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Karen Dybkær
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Journal Articles

A Multiomics Approach for Longitudinal Treatment Response Evaluation of Chronic Lymphocytic Leukemia Patients Receiving BTK Inhibitor Monotherapy

Marcus Høy Hansen, Sólja Remisdóttir Veyhe, Oriane Cédile, Sara Kamuk Dahlmann, Karen Juul-Jensen, Henrik Frederiksen, Mads Thomassen, Karen Dybkaer, Niels Abildgaard, Charlotte Guldborg Nyvold
Journal: Blood
Blood (2024) 144 (Supplement 1): 6768.
https://doi.org/10.1182/blood-2024-198086
Published: 2024
Journal Articles

Neuronal-Glial and Immune Microenvironment Signatures Show Prognostic Effects in Primary CNS Lymphoma

Zijun Y. Xu-Monette, Xiaoxiao Wang, Govind Bhagat, Alexandar Tzankov, Qingyan Au, Carlo Visco, Harry Nunns, Alessandro La Ferlita, Lalit Sehgal, April Chiu, Heounjeong Go, Anamarija M. Perry, Huilan Rao, Mina Xu, Qiongli Zhai, Yafei Wang, Shi Wang, Wenbin Qian, Maurilio Ponzoni, Wen Shuai, Bangchen Wang, Sergio Pina-Oviedo, Luis Carrillo, Kelly Au, Santiago Montes-Moreno, Sr., Karen Dybkaer, Zenggang Pan, William Choi, Michael Møller, Luigi Racioppi, Xiaohui Zhang, Jinming Song, Shanxiang Zhang, Youli Zu, Joo Y. Song, Eric D. Hsi, Fenghuang Zhan, Benjamin M. Parsons, Aliyah R. Sohani, Weina Chen, Fabio Iwamoto, Jeremy S. Abramson, Bing Xu, Yong Li, Ken H. Young
Journal: Blood
Blood (2024) 144 (Supplement 1): 4361.
https://doi.org/10.1182/blood-2024-201598
Published: 2024
Journal Articles

Diffuse Large B-Cell Lymphoma Has a Low Frequency of dMMR and High Frequencies of DNA Mismatch Repair Protein High Expression Associated with Lower T-Cell Infiltration

Zijun Y. Xu-Monette, Li Yu, Cancan Luo, Yong Li, Govind Bhagat, Alexandar Tzankov, Carlo Visco, Xiangshan Fan, Xiaosheng Fang, Karen Dybkaer, Ali Sakhdari, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, F. B. Hagemeister, Dennis O'Malley, Qingyan Au, Harry Nunns, Heounjeong Go, Maurilio Ponzoni, Andrés José María Ferreri, Michael Møller, Benjamin M. Parsons, Joannes H.J.M. Van Krieken, Miguel Piris, Jane Winter, Bing Xu, Mingzhi Zhang, Ken H. Young
Journal: Blood
Blood (2023) 142 (Supplement 1): 6079.
https://doi.org/10.1182/blood-2023-178366
Published: 2023
Journal Articles

CDCA2 Is a Predictive Marker and Mediator of Bortezomib Response in Diffuse Large B-Cell Lymphoma

Hanne Due, Issa Ismail Issa, Martin Thomsen, Maja Zimmer Jakobsen, Hulda Haraldsdóttir, Rasmus Froberg Brøndum, Karen Dybkaer
Journal: Blood
Blood (2023) 142 (Supplement 1): 1617.
https://doi.org/10.1182/blood-2023-173803
Published: 2023
Journal Articles

Tumor-Infiltrating Normal B Lymphocytes Have Remarkable Prognostic Effects and Are Crucial for Antitumor Immune Responses in Diffuse Large B-Cell Lymphoma

Zijun Y. Xu-Monette, Yong Li, Thomas Snyder, Tiantian Yu, Tingxun LU, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Wenbin Qian, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Frederick Hagemeister, Heounjeong Go, Maurilio Ponzoni, Andrés José María Ferreri, Michael Møller, Benjamin M. Parsons, Joannes H.J.M. Van Krieken, Yingjun Wang, Miguel Angel Piris, Jane Winter, Qingyan Au, Ilan Kirsch, Mingzhi Zhang, John D Shaughnessy, Jr, Bing Xu, Ken H. Young
Journal: Blood
Blood (2023) 142 (Supplement 1): 429.
https://doi.org/10.1182/blood-2023-179972
Published: 2023
Journal Articles

Determining Clinical Course of Diffuse Large B-Cell Lymphoma Using Targeted Transcriptome and Machine Learning Algorithms

Maher Albitar, Hong Zhang, Andre H. Goy, Zijun Xu-Monette, Govind Bhagat, Carlo Visco, Alexandar Tzankov, Xiaosheng Fang, Feng Zhu, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, F. B. Hagemeister, Jooryung Huh, Maurilio Ponzoni, Andrés J M Ferreri, Michael Moller, Benjamin M Parsons, Joannes H.J.M. Van Krieken, Miguel Angel Piris, Jane N. Winter, Yong Li, Bing Xu, Ken H. Young
Journal: Blood
Blood (2021) 138 (Supplement 1): 2395.
https://doi.org/10.1182/blood-2021-148841
Published: 2021
Journal Articles

Addition of Drug-Response Specific Micro-RNAs to the International Prognostic Index Improves Prognostic Stratification of GCB-DLBCL Patients Treated with R-CHOP

Karen Dybkær, PhD, Hanne Due, MSc, Rasmus Froberg Brøndum, PhD, Ken H. Young, MD PhD, Martin Bøgsted, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1623.
https://doi.org/10.1182/blood-2019-122351
Published: 2019
Journal Articles

Cell of Origin Classification of DLBCL Using Targeted NGS Expression Profiling and Deep Learning

Maher Albitar, MD, Zijun Yidan Xu-Monette, PhD, Babak Shahbaba, PhD, Ivan De Dios, BS, Yingjun Wang, Deng Manman, MD, Alexandar Tzankov, MD, Carlo Visco, Govind Bhagat, MD, Karen Dybkær, PhD, Wayne Tam, MD PhD, Eric D. Hsi, MD, Maurilio Ponzoni, MD, Andres JM Ferreri, MD, Michael Moller, Miguel A. Piris, Joannes H.J.M. Van Krieken, PhDMD, Youli Zu, MD PhD, Wanlong Ma, Hagop M. Kantarjian, MD, Yong Li, PhD, Ken H. Young, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2891.
https://doi.org/10.1182/blood-2019-126927
Published: 2019
Journal Articles

MYC and BCL2 mRNA Expression As Determined By NGS Predicts Survival in DLBCL in GCB but Not in ABC Subgroup

Maher Albitar, MD, Xu‐Monette Y Zijun, PhD, Yingjun Wang, Deng Manman, MD, Alexandar Tzankov, Carlo Visco, Govind Bhagat, MD, Karen Dybkær, PhD, Wayne Tam, MD PhD, Eric D. Hsi, MD, Maurilio Ponzoni, MD, Andres JM Ferreri, MD, Michael Boe Møller, Miguel A. Piris, PhD MD, Han van Krieken, MD, Ivan De Dios, BS, Youli Zu, MD PhD, Jane N Winter, MD, Hagop M. Kantarjian, MD, Yong Li, PhD, Ken H. Young
Journal: Blood
Blood (2019) 134 (Supplement_1): 5092.
https://doi.org/10.1182/blood-2019-128492
Published: 2019
Journal Articles

Higher Stability of Mutant mRNA As Compared to Wild-Type mRNA in Diffuse Large B-Cell Lymphoma

Maher Albitar, MD, Zijun Yidan Xu-Monette, PhD, Wanlong Ma, Yingjun Wang, Deng Manman, MD, Alexandar Tzankov, MD, Carlo Visco, Govind Bhagat, MD, Karen Dybkær, PhD, Ivan De Dios, BS, Wayne Tam, MD PhD, Eric D. Hsi, MD, Maurilio Ponzoni, MD, Andres JM Ferreri, MD, Michael Boe Møller, Miguel A. Piris, Joannes H.J.M. Van Krieken, PhDMD, Youli Zu, MD PhD, Hagop M. Kantarjian, MD, Yong Li, PhD, Ken H. Young
Journal: Blood
Blood (2019) 134 (Supplement_1): 1499.
https://doi.org/10.1182/blood-2019-128516
Published: 2019
Journal Articles

Acute Myeloid Leukemia Classification System That Associates Normal Myeloid-Cell Subset Gene Signatures with Prognosis

Anna Amanda Schönherz, PhD, Julie Støve Bødker, PhD, Alexander Schmitz, Rasmus Froberg Brøndum, Senior Bioinformatician, Lasse Hjort Jakobsen, MSc, Marianne Tang Severinsen, MD PhD, Tarec Christoffer El-Galaly, MD PhD, Karen Dybkær, Professor, Martin Bøgsted, Professor, Hans Erik Johnsen, MD Professor
Journal: Blood
Blood (2017) 130 (Supplement 1): 2689.
https://doi.org/10.1182/blood.V130.Suppl_1.2689.2689
Published: 2017
Journal Articles

Clinical Significance of PD-1 and PD-L1 Expression and Ongoing Interaction in the Tumor Microenvironment in Diffuse Large B Cell Lymphoma (DLBCL) Treated with R-CHOP

Zijun Yidan Xu-Monette, PhD, Li Yu, MD, Thai Tran, Lisa Adams, Nathan Roscoe, Ganiraju Manyam, Carlo Visco, Alexandar Tzankov, Karen Dybkær, PhD, Govind Bhagat, MD, April Chiu, MD, Wayne Tam, MD PhD, Youli Zu, MD PhD, Eric D. Hsi, MD, Joannes H.J.M. Van Krieken, PhDMD, Jooryung Huh, MD PhD, Maurilio Ponzoni, MD, Andres Ferreri, MD, Michael Boe Møller, Miguel Angel Piris, PhDMD, Jane N. Winter, MD, L. Jeffrey Medeiros, MD, George Rassidakis, MD PhD, Christine Angela Vaupel, PhD, Yong Li, PhD, Naveen Dakappagari, Ken H. Young, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 197.
https://doi.org/10.1182/blood.V130.Suppl_1.197.197
Published: 2017
Journal Articles

B-Cell Differentiation Dependent Classification of Diffuse Large B-Cell Lymphoma By the Nanostring Technology

Thomas Yssing Michaelsen, BS, Rasmus Froberg Brøndum, Senior Bioinformatician, Julia Richter, PhD, Wolfram Klapper, MD, Mads Albertsen, Associate Professor, Hans Erik Johnsen, MD Professor, Karen Dybkær, Professor, Tarec Christoffer El-Galaly, MD PhD, Martin Bøgsted, Professor
Journal: Blood
Blood (2017) 130 (Supplement 1): 3995.
https://doi.org/10.1182/blood.V130.Suppl_1.3995.3995
Published: 2017
Journal Articles

Beneficial Effect of Microrna-155 in Vincristine Response and Clinical Outcome in Especially GCB Diffuse Large B-Cell Lymphoma

Hanne Due, MSc, Anna Amanda Schönherz, PhD, Laura Barett Ryø, MSc, Anne Stidsholt Roug, MD Ass. Prof, Hans Erik Johnsen, MD Professor, Martin Bøgsted, Professor, Jacob Giehm Mikkelsen, Prof, Karen Dybkær, Professor
Journal: Blood
Blood (2017) 130 (Supplement 1): 2838.
https://doi.org/10.1182/blood.V130.Suppl_1.2838.2838
Published: 2017
Journal Articles

Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma

Clinical Trials & Observations
Zijun Y. Xu-Monette, Ling Li, John C. Byrd, Kausar J. Jabbar, Ganiraju C. Manyam, Charlotte Maria de Winde, Michiel van den Brand, Alexandar Tzankov, Carlo Visco, Jing Wang, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W. L. Choi, Jooryung Huh, Maurilio Ponzoni, Andrés J. M. Ferreri, Michael B. Møller, Ben M. Parsons, Jane N. Winter, Michael Wang, Frederick B. Hagemeister, Miguel A. Piris, J. Han van Krieken, L. Jeffrey Medeiros, Yong Li, Annemiek B. van Spriel, Ken H. Young
Journal: Blood
Blood (2016) 128 (26): 3083–3100.
https://doi.org/10.1182/blood-2016-05-715094
Published: 2016
Includes: Supplemental data
Journal Articles

Normal B-Cell Gene Expression Signatures Classifies Chronic Lymphocytic Leukemia into Distinct Subtypes - Indication of Plasticity

Caroline Holm Nørgaard, BSc.MD, Lasse Hjort Jakobsen, MS, Andrew J. Gentles, PhD, Karen Dybkaer, Professor MSO, Julie Støve Bødker, PhD, Alexander Schmitz, PhD, Preben Johansen, MD, Karsten Spiekermann, MD, Tobias Herold, MD, Tarec Christoffer El-Galaly, MD, Hans Erik Johnsen, MDDMSc, Martin Bøgsted, Professor MSO
Journal: Blood
Blood (2016) 128 (22): 2017.
https://doi.org/10.1182/blood.V128.22.2017.2017
Published: 2016
Journal Articles

Subtyping of B-Cell Malignancies By B-Cell Subset Associated Gene Signatures (BAGS), Generated from Human Primary and Secondary Lymphoid Organs.

Julie Støve Bødker, PhD, Alexander Schmitz, Dr. rer. nat., Anders Ellern Bilgrau, PhDstudent, Andreas Rasmussen, M.Sc., Lasse Hjort Jakobsen, PhDstudent, Tarec Christoffer El-Galaly, MD, Hans Erik Johnsen, Karen Dybkær, Professor, Martin Bøgsted, Professor
Journal: Blood
Blood (2015) 126 (23): 5347.
https://doi.org/10.1182/blood.V126.23.5347.5347
Published: 2015
Journal Articles

High Expression of CXCR4 Impairs Anti-CD20 Monoclonal Antibody (Rituximab)-Dependent Cytotoxicity in Diffuse Large B-Cell Lymphoma

Linn Rønlev Reinholdt, PhDStudent, Maria Bach Laursen, PhD, Steffen Falgreen, PhD, Alexander Schmitz, Dr. rer. nat., Julie Støve Bødker, PhD, Martin Boegsted, Professor MSO, Hans Erik Johnsen, Professor, MD, Karen Dybkaer, Professor MSO
Journal: Blood
Blood (2015) 126 (23): 1455.
https://doi.org/10.1182/blood.V126.23.1455.1455
Published: 2015
Journal Articles

Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma

Javeed Iqbal, Yulei Shen, Xin Huang, Yanyan Liu, Laura Wake, Cuiling Liu, Karen Deffenbacher, Cynthia M. Lachel, Chao Wang, Joseph Rohr, Shuangping Guo, Lynette M. Smith, George Wright, Sharathkumar Bhagavathi, Karen Dybkaer, Kai Fu, Timothy C. Greiner, Julie M. Vose, Elaine Jaffe, Lisa Rimsza, Andreas Rosenwald, German Ott, Jan Delabie, Elias Campo, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, James O. Armitage, Dennis D. Weisenburger, Louis M. Staudt, Randy D. Gascoyne, Timothy W. McKeithan, Wing C. Chan
Journal: Blood
Blood (2015) 125 (7): 1137–1145.
https://doi.org/10.1182/blood-2014-04-566778
Published: 2015
Includes: Supplemental data
Journal Articles

A Diffuse Large B-Cell Lymphoma Classification System That Associates Normal B-Cell Subset Phenotypes with Prognosis

Karen Dybkær, Martin Bøgsted, Steffen Falgreen, MSc, PhD, Malene Krag Kjeldsen, Alexander Schmitz, Julie Støve Bødker, MSc, PhD, Anders Ellern Bilgrau, Zijun Y. Xu-Monette, PhD, Li Ling, Kim Steve Bergkvist, Maria Bach Laursen, MSc, PhD, Maria Rodrigo-Domingo, Sara Correia Marques, Sophie Bech Rasmussen, Mette Nyegaard, PhD, Michael Gaihede, MD PhD, Michael B. Møller, MD DMSc, Richard Samworth, Rajen Shah, Preben Johansen, Tarec Christoffer El-Galaly, Ken H. Young, MD PhD, Hans Erik Johnsen
Journal: Blood
Blood (2014) 124 (21): 2973.
https://doi.org/10.1182/blood.V124.21.2973.2973
Published: 2014