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Journal Articles

Self-Supporting Human Acute Myeloid Leukemia (AML) Bone Marrow Organoids Established from Patient-Derived Xenografts Mimic the Human AML Microenvironment, with Distinct Cytokine Kinetics Correlating with Dynamic Cell Proliferation and Metabolic Shifts

Alejandro De Janon, Aashis Thapa, Fang Zhou, Ahmet Coskun, Athanasios Mantalaris, Douglas K. Graham, Deborah DeRyckere, Nicki Panoskaltsis

Blood (2023) 142 (Supplement 1): 1337.

https://doi.org/10.1182/blood-2023-189230

Published: 2023

Journal Articles

A Dynamic Personalized Human 3D Organoid for the Study of the Tumor Microenvironment and Metabolism in Acute Myeloid Leukemia Using Patient-Derived Xenografts

Alejandro De Janon, Madison Stout, Diana Fridlyand, Zhou Fang, Ahmet F. Coskun, Douglas K Graham, Athanasios Mantalaris, Deborah DeRyckere, Nicki Panoskaltsis

Blood (2022) 140 (Supplement 1): 1203–1204.

https://doi.org/10.1182/blood-2022-170225

Published: 2022

Journal Articles

Establishment of a Spontaneous Stromal Microenvironment from Cord Blood Supports Human Dynamic Erythropoietic Temporal Maturation in Long-Term Serum- and Cytokine-Free 3D Cultures and Reveals a Distinct CD44 hi Population

Susana Brito Dos Santos, MSc PhD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2019) 134 (Supplement_1): 2219.

https://doi.org/10.1182/blood-2019-131085

Published: 2019

Journal Articles

Metabolism of Acute Myeloid Leukemia Cell Lines Alters with Passage in 2D Culture and Remains Stable in 3D

Sophia Zemenides, BSc, MBBS, MRCP, MSc, Joana Dos Santos, MSc, Louise Enfield, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD FRCP

Blood (2018) 132 (Supplement 1): 2787.

https://doi.org/10.1182/blood-2018-99-118648

Published: 2018

Journal Articles

Personalized and Optimized Low-Dose and Intensive Chemotherapy Treatments for Patients with Acute Myeloid Leukemia (AML)

Ana Luz Quiroga-Campano, PhD MSc, BSc, Louise Enfield, Matthew Foster, BS, Margaritis Kostoglou, PhD, Michael Georgiadis, PhD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD FRCP

Blood (2018) 132 (Supplement 1): 3500.

https://doi.org/10.1182/blood-2018-99-119258

Published: 2018

Journal Articles

Primary Chronic Lymphocytic Leukemia Cells Can be Maintained Long-Term in Serum-Free, Cytokine-Free 3D Culture

Joana Dos Santos, MSc, Louise Enfield, Susana Brito Dos Santos, MSc, Mark C Allenby, MSc, Sophie Zemenides, MD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD FRCP

Blood (2017) 130 (Supplement 1): 2989.

https://doi.org/10.1182/blood.V130.Suppl_1.2989.2989

Published: 2017

Journal Articles

Precision Chemotherapy for Patients with Acute Myeloid Leukemia Using the πiChemo Prediction and Optimization Tool

Ana Luz Quiroga-Campano, BSc, MSc, PhD, Athanasios Mantalaris, PhD, Margaritis Kostoglou, PhD, Michael Georgiadis, PhD, Nicki Panoskaltsis, MD PhD FRCP

Blood (2017) 130 (Supplement 1): 2074.

https://doi.org/10.1182/blood.V130.Suppl_1.2074.2074

Published: 2017

Journal Articles

A Collaborative Pharmacist-Physician Multi-Professional Pre-Chemotherapy Assessment in Hematology Cancer Patients Is an Efficient & Cost-Effective Model for Service Delivery of Outpatient Systemic Anti-Cancer Therapy (SACT)

Ghada Zakout, FRCPath, MRCP, MBBS, Hei Wan Ng, MRPharmS, PGDip, IPresc, Nicki Panoskaltsis, MD PhD FRCP

Blood (2017) 130 (Supplement 1): 2125.

https://doi.org/10.1182/blood.V130.Suppl_1.2125.2125

Published: 2017

Journal Articles

Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide

Blood (2017) 130 (17): 1889–1897.

https://doi.org/10.1182/blood-2017-05-785790

Published: 2017

Includes: Supplemental data

Journal Articles

Spatiotemporal Mapping of Erythroid, Stromal, and Osteogenic Niche Formation to Support Physiologic Red Cell Production in a Three-Dimensional Hollow Fibre Perfusion Bioreactor

Mark C. Allenby, MSc, Asma Tahlawi, MSc, Ruth Misener, PhD, Susana Brito dos Santos, MSc, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2016) 128 (22): 3885.

https://doi.org/10.1182/blood.V128.22.3885.3885

Published: 2016

Journal Articles

Early Erythroid Development Is Enhanced with Hypoxia and Terminal Maturation with Normoxia in a 3D Ex Vivo Physiologic Eythropoiesis Model

Susana Brito dos Santos, MSc, Mark C. Allenby, MSc, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2016) 128 (22): 2453.

https://doi.org/10.1182/blood.V128.22.2453.2453

Published: 2016

Journal Articles

A Randomised Assessment of Ganetespib Combined with Low Dose Ara-C Versus Low Dose Ara-C in Older Patients with Acute Myeloid Leukaemia: Results of the LI-1 Trial

Michael Dennis, FRCPath, Robert K Hills, DPhil, Ian Thomas, Sunil Gupta, MBBS, MRCP, FRCPath, Nicki Panoskaltsis, MD, Mhairi Copland, PhD BSc, MB, ChB, MRCP, FRCPath, Alan K. Burnett, MD FRCP, Nigel H Russell, MD

Blood (2016) 128 (22): 2827.

https://doi.org/10.1182/blood.V128.22.2827.2827

Published: 2016

Journal Articles

Correlation Between Treatment Outcomes, Baseline Characteristics and Molecular Responses in the Majic Study Which Compared Ruxolitinib to Best Available Therapy in Essential Thrombocythemia

Blood (2016) 128 (22): 1929.

https://doi.org/10.1182/blood.V128.22.1929.1929

Published: 2016

Journal Articles

Effect of Oxygen and 3D Microenvironment on Physiologic Erythropoiesis

Susana Brito dos Santos, MSc, Mark Allenby, MSc, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2015) 126 (23): 3600.

https://doi.org/10.1182/blood.V126.23.3600.3600

Published: 2015

Journal Articles

Use of Mathematical Modelling Indicates That Patients Treated for Acute Myeloid Leukaemia (AML) Are Undertreated When Ideal Body Weight Is Used to Dose Chemotherapy

María Fuentes-Garí, PhD, Sophie Zemenides, MBBS, MRCP, MSc, BSc, Ruth Misener, PhD, Michael C. Georgiadis, PhD, Efstratios N. Pistikopoulos, PhD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2015) 126 (23): 4522.

https://doi.org/10.1182/blood.V126.23.4522.4522

Published: 2015

Journal Articles

Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia

Mike Dennis, Nigel Russell, Robert K. Hills, Claire Hemmaway, Nicki Panoskaltsis, Mary-Frances McMullin, Lars Kjeldsen, Helen Dignum, Ian F. Thomas, Richard E. Clark, Don Milligan, Alan K. Burnett

Blood (2015) 125 (19): 2923–2932.

https://doi.org/10.1182/blood-2014-10-608117

Published: 2015

Includes: Supplemental data

Journal Articles

A Randomised Assessment of Vosaroxin Monotherapy and Vosaroxin Combined with Low Dose Ara-C Versus Low Dose Ara-C in Older Patients with Acute Myeloid Leukaemia

Michael Dennis, MD, Nigel H. Russell, MD, Nicki Panoskaltsis, MD, Claire Jane Hemmaway, MD, Donald Milligan, MD, Richard E Clark, MBBS MD, Robert K. Hills, MA MSc DPhil, Alan K Burnett, MD

Blood (2014) 124 (21): 3747.

https://doi.org/10.1182/blood.V124.21.3747.3747

Published: 2014

Journal Articles

Optimized Patient- and Leukemia-Specific Chemotherapy Protocols For The Treatment Of Acute Myeloid Leukemia

Nicki Panoskaltsis, MD, PhD, FRCP, Eleni Pefani, Athanasios Mantalaris, PhD, Michael Georgiadis, PhD, Efstratios Pistikopoulos, PhD

Blood (2013) 122 (21): 4227.

https://doi.org/10.1182/blood.V122.21.4227.4227

Published: 2013

Journal Articles

Biology Of Mixed Phenotype Acute Leukemia In Successful Long-Term Cytokine-Free Three-Dimensional (3D) Static and Perfused 3D Hollow-Fibre Bioreactor Culture

Maria Rende, PhD, Athanasios Mantalaris, PhD, Ricardo Morilla, Nayef Aqel, MD, Nicki Panoskaltsis, MD, PhD, FRCP

Blood (2013) 122 (21): 2603.

https://doi.org/10.1182/blood.V122.21.2603.2603

Published: 2013

Journal Articles

Physiologic Erythropoiesis with Enhanced Globin Switching and Endogenous Cytokine Production in a Long-Term Serum-free in Vitro human Bone Marrow Biomimicry

Maria Rende, PhD, Iliana Fauzi, PhD, Teresa Mortera-Blanco, PhD, Johao Miguel da Costa Medeiros, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD, PhD

Blood (2012) 120 (21): 276.

https://doi.org/10.1182/blood.V120.21.276.276

Published: 2012

NARROW

Self-Supporting Human Acute Myeloid Leukemia (AML) Bone Marrow Organoids Established from Patient-Derived Xenografts Mimic the Human AML Microenvironment, with Distinct Cytokine Kinetics Correlating with Dynamic Cell Proliferation and Metabolic Shifts

A Dynamic Personalized Human 3D Organoid for the Study of the Tumor Microenvironment and Metabolism in Acute Myeloid Leukemia Using Patient-Derived Xenografts

Establishment of a Spontaneous Stromal Microenvironment from Cord Blood Supports Human Dynamic Erythropoietic Temporal Maturation in Long-Term Serum- and Cytokine-Free 3D Cultures and Reveals a Distinct CD44 hi Population

Metabolism of Acute Myeloid Leukemia Cell Lines Alters with Passage in 2D Culture and Remains Stable in 3D

Personalized and Optimized Low-Dose and Intensive Chemotherapy Treatments for Patients with Acute Myeloid Leukemia (AML)

Primary Chronic Lymphocytic Leukemia Cells Can be Maintained Long-Term in Serum-Free, Cytokine-Free 3D Culture

Precision Chemotherapy for Patients with Acute Myeloid Leukemia Using the πiChemo Prediction and Optimization Tool

A Collaborative Pharmacist-Physician Multi-Professional Pre-Chemotherapy Assessment in Hematology Cancer Patients Is an Efficient & Cost-Effective Model for Service Delivery of Outpatient Systemic Anti-Cancer Therapy (SACT)

Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide

Spatiotemporal Mapping of Erythroid, Stromal, and Osteogenic Niche Formation to Support Physiologic Red Cell Production in a Three-Dimensional Hollow Fibre Perfusion Bioreactor

Early Erythroid Development Is Enhanced with Hypoxia and Terminal Maturation with Normoxia in a 3D Ex Vivo Physiologic Eythropoiesis Model

A Randomised Assessment of Ganetespib Combined with Low Dose Ara-C Versus Low Dose Ara-C in Older Patients with Acute Myeloid Leukaemia: Results of the LI-1 Trial

Correlation Between Treatment Outcomes, Baseline Characteristics and Molecular Responses in the Majic Study Which Compared Ruxolitinib to Best Available Therapy in Essential Thrombocythemia

Effect of Oxygen and 3D Microenvironment on Physiologic Erythropoiesis

Use of Mathematical Modelling Indicates That Patients Treated for Acute Myeloid Leukaemia (AML) Are Undertreated When Ideal Body Weight Is Used to Dose Chemotherapy

Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia

A Randomised Assessment of Vosaroxin Monotherapy and Vosaroxin Combined with Low Dose Ara-C Versus Low Dose Ara-C in Older Patients with Acute Myeloid Leukaemia

Optimized Patient- and Leukemia-Specific Chemotherapy Protocols For The Treatment Of Acute Myeloid Leukemia

Biology Of Mixed Phenotype Acute Leukemia In Successful Long-Term Cytokine-Free Three-Dimensional (3D) Static and Perfused 3D Hollow-Fibre Bioreactor Culture

Physiologic Erythropoiesis with Enhanced Globin Switching and Endogenous Cytokine Production in a Long-Term Serum-free in Vitro human Bone Marrow Biomimicry

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American Society of Hematology

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American Society of Hematology

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