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Journal Articles

S100A4 Expression Protects AML Cells from V-Atpase Mediated Apoptosis Via the Nuclear Receptor Coactivator, NCOA7

Rehab Nawaf S Alanazi, Sian Rizzo, Amanda Gilkes, Steven Knapper, Richard L Darley, Alex Tonks

Blood (2024) 144 (Supplement 1): 6129.

https://doi.org/10.1182/blood-2024-205676

Published: 2024

Journal Articles

PKC-Epsilon Overexpression Is Associated with Poor Outcomes in AML and Promotes Chemoresistance and Hematopoietic Stem Cell Quiescence

Rachael Louise Nicholson, BSc, Steven Knapper, DM, Alex Tonks, PhD, Richard L Darley, PhD

Blood (2019) 134 (Supplement_1): 2704.

https://doi.org/10.1182/blood-2019-128184

Published: 2019

Journal Articles

Overexpression or Deficiency of RUNX3 Results in Defective Normal Human Hematopoietic Development Similar to RUNX1-ETO Expression in AML

Ana Catarina Menezes, MSc, BSc, Steven Knapper, DM, Richard L Darley, PhD, Alex Tonks, PhD

Blood (2019) 134 (Supplement_1): 2527.

https://doi.org/10.1182/blood-2019-130798

Published: 2019

Journal Articles

Integrated Nuclear Proteomics and Transcriptomics Identifies New High Frequency Dysregulated Transcription Factors in AML

Chinmay R Munje, BSc PhD, Andrew J. K. Williamson, BSc, PhD, Samuel Taylor, BSc, PhD, Robert K. Hills, MA, MSc, DPhil, Steven Knapper, DM BMBCh, Alan K. Burnett, MD, Andrew Pierce, BSc, PhD, Anthony Whetton, BSc, PhD, Richard L. Darley, BSc PhD, Alex Tonks, BSc PhD

Blood (2014) 124 (21): 3554.

https://doi.org/10.1182/blood.V124.21.3554.3554

Published: 2014

Journal Articles

CD200 and PD1-L1 in AML Are Associated with Expanded PD-1 + Late Differentiated CD8 + T Cells and a Decreased CD4:CD8 Ratio: a New Link Between Distinct Immunosuppressive Pathways

Steven Coles, PhD, Marie N Gilmore, PhD, Reiss Reid, PhD, Steven Knapper, DM BMBCh, Alan K. Burnett, MDFRCP, Steven Man, PhD, Alex Tonks, PhD, Richard L Darley, PhD

Blood (2014) 124 (21): 992.

https://doi.org/10.1182/blood.V124.21.992.992

Published: 2014

Journal Articles

A Subpopulation of Blasts with Attenuated p38 MAPK Response Is Seen in Virtually All AML Patients and AML Cell Lines and Is Defined By Cells with Augmented Lipid-Associated Anti-Oxidant Defense

Paul S. Hole, PhD, Sara Davies, MSc, Chinmay R Munje, BSc PhD, Sandra Kreuser, BSc, Robert K. Hills, MA MSc DPhil, Nader Omidvar, PhD, Steven Knapper, DM BMBCh, Alan K. Burnett, MDFRCP, Alex Tonks, BSc PhD, Richard L. Darley, BSc PhD

Blood (2014) 124 (21): 785.

https://doi.org/10.1182/blood.V124.21.785.785

Published: 2014

Journal Articles

Analysis of ROS-Responsive Genes in Mutant RAS Expressing Hematopoietic Progenitors Identifies the Glycolytic Pathway As a Major Target Promoting Both Proliferation and Survival

Goitseone Lucy Hopkins, BSc (Hons) MSc, Andrew J Robinson, BSc MRes, Paul S Hole, PhD, Richard L. Darley, BSc PhD, Alex Tonks, BSc PhD

Blood (2014) 124 (21): 2210.

https://doi.org/10.1182/blood.V124.21.2210.2210

Published: 2014

Journal Articles

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling

Paul S. Hole, Joanna Zabkiewicz, Chinmay Munje, Zarabeth Newton, Lorna Pearn, Paul White, Nuria Marquez, Robert K. Hills, Alan K. Burnett, Alex Tonks, Richard L. Darley

Blood (2013) 122 (19): 3322–3330.

https://doi.org/10.1182/blood-2013-04-491944

Published: 2013

Includes: Supplemental data

Journal Articles

Identification of the Wnt Signalling Protein, TCF7L2 As a Significantly Overexpressed Transcription Factor in AML

Siti Sarah Daud, MMedSc, Sara L Pumford, MPhil, Marie N Gilmour, PhD, Amanda F Gilkes, MSc, Alan K Burnett, MD, Robert Hills, MA, MSc, DPhil, Alex Tonks, PhD, Richard L Darley, PhD

Blood (2012) 120 (21): 1281.

https://doi.org/10.1182/blood.V120.21.1281.1281

Published: 2012

Journal Articles

Distinct Regulation of β- and γ-Catenin throughout Hematopoietic Development Contrasts with Their Cooperative Roles In Acute Myeloid Leukemia.

Rhys Gareth Morgan, BSc, Lorna Pearn, Kate Liddiard, PhD, Robert Hills, MA, MSc, DPhil, Alan Burnett, MD, Alex Tonks, PhD, Richard L Darley, PhD

Blood (2010) 116 (21): 1573.

https://doi.org/10.1182/blood.V116.21.1573.1573

Published: 2010

Journal Articles

Over-Expression of CD200 In Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-Lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity

Steven J Coles, PhD, Stephen Man, PhD, Robert Hills, MA, MSc, DPhil, Eddie CY Wang, PhD, Alan Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD

Blood (2010) 116 (21): 491.

https://doi.org/10.1182/blood.V116.21.491.491

Published: 2010

Journal Articles

PDK1 Overexpression In Acute Myeloid Leukemia; Clinical Significance and Potential as a Therapeutic Target

Joanna Zabkiewicz, PhD, Lorna Pearn, Robert Hills, MA, MSc, DPhil, Rhys, Gareth Morgan, BSc, Alan Burnett, MD, Alex Tonks, PhD, Richard L Darley, PhD

Blood (2010) 116 (21): 2162.

https://doi.org/10.1182/blood.V116.21.2162.2162

Published: 2010

Journal Articles

Large-Scale Integration of Gene Profiling Identifies TCF7L2/TCF4 as the Most Frequently Dysregulated Wnt Signaling Component In AML

Siti Sarah Daud, Alan K Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD

Blood (2010) 116 (21): 2480.

https://doi.org/10.1182/blood.V116.21.2480.2480

Published: 2010

Journal Articles

Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34 + hematopoietic progenitor cells

Paul S. Hole, Lorna Pearn, Amanda J. Tonks, Philip E. James, Alan K. Burnett, Richard L. Darley, Alex Tonks

Blood (2010) 115 (6): 1238–1246.

https://doi.org/10.1182/blood-2009-06-222869

Published: 2010

Includes: Supplemental data

Journal Articles

Ras Promotes Production of Reactive Oxygen Species in Normal Human CD34 + Cells: Role in Promoting Cell Survival and Protein Phosphorylation

Paul S Hole, BA, Lorna Pearn, Philip E James, PhD, Alan Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD

Blood (2008) 112 (11): 3797.

https://doi.org/10.1182/blood.V112.11.3797.3797

Published: 2008

Journal Articles

The role of PKC and PDK1 in monocyte lineage specification by Ras

Lorna Pearn, Janet Fisher, Alan K. Burnett, Richard L. Darley

Blood (2007) 109 (10): 4461–4469.

https://doi.org/10.1182/blood-2006-09-047217

Published: 2007

Journal Articles

Expression of RUNX1-RUNX1T1 Alone Has No Effect on the Intrinsic Susceptibility to Cytotoxic Chemicals.

Alex Tonks, PhD, Lorna Pearn, Amanda Tonks, PhD, Ken I. Mills, PhD, Alan K. Burnett, MD, Richard L. Darley, PhD

Blood (2006) 108 (11): 2602.

https://doi.org/10.1182/blood.V108.11.2602.2602

Published: 2006

Journal Articles

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

Alex Tonks, Lorna Pearn, Amanda J. Tonks, Laurence Pearce, Terry Hoy, Sarah Phillips, Janet Fisher, James R. Downing, Alan K. Burnett, Richard L. Darley

Blood (2003) 101 (2): 624–632.

https://doi.org/10.1182/blood-2002-06-1732

Published: 2003

Journal Articles

Protein kinase C mediates mutant N-Ras–induced developmental abnormalities in normal human erythroid cells

Richard L. Darley, Lorna Pearn, Nader Omidvar, Marion Sweeney, Janet Fisher, Sarah Phillips, Terry Hoy, Alan K. Burnett

Blood (2002) 100 (12): 4185–4192.

https://doi.org/10.1182/blood-2002-05-1358

Published: 2002

NARROW

S100A4 Expression Protects AML Cells from V-Atpase Mediated Apoptosis Via the Nuclear Receptor Coactivator, NCOA7

PKC-Epsilon Overexpression Is Associated with Poor Outcomes in AML and Promotes Chemoresistance and Hematopoietic Stem Cell Quiescence

Overexpression or Deficiency of RUNX3 Results in Defective Normal Human Hematopoietic Development Similar to RUNX1-ETO Expression in AML

Integrated Nuclear Proteomics and Transcriptomics Identifies New High Frequency Dysregulated Transcription Factors in AML

CD200 and PD1-L1 in AML Are Associated with Expanded PD-1 + Late Differentiated CD8 + T Cells and a Decreased CD4:CD8 Ratio: a New Link Between Distinct Immunosuppressive Pathways

A Subpopulation of Blasts with Attenuated p38 MAPK Response Is Seen in Virtually All AML Patients and AML Cell Lines and Is Defined By Cells with Augmented Lipid-Associated Anti-Oxidant Defense

Analysis of ROS-Responsive Genes in Mutant RAS Expressing Hematopoietic Progenitors Identifies the Glycolytic Pathway As a Major Target Promoting Both Proliferation and Survival

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling

Identification of the Wnt Signalling Protein, TCF7L2 As a Significantly Overexpressed Transcription Factor in AML

Distinct Regulation of β- and γ-Catenin throughout Hematopoietic Development Contrasts with Their Cooperative Roles In Acute Myeloid Leukemia.

Over-Expression of CD200 In Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-Lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity

PDK1 Overexpression In Acute Myeloid Leukemia; Clinical Significance and Potential as a Therapeutic Target

Large-Scale Integration of Gene Profiling Identifies TCF7L2/TCF4 as the Most Frequently Dysregulated Wnt Signaling Component In AML

Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34 + hematopoietic progenitor cells

Ras Promotes Production of Reactive Oxygen Species in Normal Human CD34 + Cells: Role in Promoting Cell Survival and Protein Phosphorylation

The role of PKC and PDK1 in monocyte lineage specification by Ras

Expression of RUNX1-RUNX1T1 Alone Has No Effect on the Intrinsic Susceptibility to Cytotoxic Chemicals.

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

Protein kinase C mediates mutant N-Ras–induced developmental abnormalities in normal human erythroid cells

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American Society of Hematology

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American Society of Hematology

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