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Journal Articles

Declining Autophagic Flux Underlies Mitochondrial and Platelet Defects in Aging

Guadalupe Rojas-Sanchez, Jorge Calzada-Martinez, Orlando Esparza, Giovanny Hernandez, Gabriela Dveksler, Ken Jones, Lucas Ting, Catherine Jankowski, Marguerite Kelher, Marilyn Manco-Johnson, Andrew Thorburn, Paola Maycotte, José A López, Pavel Davizon-Castillo

Blood (2024) 144 (Supplement 1): 2547.

https://doi.org/10.1182/blood-2024-211413

Published: 2024

Journal Articles

Erythrocytes from Sickle Cell Mice Activate the Endothelium and Blood Cells and Induce Vaso-Occlusion When Transfused into ADAMTS13-Deficient Mice: Role of Lipid Degradation

Reheman Adili, Junmei Chen, Nicole Roads, Richard Maldonado, Hallie Lazaro, Dominic W. Chung, Xiaoyun Fu, José A. López

Blood (2024) 144 (Supplement 1): 3864.

https://doi.org/10.1182/blood-2024-208264

Published: 2024

Journal Articles

A Novel Mouse Model of Acute Sickle Cell Vaso-Occlusion

Reheman Adili, Junmei Chen, Nicole Roads, Hallie Lazaro, Richard Maldonado, Dominic W. Chung, José A. López

Blood (2024) 144 (Supplement 1): 5278.

https://doi.org/10.1182/blood-2024-208195

Published: 2024

Journal Articles

Streptococcus Gordonii Binds VWF Via Its Sialoglycan-Binding Adhesins Under Shear to Initiate Infective Endocarditis

Martha M.S. Sim, Ava Obenaus, Richard Maldonado, Jennie Le, Lesley Martínez Rodríguez, Barbara Bensing, Paul Sullam, Wendy Thomas, Nathan Sniadecki, Junmei Chen, Jose A. Lopez

Blood (2024) 144 (Supplement 1): 3998.

https://doi.org/10.1182/blood-2024-208774

Published: 2024

Journal Articles

HDL and HDL-Mimetic Nanoparticles Prevent Induced TTP and Interrupt the Course of Ongoing Episodes of the Disease

Reheman Adili, Nicole Roads, Hallie Lazaro, Jeffrey Harris, Minhua Ling, Junmei Chen, José A. López, Dominic W. Chung

Blood (2024) 144 (Supplement 1): 184.

https://doi.org/10.1182/blood-2024-199737

Published: 2024

Journal Articles

Protein-Peptide Interactions in Endothelial Cell Von Willebrand Factor Secretion and Exocytosis

Melanie Salinas, José A. López, Misuk Bae

Blood (2024) 144 (Supplement 1): 5526.

https://doi.org/10.1182/blood-2024-212398

Published: 2024

Journal Articles

An Important Role for P-Selectin in Thrombotic Microangiopathy

Raymond Adili, Nicole Roads, Hallie Lazaro, Junmei Chen, Dominic W. Chung, José A. López

Blood (2024) 144 (Supplement 1): 182.

https://doi.org/10.1182/blood-2024-208039

Published: 2024

Journal Articles

High-Density Lipoprotein Inhibits Microvascular and Arterial Thrombosis in Mice By Attenuating VWF Self-Association

Raymond Adili, Nicole Rhoads, Jeffrey Harris, Minhua Ling, Junmei Chen, Jose A. Lopez, Dominic W. Chung

Blood (2023) 142 (Supplement 1): 3936.

https://doi.org/10.1182/blood-2023-178884

Published: 2023

Journal Articles

Inflammation Mediated By TNFα Disrupts the Autophagic Flux and Oxidative Phosphorylation of Megakaryocytes and Platelets through the Downregulation of STX17

Guadalupe Rojas-Sanchez, Jorge Calzada-Martinez, Brandon McMahon, Orlando Esparza, Giovanny Hernandez, Dennis L Le, Eric Wartchow, Tzu Phang, Travis Nemkov, Angelo D'Alessandro, Paola Maycotte, Andrew Thorburn, Jose A. Lopez, Pavel Davizon-Castillo

Blood (2023) 142 (Supplement 1): 2567.

https://doi.org/10.1182/blood-2023-185498

Published: 2023

Journal Articles

TRPM8 Contributes to Early Temperature-Induced Platelet Activation

Anastasiia Stratiievska, Olga Filippova, Hasan Tahsin Ozpolat, Daire Byrne, S. Lawrence Bailey, Molly Mollica, Jeffrey Harris, Kali Esancy, Ajay Daka, Nathan Sniadecki, Jose A. Lopez, Moritz Stolla

Blood (2023) 142 (Supplement 1): 5566.

https://doi.org/10.1182/blood-2023-174122

Published: 2023

Journal Articles

The Actin Bundling Protein L-Plastin Mediates Platelet Force Generation and Thrombosis

Seema Bhatlekar, Shancy Jacob, Marina Tistao, Molly Y Mollica, Nicole Rhoads, Lili Chen, Bhanu Kanth Manne, Darian Murray, Siqi Guo, Sharon Celeste Morley, Jesse W Rowley, Matthew T. Rondina, Raymond Adili, Jose A. Lopez, Li Guo

Blood (2023) 142 (Supplement 1): 2560.

https://doi.org/10.1182/blood-2023-178052

Published: 2023

Journal Articles

Steady-State Von Willebrand Factor Antigen Levels Predict Low Platelet Counts and Risk for Complications in Hospitalizations for Painful Sickle Cell Vaso-Occlusive Episodes

Xu Zhang, Binal Shah, Jin Han, Jose A. Lopez, Dominic W. Chung, Junmei Chen, Victor R. Gordeuk, Santosh L. Saraf

Blood (2023) 142 (Supplement 1): 2483.

https://doi.org/10.1182/blood-2023-190297

Published: 2023

Journal Articles

Self-Association of Von Willebrand Factor (VWF) into Prothrombotic Fibers Is Most Potently Enhanced By the Highly Atherogenic Small, Dense Fraction of Low-Density Lipoprotein (sd-LDL)

Junmei Chen, Forrest Nussdorfer, Raymond Adili, Kimsey Platten, Nicole Rhoads, Richard Maldonado, Franklin Reed, Yi Wang, Minhua Ling, Sergio Fazio, Xiaoyun Fu, Nathalie Pamir, Jose A. Lopez, Dominic W. Chung

Blood (2023) 142 (Supplement 1): 504.

https://doi.org/10.1182/blood-2023-188325

Published: 2023

Journal Articles

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Reheman Adili, Nathalie Pamir, Forrest Nussdorfer, Alexander St. John, Minhua Ling, Jennie Le, Jeff Harris, Nicole Rhoads, Yi Wang, Xiaoyun Fu, Junmei Chen, Sergio Fazio, Jonathan R. Lindner, José A. López

Blood (2023) 142 (13): 1156–1166.

https://doi.org/10.1182/blood.2023019749

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Unfolded Von Willebrand Factor Interacts with Protein S and Limits Its Anticoagulant Activity

Martha MS Sim, Hammodah Alfar, Melissa Hollifield, Dominic W. Chung, Xiaoyun Fu, Meenakshi Banerjee, Chi Peng, Xian Li, Alice Thornton, James Z Porterfield, Jamie Sturgill, Gail A Sievert, Marietta Barton-Baxter, Kenneth S Campbell, Jerold G Woodward, José A. López, Sidney W Whiteheart, Beth A Garvy, Jeremy P Wood

Blood (2022) 140 (Supplement 1): 2710–2711.

https://doi.org/10.1182/blood-2022-162612

Published: 2022

Journal Articles

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Raymond Adili, Nathalie Pamir, Forrest D Nussdorfer, Alexander E St. John, Minhua Ling, Jennie Le, Jeff Harris, Junmei Chen, Sergio Fazio, Jonathan Lindner, José A. López

Blood (2022) 140 (Supplement 1): 1660–1661.

https://doi.org/10.1182/blood-2022-170092

Published: 2022

Journal Articles

Dysregulated Autophagy in Platelets from JAK2 V617F -Positive Polycythemia Vera and Essential Thrombocythemia Underlies Bioenergetic Failure As a Possible Mechanism for Thrombohemorrhagic Complications

Guadalupe Rojas Sanchez, Orlando Esparza, Brandon McMahon, Giovanny Hernandez, Dennis Le, Travis Nemkov, Angelo D'Alessandro, Andrew Thorburn, José A. López, Pavel Davizon-Castillo

Blood (2022) 140 (Supplement 1): 9590–9591.

https://doi.org/10.1182/blood-2022-170014

Published: 2022

Journal Articles

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Bojing Shao, Christopher Hoover, Huiping Shi, Yuji Kondo, Robert H. Lee, Junmei Chen, Xindi Shan, Jianhua Song, J. Michael McDaniel, Meixiang Zhou, Samuel McGee, Karen Vanhoorelbeke, Wolfgang Bergmeier, José A. López, James N. George, Lijun Xia

Blood (2022) 139 (16): 2523–2533.

https://doi.org/10.1182/blood.2021012896

Published: 2022

Includes: Supplemental data

Journal Articles

Introduction to a review series on platelets and cancer

José A. López

Blood (2021) 137 (23): 3151–3152.

https://doi.org/10.1182/blood.2020010237

Published: 2021

Journal Articles

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

Alexander E St. John, MD, Yi Wang, PhD, Junmei Chen, PhD, Warren Osborn, Xu Wang, MD, Esther Lim, BS, Dominic W. Chung, PhD, Susan Stern, MD, Nathan White, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MDBS

Blood (2020) 136 (Supplement 1): 9–10.

https://doi.org/10.1182/blood-2020-141361

Published: 2020

NARROW

Declining Autophagic Flux Underlies Mitochondrial and Platelet Defects in Aging

Erythrocytes from Sickle Cell Mice Activate the Endothelium and Blood Cells and Induce Vaso-Occlusion When Transfused into ADAMTS13-Deficient Mice: Role of Lipid Degradation

A Novel Mouse Model of Acute Sickle Cell Vaso-Occlusion

Streptococcus Gordonii Binds VWF Via Its Sialoglycan-Binding Adhesins Under Shear to Initiate Infective Endocarditis

HDL and HDL-Mimetic Nanoparticles Prevent Induced TTP and Interrupt the Course of Ongoing Episodes of the Disease

Protein-Peptide Interactions in Endothelial Cell Von Willebrand Factor Secretion and Exocytosis

An Important Role for P-Selectin in Thrombotic Microangiopathy

High-Density Lipoprotein Inhibits Microvascular and Arterial Thrombosis in Mice By Attenuating VWF Self-Association

Inflammation Mediated By TNFα Disrupts the Autophagic Flux and Oxidative Phosphorylation of Megakaryocytes and Platelets through the Downregulation of STX17

TRPM8 Contributes to Early Temperature-Induced Platelet Activation

The Actin Bundling Protein L-Plastin Mediates Platelet Force Generation and Thrombosis

Steady-State Von Willebrand Factor Antigen Levels Predict Low Platelet Counts and Risk for Complications in Hospitalizations for Painful Sickle Cell Vaso-Occlusive Episodes

Self-Association of Von Willebrand Factor (VWF) into Prothrombotic Fibers Is Most Potently Enhanced By the Highly Atherogenic Small, Dense Fraction of Low-Density Lipoprotein (sd-LDL)

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Unfolded Von Willebrand Factor Interacts with Protein S and Limits Its Anticoagulant Activity

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Dysregulated Autophagy in Platelets from JAK2 V617F -Positive Polycythemia Vera and Essential Thrombocythemia Underlies Bioenergetic Failure As a Possible Mechanism for Thrombohemorrhagic Complications

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Introduction to a review series on platelets and cancer

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

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American Society of Hematology

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