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Journal Articles

Cytarabine Resistance Leads to a Specific Mutator Phenotype in Leukemic Cells

Dengchao Cao, Mianmian Yin, Timour Baslan, Ryan Bertoli, Zhenhua Zhang, Yuelin Zhu, Paul S. Meltzer, Peter D. Aplan

Blood (2024) 144 (Supplement 1): 1404.

https://doi.org/10.1182/blood-2024-208319

Published: 2024

Journal Articles

HoxBlinc LncRNA Reprograms CTCF Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98 Fusion Transformed Leukemia

Karina Hamamoto, Ganqian Zhu, Julia Lesperance, Huacheng Luo, Ying D Li, Nupur Nigam, Arati Sharma, Feng-Chun Yang, David F. Claxton, Yi Qiu, Peter D. Aplan, Mingjiang Xu, Suming Huang

Blood (2024) 144 (Supplement 1): 4108.

https://doi.org/10.1182/blood-2024-199171

Published: 2024

Journal Articles

The Hypomethylating Agent 5-Aza-4‘-Thio-2‘-Deoxycytidine Targets Early B Progenitor Cells and Leads to B Cell Precursor Acute Lymphoblastic Leukemia in Rag1 Knockout Mice

Vijay Negi, Ryan Bertoli, Emily Muenzer, Peter D. Aplan

Blood (2024) 144 (Supplement 1): 4126.

https://doi.org/10.1182/blood-2024-208171

Published: 2024

Journal Articles

Bcor Truncation Mutations Collaborate with a U2AF1 S34F Mutant to Promote Clonal Hematopoiesis and MDS

Yang Jo Chung, Anthony Wokasch, Masahiro Onozawa, Peter D. Aplan

Blood (2023) 142 (Supplement 1): 4586.

https://doi.org/10.1182/blood-2023-189251

Published: 2023

Journal Articles

Mcm2 Deficiency Leads to Bone Marrow Failure and Lymphoid Malignancies Dependent on Age and Genetic Background

Toshihiro Matsukawa, Yin Mianmian, Timour Baslan, Yang Jo Chung, Dengchao Cao, Ryan Bertoli, Jack Zhu, Robert L. Walker, Amy Freeland, Erik Knudsen, Paul S. Meltzer, Peter D. Aplan

Blood (2021) 138 (Supplement 1): 2223.

https://doi.org/10.1182/blood-2021-147373

Published: 2021

Journal Articles

Disruption of the Normal Hematopoietic Hierarchy Leading to Stem Cell Exhaustion in an Animal Model of Myelodysplastic Syndrome

Yang Jo Chung, PhD, Peter D. Aplan, MD

Blood (2019) 134 (Supplement_1): 1698.

https://doi.org/10.1182/blood-2019-128707

Published: 2019

Journal Articles

Idh2R140Q Cooperates with NHD13 to Induce Immature T Cell Leukemia By Targeting Early T Cell Progenitors or DN2 Thymocytes

Vijay Negi, PhD, Liat Goldberg, PhD, Yang Jo Chung, PhD, Masahiro Onozawa, MD, Peter D. Aplan, MD

Blood (2019) 134 (Supplement_1): 1346.

https://doi.org/10.1182/blood-2019-128675

Published: 2019

Journal Articles

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background

Mianmian Yin, Yang Jo Chung, R. Coleman Lindsley, Robert L. Walker, Yuelin J. Zhu, Benjamin L. Ebert, Paul S. Meltzer, Peter D. Aplan

Blood (2019) 133 (24): 2610–2614.

https://doi.org/10.1182/blood.2018864173

Published: 2019

Journal Articles

Engineered Bcor Mutations Lead to Acute Lymphoblastic Leukemia of Progenitor B-1 Lymphocyte Origin in a Sensitized Background

Mianmian Yin, PhD, Yang Jo Chung, PhD, R. Coleman Lindsley, MD, PhD, Yeulin Zhu, PhD, Robert L. Walker, PhD, Benjamin L. Ebert, MDPhD, Paul S. Meltzer, MD PhD, Peter D. Aplan, MD

Blood (2018) 132 (Supplement 1): 1331.

https://doi.org/10.1182/blood-2018-99-115388

Published: 2018

Journal Articles

Mice with a Unique Mutator Phenotype Allow Detection of Lymphoid Leukemia Tumor Suppressor Genes

Mianmian Yin, PhD, Timour Baslan, PhD, Amy Freeland, PhD, Toshihiro Matsukawa, PhD, Steven C. Pruitt, PhD, Peter D. Aplan, MD

Blood (2018) 132 (Supplement 1): 1332.

https://doi.org/10.1182/blood-2018-99-115176

Published: 2018

Journal Articles

A Novel DNA Methyltransferase Inhibitor Is Effective in an In Vivo Model of Myelodysplastic Syndrome

Ghanwa Khawaja, BS, Yang Jo Chung, PhD, Eunsil Park, MD, Micheal Difilippantonio, PhD, James H. Doroshow, MD, Peter D. Aplan, MD

Blood (2018) 132 (Supplement 1): 1804.

https://doi.org/10.1182/blood-2018-99-119265

Published: 2018

Journal Articles

Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS

Darlene A. Monlish, Sima T. Bhatt, Eric J. Duncavage, Zev J. Greenberg, John L. Keller, Molly P. Romine, Wei Yang, Peter D. Aplan, Matthew J. Walter, Laura G. Schuettpelz

Blood (2018) 131 (9): 1032–1035.

https://doi.org/10.1182/blood-2017-08-801944

Published: 2018

Includes: Supplemental data

Journal Articles

Activation of SIRT1 Deacetylase As a Therapeutic Approach for Myelodysplastic Syndromes By Restoring TET2 Function

Blood (2017) 130 (Supplement 1): 2497.

https://doi.org/10.1182/blood.V130.Suppl_1.2497.2497

Published: 2017

Journal Articles

Aberrant Hedgehog Signaling in Myelodysplastic Syndrome Accelerates Leukemic Transformation Via Smoothened-Dependent and Smoothened-Independent Gli1 Activation

Bonnie W Lau, MD PhD, Kyounghee Huh, MS, Rafael Madero-Marroquin, MD, Federico De Marchi, MD, Yiting Lim, PhD, Francisco Lobo, PhD, Luigi Marchionni, PhD, Peter D. Aplan, MD, William Matsui, MD, Lukasz P. Gondek, MD PhD

Blood (2017) 130 (Supplement 1): 1676.

https://doi.org/10.1182/blood.V130.Suppl_1.1676.1676

Published: 2017

Journal Articles

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

Stacy Cooper, MD, Hong Guo, MD PhD, Justin Thomas, Jay L. Hess, MD PhD, Peter D. Aplan, MD, Donald Small, MD PhD, Alan D. Friedman, MD

Blood (2016) 128 (22): 2691.

https://doi.org/10.1182/blood.V128.22.2691.2691

Published: 2016

Journal Articles

Thymic Precursor Cells Generate Acute Myeloid Leukemia in NUP98-PHF23/NUP98-HOXD13 Double Transgenic Mice

Subhadip Kundu, PhD, Eun Sil Park, MD, Yang Jo Chung, PhD, Trevor Stephen Barlowe, BA, Peter D. Aplan, MD

Blood (2016) 128 (22): 2883.

https://doi.org/10.1182/blood.V128.22.2883.2883

Published: 2016

Journal Articles

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment

Sarah D. Cramer, Peter D. Aplan, Scott K. Durum

Blood (2016) 128 (4): 473–478.

https://doi.org/10.1182/blood-2016-03-679209

Published: 2016

Journal Articles

All- trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD + leukemia stem cells in vitro and in vivo

Hayley S. Ma, Sarah M. Greenblatt, Courtney M. Shirley, Amy S. Duffield, J. Kyle Bruner, Li Li, Bao Nguyen, Eric Jung, Peter D. Aplan, Gabriel Ghiaur, Richard J. Jones, Donald Small

Blood (2016) 127 (23): 2867–2878.

https://doi.org/10.1182/blood-2015-05-646786

Published: 2016

Includes: Supplemental data

Journal Articles

Mouse Modeling of GATA2 Related MDS/AML

Lisa J. McReynolds, MD PhD, Peter D. Aplan, MD, Donald Small, MD PhD, Li Ding, MD, Kirby D. Johnson, Emery H Bresnick, PhD, Steven M. Holland, MD

Blood (2015) 126 (23): 2855.

https://doi.org/10.1182/blood.V126.23.2855.2855

Published: 2015

Journal Articles

Mixed Lineage Leukemia Rearrangements ( MLL- R ) Are Determinants of High Risk Disease in Homeobox A (HOXA)- deregulated T-Lineage Acute Lymphoblastic Leukemia: A Children's Oncology Group Study

Blood (2015) 126 (23): 694.

https://doi.org/10.1182/blood.V126.23.694.694

Published: 2015

NARROW

Cytarabine Resistance Leads to a Specific Mutator Phenotype in Leukemic Cells

HoxBlinc LncRNA Reprograms CTCF Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98 Fusion Transformed Leukemia

The Hypomethylating Agent 5-Aza-4‘-Thio-2‘-Deoxycytidine Targets Early B Progenitor Cells and Leads to B Cell Precursor Acute Lymphoblastic Leukemia in Rag1 Knockout Mice

Bcor Truncation Mutations Collaborate with a U2AF1 S34F Mutant to Promote Clonal Hematopoiesis and MDS

Mcm2 Deficiency Leads to Bone Marrow Failure and Lymphoid Malignancies Dependent on Age and Genetic Background

Disruption of the Normal Hematopoietic Hierarchy Leading to Stem Cell Exhaustion in an Animal Model of Myelodysplastic Syndrome

Idh2R140Q Cooperates with NHD13 to Induce Immature T Cell Leukemia By Targeting Early T Cell Progenitors or DN2 Thymocytes

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background

Engineered Bcor Mutations Lead to Acute Lymphoblastic Leukemia of Progenitor B-1 Lymphocyte Origin in a Sensitized Background

Mice with a Unique Mutator Phenotype Allow Detection of Lymphoid Leukemia Tumor Suppressor Genes

A Novel DNA Methyltransferase Inhibitor Is Effective in an In Vivo Model of Myelodysplastic Syndrome

Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS

Activation of SIRT1 Deacetylase As a Therapeutic Approach for Myelodysplastic Syndromes By Restoring TET2 Function

Aberrant Hedgehog Signaling in Myelodysplastic Syndrome Accelerates Leukemic Transformation Via Smoothened-Dependent and Smoothened-Independent Gli1 Activation

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

Thymic Precursor Cells Generate Acute Myeloid Leukemia in NUP98-PHF23/NUP98-HOXD13 Double Transgenic Mice

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment

All- trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD + leukemia stem cells in vitro and in vivo

Mouse Modeling of GATA2 Related MDS/AML

Mixed Lineage Leukemia Rearrangements ( MLL- R ) Are Determinants of High Risk Disease in Homeobox A (HOXA)- deregulated T-Lineage Acute Lymphoblastic Leukemia: A Children's Oncology Group Study

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American Society of Hematology

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ASH Publications

American Society of Hematology

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