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Journal Articles

Self-Supporting Human Acute Myeloid Leukemia (AML) Bone Marrow Organoids Established from Patient-Derived Xenografts Mimic the Human AML Microenvironment, with Distinct Cytokine Kinetics Correlating with Dynamic Cell Proliferation and Metabolic Shifts

Alejandro De Janon, Aashis Thapa, Fang Zhou, Ahmet Coskun, Athanasios Mantalaris, Douglas K. Graham, Deborah DeRyckere, Nicki Panoskaltsis

Blood (2023) 142 (Supplement 1): 1337.

https://doi.org/10.1182/blood-2023-189230

Published: 2023

Journal Articles

A Dynamic Personalized Human 3D Organoid for the Study of the Tumor Microenvironment and Metabolism in Acute Myeloid Leukemia Using Patient-Derived Xenografts

Alejandro De Janon, Madison Stout, Diana Fridlyand, Zhou Fang, Ahmet F. Coskun, Douglas K Graham, Athanasios Mantalaris, Deborah DeRyckere, Nicki Panoskaltsis

Blood (2022) 140 (Supplement 1): 1203–1204.

https://doi.org/10.1182/blood-2022-170225

Published: 2022

Journal Articles

Establishment of a Spontaneous Stromal Microenvironment from Cord Blood Supports Human Dynamic Erythropoietic Temporal Maturation in Long-Term Serum- and Cytokine-Free 3D Cultures and Reveals a Distinct CD44 hi Population

Susana Brito Dos Santos, MSc PhD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2019) 134 (Supplement_1): 2219.

https://doi.org/10.1182/blood-2019-131085

Published: 2019

Journal Articles

Personalized and Optimized Low-Dose and Intensive Chemotherapy Treatments for Patients with Acute Myeloid Leukemia (AML)

Ana Luz Quiroga-Campano, PhD MSc, BSc, Louise Enfield, Matthew Foster, BS, Margaritis Kostoglou, PhD, Michael Georgiadis, PhD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD FRCP

Blood (2018) 132 (Supplement 1): 3500.

https://doi.org/10.1182/blood-2018-99-119258

Published: 2018

Journal Articles

Metabolism of Acute Myeloid Leukemia Cell Lines Alters with Passage in 2D Culture and Remains Stable in 3D

Sophia Zemenides, BSc, MBBS, MRCP, MSc, Joana Dos Santos, MSc, Louise Enfield, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD FRCP

Blood (2018) 132 (Supplement 1): 2787.

https://doi.org/10.1182/blood-2018-99-118648

Published: 2018

Journal Articles

Primary Chronic Lymphocytic Leukemia Cells Can be Maintained Long-Term in Serum-Free, Cytokine-Free 3D Culture

Joana Dos Santos, MSc, Louise Enfield, Susana Brito Dos Santos, MSc, Mark C Allenby, MSc, Sophie Zemenides, MD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD FRCP

Blood (2017) 130 (Supplement 1): 2989.

https://doi.org/10.1182/blood.V130.Suppl_1.2989.2989

Published: 2017

Journal Articles

Precision Chemotherapy for Patients with Acute Myeloid Leukemia Using the πiChemo Prediction and Optimization Tool

Ana Luz Quiroga-Campano, BSc, MSc, PhD, Athanasios Mantalaris, PhD, Margaritis Kostoglou, PhD, Michael Georgiadis, PhD, Nicki Panoskaltsis, MD PhD FRCP

Blood (2017) 130 (Supplement 1): 2074.

https://doi.org/10.1182/blood.V130.Suppl_1.2074.2074

Published: 2017

Journal Articles

Spatiotemporal Mapping of Erythroid, Stromal, and Osteogenic Niche Formation to Support Physiologic Red Cell Production in a Three-Dimensional Hollow Fibre Perfusion Bioreactor

Mark C. Allenby, MSc, Asma Tahlawi, MSc, Ruth Misener, PhD, Susana Brito dos Santos, MSc, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2016) 128 (22): 3885.

https://doi.org/10.1182/blood.V128.22.3885.3885

Published: 2016

Journal Articles

Early Erythroid Development Is Enhanced with Hypoxia and Terminal Maturation with Normoxia in a 3D Ex Vivo Physiologic Eythropoiesis Model

Susana Brito dos Santos, MSc, Mark C. Allenby, MSc, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2016) 128 (22): 2453.

https://doi.org/10.1182/blood.V128.22.2453.2453

Published: 2016

Journal Articles

Effect of Oxygen and 3D Microenvironment on Physiologic Erythropoiesis

Susana Brito dos Santos, MSc, Mark Allenby, MSc, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2015) 126 (23): 3600.

https://doi.org/10.1182/blood.V126.23.3600.3600

Published: 2015

Journal Articles

Use of Mathematical Modelling Indicates That Patients Treated for Acute Myeloid Leukaemia (AML) Are Undertreated When Ideal Body Weight Is Used to Dose Chemotherapy

María Fuentes-Garí, PhD, Sophie Zemenides, MBBS, MRCP, MSc, BSc, Ruth Misener, PhD, Michael C. Georgiadis, PhD, Efstratios N. Pistikopoulos, PhD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2015) 126 (23): 4522.

https://doi.org/10.1182/blood.V126.23.4522.4522

Published: 2015

Journal Articles

Biology Of Mixed Phenotype Acute Leukemia In Successful Long-Term Cytokine-Free Three-Dimensional (3D) Static and Perfused 3D Hollow-Fibre Bioreactor Culture

Maria Rende, PhD, Athanasios Mantalaris, PhD, Ricardo Morilla, Nayef Aqel, MD, Nicki Panoskaltsis, MD, PhD, FRCP

Blood (2013) 122 (21): 2603.

https://doi.org/10.1182/blood.V122.21.2603.2603

Published: 2013

Journal Articles

Optimized Patient- and Leukemia-Specific Chemotherapy Protocols For The Treatment Of Acute Myeloid Leukemia

Nicki Panoskaltsis, MD, PhD, FRCP, Eleni Pefani, Athanasios Mantalaris, PhD, Michael Georgiadis, PhD, Efstratios Pistikopoulos, PhD

Blood (2013) 122 (21): 4227.

https://doi.org/10.1182/blood.V122.21.4227.4227

Published: 2013

Journal Articles

Physiologic Erythropoiesis with Enhanced Globin Switching and Endogenous Cytokine Production in a Long-Term Serum-free in Vitro human Bone Marrow Biomimicry

Maria Rende, PhD, Iliana Fauzi, PhD, Teresa Mortera-Blanco, PhD, Johao Miguel da Costa Medeiros, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD, PhD

Blood (2012) 120 (21): 276.

https://doi.org/10.1182/blood.V120.21.276.276

Published: 2012

Journal Articles

Ex Vivo T hree-Dimensional (3D) Functional biomimicry for the Long-Term Cytokine-Free Culture of Human Primary Acute Myeloid Leukemia (AML)

Maria Rende, PhD, Teresa Mortera-Blanco, PhD, Nayef Aqel, MD, Sarah Ryley, BSc, DipRCPath, Ricardo Morilla, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD, PhD

Blood (2012) 120 (21): 4896.

https://doi.org/10.1182/blood.V120.21.4896.4896

Published: 2012

Journal Articles

Long-Term, Cytokine-Free Ex Vivo Expansion of Human Cord Blood Mononuclear Cells Using a Novel Closed-Loop 3D Dual Hollow Fibre Perfused Bioreactor

Maria Rende, PhD, Hugo Macedo, Andrew G. Livingston, PhD, Kang Li, PhD, Nicki Panoskaltsis, MD, PhD, FRCP, Athanasios Mantalaris, PhD

Blood (2010) 116 (21): 828.

https://doi.org/10.1182/blood.V116.21.828.828

Published: 2010

Journal Articles

Effects of Single-Agent, Low Dose Exogenous Erythropoietin In a Long-Term In Vitro serum-Free 3D Culture of Human Cord Blood Mononuclear Cells for Directed Erythropoiesis

Teresa Mortera Blanco, PhD, Athanasios Mantalaris, PhD, Joseph Santiapillai, Alexander Bismarck, PhD, Nicki Panoskaltsis, MD, PhD

Blood (2010) 116 (21): 341.

https://doi.org/10.1182/blood.V116.21.341.341

Published: 2010

Journal Articles

A Novel, Three Dimensional (3D) Culture System for the Efficient, Single-Step Erythropoietic Differentiation of Mouse Embryonic Stem Cells (mESCs)

Iliana Fauzi, Nicki Panoskaltsis, MD, PhD, Athanasios Mantalaris, PhD

Blood (2010) 116 (21): 2044.

https://doi.org/10.1182/blood.V116.21.2044.2044

Published: 2010

Journal Articles

Long-Term in Vitro Cytokine-Free and Serum-Free Culture of Human Cord Blood Mononuclear Cells in a Three-Dimensional Scaffold.

Teresa Mortera-Blanco, PhD, Athanasios Mantalaris, PhD, Alexander Bismarck, PhD, Nicki Panoskaltsis, MD, PhD

Blood (2009) 114 (22): 503.

https://doi.org/10.1182/blood.V114.22.503.503

Published: 2009

NARROW

Self-Supporting Human Acute Myeloid Leukemia (AML) Bone Marrow Organoids Established from Patient-Derived Xenografts Mimic the Human AML Microenvironment, with Distinct Cytokine Kinetics Correlating with Dynamic Cell Proliferation and Metabolic Shifts

A Dynamic Personalized Human 3D Organoid for the Study of the Tumor Microenvironment and Metabolism in Acute Myeloid Leukemia Using Patient-Derived Xenografts

Establishment of a Spontaneous Stromal Microenvironment from Cord Blood Supports Human Dynamic Erythropoietic Temporal Maturation in Long-Term Serum- and Cytokine-Free 3D Cultures and Reveals a Distinct CD44 hi Population

Personalized and Optimized Low-Dose and Intensive Chemotherapy Treatments for Patients with Acute Myeloid Leukemia (AML)

Metabolism of Acute Myeloid Leukemia Cell Lines Alters with Passage in 2D Culture and Remains Stable in 3D

Primary Chronic Lymphocytic Leukemia Cells Can be Maintained Long-Term in Serum-Free, Cytokine-Free 3D Culture

Precision Chemotherapy for Patients with Acute Myeloid Leukemia Using the πiChemo Prediction and Optimization Tool

Spatiotemporal Mapping of Erythroid, Stromal, and Osteogenic Niche Formation to Support Physiologic Red Cell Production in a Three-Dimensional Hollow Fibre Perfusion Bioreactor

Early Erythroid Development Is Enhanced with Hypoxia and Terminal Maturation with Normoxia in a 3D Ex Vivo Physiologic Eythropoiesis Model

Effect of Oxygen and 3D Microenvironment on Physiologic Erythropoiesis

Use of Mathematical Modelling Indicates That Patients Treated for Acute Myeloid Leukaemia (AML) Are Undertreated When Ideal Body Weight Is Used to Dose Chemotherapy

Biology Of Mixed Phenotype Acute Leukemia In Successful Long-Term Cytokine-Free Three-Dimensional (3D) Static and Perfused 3D Hollow-Fibre Bioreactor Culture

Optimized Patient- and Leukemia-Specific Chemotherapy Protocols For The Treatment Of Acute Myeloid Leukemia

Physiologic Erythropoiesis with Enhanced Globin Switching and Endogenous Cytokine Production in a Long-Term Serum-free in Vitro human Bone Marrow Biomimicry

Ex Vivo T hree-Dimensional (3D) Functional biomimicry for the Long-Term Cytokine-Free Culture of Human Primary Acute Myeloid Leukemia (AML)

Long-Term, Cytokine-Free Ex Vivo Expansion of Human Cord Blood Mononuclear Cells Using a Novel Closed-Loop 3D Dual Hollow Fibre Perfused Bioreactor

Effects of Single-Agent, Low Dose Exogenous Erythropoietin In a Long-Term In Vitro serum-Free 3D Culture of Human Cord Blood Mononuclear Cells for Directed Erythropoiesis

A Novel, Three Dimensional (3D) Culture System for the Efficient, Single-Step Erythropoietic Differentiation of Mouse Embryonic Stem Cells (mESCs)

Long-Term in Vitro Cytokine-Free and Serum-Free Culture of Human Cord Blood Mononuclear Cells in a Three-Dimensional Scaffold.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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