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Joan Bladé, MD, PhD
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Journal Articles

Immunoparesis Defined By Heavy/Light Chain Pair Suppression in Smoldering Multiple Myeloma Patients Shows Isotype Specificity

Ignacio Isola, MD, David Moreno, MD, Esther Moga, MD PhD, Mari-Pau Mena, PhD, Natalia Tovar, Luis Gerardo Rodríguez-Lobato, MD PhD, M. Teresa Cibeira, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, Carlos Fernandez de Larrea, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-139737
Published: 2020
Journal Articles

Clinical Significance and Biomarkers to Predict Unsustained Complete Remission in Transplant-Eligible Multiple Myeloma

Ana Jimenez-Ubieto, Bruno Paiva, PhD, Joaquin Martinez Lopez, María Teresa Cedena, MD, Noemi Puig, MD PhD, Albert Oriol, MD, Maria Jesús Blanchard, MD, Rafael Rios, MD PhD, Lucia Lopez-Anglada, PhD, Jesús Martín, Rafael Martínez, Anna Sureda Balari, MD PhD, Miguel Hernández, Javier de la Rubia, Isabel Krsnik, MD PhD, Valentin Cabañas, MD, Luis Palomera, MD PhD, Joan Bargay, MD, Jose Maria Moraleda, MD PhD, Laura Rosiñol, María-Victoria Mateos, MD PhD, Jesus F. San-Miguel, MD PhD, Joan Bladé, MD PhD, Juan-José Lahuerta, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136181
Published: 2020
Journal Articles

Discordances between Immunofixation (IFx) and Minimal Residual Disease (MRD) Assessment with Next-Generation Flow (NGF) and Sequencing (NGS) in Patients (Pts) with Multiple Myeloma (MM): Clinical and Pathogenic Significance

Sara Rodríguez, PhD, Ibai Goicoechea, PhD, Katerina Gemenetzi, Cirino Botta, MDPhD, Andreas Agathangelidis, PhD, Noemi Puig, MD PhD, María Teresa Cedena, MD, Alejandro Medina, MD, Rafael Valdés-Mas, Juan José Garcés, José J Pérez, Leire Burgos, María José Calasanz, PhD, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Sarvide Sarai, Felipe Prosper, MD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Ana Jiménez Ubieto, MDPhD, Joaquin Martinez Lopez, Juan Jose Lahuerta, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, María-Victoria Mateos, MD PhD, Anastasia Chatzidimitriou, Jesus F. San-Miguel, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136258
Published: 2020
Journal Articles

Randomized, Open-Label, Non-Inferiority, Phase 3 Study of Subcutaneous (SC) Versus Intravenous (IV) Daratumumab (DARA) Administration in Patients with Relapsed or Refractory Multiple Myeloma: Columba Update

Saad Z. Usmani, MD, Maria-Victoria Mateos, MD PhD, Hareth Nahi, MD PhD, Sebastian Grosicki, MD PhD, Vladimir I. Vorobyev, MD PhD, Ivan Spicka, MD PhD Prof, Vania T.M. Hungria, MD PhD, Sibirina Korenkova, Max Flogegard, Joan Bladé, MD PhD, Philippe Moreau, MD, Martin F. Kaiser, Shinsuke Iida, MD PhD, Jacob P. Laubach, MD, Tara Masterson, Kristen Anne Lantz, PhD, Lisa O'Rourke, MSN, RN, Christoph Heuck, Xiang Qin, Dolly A. Parasrampuria, PhD, Ming Qi, Nizar Bahlis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1865.
https://doi.org/10.1182/blood-2019-122765
Published: 2019
Journal Articles

Final Analysis of a Phase 1b Study of Daratumumab in Combination with Carfilzomib and Dexamethasone for Relapsed or Refractory Multiple Myeloma (RRMM)

Ajai Chari, MD, Sagar Lonial, Joaquin Martinez-Lopez, MD PhD, Maria-Victoria Mateos, Joan Bladé, MD PhD, Lotfi Benboubker, MD, Albert Oriol, Paula Rodriguez Otero, Luis Pineiro, Andrzej Jakubowiak, MD PhD, Yunsi Olyslager, Jianping Wang, Ivo Nnane, Jon Ukropec, PhD, Martin Shreeve, Ming Qi, MD PhD, Philippe Moreau, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1876.
https://doi.org/10.1182/blood-2019-123539
Published: 2019
Journal Articles

Randomized, Open-Label, Non-Inferiority, Phase 3 Study of Subcutaneous (SC) Versus Intravenous (IV) Daratumumab (DARA) Administration in Patients (Pts) with Relapsed or Refractory Multiple Myeloma (RRMM): Body Weight Subgroup Analysis of Columba

Maria-Victoria Mateos, MD PhD, Saad Z. Usmani, MD, Sebastian Grosicki, MD PhD, Vladimir I. Vorobyev, MD PhD, Ivan Spicka, MD PhD Prof, Vania T.M. Hungria, MD PhD, Sibirina Korenkova, Nizar Bahlis, MD, Max Flogegard, Joan Bladé, MD PhD, Philippe Moreau, MD, Martin F. Kaiser, Shinsuke Iida, MD PhD, Jacob P. Laubach, MD, Tara Masterson, Kristen Anne Lantz, PhD, Lisa O'Rourke, MSN, RN, Xiang Qin, Dolly A. Parasrampuria, PhD, Christoph Heuck, Ming Qi, MD PhD, Hareth Nahi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1906.
https://doi.org/10.1182/blood-2019-122501
Published: 2019
Journal Articles

Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes

Cirino Botta, MD, Cristina Pérez Ruiz, Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Aintzane Zabaleta, PhD, Leire Burgos, Catarina Maia, Sara Rodríguez, PhD, Idoia Rodriguez, Sarai Sarvide, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Laura Rosinol Dachs, Albert Oriol, MD, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda, MD PhD, Rafael Martínez, Jesús Martín, Joan Bargay, MD PhD, Javier De La Rubia, Marco Rossi, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD, Massimo Gentile, Juana Merino, Felipe Prosper, MD PhD, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Juan-José Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 506.
https://doi.org/10.1182/blood-2019-123974
Published: 2019
Journal Articles

Qip-Mass Spectrometry in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Residual Disease IMWG Response Assessment

Noemi Puig, MD PhD, Maria-Victoria Mateos, Teresa Contreras, Bruno Paiva, PhD, María Teresa Cedena, José J Pérez, Irene Aires, Cristina Agullo, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez De La Calle, MD PhD, Marta Sonia Gonzalez, MD, Albert Oriol, Norma C. Gutierrez, MD PhD, Rafael Rios, MD PhD, Laura Rosiñol, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Javier de la Rubia, MD PhD, Ana Isabel Teruel, MDcal Doctor, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel-Teodoro Hernández, Javier López, MD, Jesús Martín, Aránzazu García Mateo, PhD, Ramón García-Sanz, MD PhD, Enrique M. Ocio, Joan Bladé, MD PhD, Juan-José Lahuerta, MD PhD, Jesus F. San-Miguel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 581.
https://doi.org/10.1182/blood-2019-127717
Published: 2019
Journal Articles

Tandem Autologous-Autologous Vs. Autologous-Allogeneic Transplantation for Newly Diagnosed Multiple Myeloma: Pooled Analysis of 1,338 Patients from Four Trials with Long-Term Follow up

Luciano J. Costa, MD PhD, Simona Iacobelli, Marcelo C. Pasquini, MD, Riddhi Modi, PhD, Luisa Giaccone, Joan Bladé, MD PhD, Stefan Schonland, Andrea Evangelista, Jose A. Perez-Simon, MD PhD, Parameswaran Hari, MBBS, MD, Elizabeth E. Brown, PhD MPH, Sergio A Giralt, MD, Francesca Patriarca, Edward A. Stadtmauer, MD FACP, Laura Rosinol, MD PhD, Amrita Y. Krishnan, MD, Goesta Gahrton, MD PhD, Benedetto Bruno, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 259.
https://doi.org/10.1182/blood-2019-121367
Published: 2019
Journal Articles

Heavy and Light Chain Monitoring in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Residual Disease IMWG Response Assessment

Noemi Puig, MD PhD, Teresa Contreras, Bruno Paiva, PhD, María Teresa Cedena, José J Pérez, Irene Aires, Cristina Agullo, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez De La Calle, MD PhD, Marta Sonia Gonzalez, MD, Albert Oriol, Norma C. Gutierrez, MD PhD, Rafael Rios, MD PhD, Laura Rosiñol, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Javier de la Rubia, MD PhD, Ana Isabel Teruel, MDcal Doctor, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel-Teodoro Hernández, Javier López, MD, Jesús Martín, Aránzazu García Mateo, PhD, Enrique M. Ocio, Ramón García-Sanz, MD PhD, Joan Bladé, MD PhD, Juan Jose Lahuerta, MD PhD, Jesus F. San-Miguel, MD, Maria-Victoria Mateos
Journal: Blood
Blood (2019) 134 (Supplement_1): 1852.
https://doi.org/10.1182/blood-2019-128655
Published: 2019
Journal Articles

Daratumumab Plus Bortezomib, Melphalan, and Prednisone Versus Bortezomib, Melphalan, and Prednisone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Overall Survival in Alcyone

Maria-Victoria Mateos, Michele Cavo, Joan Bladé, MD PhD, Meletios A. Dimopoulos, MD, Kenshi Suzuki, MD PhD, Andrzej Jakubowiak, MD PhD, Stefan Knop, Chantal Doyen, MD, Paulo Lucio, MD PhD, Zsolt Nagy, MD PhD, Ludek Pour, MD, Mark Cook, MBChB,PhD, Sebastian Grosicki, MD PhD, Andre H Crepaldi, MD, Anna Marina Liberati, Philip Campbell, MBBS, FRACP, FRCPA, Tatiana Shelekhova, Sung-Soo Yoon, MD PhD, Genadi Iosava, MD, Tomoaki Fujisaki, MD PhD, Mamta Garg, MD FRCP, FRCPath, Maria Krevvata, PhD, Jianping Wang, Anupa Kudva, MD, Jon Ukropec, PhD, Susan Wroblewski, PhD, Rachel Kobos, MD, Jesús San-Miguel
Journal: Blood
Blood (2019) 134 (Supplement_1): 859.
https://doi.org/10.1182/blood-2019-123401
Published: 2019
Journal Articles

Curativestategy (GEM-CESAR) for High-Risk Smoldering Myeloma (SMM): Carfilzomib, Lenalidomide and Dexamethasone (KRd) As Induction Followed By HDT-ASCT, Consolidation with Krd and Maintenance with Rd

Maria-Victoria Mateos, MD PhD, Joaquin Martínez-López, MD PhD, Paula Rodriguez Otero, MD, Enrique M. Ocio, MD, Marta Sonia Gonzalez, MD, Albert Oriol, MD, Norma C. Gutierrez, MD PhD, Bruno Paiva, MD PhD, Rafael Rios, MD PhD, Laura Rosinol, MD PhD, Miguel Angel Alvarez, MD, Maria Jose Calasanz, BSc, PhD, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Noemi Puig, MD PhD, Javier De La Rubia, MD, Ana Isabel Teruel, MDcal Doctor, María Teresa Cedena, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel T Hernández, MD PhD, Javier Lopez Jimenez, MD PhD, Jesús Martín, Esther Piensa, Aránzazu García Mateo, PhD, Veronica Gonzalez De La Calle, MD PhD, Joan Bladé, MD PhD, Juan Jose Lahuerta, MD PhD, Jesus F San-Miguel, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2142.
https://doi.org/10.1182/blood-2018-99-112656
Published: 2018
Journal Articles

Split First Dose Administration of Daratumumab for the Treatment of Patients with Multiple Myeloma (MM): Clinical Pharmacology and Population Pharmacokinetic (PK) Analyses

Xu Steven Xu, Philippe Moreau, Saad Z. Usmani, MD, Sagar Lonial, MD, Andrzej Jakubowiak, MD PhD, Albert Oriol, MD, Amrita Krishnan, MD, Joan Bladé, MD PhD, Melody Luo, PhD, Yu-Nien Sun, PhD, Liping Zhang, William Deraedt, Ming Qi, MD PhD, Jon Ukropec, PhD, Pamela L Clemens, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1970.
https://doi.org/10.1182/blood-2018-99-113171
Published: 2018
Journal Articles

Smoldering Multiple Myeloma: Usefulness of Serum Heavy/Light Chain Measurements for the Evaluation of Evolving Pattern

Carlos Fernandez de Larrea, MD PhD, Ignacio Isola, MD, Esther Moga, Maria Teresa Cibeira, MD PhD, Ester Lozano, PhD, Juan I. Arostegui, Montserrat Elena, Natalia Tovar, MD PhD, Jordi Yague, Laura Rosinol, MD PhD, Joan Bladé, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4514.
https://doi.org/10.1182/blood-2018-99-117385
Published: 2018
Journal Articles

Clinical Significance and Transcriptional Profiling of Persistent Minimal Residual Disease (MRD) in Multiple Myeloma (MM) Patients with Standard-Risk (SR) and High-Risk (HR) Cytogenetics

Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Maria-Belen Vidriales, MD, Leire Burgos, Juan Flores-Montero, Norma C. Gutierrez, MD PhD, Maria Jose Calasanz, BSc, PhD, Maria Luisa Martin-Ramos, David Lara-Astiaso, PhD, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Idoia Rodriguez, Sarai Sarvide, Ramon Garcia-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Albert Oriol, MD, Rafael Rios, MD PhD, Jesús Martín, Rafael Martínez, Josep Sarra, Miguel T Hernández, MD PhD, Javier De La Rubia, MD, Isabel Krsnik, Jose Maria Moraleda, Luis Palomera, MD PhD, Joan Bargay, MD PhD, Alberto Orfao, MD PhD, Laura Rosiñol, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 112.
https://doi.org/10.1182/blood-2018-99-113312
Published: 2018
Journal Articles

Survival Improvement in the Last 45 Years in Patients with Multiple Myeloma: Real-World Data from a Single Center

Luis Gerardo Rodríguez-Lobato, MD PhD, Carlos Fernández De Larrea, MD PhD, Natalia Tovar, MD PhD, Maria Teresa Cibeira, MD PhD, Joan Bladé, MD PhD, Laura Rosinol, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5573.
https://doi.org/10.1182/blood-2018-99-112089
Published: 2018
Journal Articles

Mir-485-3p and Mir-654-3p Expression in Bone Marrow Mesenchymal Stromal Cells in Patients with Monoclonal Gammopathies Is Related to the Status of the Disease

Carlos Fernandez de Larrea, MD PhD, Tania Diaz, PhD, Alfons Navarro, PhD, Ester Lozano, PhD, Mari-Pau Mena, PhD, Ignacio Isola, MD, Natalia Tovar, MD PhD, Maria Teresa Cibeira, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3155.
https://doi.org/10.1182/blood-2018-99-112222
Published: 2018
Journal Articles

One-Year Update of a Phase 3 Randomized Study of Daratumumab Plus Bortezomib, Melphalan, and Prednisone (D-VMP) Versus Bortezomib, Melphalan, and Prednisone (VMP) in Patients (Pts) with Transplant-Ineligible Newly Diagnosed Multiple Myeloma (NDMM): Alcyone

Meletios A Dimopoulos, MD, Maria-Victoria Mateos, MD PhD, Michele Cavo, MD, Kenshi Suzuki, MD PhD, Andrzej Jakubowiak, MD PhD, Stefan Knop, Chantal Doyen, MD, Paulo Lucio, Zsolt Nagy, MD PhD, Polina Kaplan, Ludek Pour, MD, Mark Cook, MBChB,PhD, Sebastian Grosicki, MD PhD, Andre H Crepaldi, MD, Anna Marina Liberati, MD, Philip Campbell, MBBS, FRACP, FRCPA, Tatiana Shelekhova, Sung-Soo Yoon, MD PhD, Genadi Iosava, MD, Tomoaki Fujisaki, MD PhD, Mamta Garg, Christopher Chiu, PhD, Jianping Wang, Anupa Kudva, Rachel Kobos, MD, Susan Wroblewski, PhD, Ming Qi, MD PhD, Jesus F San-Miguel, MD PhD, Joan Bladé, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 156.
https://doi.org/10.1182/blood-2018-156
Published: 2018
Journal Articles

Natural History of Asymptomatic IgM Monoclonal Gammopathies: Impact of the Bone Marrow Aspiration into the Classification and Prognosis

Carlos Fernandez de Larrea, MD PhD, David Moreno, MD, Natalia Tovar, MD PhD, Maria Teresa Cibeira, MD PhD, Ignacio Isola, MD, Laura Magnano, MD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1610.
https://doi.org/10.1182/blood-2018-99-115038
Published: 2018
Journal Articles

Bone Marrow Plasma Cell Infiltration in Light Chain Amyloidosis: Impact on Organ Involvement and Outcome

Carlos Fernandez de Larrea, MD PhD, Luis Gerardo Rodríguez-Lobato, MD, Natalia Tovar, MD PhD, Laura Magnano, MD, Ignacio Isola, MD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, Mª Teresa Cibeira, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5365.
https://doi.org/10.1182/blood.V130.Suppl_1.5365.5365
Published: 2017