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Journal Articles

Brigatinib Monotherapy in Children with R/R ALK+ ALCL, IMT, or Other Solid Tumors: Updated Results from the Brigaped (ITCC-098) Phase 1 Dose-Escalation Study

Blood (2024) 144 (Supplement 1): 3108.

https://doi.org/10.1182/blood-2024-200077

Published: 2024

Journal Articles

Chronic-Phase Chronic Myeloid Leukemia Times to Death By Disease Support Tyrosine Kinase Inhibitor Dose Reductions When BCR::ABL1 Level Is <1% and Decreasing

Tomas Radivoyevitch, Brian J. Druker, Jerry Radich, Hagop Kantarjian, Wenlong Tang, Michael J. Hanley, Mingxi M. Song, Timothy Smith, Dean Bottino

Blood (2022) 140 (Supplement 1): 6793–6795.

https://doi.org/10.1182/blood-2022-159194

Published: 2022

Journal Articles

Phase I Study to Improve Anti-Viral Immunity after Cord Blood Transplantation Using Cord-Blood-Derived Multi-Virus-Specific T-Cells

Shweta Bansil, Cecilia Motta, Rachel Dicioccio, Samuel O'Brien, Haili Lang, Michael Keller, Allistair Abraham, David Jacobsohn, Blachy J Davila Saldana, Amanda L. Olson, Elizabeth J Shpall, Indreshpal Kaur, Patrick J Hanley, Catherine M Bollard

Blood (2022) 140 (Supplement 1): 10239–10240.

https://doi.org/10.1182/blood-2022-167874

Published: 2022

Journal Articles

Phase I Study Evaluating Outcomes of Autologous HIV-Specific T Cells Targeting Non-Escaped Epitopes (HST-NEET) Therapy in HIV+ Individuals on ART (NCT03485963)

Danielle K. Sohai, Michael Keller, Patrick J. Hanley, Anushree Datar, Emily Reynolds, Dennis Copertino, Chase McCann, Haili Lang, Cecilia Motta, Andrew Wilson, Rebecca Lynch, Winiffer Conce Alberto, Zabrina L. Brumme, Natalie N. Kinloch, Conrad Russell Y. Cruz, Lynsay MacLaren Ehui, Sarah Henn, R. Brad Jones, Catherine M Bollard

Blood (2022) 140 (Supplement 1): 7498–7499.

https://doi.org/10.1182/blood-2022-165775

Published: 2022

Journal Articles

SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein

Blood (2020) 136 (25): 2905–2917.

https://doi.org/10.1182/blood.2020008488

Published: 2020

Includes: Supplemental data

Journal Articles

A Phase 1/2 Study to Evaluate the Safety and Efficacy of Ponatinib with Chemotherapy in Pediatric Patients with Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)

Yousif Matloub, MD, Lia Gore, MD, Mignon L. Loh, MD, Chin-Hon Pui, MD, Michael J. Hanley, PharmD, PhD, Vickie Lu, PhD, E. Jane Leonard, MSc, Muriel Granier, Andrea Biondi, MD, Lewis B. Silverman, MD

Blood (2020) 136 (Supplement 1): 47.

https://doi.org/10.1182/blood-2020-134724

Published: 2020

Journal Articles

EBV/LMP-specific T cells maintain remissions of T- and B-cell EBV lymphomas after allogeneic bone marrow transplantation

Lauren P. McLaughlin, Rayne Rouce, Stephen Gottschalk, Vicky Torrano, George Carrum, Meng-Fen Wu, Fahmida Hoq, Bambi Grilley, Andrea M. Marcogliese, Patrick J. Hanley, Adrian P. Gee, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Catherine M. Bollard

Blood (2018) 132 (22): 2351–2361.

https://doi.org/10.1182/blood-2018-07-863654

Published: 2018

Journal Articles

Phase 1/1b Pharmacokinetic (PK) and Safety Study of the Investigational Oral Proteasome Inhibitor (PI) Ixazomib in Relapsed/Refractory Multiple Myeloma (RRMM) Patients (Pts) with Severe Renal Impairment or End-Stage Renal Disease (ESRD) Requiring Hemodialysis

Neeraj Gupta, PhD, Michael J Hanley, PhD, R. Donald Harvey, PharmD, Ashraf Z Badros, MD, Brea C. Lipe, MD, Vishal Kukreti, Jesus G. Berdeja, MD, Huyuan Yang, PhD, Ai-Min Hui, MD PhD, Xiaoquan Zhang, MD PhD, Karthik Venkatakrishnan, PhD, Ajai Chari, MD

Blood (2015) 126 (23): 4227.

https://doi.org/10.1182/blood.V126.23.4227.4227

Published: 2015

Journal Articles

A Phase 1 Study to Assess Pharmacokinetics (PK) and Safety of Ixazomib, an Oral Proteasome Inhibitor, in Patients with Moderate or Severe Hepatic Impairment

Neeraj Gupta, PhD, Michael J Hanley, PhD, Karthik Venkatakrishnan, PhD, Raymond Perez, MD, Robin E Norris, MD, John Nemunaitis, MD, Huyuan Yang, PhD, Gerald Falchook, MD, Richard Labotka, MD MS, Siqing Fu, MD PhD

Blood (2015) 126 (23): 3032.

https://doi.org/10.1182/blood.V126.23.3032.3032

Published: 2015

Journal Articles

A Novel Standardized Quantitative Suppression Assay Reveals a Diversity of Human Immune-Regulatory Cell Potency

Samantha Miner, Nancy F. Hensel, Bahey Salem, Neil Dunavin, MD, Kazushi Tanimoto, MD, Minoo Battiwalla, MD MS, Kit Lu, MD, Keyvan Keyvanfar, BS, Marianna Sabatino, David Stroncek, Patrick J Hanley, PhD, Catherine M. Bollard, MBChB, MD, Katayoun Rezvani, MD, PhD, Marcin Kortylewski, PhD, Pawel Muranski, MD, John Barrett, MD, Sawa Ito, MD

Blood (2014) 124 (21): 316.

https://doi.org/10.1182/blood.V124.21.316.316

Published: 2014

Journal Articles

Graft Versus Leukemia Response without Graft Versus Host Disease Elicited By Adoptively Transferred Multivirus-Specific T-Cells

Paul A. Castillo, MD, Jan J Melenhorst, PhD, Patrick J Hanley, PhD, Michael Keller, MD, Robert A. Krance, MD, Judith Margolin, MD, Ann Leen, PhD, Helen E. Heslop, MD, John Barrett, MD, Cliona M Rooney, PhD, Catherine M. Bollard, MD FRACP, FRCPA

Blood (2014) 124 (21): 2439.

https://doi.org/10.1182/blood.V124.21.2439.2439

Published: 2014

Journal Articles

Improving Immune Reconstitution After Cord Blood Transplantation Using Ex Vivo Expanded Virus-Specific T Cells: A Phase I Clinical Study

Patrick J Hanley, PhD, Caridad Martinez, MD, Kathryn Leung, MD, Barbara Savoldo, MD, PhD, Gianpietro Dotti, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Cliona M. Rooney, PhD, Helen E. Heslop, MD, Robert A. Krance, MD, Elizabeth J Shpall, MD, Catherine M. Bollard, MD, FRACP, FRCPA

Blood (2012) 120 (21): 224.

https://doi.org/10.1182/blood.V120.21.224.224

Published: 2012

Journal Articles

Clinical-Scale Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells to Treat Patients After Ischemic Stroke.

Patrick J Hanley, PhD, Zhuyong Mei, MD, Bing Yang, MD, Osman Mir, MD, Kaushik Parsha, MD, April Durett, R. Brent Rice, PhD, Maria G Cabreira-Hansen, PhD, Sean I Savitz, MD, Adrian P. Gee, PhD

Blood (2012) 120 (21): 3021.

https://doi.org/10.1182/blood.V120.21.3021.3021

Published: 2012

Journal Articles

Naïve T Cell-Derived CTL Recognize Atypical Epitopes of CMVpp65 with Higher Avidity Than CMV-Seropositive Donor-Derived CTL – a Basis for Treatment of Post-Transplant Viral Infection by Adoptive Transfer of T Cells From Virus-naïve Donors

Patrick J Hanley, Ph.D, J. Joseph Melenhorst, PhD, Phillip Scheinberg, MD, Gail J Demmler-Harrison, MD, Daniele Lilleri, MD, Giuseppe Gerna, MD, Helen E. Heslop, MD, Cliona M. Rooney, PhD, A. John Barrett, MD, FRCP, Elizabeth J Shpall, MD, Catherine M. Bollard, MD

Blood (2011) 118 (21): 3002.

https://doi.org/10.1182/blood.V118.21.3002.3002

Published: 2011

Journal Articles

Phase I Study to Improve Virus-Specific Immune Reconstitution After Cord Blood Transplantation Using Cord Blood-Derived Virus-Specific Cytotoxic T Lymphocytes

Patrick J Hanley, Ph.D, Caridad Martinez, MD, Kathryn Leung, MD, Barbara Savaldo, MD, Ph.D, Gianpietro Dotti, MD, Adrian P. Gee, PhD, Cliona M. Rooney, PhD, Helen E. Heslop, MD, Robert A. Krance, MD, Elizabeth J Shpall, MD, Catherine M. Bollard, MD

Blood (2011) 118 (21): 155.

https://doi.org/10.1182/blood.V118.21.155.155

Published: 2011

Journal Articles

Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

Kenneth P. Micklethwaite, Barbara Savoldo, Patrick J. Hanley, Ann M. Leen, Gail J. Demmler-Harrison, Laurence J. N. Cooper, Hao Liu, Adrian P. Gee, Elizabeth J. Shpall, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner, Catherine M. Bollard, Gianpietro Dotti

Blood (2010) 115 (13): 2695–2703.

https://doi.org/10.1182/blood-2009-09-242263

Published: 2010

Includes: Supplemental data

Journal Articles

Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation

Ann M. Leen, Anne Christin, Gary D. Myers, Hao Liu, Conrad R. Cruz, Patrick J. Hanley, Alana A. Kennedy-Nasser, Kathryn S. Leung, Adrian P. Gee, Robert A. Krance, Malcolm K. Brenner, Helen E. Heslop, Cliona M. Rooney, Catherine M. Bollard

Blood (2009) 114 (19): 4283–4292.

https://doi.org/10.1182/blood-2009-07-232454

Published: 2009

Journal Articles

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

Patrick J. Hanley, Conrad Russell Young Cruz, Barbara Savoldo, Ann M. Leen, Maja Stanojevic, Mariam Khalil, William Decker, Jeffrey J. Molldrem, Hao Liu, Adrian P. Gee, Cliona M. Rooney, Helen E. Heslop, Gianpietro Dotti, Malcolm K. Brenner, Elizabeth J. Shpall, Catherine M. Bollard

Blood (2009) 114 (9): 1958–1967.

https://doi.org/10.1182/blood-2009-03-213256

Published: 2009

Journal Articles

Prospective Analysis of Bruising in Children with and without an Inherited Bleeding Disorder.

M. Hamilton, B. Jenkins, F. Dunstan, A. Kemp, R. Liesner, E. Chalmers, J. Hanley, A. Jungmann, A. Thomas, P. Collins

Blood (2006) 108 (11): 1024.

https://doi.org/10.1182/blood.V108.11.1024.1024

Published: 2006

Journal Articles

UKHCDO Acquired Haemophilia Study: A Complete National Cohort.

P. Collins, T. Baglin, S. Brown, G. Dolan, J. Hanley, D. Keeling, R. Liesner, M. Makris, C. Hay, on Behalf of UKHCDO

Blood (2005) 106 (11): 322.

https://doi.org/10.1182/blood.V106.11.322.322

Published: 2005

NARROW

Brigatinib Monotherapy in Children with R/R ALK+ ALCL, IMT, or Other Solid Tumors: Updated Results from the Brigaped (ITCC-098) Phase 1 Dose-Escalation Study

Chronic-Phase Chronic Myeloid Leukemia Times to Death By Disease Support Tyrosine Kinase Inhibitor Dose Reductions When BCR::ABL1 Level Is <1% and Decreasing

Phase I Study to Improve Anti-Viral Immunity after Cord Blood Transplantation Using Cord-Blood-Derived Multi-Virus-Specific T-Cells

Phase I Study Evaluating Outcomes of Autologous HIV-Specific T Cells Targeting Non-Escaped Epitopes (HST-NEET) Therapy in HIV+ Individuals on ART (NCT03485963)

SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein

A Phase 1/2 Study to Evaluate the Safety and Efficacy of Ponatinib with Chemotherapy in Pediatric Patients with Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)

EBV/LMP-specific T cells maintain remissions of T- and B-cell EBV lymphomas after allogeneic bone marrow transplantation

Phase 1/1b Pharmacokinetic (PK) and Safety Study of the Investigational Oral Proteasome Inhibitor (PI) Ixazomib in Relapsed/Refractory Multiple Myeloma (RRMM) Patients (Pts) with Severe Renal Impairment or End-Stage Renal Disease (ESRD) Requiring Hemodialysis

A Phase 1 Study to Assess Pharmacokinetics (PK) and Safety of Ixazomib, an Oral Proteasome Inhibitor, in Patients with Moderate or Severe Hepatic Impairment

A Novel Standardized Quantitative Suppression Assay Reveals a Diversity of Human Immune-Regulatory Cell Potency

Graft Versus Leukemia Response without Graft Versus Host Disease Elicited By Adoptively Transferred Multivirus-Specific T-Cells

Improving Immune Reconstitution After Cord Blood Transplantation Using Ex Vivo Expanded Virus-Specific T Cells: A Phase I Clinical Study

Clinical-Scale Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells to Treat Patients After Ischemic Stroke.

Naïve T Cell-Derived CTL Recognize Atypical Epitopes of CMVpp65 with Higher Avidity Than CMV-Seropositive Donor-Derived CTL – a Basis for Treatment of Post-Transplant Viral Infection by Adoptive Transfer of T Cells From Virus-naïve Donors

Phase I Study to Improve Virus-Specific Immune Reconstitution After Cord Blood Transplantation Using Cord Blood-Derived Virus-Specific Cytotoxic T Lymphocytes

Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

Prospective Analysis of Bruising in Children with and without an Inherited Bleeding Disorder.

UKHCDO Acquired Haemophilia Study: A Complete National Cohort.

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American Society of Hematology

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