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Journal Articles

Wild-Type Calreticulin Downmodulates MPL and Impacts HSC Self-Renewal

Kiana K. Guillermo, Stefan Brooks, Lucas Wadley, Jianhong C Heidmann, Helen Huang, Jane Chen, Aanya Amin, Anaya Qamar, Brianna Hoover, Gajalakshmi Ramanathan, Angela G. Fleischman
Journal: Blood
Blood (2023) 142 (Supplement 1): 1782.
https://doi.org/10.1182/blood-2023-189705
Published: 2023
Journal Articles

Epor Stimulates Rapid Cycling and Larger Red Cells during Mouse and Human Erythropoiesis

Daniel Hidalgo, Jacob Bejder, Ramona Pop, Kyle Gellatly, Yung Hwang, S. Maxwell Scalf, Anna Eastman, Jane-Jane Chen, Lihua Julie Zhu, Jules Heuberger, Shangqin Guo, Mark J. Koury, Nikolai Baastrup Nordsborg, Merav Socolovsky
Journal: Blood
Blood (2021) 138 (Supplement 1): 852.
https://doi.org/10.1182/blood-2021-154403
Published: 2021
Journal Articles

HRI stress signaling and HbF production

Jane-Jane Chen
Journal: Blood
Blood (2020) 135 (24): 2113–2114.
https://doi.org/10.1182/blood.2020006300
Published: 2020
Journal Articles

Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

Jane-Jane Chen, Shuping Zhang
Journal: Blood
Blood (2019) 134 (20): 1697–1707.
https://doi.org/10.1182/blood.2019001915
Published: 2019
Journal Articles

Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1

Sarah Rio, Marc Gastou, Narjesse Karboul, Raphaёl Derman, Thunwarat Suriyun, Hana Manceau, Thierry Leblanc, Jamel El Benna, Caroline Schmitt, Slim Azouzi, Jérome Larghéro, Zoubida Karim, Alejandra Macias-Garcia, Jane-Jane Chen, Olivier Hermine, Geneviève Courtois, Hervé Puy, Laurent Gouya, Narla Mohandas, Lydie Da Costa
Journal: Blood
Blood (2019) 133 (12): 1358–1370.
https://doi.org/10.1182/blood-2018-09-875674
Published: 2019
Includes: Supplemental data
Journal Articles

Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation

Anindita Basak, PhD, Mathias Munschauer, PhD, Jacob C. Ulirsch, BS, Kara E. Montbleau, Christina R. Hartigan, BS, Monica Schenone, PhD, John Lian, PhD, Yaomei Wang, Yumin Huang, Xianfang Wu, Lee Gehrke, Charles M. Rice, Xiuli An, MD PhD, Helen A. Christou, Mohandas Narla, DSc, Steven A. Carr, PhD, Stuart H. Orkin, MD, Jane-Jane Chen, PhD, Eric S. Lander, Vijay G. Sankaran, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 412.
https://doi.org/10.1182/blood-2018-99-117440
Published: 2018
Journal Articles

HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency

Shuping Zhang, Alejandra Macias-Garcia, Jason Velazquez, Elena Paltrinieri, Randal J. Kaufman, Jane-Jane Chen
Journal: Blood
Blood (2018) 131 (4): 450–461.
https://doi.org/10.1182/blood-2017-08-799908
Published: 2018
Includes: Supplemental data
Journal Articles

Heme-Regulated eIF2α Kinase Coordinates Translational Repression of eIF2αP and mTORC1 Signaling during Iron Deficiency to Mitigate Ineffective Erythropoiesis

Shuping Zhang, PhD, Alejandra Macias-Garcia, PhD, Jason Velazquez, BS, Jane-Jane Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 1037.
https://doi.org/10.1182/blood.V128.22.1037.1037
Published: 2016
Journal Articles

Stress-enhanced translation of γ-globin mRNA

Jane-Jane Chen
Journal: Blood
Blood (2014) 124 (17): 2622–2623.
https://doi.org/10.1182/blood-2014-09-599290
Published: 2014
Journal Articles

Stressing HbF synthesis: role of translation?

Jane-Jane Chen, Susan Perrine
Journal: Blood
Blood (2013) 122 (4): 467–468.
https://doi.org/10.1182/blood-2013-06-506139
Published: 2013
Journal Articles

Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

Rajasekhar N. V. S. Suragani, Roshini S. Zachariah, Jason G. Velazquez, Sijin Liu, Chiao-Wang Sun, Tim M. Townes, Jane-Jane Chen
Journal: Blood
Blood (2012) 119 (22): 5276–5284.
https://doi.org/10.1182/blood-2011-10-388132
Published: 2012
Includes: Supplemental data
Journal Articles

Heme-Regulated eIF2α Kinase in Erythropoiesis and Oxidative Stress

Jane-Jane Chen, PhD
Journal: Blood
Blood (2011) 118 (21): SCI-23.
https://doi.org/10.1182/blood.V118.21.SCI-23.SCI-23
Published: 2011
Journal Articles

Oxidative Stress Signaling Pathway of Heme Regulated eIF2α Kinase in mitigating the Severity of β-Thalassemia

Rajasekhar NVS Suragani, Sijin Liu, Wanting Zhao, Jane-Jane Chen, PhD
Journal: Blood
Blood (2008) 112 (11): 127.
https://doi.org/10.1182/blood.V112.11.127.127
Published: 2008
Journal Articles

Regulation of protein synthesis by the heme-regulated eIF2α kinase: relevance to anemias

Jane-Jane Chen
Journal: Blood
Blood (2006) 109 (7): 2693–2699.
https://doi.org/10.1182/blood-2006-08-041830
Published: 2006
Journal Articles

HRI Protects Erythroid Precursors in Iron Deficiency and in β-Thalassemia by Maintaining GATA-1 and Fog-1 Expressions.

Sijin Liu, PhD, Anping Han, Ph.D, Rajasekhar Suragani, Ph.D, Jane-Jane Chen, Ph.D
Journal: Blood
Blood (2006) 108 (11): 266.
https://doi.org/10.1182/blood.V108.11.266.266
Published: 2006
Journal Articles

Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2α kinase

John S. Crosby, Peter J. Chefalo, Irene Yeh, Shong Ying, Irving M. London, Philippe Leboulch, Jane-Jane Chen
Journal: Blood
Blood (2000) 96 (9): 3241–3248.
https://doi.org/10.1182/blood.V96.9.3241
Published: 2000