. Miller
Journal: Blood
Blood (2022) 140 (23): 2451–2462.
https://doi.org/10.1182/blood.2021015184
Published: 2022
Includes: Supplemental data
Journal Articles

Off-the-Shelf, iPSC-Derived CAR-NK Cells Multiplexed-Engineered for the Avoidance of Allogeneic Host Immune Cell Rejection

Rina M Mbofung, Alan M Williams, Ken Hayama, Yijia Pan, Brian Groff, Thomas Dailey, Sonia Reyes, Sajid Mahmood, Ketan Mathavan, Greg Bonello, Quirin Hammer, Karl-Johan Malmberg, Tom Lee, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 2795.
https://doi.org/10.1182/blood-2021-153484
Published: 2021
Journal Articles

Off-the-Shelf, Multiplexed-Engineered iPSC-Derived NK Cells Mediate Potent Multi-Antigen Targeting of B-Cell Malignancies with Reduced Cytotoxicity Against Healthy B Cells

Frank Cichocki, Jode P Goodridge, Ryan Bjordahl, Svetlana Gaidarova, Sajid Mahmood, Ramzey Abujarour, Zachary Davis, Hongbo Wang, Katie Tuininga, Behiye Kodal, Martin Felices, Paul Rogers, Greg Bonello, Janel Huffman, Thomas Dailey, Tom Lee, Peter Szabo, Lilly Wong, Sarah Cooley, Bahram Valamehr, Jeffrey S. Miller
Journal: Blood
Blood (2021) 138 (Supplement 1): 407.
https://doi.org/10.1182/blood-2021-148654
Published: 2021
Journal Articles

Dual Chimeric Antigen Receptor Approach Combining Novel Tumor Targeting Strategies Circumvents Antigen Escape in Multiple Myeloma

John Reiser, Ketan Mathavan, Sajid Mahmood, Yijia Pan, Bryan Hancock, Robert Blum, Wen-I Yeh, Andrew Houk, Chia-Wei Chang, Tom Lee, Uta Hopken, John Goulding, Armin Rehm, Kai W. Wucherpfennig, Jode P Goodridge, Ryan Bjordahl, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 1718.
https://doi.org/10.1182/blood-2021-154025
Published: 2021
Journal Articles

Triple Gene-Modified iPSC-Derived NK Cells Combined with Daratumumab for Targeted Immunotherapy Against AML

Frank Cichocki, PhD, Ryan Bjordahl, PhD, Karrune Woan, MD PhD, Zachary Davis, PhD BS, Greg Bonello, Sajid Mahmood, PhD, Paul Rogers, PhD, Moyar Q. Ge, PhD, Tom Lee, PhD, Martin Felices, PhD, Bruce Walcheck, PhD, Bruce R. Blazar, MD, Bahram Valamehr, PhD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 57–58.
https://doi.org/10.1182/blood-2020-137138
Published: 2020
Journal Articles

CAR19 iPSC-Derived NK Cells Utilize the Innate Functional Potential Mediated through NKG2A-Driven Education and Override the HLA-E Check Point to Effectively Target B Cell Lymphoma

Minoru Kanaya, PhD, Camille Philippon, MSc, Artur Cieslar-Pobuda, PhD, Frank Cichocki, PhD, Michelle Saetersmoen, MSc, Sajid Mahmood, PhD, Quirin Hammer, PhD, Marianna Vincenti, MD, Merete Thune Wiiger, PhD, Hanna Julie Hoel, MSc, Lise Kveberg, PhD, Svetlana Gaidarova, MS, Ryan Bjordahl, PhD, Hui-yi Chu, PhD, Brian Groff, Matthew Denholtz, PhD, Jeffrey S. Miller, MD, Tom Lee, PhD, Dan S Kaufman, MDPhD, Jode P Goodridge, PhD, Bahram Valamehr, PhD, Karl-Johan Malmberg, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-138527
Published: 2020
Journal Articles

FT576: Multi-Specific Off-the-Shelf CAR-NK Cell Therapy Engineered for Enhanced Persistence, Avoidance of Self-Fratricide and Optimized Mab Combination Therapy to Prevent Antigenic Escape and Elicit a Deep and Durable Response in Multiple Myeloma

Jode P Goodridge, PhD, Ryan Bjordahl, PhD, Sajid Mahmood, PhD, John Reiser, PhD, Svetlana Gaidarova, MS, Robert Blum, MS, Frank Cichocki, PhD, Hui-yi Chu, PhD, Greg Bonello, PhD, Tom Lee, PhD, Brian Groff, Miguel Meza, BS, Yu-Waye Chu, MD, Bruce Walcheck, PhD, Karl-Johan Malmberg, MD PhD, Jeffrey S. Miller, MD, Armin Rehm, Uta Hopken, Bahram Valamehr, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-142750
Published: 2020
Journal Articles

FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies

Jode P Goodridge, PhD, Sajid Mahmood, PhD, Huang Zhu, PhD, Svetlana Gaidarova, MS, Robert Blum, Ryan Bjordahl, PhD, Frank Cichocki, PhD, Hui-yi Chu, PhD, Greg Bonello, PhD, Tom Lee, PhD, Brian Groff, Miguel Meza, BS, Bruce Walcheck, PhD, Karl-Johan Malmberg, MD PhD, Jeffrey S. Miller, MD, Dan S Kaufman, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 301.
https://doi.org/10.1182/blood-2019-129319
Published: 2019
Journal Articles

FT576: A Novel Multiplexed Engineered Off-the-Shelf Natural Killer Cell Immunotherapy for the Dual-Targeting of CD38 and Bcma for the Treatment of Multiple Myeloma

Ryan Bjordahl, PhD, Svetlana Gaidarova, MS, Jode P Goodridge, PhD, Sajid Mahmood, PhD, Greg Bonello, PhD, Megan Robinson, Chelsea Ruller, Mochtar Pribadi, PhD, Tom Lee, PhD, Ramzey Abujarour, PhD, Jason Dinella, PhD, Janel Huffman, MS, Hui-yi Chu, PhD, Uta Hopken, Armin Rehm, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3214.
https://doi.org/10.1182/blood-2019-131373
Published: 2019
Journal Articles

iPSC-Derived NK Cells Synergize with T Cells and Anti-PD-1 Antibody to Mediate Durable Anti-Tumor Responses In Vivo

Jeffrey S. Miller, MD, Ryan Bjordahl, PhD, Svetlana Gaidarova, MS, Sajid Mahmood, PhD, Paul Rogers, PhD, Ge Moyar, Bruce R. Blazar, MD, Dan S Kaufman, MD PhD, Bahram Valamehr, PhD, Frank Cichocki, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1933.
https://doi.org/10.1182/blood-2019-124961
Published: 2019
Journal Articles

Off-the-Shelf Natural Killer Cells with Multi-Functional Engineering Using a Novel Anti-CD19 Chimeric Antigen Receptor Combined with Stabilized CD16 and IL15 Expression to Enhance Directed Anti-Tumor Activity

Dan S Kaufman, MD PhD, Ryan Bjordahl, PhD, Huang Zhu, PhD, Robert Blum, Andres Bahena, Sajid Mahmood, PhD, Greg Bonello, PhD, Tom Lee, PhD, Bruce Walcheck, PhD, Frank Cichocki, PhD, Jeffrey S. Miller, MD, Bahram Valamehr, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4541.
https://doi.org/10.1182/blood-2018-99-113701
Published: 2018
Journal Articles

iPSC-Derived NK Cells and Anti-PD-1 Antibody Synergize to Enhance T Cell Cytokine and Cytolytic Responses Against Multiple Tumors

Frank Cichocki, PhD, Ryan Bjordahl, PhD, Svetlana Gaidarova, MS, Sajid Mahmood, PhD, Paul Rogers, PhD, Moyar Q. Ge, PhD, Dan S Kaufman, MD PhD, Sarah Cooley, MD, Bahram Valamehr, PhD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 730.
https://doi.org/10.1182/blood-2018-99-114893
Published: 2018
Journal Articles

Engineering Human Induced Pluripotent Stem Cells with Novel Chimeric Antigen Receptors to Generate Natural Killer (NK) Cell Cancer Immunotherapies with Targeted Anti-Tumor Activity

Ye Ethan Ethan Li, MD, David Hermanson, PhD, Branden Moriarity, PhD, Ryan Bjordahl, PhD, Sajid Mahmood, PhD, Bahram Valamehr, PhD, Dan Kaufman, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1905.
https://doi.org/10.1182/blood.V130.Suppl_1.1905.1905
Published: 2017