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Journal Articles

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Qiang Liu, PhD BSc, Olga I. Gan, PhD, Gabriela Krivdova, BSc, Aaron Trotman-Grant, Stephanie M. Dobson, PhD, Karin G. Hermans, Mark D. Minden, Shai Izraeli, MD, John E. Dick, PhD FRS, Jean C.Y. Wang, MD PhD, Eric R. Lechman,, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-141733

Published: 2020

Journal Articles

Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML

Andy G.X. Zeng, BSc, Amanda Mitchell, PhD, Oleksandr Galkin, PhD, Jean C.Y. Wang, MD PhD, James A. Kennedy, MDPhD, John E. Dick, PhD FRS

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-140895

Published: 2020

Journal Articles

A Stemness-Based Screen Identifies PLK1 Inhibitors for Targeting Leukemia Stem Cells in AML

Qiang Liu, PhD BSc, Amit Subedi, PhD, Samantha Yao, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Steven M Chan, MD PhD, Jean C.Y. Wang, MD PhD

Blood (2020) 136 (Supplement 1): 34–35.

https://doi.org/10.1182/blood-2020-141740

Published: 2020

Journal Articles

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Stanley W.K. Ng, Stephanie Zhi-Juan Xie, PhD, Elvin Wagenblast, PhD, Naoya Takayama, MD PhD, Liqing Jin, MD, Nathan Mbong, Alex Murison, Schoof E Erwin, Amanda Mitchell, PhD, Peter Van Galen, PhD, Mathieu Lupien, PhD, Mark D. Minden, MD PhD, Jean C.Y. Wang, MD PhD, Peter W. Zandstra, PhD, John E. Dick

Blood (2018) 132 (Supplement 1): 3832.

https://doi.org/10.1182/blood-2018-99-114314

Published: 2018

Journal Articles

Identification of Compounds That Target Acute Myeloid Leukemia Stem Cells Using a Scalable Next-Generation Screening Platform

Qiang Liu, PhD BSc, Amit Subedi, PhD, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Steven M Chan, MD PhD, Jean C.Y. Wang, MD PhD

Blood (2018) 132 (Supplement 1): 259.

https://doi.org/10.1182/blood-2018-99-115323

Published: 2018

Journal Articles

A Novel Predictor of Response to Gemtuzumab Ozogamicin Therapy in AML Provides Strategies for Sensitization of Leukemia Stem Cells in Individual Patients

Stanley W.K. Ng, Schoof E Erwin, Amanda Mitchell, PhD, Mark D. Minden, MD PhD, Lars Bullinger, MD, Hartmut Döhner, MD, Hervé Dombret, Claude Preudhomme, Meyling Cheok, BSPharm, PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD

Blood (2018) 132 (Supplement 1): 2765.

https://doi.org/10.1182/blood-2018-99-114275

Published: 2018

Journal Articles

Isolation of CD34 − and CD34 + Leukemia Stem Cells from Acute Myeloid Leukemia Blasts Using CD200

Jenny M. Ho, MD, Stephanie M. Dobson, PhD, Jessica McLeod, BSc, Veronique Voisin, PhD, Alex Murison, James Kennedy, MD PhD, Sasan Zandi, MD PhD, Kolja Eppert, MSc, PhD, Mark D. Minden, MD PhD, Mathieu Lupien, John E. Dick, PhD, Jean C.Y. Wang, MD PhD

Blood (2018) 132 (Supplement 1): 2790.

https://doi.org/10.1182/blood-2018-99-119318

Published: 2018

Journal Articles

Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells

Stephanie Zhi-Juan Xie, PhD, Kerstin Kaufmann, PhD, Olga I. Gan, PhD, Elisa Laurenti, PhD, Stanley W.K. Ng, Qiang Liu, Melissa Kleinau, Joseph Jargostf, Gareth Holmes, Chiara Luberto, PhD, Lina M Obeid, MD, Yusuf A. Hannun, MD, Jean C.Y. Wang, MD PhD, Mark D. Minden, MD PhD, John E. Dick, PhD

Blood (2018) 132 (Supplement 1): 1329.

https://doi.org/10.1182/blood-2018-99-119128

Published: 2018

Journal Articles

CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia

Jenny M. Ho, MD, Stephanie M. Dobson, Jessica McLeod, Liqing Jin, MD PhD, Stanley W.K. Ng, MSc, Amanda Mitchell, PhD, Liran I. Shlush, MD PhD, Sasan Zandi, MD PhD, Kolja Eppert, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD

Blood (2016) 128 (22): 1705.

https://doi.org/10.1182/blood.V128.22.1705.1705

Published: 2016

Journal Articles

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD, PhD, Richard M. Stone, MD, Dilara McCauley, PhD, Michael Kauffman, MD, PhD, Sharon Shacham, PhD, MBA, Jean C.Y. Wang, MD PhD, Andrew L Kung, MD, PhD, A. Thomas Look, MD

Blood (2013) 122 (21): 3932.

https://doi.org/10.1182/blood.V122.21.3932.3932

Published: 2013

Journal Articles

Blockade Of CD47 Using SIRPαFc: Role Of The Fc Region In Anti-Leukemic Activity and Tolerability

Robert A. Uger, PhD, Xinli Pang, MD, PhD, Mark Wong, PhD, Violetta House, Karen Dodge, Stephane Viau, Noel T. Vigo, Debbie Tam, Tran Truong, Liqing Jin, MD, Andrei V. Malko, Jenny Ho, MD, Tatiana K. Prasolava, PhD, Jayne S. Danska, PhD, Jean C.Y. Wang, MD PhD, Penka S. Petrova, PhD

Blood (2013) 122 (21): 3935.

https://doi.org/10.1182/blood.V122.21.3935.3935

Published: 2013

Journal Articles

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Eric R. Lechman, PhD, Bernhard Gentner, MD, Peter van Galen, Stanley Wai-Kwong Ng, Kolja Eppert, PhD, Rene Marke, Liran Slush, MD, James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Veronique Voisin, PhD, Gary Bader, PhD, Mark D. Minden, MD, PhD, Jun Lu, PhD, Jean C.Y. Wang, MD PhD, Luigi Naldini, John E. Dick, PhD

Blood (2013) 122 (21): 1647.

https://doi.org/10.1182/blood.V122.21.1647.1647

Published: 2013

Journal Articles

Functional and Phenotypic Characterization Of Acute Myeloid Leukemia By Analysis Of Diagnostic/Relapse Paired Samples

Jenny M. Ho, MD, Liran I. Shlush, MD, PhD, Amanda Mitchell, PhD, Rene Marke, Jessica McLeod, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD, PhD

Blood (2013) 122 (21): 2595.

https://doi.org/10.1182/blood.V122.21.2595.2595

Published: 2013

Journal Articles

Leukemic Engraftment In NOD. SCID Mice Is Correlated With Clinical Parameters and Predicts Outcome In Human AML

James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Jessica McLeod, Andreea C. Popescu, BSc, Andrea Arruda, MSc, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD

Blood (2013) 122 (21): 50.

https://doi.org/10.1182/blood.V122.21.50.50

Published: 2013

Journal Articles

DNMT3a Mutations Define a Pre-Leukemic Stem Cell Reservoir In Human Acute Myeloid Leukemia

Liran I. Shlush, MD, PhD, Sasan Zandi, PhD, MD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, McLeod Jessica, Monica Doedens, Medeiros Jessie, Marke Rene, McPherson J John, PhD, Thomas J Hudson, MD, Brown Andrew, PhD, Trinh M Quang, Lincoln D Stein, James A. Kennedy, MD PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD PhD, John E Dick, PhD

Blood (2013) 122 (21): 487.

https://doi.org/10.1182/blood.V122.21.487.487

Published: 2013

Journal Articles

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Blood (2011) 118 (21): 61.

https://doi.org/10.1182/blood.V118.21.61.61

Published: 2011

Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Blood (2011) 118 (21): 233.

https://doi.org/10.1182/blood.V118.21.233.233

Published: 2011

Journal Articles

Efficacy of SAR302503, a JAK2 Inhibitor, in the Treatment of a Primary Xenograft Model of Human Acute Myeloid Leukemia,

Weihsu Claire Chen, PhD, Andreea C. Popescu, Yan Xing, PhD, Gitte Gerhard, Julie S. Yuan, PhD, Mark D. Minden, MD, PhD, Cynthia Guidos, PhD, Donna E. Hogge, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD

Blood (2011) 118 (21): 3624.

https://doi.org/10.1182/blood.V118.21.3624.3624

Published: 2011

Journal Articles

Histone H3 Methylation Mediates All- Trans -Retinoic Acid Responsiveness in Acute Myeloid Leukemia

Tino Schenk, PhD, Stefanie Göllner, PhD, Weihsu Claire Chen, PhD, Louise Howell, BSc, Liqing Jin, MD, Katja Hebestreit, Hans-Ulrich Klein, PhD, Alan K Burnett, MD, Ken I. Mills, PhD, FRCPath, Laurence Marton, MD, Robert Casero, Jr., PhD, Patrick Woster, PhD, Martin Dugas, MD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Carsten Müller-Tidow, MD, Kevin Petrie, PhD, Arthur Zelent, PhD

Blood (2011) 118 (21): 224.

https://doi.org/10.1182/blood.V118.21.224.224

Published: 2011

Journal Articles

Acute Myeloid Leukemia Stem Cells Escape Innate Immune Surveillance by Macrophages through Interaction with SIRPα

Alexandre P.A. Theocharides, MD, Liqing Jin, MD, Po-Yan Cheng, Armando G. Poeppl, Tatiana K. Prasolava, PhD, Mark D. Minden, MD, PhD, John E. Dick, PhD, Jayne S. Danska, PhD, Jean C.Y. Wang, MD, PhD

Blood (2010) 116 (21): 499.

https://doi.org/10.1182/blood.V116.21.499.499

Published: 2010

NARROW

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML

A Stemness-Based Screen Identifies PLK1 Inhibitors for Targeting Leukemia Stem Cells in AML

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Identification of Compounds That Target Acute Myeloid Leukemia Stem Cells Using a Scalable Next-Generation Screening Platform

A Novel Predictor of Response to Gemtuzumab Ozogamicin Therapy in AML Provides Strategies for Sensitization of Leukemia Stem Cells in Individual Patients

Isolation of CD34 − and CD34 + Leukemia Stem Cells from Acute Myeloid Leukemia Blasts Using CD200

Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells

CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

Blockade Of CD47 Using SIRPαFc: Role Of The Fc Region In Anti-Leukemic Activity and Tolerability

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Functional and Phenotypic Characterization Of Acute Myeloid Leukemia By Analysis Of Diagnostic/Relapse Paired Samples

Leukemic Engraftment In NOD. SCID Mice Is Correlated With Clinical Parameters and Predicts Outcome In Human AML

DNMT3a Mutations Define a Pre-Leukemic Stem Cell Reservoir In Human Acute Myeloid Leukemia

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Efficacy of SAR302503, a JAK2 Inhibitor, in the Treatment of a Primary Xenograft Model of Human Acute Myeloid Leukemia,

Histone H3 Methylation Mediates All- Trans -Retinoic Acid Responsiveness in Acute Myeloid Leukemia

Acute Myeloid Leukemia Stem Cells Escape Innate Immune Surveillance by Macrophages through Interaction with SIRPα

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American Society of Hematology

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ASH Publications

American Society of Hematology

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