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Journal Articles

Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell, Mankaran Singh, MSc, Helen J Blair, PhD, Frederik W. van Delft, MD PhD, Anthony V. Moorman, PhD, John Lunec, PhDMRCR(Hon) FRCPath, Julie Irving, PhD

Blood (2020) 136 (Supplement 1): 38.

https://doi.org/10.1182/blood-2020-139536

Published: 2020

Journal Articles

Dexamethasone Pharmacokinetics Following Standard and Short Dosing Schedules in Patients on the UKALL2011 Trial

Rosanna Jackson, BSc, MSc, Philip Berry, BSc, Julie Errington, MSc, John Moppett, MD, Sujith Samarasinghe, Rachael Hough, MD BMBS, FRCP, FRCPath, Clare Rowntree, MD, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, MD, Pamela R. Kearns, PhDFRCPC, Julie Irving, PhD, Gareth J Veal, PhD

Blood (2017) 130 (Supplement 1): 101.

https://doi.org/10.1182/blood.V130.Suppl_1.101.101

Published: 2017

Journal Articles

Label-Free Analyses of Minimal Residual Disease in ALL Using Deep Learning and Imaging Flow Cytometry

Minh Doan, Marian Case, Dino Mašić, PhD, Holger Hennig, Claire McQuin, Allen Goodman, Juan Caicedo, Olaf Wolkenhauer, Huw Summers, Anne E Carpenter, Andy Filby, Paul Rees, Julie Irving, PhD

Blood (2017) 130 (Supplement 1): 1437.

https://doi.org/10.1182/blood.V130.Suppl_1.1437.1437

Published: 2017

Journal Articles

Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia

Ali Alhammer, M.Sc, Marian Case, MSc, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Julie Irving, PhD

Blood (2016) 128 (22): 4066.

https://doi.org/10.1182/blood.V128.22.4066.4066

Published: 2016

Journal Articles

Acute Leukemia of Ambiguous Lineage: A Comprehensive Survival Analysis Enables Designing New Treatment Strategies

Ondrej Hrusak, MD PhD, Valerie De Haas, MD PhD, Ales Luks, Iveta Janotova, Ester Mejstrikova, MD PhD, Kirsten Bleckmann, MD, Anja Moricke, MD, Julie Irving, PhD, Benigna Konatkowska, Thomas B. Alexander, MD MPH, Hiroto Inaba, MD PhD, Kjeld Schmiegelow, MD DMSc, Simone Stokley, FRCPath,, Jorge Gabriel Rossi, PhD, Maria Sara Felice, MD PhD, Luciano Dalla-Pozza, MB BS FRACP, Jessa Morales, Michael Dworzak, MD, Barbara Buldini, MD, Giuseppe Basso, Myriam Campbell, Maria Elena Cabrera, Neda Marinov, Sarah Elitzur, MD, Shai Izraeli, MD, Drorit Luria, PhD, Tamar Feuerstein, PhD, Alexandra Kolenova, MD PhD, Peter Svec, Elena Kreminska, Karen R. Rabin, MD, Sophia Polychronopoulou, MD PhD, Elaine da Costa, Hanne Vibeke Marquart, MD PhD, Antonis Kattamis, MD, Richard Ratei, Dirk Reinhardt, MD PhD, Anthony V Moorman, PhD, Martin Schrappe, MD, Jan Stary, MD D.Sc.

Blood (2016) 128 (22): 584.

https://doi.org/10.1182/blood.V128.22.584.584

Published: 2016

Journal Articles

Dexamethasone Accumulation in Dexamethasone Sensitive and Resistant Acute Lymphoblastic Leukemia

Rosanna K Jackson, MRes, Ali Alhammer, M.Sc, Zach Dixon, MRes, Gareth J Veal, PhD, Julie Irving, PhD

Blood (2016) 128 (22): 5140.

https://doi.org/10.1182/blood.V128.22.5140.5140

Published: 2016

Journal Articles

Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function

Lindsay Nicholson, PhD, Emily Mavin, PhD, Lynne Minto, Julie Irving, PhD, Anne Dickinson, PhD, Xiao-Nong Wang, MBBS, PhD

Blood (2015) 126 (23): 3068.

https://doi.org/10.1182/blood.V126.23.3068.3068

Published: 2015

Journal Articles

The Genomic Landscape Of Lineage Switch Acute Leukemia

Blood (2013) 122 (21): 2552.

https://doi.org/10.1182/blood.V122.21.2552.2552

Published: 2013

Journal Articles

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Blood (2013) 122 (21): 3866.

https://doi.org/10.1182/blood.V122.21.3866.3866

Published: 2013

Journal Articles

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Julie Irving, PhD, Elizabeth C. Matheson, MPhil, Lynne Minto, Helen Blair, PhD, Marian Case, MSc, Christina Halsey, MD, PhD, Isabella Swidenbank, MRes, Frida Ponthan, PhD, Renate Kirschner-Schwabe, PhD, Stefanie Groeneveld-Krentz, MSc, Jana Hof, MSc, James Allan, PhD, Christine J. Harrison, PhD, Josef Vormoor, MD, Arend Stackelberg, MD, Cornelia Eckert, PhD

Blood (2013) 122 (21): 823.

https://doi.org/10.1182/blood.V122.21.823.823

Published: 2013

Journal Articles

Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target

Lindsay Nicholson, PhD, Caroline Evans, PhD, Elizabeth C Matheson, MPhil, Lynne Minto, Christopher Keilty, Claire Schwab, Christine J Harrison, PhD, FRCPath, Andrew G. Hall, MB, BS, FRCPath, FRCP, PhD, Christopher Redfern, PhD, Anthony Whetton, PhD, Julie Irving, PhD

Blood (2011) 118 (21): 1411.

https://doi.org/10.1182/blood.V118.21.1411.1411

Published: 2011

Journal Articles

Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients

Sarra L Ryan, PhD, Vikki Rand, PhD, Claire Schwab, BSc, Heather Morrison, BSc, Elizabeth Matheson, MPhil, Lynne Minto, Thahira Rahman, PhD, Bernard Keavney, MD, Nicholas Bown, PhD, Roderick Skinner, PhD, MBChB, FRCPCH, Susanne Schnittger, PhD, Mauro Santibanez Koref, PhD, Vera Grossmann, MSc, Alexander Kohlmann, PhD, Julie Irving, PhD, Christine J Harrison, PhD, FRCPath

Blood (2011) 118 (21): 70.

https://doi.org/10.1182/blood.V118.21.70.70

Published: 2011

Journal Articles

In Acute Lymphoblastic Leukaemia, Stemness Is Frequent and Ubiquitous

Klaus Rehe, MD, Kerrie Wilson, PhD, Simon Bomken, Hesta McNeill, Martin Stanulla, MD, MSc, Monique L. Den Boer, Julie Irving, PhD, Olaf Heidenreich, Josef Vormoor, MD

Blood (2010) 116 (21): 92.

https://doi.org/10.1182/blood.V116.21.92.92

Published: 2010

Journal Articles

Analysis of BCR-ABL1 Tyrosine Kinase Domain Mutations In Primitive Chronic Myeloid Leukemia Cells Identifies a Unique Mutator Phenotype.

Xiaoyan Jiang, MD, PhD, Hannah Grant, PhD, Justin Stebbing, MD, PhD, Letizia Foroni, MD, Charles Craddock, BM, MRCP, MRCPah, MD, Mike Griffiths, MD, Richard E. Clark, MBBS, MD, FRCP, FRCPath, Stephen O'Brien, MD, PhD, Jamshid S. Khorashad, MD, PhD, Gareth Gerrard, MD, PhD, Lihui Wang, MD, PhD, Julie Irving, PhD, Meng Wang, PhD, Loraine Karran, MD, Martin JS Dyer, MA, DPhil, FRCP, FRCPath, Donna L. Forrest, MD, Karen Page, MA, PhD, Connie J. Eaves, PhD, Adrian Woolfson, PhD

Blood (2010) 116 (21): 3397.

https://doi.org/10.1182/blood.V116.21.3397.3397

Published: 2010

Journal Articles

Disease Propagating Blasts in Standard and High Risk Acute Lymphoblastic Leukemia Are Frequent and of Diverse Immunophenotype.

Klaus Rehe, MD, Kerrie Wilson, BSc, (Hons), Hesta McNeill, Martin Schrappe, MD, Julie Irving, PhD, Josef Vormoor, MD, FRCPCH

Blood (2009) 114 (22): 1421.

https://doi.org/10.1182/blood.V114.22.1421.1421

Published: 2009

Journal Articles

Quantitative Proteomic Analysis Implicates An Altered B-Cell Differentiation State as a Mechanism Underlying GC-Resistance in An Acute Lymphoblastic Leukaemia (ALL) Cell Line Model.

Lindsay Nicholson, PhD, Caroline Evans, PhD, Elizabeth Matheson, M.Phil., Lynne Minto, Christopher Keilty, Andrew Hall, PhD, FRCPath, Christopher Redfern, PhD, Anthony Whetton, PhD, Julie Irving, PhD

Blood (2009) 114 (22): 1736.

https://doi.org/10.1182/blood.V114.22.1736.1736

Published: 2009

Journal Articles

In Childhood ALL, Both Blasts with a CD20 −/Low and a CD20 High Immunophenotype Have the Ability to Transfer the Leukemia Onto Immune-Deficient NOD/Scid Y −/− Mice.

Kerrie Wilson, BSc(Hons), Klaus Rehe, MD, Simon Bomken, MD, Marian Case, MSc, Leonard Shultz, PhD, Julie Irving, PhD, Josef Vormoor, MD, FRCPCH

Blood (2008) 112 (11): 1348.

https://doi.org/10.1182/blood.V112.11.1348.1348

Published: 2008

Journal Articles

Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer

Jonathan C Strefford, PhD, Qian An, PhD, Sarah L Wright, BSc, Zoe J Konn, BSc, Elizabeth Matherson, PhD, Lynne Minto, PhD, Anthony V Moorman, PhD, Helen Parker, PhD, Andrew Hall, PhD, Julie Irving, PhD, Christine J Harrison, PhD

Blood (2008) 112 (11): 790.

https://doi.org/10.1182/blood.V112.11.790.790

Published: 2008

Journal Articles

MRD Monitoring of Childhood ALL Using Hierarchical Clustering and Support Vector Machine Learning of Complex Multi-Parameter Flow Cytometry Data.

Karel Fiser, PhD, Tomas Sieger, MSc, Angela Schumich, Julie Irving, PhD, Michael N Dworzak, MD, Josef Vormoor, MD, FRCPCH

Blood (2008) 112 (11): 1508.

https://doi.org/10.1182/blood.V112.11.1508.1508

Published: 2008

Journal Articles

The CD34 + CD38 Low CD19 + Candidate Leukemic Stem Cell Phenotype Revisited: Useful for Flow MRD Monitoring?

Kerrie Wilson, BSc(Hons), Marian Case, MSc, Lynne Minto, Simon Bailey, MD, PhD, FRCPCH, Josef Vormoor, MD, FRCPCH, Julie Irving, PhD

Blood (2008) 112 (11): 2505.

https://doi.org/10.1182/blood.V112.11.2505.2505

Published: 2008

NARROW

Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia

Dexamethasone Pharmacokinetics Following Standard and Short Dosing Schedules in Patients on the UKALL2011 Trial

Label-Free Analyses of Minimal Residual Disease in ALL Using Deep Learning and Imaging Flow Cytometry

Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia

Acute Leukemia of Ambiguous Lineage: A Comprehensive Survival Analysis Enables Designing New Treatment Strategies

Dexamethasone Accumulation in Dexamethasone Sensitive and Resistant Acute Lymphoblastic Leukemia

Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function

The Genomic Landscape Of Lineage Switch Acute Leukemia

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target

Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients

In Acute Lymphoblastic Leukaemia, Stemness Is Frequent and Ubiquitous

Analysis of BCR-ABL1 Tyrosine Kinase Domain Mutations In Primitive Chronic Myeloid Leukemia Cells Identifies a Unique Mutator Phenotype.

Disease Propagating Blasts in Standard and High Risk Acute Lymphoblastic Leukemia Are Frequent and of Diverse Immunophenotype.

Quantitative Proteomic Analysis Implicates An Altered B-Cell Differentiation State as a Mechanism Underlying GC-Resistance in An Acute Lymphoblastic Leukaemia (ALL) Cell Line Model.

In Childhood ALL, Both Blasts with a CD20 −/Low and a CD20 High Immunophenotype Have the Ability to Transfer the Leukemia Onto Immune-Deficient NOD/Scid Y −/− Mice.

Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer

MRD Monitoring of Childhood ALL Using Hierarchical Clustering and Support Vector Machine Learning of Complex Multi-Parameter Flow Cytometry Data.

The CD34 + CD38 Low CD19 + Candidate Leukemic Stem Cell Phenotype Revisited: Useful for Flow MRD Monitoring?

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American Society of Hematology

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