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Jeffrey Rubnitz
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Journal Articles

Prognostic relevance of epigenetic regulation of drug pharmacology and myeloid genes in pediatric AML

Free
Naifah Alshameri, Francisco Marchi, Soheil Meshinchi, Xueyuan Cao, Jeffrey Rubnitz, Raul Ribeiro, Stanley Pounds, Jatinder Lamba
Journal: Blood
Blood (2025) 146 (Supplement 1): 1712.
https://doi.org/10.1182/blood-2025-1712
Published: 2025
Journal Articles

Clonal evolution of pediatric Acute Myeloid Leukemia

Free
Masayuki Umeda, Pandurang Kolekar, Anna Huskey, Shruthi Suryaprakash, Hanxia Li, Tamara Westover, Jing Ma, Mike Walsh, Guangchun Song, Yanling Liu, Quang Tran, Seth Karol, Hiroto Inaba, Jeffrey Rubnitz, Raul Ribeiro, Xiaotu Ma, Jeffery Klco
Journal: Blood
Blood (2025) 146 (Supplement 1): 1721.
https://doi.org/10.1182/blood-2025-1721
Published: 2025
Journal Articles

A TFPI missense variant provides protection against severe febrile neutropenia in pediatric Acute Myeloid Leukemia

Free
Satyavardhan Rao Nittu, Richard Marrero, Xueyuan Cao, Huiyun Wu, Raul Ribeiro, Jeffrey Rubnitz, Stanley Pounds, Jatinder Lamba
Journal: Blood
Blood (2025) 146 (Supplement 1): 7028.
https://doi.org/10.1182/blood-2025-7028
Published: 2025
Journal Articles

Epigenetic priming improves survival for pediatric Acute Myeloid Leukemia: Results from the multicenter randomized AML16 trial

Free
Tanja Gruber, Stanley Pounds, Norman Lacayo, Kenneth Heym, Meret Henry, Barbara Degar, Deborah Schiff, Faisal Razzaqi, Jamie Frediani, Samuel Milanovich, Jennifer McNeer, Huiyun Wu, Lakshmi Patibandla, Emily Xiong, Tamara Westover, Ryan Hiltenbrand, Lu Wang, Priya Kumar, Gabrielle Lapping-Carr, Kayelyn Wagner, Dennis Kuo, Jessica Pollard, Nickhill Bhakta, Seth Karol, Brandon Triplett, Jatinder Lamba, Hiroto Inaba, Ching-Hon Pui, Raul Ribeiro, Jeffrey Rubnitz, Jeffery Klco
Journal: Blood
Blood (2025) 146 (Supplement 1): 3446.
https://doi.org/10.1182/blood-2025-3446
Published: 2025
Journal Articles

Transformer neural network using DNA methylation for sensitive and specific diagnosis of acute leukemia

Free
Pedro V. B. Orsini, Francisco Marchi, Anna Lux, Laura F. Crosara, Jeffrey Rubnitz, Jeffery Klco, Jatinder Lamba
Journal: Blood
Blood (2025) 146 (Supplement 1): 118.
https://doi.org/10.1182/blood-2025-118
Published: 2025
Journal Articles

EV-mirnas predict outcomes in pediatric AML: A pilot study

Free
Abdullah Alhumaid, Vivek Shastri, Zachary Greenberg, Jinmai Jiang, Raul Ribeiro, Jeffrey Rubnitz, Mei He, Thomas Schmittgen, Stanley Pounds, Jatinder Lamba
Journal: Blood
Blood (2025) 146 (Supplement 1): 3484.
https://doi.org/10.1182/blood-2025-3484
Published: 2025
Journal Articles

Proteomics reveals COX7B as a prognostically relevant oxphos-linked protein in pediatric AML

Free
Ryanne Mulligan, Ya Huang, Xueyuan Cao, Junmin Peng, Raul Ribeiro, Jeffrey Rubnitz, Stanley Pounds, Jatinder Lamba
Journal: Blood
Blood (2025) 146 (Supplement 1): 5277.
https://doi.org/10.1182/blood-2025-5277
Published: 2025
Journal Articles

Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98 -rearranged leukemia

Open Access
Masayuki Umeda, Ryan Hiltenbrand, Nicole L. Michmerhuizen, Juan M. Barajas, Melvin E. Thomas III, Bright Arthur, Michael P. Walsh, Guangchun Song, Jing Ma, Tamara Westover, Amit Kumar, Petri Pölönen, Cristina Mecucci, Danika Di Giacomo, Franco Locatelli, Riccardo Masetti, Salvatore N. Bertuccio, Martina Pigazzi, Shondra M. Pruett-Miller, Stanley Pounds, Jeffrey Rubnitz, Hiroto Inaba, Kyriakos P. Papadopoulos, Michael J. Wick, Ilaria Iacobucci, Charles G. Mullighan, Jeffery M. Klco
Journal: Blood
Blood (2025) 146 (17): 2102–2118.
https://doi.org/10.1182/blood.2025028993
Published: 2025
Includes: Supplemental data
Journal Articles

Integrative Analysis of Pediatric Acute Leukemia Identifies Immature Subtypes That Span a T Lineage and Myeloid Continuum with Distinct Prognoses

Free
Tanja A. Gruber, MD PhD, Jing Ma, PhD, Sanne Noort, MD MSc, Yu Liu, PhD, Michael P Walsh, PhD, Stephanie Nance, PhD, Yanling Liu, PhD, Yuanyuan Wang, PhD, Guangchun Song, PhD, Tamara Lamprecht, BS, John Easton, PhD, Martina Pigazzi, PhD, Marie Jarosova, PhD, Kelaidi Charikleia, MD, Jeffrey Rubnitz, MD PhD, Dirk Reinhardt, MD, Marry M. van den Heuvel-Eibrink, Prof, MD PhD, Franco Locatelli, MD PhD, Henrik Hasle, Jeffery M. Klco, MD PhD, James R. Downing, MD, Stanley Pounds, PhD, Jinghui Zhang, PhD, Christian Michel Zwaan, MD PhD, Maarten Fornerod, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 918.
https://doi.org/10.1182/blood-2019-127411
Published: 2019
Journal Articles

A 5-Gene Ara-C, Daunorubicin and Etoposide (ADE) Drug Response Score As a Prognostic Tool to Predict AML Treatment Outcome

Free
Abdelrahman H. Elsayed, MSc, Huiyun Wu, PhD, Xueyuan Cao, PhD, Susana C. Raimondi, PhD, James R. Downing, MD, Raul Ribeiro, MD, Tanja A. Gruber, MD PhD, Rhonda E. Ries, MA, Soheil Meshinchi, MD PhD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, M.Sc., PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1429.
https://doi.org/10.1182/blood-2019-128787
Published: 2019
Journal Articles

Safety and Efficacy of Venetoclax in Combination with Navitoclax in Adult and Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Free
Norman J. Lacayo, MD, Vinod A. Pullarkat, MD, Wendy Stock, MD, Elias Jabbour, MD, Ashish Bajel, MBBS, FRACP, FRCPA, Jeffrey Rubnitz, MD PhD, Jessica Leonard, MD, Charles G. Mullighan, MBBS, MD, Seong Lin Khaw, MD, Susan I. Vear, MD MSCI, Joseph T. Opferman, PhD, Ahmed Hamed Salem, PhD FCP, Michelle Schmidt, Bo Tong, PhD, Lang Zhou, PhD, Jeremy A. Ross, PhD, Lindsey Bensman, Amanda Jacobson, PhD, Robin Norris, MD MS, MPH, Thomas Alexander, MDMPH
Journal: Blood
Blood (2019) 134 (Supplement_1): 285.
https://doi.org/10.1182/blood-2019-126977
Published: 2019
Journal Articles

Home or Away from Home: A Multi-Institution Study Comparing Medical Outcomes, Patient Perspectives, and Health-Related Quality of Life for Outpatient Versus Inpatient Management after Chemotherapy for Pediatric Acute Myeloid Leukemia

Free
Kelly D Getz, Yimei Li, PhD, Julia E Szymczak, PhD, Catherine Aftandilian, MD, Staci D. Arnold, MD MBA, MPH, Kira O Bona, MDMPH, Emi Caywood, MD, Anderson B. Collier, MD, Maria Monica Monica Gramatges, MD PhD, Meret Henry, MD, Craig Lotterman, MD, Kelly Maloney, MD, Amir Mian, Rajen Mody, MD MS, Elizabeth A. Raetz, MD, Jeffrey Rubnitz, MD PhD, Anupam Verma, MD, Naomi Winick, MD, Jennifer J. Wilkes, MDMSCE, Jennifer C. Yu, MD, Brian T. Fisher, DO, MSCE, Richard Aplenc, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 379.
https://doi.org/10.1182/blood-2019-131761
Published: 2019
Journal Articles

Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid Leukemia

Free
Seth E Karol, MD, Thomas Alexander, MDMPH, Amit Budraja, PhD, Stanley Pounds, PhD, Kristin E Canavera, PhD, Lei Wang, MS, Joshua Wolf, MBBS, PhD, Jeffery M. Klco, MD PhD, Ahmed Hamed Salem, PhD FCP, Tammy Palenski, PhD, Norman J. Lacayo, MD, Ching-Hon Pui, MD, Joseph T. Opferman, PhD, Jeffrey Rubnitz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 178.
https://doi.org/10.1182/blood-2019-127716
Published: 2019
Journal Articles

Venetoclax and Navitoclax in Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Free
Thomas Alexander, MD MPH, Norman J. Lacayo, MD, Vinod A. Pullarkat, MD, Elias J. Jabbour, MD, Seong Lin Khaw, MD, Charles G. Mullighan, MBBS, MD, Ashish Bajel, MBBS, FRACP, FRCPA, Jessica Leonard, MD, Robin Norris, MD, Jeffrey Rubnitz, MD PhD, Susan I. Vear, MD MSCI, Michelle Schmidt, Bo Tong, PhD, Ying Zhou, PhD, Jeremy A. Ross, PhD, Lindsey Rosenwinkel, Amanda Jacobson, PhD, Su Young Kim, MD PhD, Wendy Stock, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3966.
https://doi.org/10.1182/blood-2018-99-113464
Published: 2018
Journal Articles

Outcome of Infants Younger Than 1 Year with Acute Lymphoblastic Leukemia Treated with the Interfant-06 Protocol; Results from an International Randomised Study

Free
Rob Pieters, MDPhDMSc, Paola De Lorenzo, PhD, Philip Ancliffe, Luis Alberto Aversa, MD, Benoit Brethon, Andrea Biondi, MD, Myriam Campbell, Gabriele Escherich, Alina Ferster, MD, Rebecca Gardner, MD, Rishi Sury Kotecha, MBBChir, MRCP, FRACP, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Franco Locatelli, Andishe Attarbaschi, Christina Peters, MD, Jeffrey Rubnitz, MD PhD, Lewis B. Silverman, MD, Jan Stary, MD PhD, Tomasz Szczepanski, MD PhD, Ajay Vora, MD, Martin Schrappe, MD PhD, Maria Grazia Valsecchi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 655.
https://doi.org/10.1182/blood-2018-99-112854
Published: 2018
Journal Articles

Integrated Genome Wide Association Study (GWAS) Identifies SNPs Associated with Outcome in Pediatric AML

Free
Abdelrahman H Elsayed, MSc, Huiyun Wu, PhD, Xueyuan Cao, PhD, Soheil Meshinchi, MD PhD, Raul Ribeiro, MD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2758.
https://doi.org/10.1182/blood-2018-99-120367
Published: 2018
Journal Articles

Pediatric LSC3 (pLSC3) Score Derived from DNMT3B-CD34-GPR56 As a Prognostic Tool to Predict AML Patient Outcome: Results from Two Independent Pediatric AML Cohorts

Free
Abdelrahman H Elsayed, MSc, Huiyun Wu, PhD, Xueyuan Cao, PhD, Susana C. Raimondi, PhD, James R. Downing, MD, Raul Ribeiro, MD, Tanja A. Gruber, MD PhD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 290.
https://doi.org/10.1182/blood-2018-99-116462
Published: 2018
Journal Articles

Metabolomics Profiling Reveals Markers for Chemosensitivity and Clinical Outcomes in Pediatric AML Patients

Free
Bradley Stockard, PharmD, Huiyun Wu, PhD, Joy D. Guingab, PhD, Timothy J. Garrett, PhD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1536.
https://doi.org/10.1182/blood-2018-99-116665
Published: 2018
Journal Articles

Methylation of DNMT3B Strongly Associates with the Methylome, Cytogenetic Risk Groups, and Prognosis of Pediatric Acute Myeloid Leukemia

Free
Jatinder K Lamba, PhD, Stanley Pounds, Xueyuan Cao, Susana C. Raimondi, PhD, James R. Downing, MD, Raul C Ribeiro, Jeffrey Rubnitz
Journal: Blood
Blood (2015) 126 (23): 2434.
https://doi.org/10.1182/blood.V126.23.2434.2434
Published: 2015
Journal Articles

Cytarabine-Induced Gene Expression Signatures in AML Patients and Its Association with Clinical Outcome.

Free
Jatinder K. Lamba, PhD, Stanley Pounds, PhD, Xueyuan Cao, PhD, Kristine Crews, PharmD, Dario Campana, MD., PhD, James R. Downing, MD, Raul Ribeiro, MD, Jeffrey Rubnitz, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2470.
https://doi.org/10.1182/blood.V120.21.2470.2470
Published: 2012