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Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 20.

https://doi.org/10.1182/blood-2020-139305

Published: 2020

Journal Articles

Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

Katarzyna Szoltysek, PhD, Helen Blair, Sirintra Nakjang, Ricky Tirtakusuma, Mankaran Singh, Ryan Nelson, Hesta McNeill, Catherine Dodd, Melanie Beckett, Lynsey McKenzie, Edward Law, Josef Vormoor, MD PhD, Deepali Pal, Olaf Heidenreich

Blood (2019) 134 (Supplement_1): 3952.

https://doi.org/10.1182/blood-2019-124818

Published: 2019

Journal Articles

The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia

Shalini Sankar, Miriam Guillen Navarro, Frida Ponthan, PhD, Simon Bomken, MD, Sirintra Nakjang, Vasily Grinev, PhD, Hesta McNeill, Michel C Zwaan, MD PhD, Josef Vormoor, MD PhD, Ronald W. Stam, PhD, Olaf Heidenreich

Blood (2019) 134 (Supplement_1): 1237.

https://doi.org/10.1182/blood-2019-124787

Published: 2019

Journal Articles

Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

Lynsey McKenzie, PhD, Natalia Martinez-Soria, PhD, Julia Draper, DPhil, Sirintra Nakjang, PhD, Helen J Blair, PhD, Christian Wichmann, MD, Josef Vormoor, MD FRCPCH, Constanze Bonifer, PhD, Georges Lacaud, PhD, Olaf Heidenreich, PhD

Blood (2016) 128 (22): 835.

https://doi.org/10.1182/blood.V128.22.835.835

Published: 2016

Journal Articles

Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia

Ali Alhammer, M.Sc, Marian Case, MSc, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Julie Irving, PhD

Blood (2016) 128 (22): 4066.

https://doi.org/10.1182/blood.V128.22.4066.4066

Published: 2016

Journal Articles

High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity

Alex Elder, PhD, Helen Blair, PhD, Katherine Dormon, Simon Bomken, PhD MBBS, Simon J Cockell, PhD, Olaf Heidenreich, PhD, Josef Vormoor, MD FRCPCH

Blood (2015) 126 (23): 844.

https://doi.org/10.1182/blood.V126.23.844.844

Published: 2015

Journal Articles

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

Katherine Dormon, MSci, Elda S Latif, PhD, Matthew Bashton, PhD, Deepali Pal, PhD, Matthew Selby, MSci, Helen Blair, PhD, Vikki Rand, PhD, Andrew G Hall, PhD, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD

Blood (2015) 126 (23): 2619.

https://doi.org/10.1182/blood.V126.23.2619.2619

Published: 2015

Journal Articles

A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL

Frida Ponthan, PhD, Simon Bomken, PhD MBBS, Deepali Pal, PhD, Alex Elder, PhD, Hesta McNeill, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD

Blood (2014) 124 (21): 2390.

https://doi.org/10.1182/blood.V124.21.2390.2390

Published: 2014

Journal Articles

Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing

Natalie Bell, PhD, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Chris Bacon, MBChB, PhD, Vikki Rand, PhD, Olaf Heidenreich, PhD, Simon Bomken, PhD MBBS

Blood (2014) 124 (21): 5501.

https://doi.org/10.1182/blood.V124.21.5501.5501

Published: 2014

Journal Articles

The Genomic Landscape Of Lineage Switch Acute Leukemia

Blood (2013) 122 (21): 2552.

https://doi.org/10.1182/blood.V122.21.2552.2552

Published: 2013

Journal Articles

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Blood (2013) 122 (21): 3866.

https://doi.org/10.1182/blood.V122.21.3866.3866

Published: 2013

Journal Articles

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Julie Irving, PhD, Elizabeth C. Matheson, MPhil, Lynne Minto, Helen Blair, PhD, Marian Case, MSc, Christina Halsey, MD, PhD, Isabella Swidenbank, MRes, Frida Ponthan, PhD, Renate Kirschner-Schwabe, PhD, Stefanie Groeneveld-Krentz, MSc, Jana Hof, MSc, James Allan, PhD, Christine J. Harrison, PhD, Josef Vormoor, MD, Arend Stackelberg, MD, Cornelia Eckert, PhD

Blood (2013) 122 (21): 823.

https://doi.org/10.1182/blood.V122.21.823.823

Published: 2013

Journal Articles

Mir∼17-92 Identifies BCL2 As a Therapeutic Target In BCR-ABL Positive B-Lineage Acute Lymphoblastic Leukemia

Matthias Eder, MD, Alex Elder, David Barzan, Karin Battmer, Simon Bomken, Melanie Ricke-Hoch, Anke Schröder, Letizia Venturini, Heike Pfeiffer, Helen J Blair, PhD, Josef Vormoor, MD, Oliver G. Ottmann, MD, Arnold Ganser, Andreas Pich, Denise Hilfiker-Kleiner, Olaf Heidenreich, PhD, Michaela Scherr

Blood (2013) 122 (21): 835.

https://doi.org/10.1182/blood.V122.21.835.835

Published: 2013

Journal Articles

Significance of Fusion Genes for Maintenance of Leukaemia

Frida Ponthan, PhD, Hesta McNeill, Lars Buechler, PhD, Vasily Grinev, PhD, Josef Vormoor, MD, FRCPCH, Olaf Heidenreich, PhD

Blood (2011) 118 (21): 2455.

https://doi.org/10.1182/blood.V118.21.2455.2455

Published: 2011

Journal Articles

Lentiviral Transduction of Patient Derived Leukaemic Blasts Allowing In Vivo Bioluminescent Monitoring in An NSG Model of Leukaemia Stem Cell Maintenance,

Simon Bomken, MBBS, Lars Buechler, PhD, Klaus Rehe, MD, Frida Ponthan, PhD, Helen Blair, PhD, Olaf Heidenreich, PhD, Josef Vormoor, MD

Blood (2011) 118 (21): 4000.

https://doi.org/10.1182/blood.V118.21.4000.4000

Published: 2011

Journal Articles

Central Nervous System Involvement in a Xenograft Model of Pre-B Acute Lymphoblastic Leukaemia Is Associated with Dysfunctional CXCR4 Expression and Upregulation of the Neurotropic Chemokine Receptors CCR6 and CX3CR1,

Christina Halsey, MD, PhD, Mark TS Williams, PhD, Yasar Yousafzai, MD, Klaus Rehe, MD, Olaf Heidenreich, PhD, Josef Vormoor, MD, Brenda Gibson, Gerard Graham, PhD

Blood (2011) 118 (21): 3449.

https://doi.org/10.1182/blood.V118.21.3449.3449

Published: 2011

Journal Articles

In Acute Lymphoblastic Leukaemia, Stemness Is Frequent and Ubiquitous

Klaus Rehe, MD, Kerrie Wilson, PhD, Simon Bomken, Hesta McNeill, Martin Stanulla, MD, MSc, Monique L. Den Boer, Julie Irving, PhD, Olaf Heidenreich, Josef Vormoor, MD

Blood (2010) 116 (21): 92.

https://doi.org/10.1182/blood.V116.21.92.92

Published: 2010

Journal Articles

ANGIOPOIETIN1 - a Novel Factor Implicated In MLL-Rearranged Acute Lymphoblastic Leukemia and Regulated In a Fusion Gene-Dependent Manner

Patricia Garrido Castro, Dipl.-Biochem., Simon Bomken, MD, Lidija Seslija, Ronald Stam, PhD, Elda S Latif, Michael A Batey, MPhil, Hesta McNeill, Rob Pieters, MD, PhD, Josef Vormoor, MD, Prof., Johann Greil, MD, Olaf Heidenreich, PhD

Blood (2010) 116 (21): 66.

https://doi.org/10.1182/blood.V116.21.66.66

Published: 2010

Journal Articles

CD19-Redirected Cytotoxic T Cells Prevent Engraftment of Primary Human Leukemia Cells In Vivo.

Silke Landmeier, PhD, Bianca Altvater, PhD, Sibylle Pscherer, Jutta Meltzer, Josef Vormoor, MD, FRCPCH, Juan F Vera, MD, Martin Pule, MD, Marc Hotfilder, PhD, Heribert Juergens, MD, Claudia Rossig, MD

Blood (2009) 114 (22): 3025.

https://doi.org/10.1182/blood.V114.22.3025.3025

Published: 2009

Journal Articles

Disease Propagating Blasts in Standard and High Risk Acute Lymphoblastic Leukemia Are Frequent and of Diverse Immunophenotype.

Klaus Rehe, MD, Kerrie Wilson, BSc, (Hons), Hesta McNeill, Martin Schrappe, MD, Julie Irving, PhD, Josef Vormoor, MD, FRCPCH

Blood (2009) 114 (22): 1421.

https://doi.org/10.1182/blood.V114.22.1421.1421

Published: 2009

NARROW

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia

Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia

High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL

Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing

The Genomic Landscape Of Lineage Switch Acute Leukemia

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Mir∼17-92 Identifies BCL2 As a Therapeutic Target In BCR-ABL Positive B-Lineage Acute Lymphoblastic Leukemia

Significance of Fusion Genes for Maintenance of Leukaemia

Lentiviral Transduction of Patient Derived Leukaemic Blasts Allowing In Vivo Bioluminescent Monitoring in An NSG Model of Leukaemia Stem Cell Maintenance,

Central Nervous System Involvement in a Xenograft Model of Pre-B Acute Lymphoblastic Leukaemia Is Associated with Dysfunctional CXCR4 Expression and Upregulation of the Neurotropic Chemokine Receptors CCR6 and CX3CR1,

In Acute Lymphoblastic Leukaemia, Stemness Is Frequent and Ubiquitous

ANGIOPOIETIN1 - a Novel Factor Implicated In MLL-Rearranged Acute Lymphoblastic Leukemia and Regulated In a Fusion Gene-Dependent Manner

CD19-Redirected Cytotoxic T Cells Prevent Engraftment of Primary Human Leukemia Cells In Vivo.

Disease Propagating Blasts in Standard and High Risk Acute Lymphoblastic Leukemia Are Frequent and of Diverse Immunophenotype.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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