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Journal Articles

Chromatin remodeler SATB2 thorough Bmi1/PRC1 activity controls transformation and reprogramming of ph+ B-cell progenitors

Shakyrah Smith, Michael Kotliar, Mark Wunderlich, Ashley Wellendorf, Sarmistha Das, Benjamin Mizukawa, Artem Barski, Shesh Rai, Jose Cancelas, Ramesh Nayak

Blood (2025) 146 (Supplement 1): 5032.

https://doi.org/10.1182/blood-2025-5032

Published: 2025

Journal Articles

Modal CAR T cells: A synthetic cytokine circuit to overcome TGFβ-mediated immunosuppression in AML

Fuguo Liu, Xingyu Deng, Veronica Hui, Maily Nguyen, Wenxin Xu, Mubin Tarannum, Andreia Maia, Shaobo Yang, Remy Dulery, Stephanie Sendker, Alaa Ali, John Koreth, Jose Cancelas, Jianzhu Chen, Robert Soiffer, Catherine Wu, Jerome Ritz, Toni Choueiri, Rizwan Romee

Blood (2025) 146 (Supplement 1): 4096.

https://doi.org/10.1182/blood-2025-4096

Published: 2025

Journal Articles

SEPTIN6 mutations in pediatric myelodysplastic syndrome disrupt nuclear actin organization

Xin Jiang, Safa Mohamad, Yu Zhou, Chad Harris, Jose Cancelas, David Williams

Blood (2025) 146 (Supplement 1): 4999.

https://doi.org/10.1182/blood-2025-4999

Published: 2025

Journal Articles

Melatonin, wnt and S1P signaling regulate diurnal bone marrow mesenchymal stem cell metabolism, cell size and function

Priyasmita Chakrabarti, Abhishek Singh, Orit Kollet, Jose Cancelas, Tsvee Lapidot

Blood (2025) 146 (Supplement 1): 431.

https://doi.org/10.1182/blood-2025-431

Published: 2025

Journal Articles

Bone marrow microenvironment retinoic acid receptor signaling represses multipotential progenitor dependent B cell lymphopoiesis through secretion of resistin

Parash Prasad, Angelo D'Alessandro, Ashley Wellendorf, Leo Mejia, Mercedes Ricote, Nathan Salomonis, Jose Cancelas

Blood (2025) 146 (Supplement 1): 1405.

https://doi.org/10.1182/blood-2025-1405

Published: 2025

Journal Articles

Apheresis blood processing with heparin improves stem cell collection outcomes for sickle cell gene therapy

David Justus, Carly Howard, Ellen Proeung, Aimee Sarnie, Jen Fortin, Erica Esrick, Matthew Heeney, Daniel Bauer, Sarah Nikiforow, Jose Cancelas, Leslie Lehmann, David Williams, John Manis

Blood (2025) 146 (Supplement 1): 6096.

https://doi.org/10.1182/blood-2025-6096

Published: 2025

Journal Articles

The Dominant Negative Acting VPS4A E228Q Mutation Causes Dyserythropoiesis in Human iPSC-Derived Erythroblast Cultures That Phenocopies Cimdag Syndrome-Associated Anemia

Courtney Gatterdam, Sana Emberesh, Yasmin Elgammal, Carolyn Lutzko, Lionel Blanc, Jose Cancelas, Theodosia A. Kalfa, Katie Seu

Blood (2024) 144 (Supplement 1): 2458.

https://doi.org/10.1182/blood-2024-211628

Published: 2024

Journal Articles

Bone Marrow Adipocyte Secreted Resistin Is a Positive Regulator of Long-Term Hematopoietic Stem Cell Engraftment and Myelopoiesis

Parash Prasad, Angelo D'Alessandro, Grace Oh, Ashley Wellendorf, Mercedes Ricote, Nathan Salomonis, Jose Cancelas

Blood (2024) 144 (Supplement 1): 560.

https://doi.org/10.1182/blood-2024-210644

Published: 2024

Journal Articles

Hematopoietic Flt3+ Multipotent Progenitors Are Organized in Discrete Functionally and Hierarchically Distinct Populations

Michael Solomon, Baobao (Annie) Song, Vinothini Govindarajah, Samantha Good, James Bartram, Jose Cancelas, Marie-Dominique Filippi, Nathan Salomonis, H. Leighton Grimes, Damien Reynaud

Blood (2022) 140 (Supplement 1): 1981–1982.

https://doi.org/10.1182/blood-2022-159781

Published: 2022

Journal Articles

Role of mTOR in Hematopoiesis and Hematopoietic Stem Cell Regulation.

Fukun Guo, PhD, Wei Liu, MD, MS, Kankana Chava, Jose Cancelas, MD, PhD, George Thomas, Sara C Kozma, PhD, Yi Zheng, PhD

Blood (2009) 114 (22): 1490.

https://doi.org/10.1182/blood.V114.22.1490.1490

Published: 2009

Journal Articles

Connexin-43 Regulates the Cell Cycle Entry of Hematopoietic Stem Cells within the Stem Cell Niche.

Daniel Gonzalez-Nieto, PhD, Gabriel Ghiaur, MD, PhD, Lina Li, DDS, PhD, Jorden Arnett, Susan Dunn, Glenn Fishman, MD, David Gutstein, Roberto Civitelli, Jose Cancelas, MD, PhD

Blood (2009) 114 (22): 1500.

https://doi.org/10.1182/blood.V114.22.1500.1500

Published: 2009

Journal Articles

Bmi-1 Overexpression Synergizes with p210-BCR-ABL to Induce Stem Cell and Progenitor Transformation.

Amitava Sengupta, PhD, Jorden Arnett, Susan Dunn, Jose Cancelas, MD, PhD

Blood (2009) 114 (22): 3251.

https://doi.org/10.1182/blood.V114.22.3251.3251

Published: 2009

Journal Articles

Deletion of Rac2 inhibits Proliferation of Chronic Myelogenous Leukemia (CML) Stems Cells and Progenitors (HSC/P) In Vivo and Promotes Survival of Scl/p210-BCR-ABL Mice.

Amitava Sengupta, PhD, Jorden Arnett, Susan Dunn, Jose Cancelas, MD, PhD

Blood (2009) 114 (22): 3253.

https://doi.org/10.1182/blood.V114.22.3253.3253

Published: 2009

Journal Articles

FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor.

Joshua Oaks, BS, Paolo Neviani, PhD, A. Mukhopadhyay, Ramasamy Santhanam, PhD, Y. Ma, Charlene Mao, Guido Marcucci, MD, Ching-Shih Chen, Jorge Cortes, MD, Michael A. Caligiuri, M.D., Peter Hokland, Sr., Claudia Huettner, PhD, Steffen Koschmieder, MD, Jose Cancelas, MD, PhD, Roger Briesewitz, PhD, Ravi Bhatia, MD, Denis-Claude Roy, MD, Besim Ogretmen, PhD, Danilo Perrotti, MD, PhD

Blood (2009) 114 (22): 3259.

https://doi.org/10.1182/blood.V114.22.3259.3259

Published: 2009

Journal Articles

Connexin-43 Expression Regulates the Migration of Hematopoietic Stem Cells and Progenitors towards and From Bone Marrow.

Daniel Gonzalez-Nieto, PhD, Kyung-Hee Chang, PhD, Anja Koehler, Jorden Arnett, Susan Dunn, Lina Li, DDS, PhD, Gabriel Ghiaur, MD, PhD, Amitava Sengupta, PhD, Glenn Fishman, MD, David Gutstein, MD, PhD, Roberto Civitelli, MD, Luis Barrio, MD, PhD, Matthias Gunzer, PhD, Jose Cancelas, MD, PhD

Blood (2009) 114 (22): 562.

https://doi.org/10.1182/blood.V114.22.562.562

Published: 2009

Journal Articles

Vav3 and Rac2 Activation Are Required for B Progenitor Transformation Induced by p190-BCR-ABL.

Kyung-Hee Chang, PhD, Abel Sanchez-Aguilera, PhD, Amitava Sengupta, PhD, Jorden Arnett, Susan Dunn, David A Williams, Jose Cancelas, MD, PhD

Blood (2009) 114 (22): 449.

https://doi.org/10.1182/blood.V114.22.449.449

Published: 2009

Journal Articles

Leukemic Stem Cells and Progenitors Demonstrate Impaired Interaction with the Hematopoietic Microenvironment in Vivo in An Inducible Murine Model of Chronic Myelogenous Leukemia

Amitava Sengupta, PhD, Jose Cancelas, MD, PhD

Blood (2008) 112 (11): 191.

https://doi.org/10.1182/blood.V112.11.191.191

Published: 2008

Journal Articles

Stem Cell Factor Signaling Collaborates in the Development of FIP1L1/PDGFRα Induced Chronic Eosinophilic Leukemia in a Murine Model

Yoshiyuki Yamada, MD, PhD, Marc E Rothenberg, MD, PhD, Melissa McBride, Abel Sanchez-Aguilera, PhD, Jose Cancelas, MD, PhD

Blood (2008) 112 (11): 470.

https://doi.org/10.1182/blood.V112.11.470.470

Published: 2008

Journal Articles

Rac GTPases Modulate Migration of Hematopoietic Progenitor Cells in an SDF-1α Dependent Manner in a Tumor Model.

Stephan Goettig, Andreas Pinter, Erika Deak, Christine Stroebele, Erhard Seifried, Jose Cancelas, David A. Williams, Jens Gille, Reinhard Henschler

Blood (2007) 110 (11): 222.

https://doi.org/10.1182/blood.V110.11.222.222

Published: 2007

Journal Articles

RhoH-Deficient Mice Show Altered B Cell Populations In Vivo.

Abel Sanchez-Aguilera, PhD, Jose Cancelas, MD, PhD, David A. Williams, MD

Blood (2007) 110 (11): 2307.

https://doi.org/10.1182/blood.V110.11.2307.2307

Published: 2007

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Chromatin remodeler SATB2 thorough Bmi1/PRC1 activity controls transformation and reprogramming of ph+ B-cell progenitors

Modal CAR T cells: A synthetic cytokine circuit to overcome TGFβ-mediated immunosuppression in AML

SEPTIN6 mutations in pediatric myelodysplastic syndrome disrupt nuclear actin organization

Melatonin, wnt and S1P signaling regulate diurnal bone marrow mesenchymal stem cell metabolism, cell size and function

Bone marrow microenvironment retinoic acid receptor signaling represses multipotential progenitor dependent B cell lymphopoiesis through secretion of resistin

Apheresis blood processing with heparin improves stem cell collection outcomes for sickle cell gene therapy

The Dominant Negative Acting VPS4A E228Q Mutation Causes Dyserythropoiesis in Human iPSC-Derived Erythroblast Cultures That Phenocopies Cimdag Syndrome-Associated Anemia

Bone Marrow Adipocyte Secreted Resistin Is a Positive Regulator of Long-Term Hematopoietic Stem Cell Engraftment and Myelopoiesis

Hematopoietic Flt3+ Multipotent Progenitors Are Organized in Discrete Functionally and Hierarchically Distinct Populations

Role of mTOR in Hematopoiesis and Hematopoietic Stem Cell Regulation.

Connexin-43 Regulates the Cell Cycle Entry of Hematopoietic Stem Cells within the Stem Cell Niche.

Bmi-1 Overexpression Synergizes with p210-BCR-ABL to Induce Stem Cell and Progenitor Transformation.

Deletion of Rac2 inhibits Proliferation of Chronic Myelogenous Leukemia (CML) Stems Cells and Progenitors (HSC/P) In Vivo and Promotes Survival of Scl/p210-BCR-ABL Mice.

FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor.

Connexin-43 Expression Regulates the Migration of Hematopoietic Stem Cells and Progenitors towards and From Bone Marrow.

Vav3 and Rac2 Activation Are Required for B Progenitor Transformation Induced by p190-BCR-ABL.

Leukemic Stem Cells and Progenitors Demonstrate Impaired Interaction with the Hematopoietic Microenvironment in Vivo in An Inducible Murine Model of Chronic Myelogenous Leukemia

Stem Cell Factor Signaling Collaborates in the Development of FIP1L1/PDGFRα Induced Chronic Eosinophilic Leukemia in a Murine Model

Rac GTPases Modulate Migration of Hematopoietic Progenitor Cells in an SDF-1α Dependent Manner in a Tumor Model.

RhoH-Deficient Mice Show Altered B Cell Populations In Vivo.

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