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Journal Articles

Therapeutic Repurposing of Brincidofovir in Non-Hodgkin Lymphoma - Potential Synergy with Immune Checkpoint Blockade

Jason Yongsheng Chan, Elizabeth Chun Yong Lee, Kelila Xin Ye Chai, Boon Yee Lim, Zhimei Li, Jing Yi Lee, Bavani Kannan, Tun Kiat Ko, Jessica Sook-Ting Kok, Kah Suan Lim, Nur Ayuni Muhammad Taib, Dachuan Huang, Jing Quan Lim, Masatoshi Hazama, Koji Fukushima, Bin Tean Teh, Soon Thye Lim, Choon Kiat Ong
Journal: Blood
Blood (2024) 144 (Supplement 1): 4172.
https://doi.org/10.1182/blood-2024-202761
Published: 2024
Journal Articles

Single-cell landscape of idiopathic multicentric Castleman disease in identical twins

Brief Report
Jason Yongsheng Chan, Jui Wan Loh, Jing Quan Lim, Herty Liany, Elizabeth Chun Yong Lee, Jing Yi Lee, Bavani Kannan, Boon Yee Lim, Zexi Guo, Kerry Lim, Jeslin Chian Hung Ha, Cedric Chuan-Young Ng, Tun Kiat Ko, Dachuan Huang, Dominique Yuan Bin Seow, Chee Leong Cheng, Sock Hoai Chan, Joanne Ngeow, Bin Tean Teh, Soon Thye Lim, Choon Kiat Ong
Journal: Blood
Blood (2024) 143 (18): 1837–1844.
https://doi.org/10.1182/blood.2023021992
Published: 2024
Includes: Supplemental data
Journal Articles

Therapeutic Repurposing of Brincidofovir in Natural Killer/T-Cell Lymphoma Reveals Potent Induction of Replication Stress, Sting Pathway Activation and Immunogenic Cell Death

Jason Yongsheng Chan, Elizabeth Chun Yong Lee, Kelila Xin Ye Chai, Jing Yi Lee, Bavani Kannan, Boon Yee Lim, Jessica Sook-Ting Kok, Zhimei Li, Jui Wan Loh, Tun Kiat Ko, Kah Suan Lim, Cedric Chuan-Young Ng, Kerry Lim, Dachuan Huang, Jing Quan Lim, Masatoshi Hazama, Koji Fukushima, Bin Tean Teh, Soon Thye Lim, Choon Kiat Ong
Journal: Blood
Blood (2022) 140 (Supplement 1): 2256–2257.
https://doi.org/10.1182/blood-2022-163243
Published: 2022
Journal Articles

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia

Tun Kiat Ko, Asif Javed, Kian Leong Lee, Thushangi N. Pathiraja, Xingliang Liu, Simeen Malik, Sheila Xinxuan Soh, Xiu Ting Heng, Naoto Takahashi, Joanna H. J. Tan, Ravi Bhatia, Alexis J. Khng, Wee-Joo Chng, Yee Yen Sia, David A. Fruman, King Pan Ng, Zhu En Chan, Kim Jiajing Xie, Qiangze Hoi, Cheryl Xueli Chan, Audrey S. M. Teo, Oscar Velazquez Camacho, Wee Yang Meah, Chiea Chuen Khor, Chin Thing J. Ong, Wei Jia W. Soon, Patrick Tan, Pauline C. Ng, Charles Chuah, Axel M. Hillmer, S. Tiong Ong
Journal: Blood
Blood (2020) 135 (26): 2337–2353.
https://doi.org/10.1182/blood.2020004834
Published: 2020
Includes: Supplemental data
Journal Articles

The Genomic and Epigenomic Landscapes of Blast Crisis Transformation in Chronic Myeloid Leukemia

S. Tiong Ong, MD, Thushangi Pathiraja, PhD, Asif Javed, PhD, Xin Xuan Sheila Soh, Simeen Malik, PhD, Joanna H.J. Tan, Tun Kiat Ko, PhD, Charles Chuah, Naoto Takahashi, MD, PhD, Ravi Bhatia, MD, King Pan Ng, PhD, Wee Joo Chng, MD PhD, Chandana Tennakoon, PhD, Qiangze Hoi, Peiyong Guan, Audrey S.M. Teo, Wah Heng Lee, PhD, Patrick Tan, MD PhD, Win Kin Sung, PhD, Pauline Ng, PhD, Axel Hillmer, PhD
Journal: Blood
Blood (2015) 126 (23): 3737.
https://doi.org/10.1182/blood.V126.23.3737.3737
Published: 2015
Journal Articles

Functional Analysis of the CML Blast Crisis Transcriptome and Epigenome Using Crispr-CAS9 and Pharmacologic Approaches

Tun Kiat Ko, PhD, Xin Xuan Sheila Soh, Willie Yu, PhD, Peter S. Winter, Thushangi Pathiraja, PhD, Asif Javed, PhD, Simeen Malik, PhD, Joanna H.J. Tan, Charles Chuah, MD PhD, Naoto Takahashi, MD, PhD, Ravi Bhatia, MD, Wee Joo Chng, MD PhD, Peter Valent, MD, Sabine Cerny-Reiterer, DVM, King Pan Ng, PhD, Chandana Tennakoon, PhD, Qiangze Hoi, Peiyong Guan, Audrey S.M. Teo, Wah Heng Lee, PhD, Patrick Tan, MD PhD, Win Kin Sung, PhD, Pauline Ng, PhD, Axel Hillmer, PhD, Kris C. Wood, PhD, Steve Rozen, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2015) 126 (23): 2764.
https://doi.org/10.1182/blood.V126.23.2764.2764
Published: 2015
Journal Articles

The BIM Deletion Polymorphism: A Paradigm Of a Permissive Interaction Between Germline and Acquired TKI Resistance Factors In Chronic Myeloid Leukemia

Tun Kiat Ko, PhD, Charles Chuah, MD, John W.J. Huang, King-Pan Ng, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2013) 122 (21): 3977.
https://doi.org/10.1182/blood.V122.21.3977.3977
Published: 2013
Journal Articles

The BCL-2 Inhibitor ABT-199 Enhances Imatinib-Induced Cell Death In Chronic Phase CML Progenitors

Tun Kiat Ko, PhD, Charles Chuah, MD, John Huang, King-Pan Ng, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2013) 122 (21): 3978.
https://doi.org/10.1182/blood.V122.21.3978.3978
Published: 2013
Journal Articles

A Common Deletion Polymorphism in the BIM Gene Contributes to Intrinsic Imatinib Resistance in Chronic Myelogenous Leukemia

Axel M Hillmer, PhD, King-Pan Ng, PhD, Charles Chuah, MBChB, FRCPE, MD, Wen Chun Juan, B.Sc, Tun-Kiat Ko, PhD, Audrey S.M. Teo, M.Sc, Pramila N Ariyaratne, M.Sc, Naoto Takahashi, MD, PhD, Kenichi Sawada, MD, PhD, Yao Fei, M.Sc, Wah Heng Lee, PhD, Weijie Huang, B.Sc, John C Allen, Jr., PhD, Xing Yi Woo, PhD, Niranjan Nagarajan, PhD, Vikrant Kumar, PhD, Anbupalam Thalamuthu, PhD, Wan Ting Poh, B.S, Ai Leen Ang, MBBS, MMed, (Internal, Medicine), Hae Tha Mya, M.B.B.S, Gee Fung How, PhD, Li Yi Yang, B.Sc, Liang Piu Koh, M.B.B.S, Veera S Nadarajan, M.B.B.S, Wee-Joo Chng, M.B.Ch.B, Hein Than, M.B.B.S, Lay Cheng Lim, MD, Yeow-Tee Goh, MBBS, MMed, Markus M Nöthen, M.D, Tien Y Wong, M.D, PhD, Atif Shahab, PhD, Xiaoan Ruan, PhD, Valère Cacheux-Rataboul, PhD, Wing-Kin Sung, PhD, Yijun Ruan, PhD, S. Tiong Ong, M.A., M.B.B.Ch., M.R.C.P., (UK)
Journal: Blood
Blood (2011) 118 (21): 1666.
https://doi.org/10.1182/blood.V118.21.1666.1666
Published: 2011