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Nick Van Gastel
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Journal Articles

Targeting Mitochondrial Metabolism to Promote Viral Mimicry and Type I Interferon Response in Acute Myeloid Leukemia

Nithya Balasundaram, Hernan Tirado Andreas, Fleur Leguay, Nick Van Gastel
Journal: Blood
Blood (2024) 144 (Supplement 1): 827.
https://doi.org/10.1182/blood-2024-210257
Published: 2024
Journal Articles

Modulating mRNA Translation Fidelity As a Novel Mechanism for AML Chemoresistance

Christina Mayerhofer, Dan Li, Trine A. Kristiansen, Ernst Mayerhofer, Azeem Sharda, Lingli He, Michael Mazzola, Giulia Schiroli, Karin Gustafsson, Sam Keyes, Anna Kiem, Eve Crompton, Yanxin Xu, Zhixun Dou, Charles Vidoudez, Peter G. Miller, Nick Van Gastel, David Scadden
Journal: Blood
Blood (2024) 144 (Supplement 1): 2727.
https://doi.org/10.1182/blood-2024-205125
Published: 2024
Journal Articles

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Rushdia Zareen Yusuf, Borja Saez, Azeem Sharda, Nick van Gastel, Vionnie W. C. Yu, Ninib Baryawno, Elizabeth W. Scadden, Sanket Acharya, Shrikanta Chattophadhyay, Cherrie Huang, Vasanthi Viswanathan, Dana S'aulis, Julien Cobert, David B. Sykes, Mark A. Keibler, Sudeshna Das, John N. Hutchinson, Michael Churchill, Siddhartha Mukherjee, Dongjun Lee, Francois Mercier, John Doench, Lars Bullinger, David J. Logan, Stuart Schreiber, Gregory Stephanopoulos, William B. Rizzo, David T. Scadden
Journal: Blood
Blood (2020) 136 (11): 1303–1316.
https://doi.org/10.1182/blood.2019001808
Published: 2020
Includes: Supplemental data
Journal Articles

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

Nick van Gastel, PhD, Jessica B. Spinelli, PhD, Azeem Sharda, MS, Amir Schajnovitz, PhD, Ninib Baryawno, PhD, Catherine S Rhee, PhD, Toshihiko Oki, MD PhD, Eliane Grace, Heather J. Soled, Charles Vidoudez, PhD, Sunia A. Trauger, PhD, Marcia C. Haigis, PhD, David T. Scadden, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3725.
https://doi.org/10.1182/blood-2019-124789
Published: 2019
Journal Articles

Untargeted Metabolomics Identifies Glutamine Metabolism As a Driver of Chemoresistance in Acute Myeloid Leukemia

Nick van Gastel, PhD, Amir Schajnovitz, PhD, Charles Vidoudez, PhD, Toshihiko Oki, MD PhD, Azeem Sharda, MS, Sunia A. Trauger, PhD, David T. Scadden, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2523.
https://doi.org/10.1182/blood.V130.Suppl_1.2523.2523
Published: 2017