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S. Tiong Ong
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Journal Articles

A single-cell atlas identifies pretreatment features of primary imatinib resistance in chronic myeloid leukemia

Vaidehi Krishnan, Florian Schmidt, Zahid Nawaz, Prasanna Nori Venkatesh, Kian Leong Lee, Xi Ren, Zhu En Chan, Mengge Yu, Meera Makheja, Nirmala Arul Rayan, Michelle Gek Liang Lim, Alice Man Sze Cheung, Sudipto Bari, Wee Joo Chng, Hein Than, John Ouyang, Owen Rackham, Tuan Zea Tan, William Ying Khee Hwang, Charles Chuah, Shyam Prabhakar, S. Tiong Ong
Journal: Blood
Blood (2023) 141 (22): 2738–2755.
https://doi.org/10.1182/blood.2022017295
Published: 2023
Includes: Supplemental data
Journal Articles

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia

Tun Kiat Ko, Asif Javed, Kian Leong Lee, Thushangi N. Pathiraja, Xingliang Liu, Simeen Malik, Sheila Xinxuan Soh, Xiu Ting Heng, Naoto Takahashi, Joanna H. J. Tan, Ravi Bhatia, Alexis J. Khng, Wee-Joo Chng, Yee Yen Sia, David A. Fruman, King Pan Ng, Zhu En Chan, Kim Jiajing Xie, Qiangze Hoi, Cheryl Xueli Chan, Audrey S. M. Teo, Oscar Velazquez Camacho, Wee Yang Meah, Chiea Chuen Khor, Chin Thing J. Ong, Wei Jia W. Soon, Patrick Tan, Pauline C. Ng, Charles Chuah, Axel M. Hillmer, S. Tiong Ong
Journal: Blood
Blood (2020) 135 (26): 2337–2353.
https://doi.org/10.1182/blood.2020004834
Published: 2020
Includes: Supplemental data
Journal Articles

The Genomic and Epigenomic Landscapes of Blast Crisis Transformation in Chronic Myeloid Leukemia

S. Tiong Ong, MD, Thushangi Pathiraja, PhD, Asif Javed, PhD, Xin Xuan Sheila Soh, Simeen Malik, PhD, Joanna H.J. Tan, Tun Kiat Ko, PhD, Charles Chuah, Naoto Takahashi, MD, PhD, Ravi Bhatia, MD, King Pan Ng, PhD, Wee Joo Chng, MD PhD, Chandana Tennakoon, PhD, Qiangze Hoi, Peiyong Guan, Audrey S.M. Teo, Wah Heng Lee, PhD, Patrick Tan, MD PhD, Win Kin Sung, PhD, Pauline Ng, PhD, Axel Hillmer, PhD
Journal: Blood
Blood (2015) 126 (23): 3737.
https://doi.org/10.1182/blood.V126.23.3737.3737
Published: 2015
Journal Articles

Functional Analysis of the CML Blast Crisis Transcriptome and Epigenome Using Crispr-CAS9 and Pharmacologic Approaches

Tun Kiat Ko, PhD, Xin Xuan Sheila Soh, Willie Yu, PhD, Peter S. Winter, Thushangi Pathiraja, PhD, Asif Javed, PhD, Simeen Malik, PhD, Joanna H.J. Tan, Charles Chuah, MD PhD, Naoto Takahashi, MD, PhD, Ravi Bhatia, MD, Wee Joo Chng, MD PhD, Peter Valent, MD, Sabine Cerny-Reiterer, DVM, King Pan Ng, PhD, Chandana Tennakoon, PhD, Qiangze Hoi, Peiyong Guan, Audrey S.M. Teo, Wah Heng Lee, PhD, Patrick Tan, MD PhD, Win Kin Sung, PhD, Pauline Ng, PhD, Axel Hillmer, PhD, Kris C. Wood, PhD, Steve Rozen, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2015) 126 (23): 2764.
https://doi.org/10.1182/blood.V126.23.2764.2764
Published: 2015
Journal Articles

Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition

King Pan Ng, Aditi Manjeri, Kian Leong Lee, Weijie Huang, Soo Yong Tan, Charles T. H. Chuah, Lorenz Poellinger, S. Tiong Ong
Journal: Blood
Blood (2014) 123 (21): 3316–3326.
https://doi.org/10.1182/blood-2013-07-511907
Published: 2014
Includes: Supplemental data
Journal Articles

Dual Specific Inhibitors Of The BCR-ABL and MNK Kinases As Potential Therapeutics For Blast Crisis Chronic Myeloid Leukemia

Sharon Lim, Joseph Cherian, Kassoum Nacro, Yun Shan Chew, Meng Ling Choong, Jun Ding Li, Samantha Guo, Melvyn Ho, Joma Joy, Perlyn Kwek, May Ann Lee, Boping Liu, Vithya Manoharan, Esther Ong, Vishal Pendharkar, Zhi Ying Poh, Anders Poulsen, Kanda Sangthongpitag, Kannan Srinivararaghavan, Siew Peng Tan, Haiyan Yang, Thomas H. Keller, Charles Chuah, MD, S. Tiong Ong, Jeffrey Hill, Alex Matter
Journal: Blood
Blood (2013) 122 (21): 2702.
https://doi.org/10.1182/blood.V122.21.2702.2702
Published: 2013
Journal Articles

Multi-Agent Chemotherapy Overcomes Steroid Resistance Conferred by a BIM Deletion Polymorphism in Pediatric Acute Lymphoblastic Leukemia (ALL)

Sheila X.X. Soh, Joshua Y.S. Lim, John W.J. Huang, Shirley K.Y. Kham, Allen E.J. Yeoh, S. Tiong Ong
Journal: Blood
Blood (2013) 122 (21): 2544.
https://doi.org/10.1182/blood.V122.21.2544.2544
Published: 2013
Journal Articles

The BIM Deletion Polymorphism: A Paradigm Of a Permissive Interaction Between Germline and Acquired TKI Resistance Factors In Chronic Myeloid Leukemia

Tun Kiat Ko, PhD, Charles Chuah, MD, John W.J. Huang, King-Pan Ng, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2013) 122 (21): 3977.
https://doi.org/10.1182/blood.V122.21.3977.3977
Published: 2013
Journal Articles

The BCL-2 Inhibitor ABT-199 Enhances Imatinib-Induced Cell Death In Chronic Phase CML Progenitors

Tun Kiat Ko, PhD, Charles Chuah, MD, John Huang, King-Pan Ng, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2013) 122 (21): 3978.
https://doi.org/10.1182/blood.V122.21.3978.3978
Published: 2013
Journal Articles

Targeting of a Novel MNK-eIF4E-b-Catenin Axis in Blast Crisis Chronic Myelogenous Leukemia Inhibits Leukemia Stem Cell Function

Sharon Lim, PhD, Tzuen Yih Saw, Sandy Chang, Min Zhang, MD, Matthew Robert Janes, MPH, David A Fruman, PhD, David A. Rizzieri, MD, Soo-Yong Tan, MBBS, FRCPath, DPhil, Charles Chuah, MD, S. Tiong Ong, MD
Journal: Blood
Blood (2011) 118 (21): 963.
https://doi.org/10.1182/blood.V118.21.963.963
Published: 2011
Journal Articles

A Common Deletion Polymorphism in the BIM Gene Contributes to Intrinsic Imatinib Resistance in Chronic Myelogenous Leukemia

Axel M Hillmer, PhD, King-Pan Ng, PhD, Charles Chuah, MBChB, FRCPE, MD, Wen Chun Juan, B.Sc, Tun-Kiat Ko, PhD, Audrey S.M. Teo, M.Sc, Pramila N Ariyaratne, M.Sc, Naoto Takahashi, MD, PhD, Kenichi Sawada, MD, PhD, Yao Fei, M.Sc, Wah Heng Lee, PhD, Weijie Huang, B.Sc, John C Allen, Jr., PhD, Xing Yi Woo, PhD, Niranjan Nagarajan, PhD, Vikrant Kumar, PhD, Anbupalam Thalamuthu, PhD, Wan Ting Poh, B.S, Ai Leen Ang, MBBS, MMed, (Internal, Medicine), Hae Tha Mya, M.B.B.S, Gee Fung How, PhD, Li Yi Yang, B.Sc, Liang Piu Koh, M.B.B.S, Veera S Nadarajan, M.B.B.S, Wee-Joo Chng, M.B.Ch.B, Hein Than, M.B.B.S, Lay Cheng Lim, MD, Yeow-Tee Goh, MBBS, MMed, Markus M Nöthen, M.D, Tien Y Wong, M.D, PhD, Atif Shahab, PhD, Xiaoan Ruan, PhD, Valère Cacheux-Rataboul, PhD, Wing-Kin Sung, PhD, Yijun Ruan, PhD, S. Tiong Ong, M.A., M.B.B.Ch., M.R.C.P., (UK)
Journal: Blood
Blood (2011) 118 (21): 1666.
https://doi.org/10.1182/blood.V118.21.1666.1666
Published: 2011
Journal Articles

Overexpression and Phosphorylation of eIF4E Is Required for Beta-Catenin Activation in Blast Crisis Chronic Myelogenous Leukemia.

Sharon Lim, PhD, T. Yih Saw, MSc, Charles Chuah, MD, S. Tiong Ong, MD
Journal: Blood
Blood (2009) 114 (22): 41.
https://doi.org/10.1182/blood.V114.22.41.41
Published: 2009
Journal Articles

Physiologic Hypoxia Protects Chronic Myelogenous Leukemia Progenitors From Elimination by Imatinib Mesylate.

King-Pan Ng, PhD, Tuang Yeow Poh, PhD, Wen Tian Sun, PhD, Charles Chuah, MD, S. Tiong Ong, MD
Journal: Blood
Blood (2009) 114 (22): 2181.
https://doi.org/10.1182/blood.V114.22.2181.2181
Published: 2009
Journal Articles

Enhanced Killing of Chronic Myelogenous Leukemia Cells by Rapamycin and Imatinib Is Associated with Differential Inhibition of 4E-BP1 and eIF4E Phosphorylation and Decreased Protein Expression by Non-Overlapping Mechanisms.

James C. Moore, M.D., Chi Ly, Halbur Luke, M.D., S. Tiong Ong, M.D.
Journal: Blood
Blood (2004) 104 (11): 1993.
https://doi.org/10.1182/blood.V104.11.1993.1993
Published: 2004