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Linda Holmfeldt, PhD
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Journal Articles

Genomic and Transcriptomic Characterization of Adult and Pediatric Relapsed Acute Myeloid Leukemia Reveals Novel Therapeutic Targets

Svea Stratmann, Sara A Yones, Jitong Sun, PhD, Aron Skaftason, Markus Mayrhofer, PhD, Nina Norgren, PhD, Morten Krogh Herlin, MD, Anna Eriksson, PhD, Martin Hoglund, MD, Josefine Palle, PhD, Kirsi Jahnukainen, MD PhD, Katja Pokrovskaja Tamm, PhD, Lucia Cavelier, PhD, Linda Holmfeldt, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-139427
Published: 2020
Journal Articles

BCL-2, a Therapeutic Target for High Risk Hypodiploid B-Cell Acute Lymphoblastic Leukemia

Ernesto Diaz-Flores, PhD, Evan Q. Comeaux, PhD, Kailyn Kim, Kyle Beckman, BS, Kara L. Davis, DO, Kevin Wu, Jon Akutagawa, Linda Holmfeldt, PhD, Benjamin S. Braun, MD PhD, Charles Mullighan, MBBS, MSc, MD, Mignon L. Loh, MD
Journal: Blood
Blood (2016) 128 (22): 280.
https://doi.org/10.1182/blood.V128.22.280.280
Published: 2016
Journal Articles

An Oncogene-Regulated Epigenetic Switch in T Cell Acute Lymphoblastic Leukemia

Panagiotis Ntziachristos, PhD, Aristotelis Tsirigos, Grant Welstead, Thomas Trimarchi, Linda Holmfeldt, PhD, Takashi Satoh, Elisabeth M. Paietta, PhD, Martin S. Tallman, MD, Jacob M. Rowe, MD, Giovanni Tonon, MDPhD, Jared Becksfort, MS, Laurens Kruidenier, Rab K Prinjha, Pieter Van Vlierberghe, Rudolph Jaenisch, PhD, Adolfo A. Ferrando, MD PhD, Charles G. Mullighan, MBBS, MSc, MD, Iannis Aifantis
Journal: Blood
Blood (2014) 124 (21): 56.
https://doi.org/10.1182/blood.V124.21.56.56
Published: 2014
Journal Articles

Genomic- and Transcriptomic Profiling Of Acute Lymphoblastic Leukemia With Dicentric Chromosomes

Linda Holmfeldt, PhD, Paolo Vignali, Debbie Payne-Turner, Jing Ma, PhD, Guangchun Song, Pankaj Gupta, Michael Rusch, BA, Jinghui Zhang, PhD, Nyla A. Heerema, PhD, Susana C Raimondi, PhD, Andrew J. Carroll, PhD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Charles G. Mullighan, MBBS, MSc, MD, FRACP, FRCPA
Journal: Blood
Blood (2013) 122 (21): 234.
https://doi.org/10.1182/blood.V122.21.234.234
Published: 2013
Journal Articles

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Jinghui Zhang, PhD, Li Ding, PhD, Linda Holmfeldt, PhD, Gang Wu, PhD, Susan L. Heatley, Ph.D., Debbie Payne-Turner, John Easton, PhD, Xiang Chen, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Charles Lu, PhD, Shann-Ching Chen, PhD, Racquel Collins-Underwood, PhD, Jing Ma, PhD, Kathryn G. Roberts, PhD, Stanley Pounds, PhD, Lei Wei, PhD, Anatoly Ulyanov, PhD, Jared Becksfort, Pankaj Gupta, Robert Huether, PhD, Richard Kriwacki, PhD, Daniel McGoldrick, David Zhao, Daniel Alford, Stephen Espy, Kiran Chand Bobba, Guangchun Song, Deqing Pei, MS, Cheng Cheng, PhD, Stefan Roberts, Michael Barbato, Dario Campana, MD, PhD, Elaine Coustan-Smith, MS, William E. Evans, PharmD, Sheila A Shurtleff, PhD, Maria Kleppe, Jan Cools, PhD, Kristin Shimano, Michelle L. Hermiston, MD, PhD, Sergei Doulatov, PhD, Kolja Eppert, PhD, Elisa Laurenti, PhD, Faiyaz Notta, PhD, John E Dick, PhD, Giuseppe Basso, MD PhD, Stephen P. Hunger, MD, Mignon L Loh, MD, Meenakshi Devidas, PhD, Brent L. Wood, MD, PhD, Stuart S. Winter, MD, Kimberly Dunsmore, MD, Robert S. Fulton, MS, Lucinda A. Fulton, MS, Xin Hong, PhD, Christopher C. Harris, BS, David J. Dooling, PhD, Kerri Ochoa, Kimberly J Johnson, John C Obenauer, Ching-Hon Pui, MD, Susana C. Raimondi, PhD, Clayton W Naeve, PhD, Timothy J Ley, MD, Elaine R Mardis, PhD, Richard K Wilson, PhD, James R Downing, MD, Charles G Mullighan, MBBS, MD, FRACP, FRCPA, MSc
Journal: Blood
Blood (2011) 118 (21): 68.
https://doi.org/10.1182/blood.V118.21.68.68
Published: 2011
Journal Articles

Whole Genome Sequence Analysis of 22 MLL Rearranged Infant Acute Lymphoblastic Leukemias Reveals Remarkably Few Somatic Mutations: A Report From the St Jude Children‘s Research Hospital - Washington University Pediatric Cancer Genome Project

Anna K. Andersson, PhD, Jing Ma, PhD, Jianmin Wang, PhD, Xiang Chen, PhD, Michael Rusch, BA, Gang Wu, PhD, John Easton, PhD, Matthew Parker, PhD, Susana C. Raimondi, PhD, Linda Holmfeldt, PhD, Amanda Larson Gedman, PhD, Guanchun Song, PhD, Jared Becksfort, Pankaj Gupta, Anatoly Ulyanov, PhD, Debbie Payne-Turner, Rosemary Sutton, PhD, Nicola V Venn, BSc.Hons, Albert Chetcuti, PhD, Amanda Rush, PhD, Daniel Catchpoole, PhD, Jesper Heldrup, MD, Thoas Fioretos, MD, PhD, Xin Hong, PhD, Charles Lu, PhD, Li Ding, PhD, Ching-Hon Pui, MD, Sheila A Shurtleff, PhD, Tanja A Gruber, MD, PhD, Charles G Mullighan, MBBS, MD, FRACP, FRCPA, MSc, Elaine R Mardis, PhD, Richard K. Wilson, PhD, Jinghui Zhang, PhD, James R. Downing, MD
Journal: Blood
Blood (2011) 118 (21): 69.
https://doi.org/10.1182/blood.V118.21.69.69
Published: 2011
Journal Articles

Genome-Wide Analysis of Genetic Alterations In Hypodiploid Acute Lymphoblastic Leukemia Identifies a High Frequency of Mutations Targeting the IKAROS Gene Family and Ras Signaling

Linda Holmfeldt, PhD, Jinghui Zhang, Ph.D., Jing Ma, Ph.D., Meenakshi Devidas, PhD, Andrew J. Carroll, PhD, Nyla A. Heerema, Ph.D., Julie M. Gastier-Foster, PhD, Susana C. Raimondi, PhD, Mignon L. Loh, M.D., Stephen Hunger, MD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc
Journal: Blood
Blood (2010) 116 (21): 411.
https://doi.org/10.1182/blood.V116.21.411.411
Published: 2010