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Persis J Amrolia, FRCP, FRCPath, PhD
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Journal Articles

Intention to Treat Analysis of Real-World Outcomes Following Tisgenlecleucel Therapy for Pediatric and Young Adult ALL through a National Access Programme

Sara Ghorashian, FRCPath, PhD, Caroline Furness, Michelle Cummins, John A Snowden, BSc (Hons), MBChB, MD FRCP, FRCPath, Maeve A O'Reilly, MBBCHBAO, Claire Roddie, PhD MD, Lorna Neill, Emma Nicholson, Caroline Besley, MBBChir, MRCPath, MRCP, Sridhar Chaganti, MDPhDMRCP,FRCPath, John Gillson, MD, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Anna Castleton, FRCPath, Amit Patel, MBBS,PhDFRCPath,MRCP, Peter Clark, MA MDFRCP, Robert Fernley, Robert Wynn, MD, Ajay Vora, MD, David I. Marks, MB, MS, FRACP, PhD FRCPath, Geoff Shenton, Persis J Amrolia, FRCP, FRCPath, PhD, Denise Bonney, Rachael E Hough, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-138438
Published: 2020
Journal Articles

The Enhanced Functionality of Low-Affinity CD19 CAR T Cells Is Associated with Activation Priming and Polyfunctional Cytokine Phenotype

Ilaria M. Michelozzi, PhD, Eduardo Gomez-Castaneda, PhD, Ruben V.C. Pohle, Ferran Cardoso Rodriguez, Jahangir Sufi, Pau Puigdevall, PhD, Meera Subramaniyam, Si Wei Wu, Aleks Guvenel, PhD, Sara Ghorashian, FRCPath, PhD, Martin Pule, MDPhD, Christopher J. Tape, PhD, Sergi Castellano, PhD, Persis J Amrolia, FRCP, FRCPath, PhD, Alice Giustacchini, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 52–53.
https://doi.org/10.1182/blood-2020-141249
Published: 2020
Journal Articles

T-Cell Reconstitution after Unrelated Donor HSCT Using Immunotherapy with CD25/71 Allodepleted Donor T Cells: Results of the Randomised Icat Study

Karl S Peggs, Sarah J Albon, MSc, Catherine Irving, BSc, Rachel Richardson, MSc, Joan Casanovas-Company, Rebecca Wallace, Aleks Guvenel, PhD, Sara Ghorashian, FRCPath, PhD, Angela Collura, Meera Subramaniyam, Barry Flutter, Bilyana Popova, Fernanda Castro, Andre Lopes, Kim Champion, Oliver Schofield, Laura Clifton-Hadley, PhDBSc, Thomas Taylor, Timothy Pulham, BSc, MPhil, Stuart Ings, Robert Herlihy, Maria Farrell, Rachael Wilding, Wendy Ogden, Stuart Adams, PhD, Gulrukh Ahsan, Kimberly C Gilmour, Stephen Mackinnon, MD, Eleni Tholouli, MD MRCPath, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1995.
https://doi.org/10.1182/blood-2019-124404
Published: 2019
Journal Articles

Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Shimobi Onuoha, PhD, Gary Wright, Jack Luke Bartram, MD, Rachel Richardson, MSc, Sarah J Albon, MSc, Joan Casanovas Company, Fernanda Castro, Bilyana Popova, Krystal Villanueva, Jenny Yeung, Aleks Guvenel, PhD, Patrycja Wawrzyniecka, Danielle Pinner, Jan Chu, Giovanna Lucchini, Juliana Silva, MD, Oana Ciocarlie, Arina Lazareva, Sarah Inglott, Kimberly Gilmour, Gulrukh Ahsan, Kim Champion, Andre Lopes, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Denise Bonney, Sujith Samarasinghe, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, Paul Veys, MD PhD, Rachael E Hough, MD, Robert Wynn, Martin Pule, MD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 225.
https://doi.org/10.1182/blood-2019-125009
Published: 2019
Journal Articles

Clonal Dynamics of Early Responder and Long-Term Surviving CAR-T Cells in Humans

Christine Rivat, Natalia Izotova, Rachel Richardson, MSc, Danilo Pellin, Rachael Hough, Robert Wynn, MD, Kim Champion, Andre Lopes, Sara Ghorashian, FRCPath, PhD, Martin Pule, Adrian J. Thrasher, MBBS, PhD FMedSci, Luca Biasco, PhD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 52.
https://doi.org/10.1182/blood-2019-125916
Published: 2019
Journal Articles

Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy Targeting CD19 and CD22, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael E Hough, MD, Ajay Vora, Denise Bonney, Paul Veys, MD PhD, Robert Chiesa, Kanchan Rao, Liz Clark, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, MD, Vijay G R Peddareddigari
Journal: Blood
Blood (2019) 134 (Supplement_1): 2620.
https://doi.org/10.1182/blood-2019-123424
Published: 2019
Journal Articles

Molecular MRD Monitoring Is Feasible in the Majority of Children with AML and Is Highly Predictive of Outcome: Results from the International MyeChild01 Study

Jelena Jovanovic, PhD, Nicola Potter, PhD, Anju Kanda, MSc, Claire Schwab, PhD, Aimee E Jackson, MSc, Richard Dillon, MA, PhD MRCP, FRCPath, Anna Lawson, BSc, Manohursingh Runglall, MSc, Paresh Vyas, MD PhD, Paul Virgo, Geoff Shenton, Nicholas Heaney, Beki James, MD, Katharine Patrick, MD, Persis J Amrolia, FRCP, FRCPath, PhD, Jean-Hugues Dalle, MD PhD, Gerard Michel, MD, Andrew S. Moore, MBBS,FRACP,PhD, Hélène Lapillonne, MD PhD, Claude Preudhomme, PharmD, PhD, Guy Leverger, MD, Owen P Smith, MD, Andre Baruchel, MD, Yves Bertrand, MD, Arnaud Petit, MD PhD, Keith Wheatley, DPhil, Pamela R. Kearns, PhDFRCPC, Christine J. Harrison, PhD FRCPath, Brenda Gibson, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1393.
https://doi.org/10.1182/blood-2019-125257
Published: 2019
Journal Articles

Simultaneous Targeting of CD19 and CD22: Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Denise Bonney, Paul Veys, MD PhD, Kanchan Rao, Robert Chiesa, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, PhD, Vijay G R Peddareddigari
Journal: Blood
Blood (2018) 132 (Supplement 1): 279.
https://doi.org/10.1182/blood-2018-99-118616
Published: 2018