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Journal Articles

DOCK1 Expression Enhances the Activity of the Notch Signaling Pathway and Promotes the Proliferation and Survival of Acute Myeloid Leukemia Cells

Ming-En Lin, Yueh-Chwen Hsu, Hsueh-Ling Chiu, Chi-Yuan Yao, Chia-Hua Liu, Chein-Jun Kao, Chang-I Li, Chang-Tsu Yuan, Yi-Tsung Yang, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien
Journal: Blood
Blood (2024) 144 (Supplement 1): 6148.
https://doi.org/10.1182/blood-2024-209830
Published: 2024
Journal Articles

Longitudinal Molecular Profiling in Patients with IDH1 -Mutant Newly Diagnosed Acute Myeloid Leukemia Treated with Ivosidenib

Sung Choe, PhD, Hongfang Wang, PhD, Gail J. Roboz, MD, Courtney D. DiNardo, MD MSCE, Eytan M. Stein, MD, Alice S. Mims, MD, Gabrielle T. Prince, MD, Justin M. Watts, MD, Bin Fan, PhD, Parham Nejad, BSc, Vickie Zhang, PhD, Hua Liu, PhD, Eyal C. Attar, MD, Bin Wu, PhD, Richard M. Stone, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-136589
Published: 2020
Journal Articles

Ivosidenib Improves Overall Survival Relative to Standard Therapies in Relapsed or Refractory Mutant IDH1 AML: Results from Matched Comparisons to Historical Controls

Peter Paschka, MD, Hervé Dombret, MD, Xavier Thomas, MD PhD, Christian Recher, MD PhD, Sylvain Chantepie, MD, Pau Montesinos Fernandez, MD PhD, Evelyn Acuña-Cruz, MD, Paresh Vyas, MRCP, FRCP, FRCPath, Karl-Anton Kreuzer, MD, Michael Heuser, Klaus H. Metzeler, MD, Michael Dennis, MD, Bruno Quesnel, MD PhD, Mathilde Hunault-Berger, MDPhD, Mohamad Mohty, MD PhD, Arnaud Pigneux, MD PhD, Stephane De Botton, Daniela Weber, MSc, Konstanze Döhner, Gary Milkovich, PharmD, John Reitan, PharmD, Sarah C MacDonald, SD, Deborah Casso, MPH, Michael Storm, MSc, Hua Liu, PhD, Stephanie M. Kapsalis, BS, Eyal C. Attar, MD, Thomas Winkler, MD, Hartmut Döhner, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-136957
Published: 2020
Journal Articles

Waldenström's Macroglobulinaemia in the Modern Era: Real World Outcomes and Prognostication across 35 Chinese Academic Hospitals

Xin-xin Cao, MD, Shuhua Yi, MD, Zhongxing Jiang, MD, Jingsong He, MD, Wei Yang, Juan Du, Jr., MD, Chunyan Sun, MD PhD, Yu Wu, MD, Chen Wenming, MD, Xiao-jun Liu, Bingzong Li, MDPhD, Chunrui Li, MDPhD, Wei Sang, Qin-hua Liu, Xiaoxia Chu, Li Fei, Ou Bai, Min Mao, Rong Fu, PhD, Wei WANG, MD, Lihong Liu, MD, Luqun Wang, MDPhD, Yujun Dong, MD, Jun Luo, DO, Zhenling Li, Yongqiang Wei, Qi-ke Zhang, Jing Liu, Kaiyang Ding, Liang Zou, Bi-yun Chen, Luoming Hua, PhD, Hongmei Jing, Juan He, PhD, Liang Wang, Lugui Qiu, MD, Jian Li, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-134785
Published: 2020
Journal Articles

Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1 -mutant acute myeloid leukemia

Clinical Trials & Observations
Gail J. Roboz, Courtney D. DiNardo, Eytan M. Stein, Stéphane de Botton, Alice S. Mims, Gabrielle T. Prince, Jessica K. Altman, Martha L. Arellano, Will Donnellan, Harry P. Erba, Gabriel N. Mannis, Daniel A. Pollyea, Anthony S. Stein, Geoffrey L. Uy, Justin M. Watts, Amir T. Fathi, Hagop M. Kantarjian, Martin S. Tallman, Sung Choe, David Dai, Bin Fan, Hongfang Wang, Vickie Zhang, Katharine E. Yen, Stephanie M. Kapsalis, Denice Hickman, Hua Liu, Samuel V. Agresta, Bin Wu, Eyal C. Attar, Richard M. Stone
Journal: Blood
Blood (2020) 135 (7): 463–471.
https://doi.org/10.1182/blood.2019002140
Published: 2020
Includes: Supplemental data
Journal Articles

Complex Polyclonal Resistance Mechanisms to Ivosidenib Monotherapy in IDH1 -Mutant Relapsed or Refractory Acute Myeloid Leukemia Revealed By Single Cell Sequencing Analyses

Hongfang Wang, PhD, Sung Choe, PhD, Courtney D. DiNardo, MD MSc, Eytan M. Stein, MD, Stéphane de Botton, MD PhD, Amir T. Fathi, MD, Martin S. Tallman, MD, Hagop M. Kantarjian, MD, Richard M. Stone, MD, Lynn Quek, MD PhD, Vickie Zhang, PhD, Hua Liu, PhD, Eyal C. Attar, MD, Bin Wu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 541.
https://doi.org/10.1182/blood-2019-122703
Published: 2019
Journal Articles

Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1 -Mutant Relapsed or Refractory Acute Myeloid Leukemia

Sung Choe, PhD, Hongfang Wang, PhD, Courtney D. DiNardo, MD MSc, Eytan M. Stein, MD, Stephane De Botton, Amir T. Fathi, MD, Martin S. Tallman, MD, Hagop M. Kantarjian, MD, Richard M. Stone, MD, Lynn Quek, MD PhD, Zenon Konteatis, PhD, Lenny Dang, PhD, Vickie Zhang, PhD, Hua Liu, PhD, Eyal C. Attar, MD, Bin Wu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 545.
https://doi.org/10.1182/blood-2019-122671
Published: 2019
Journal Articles

Ivosidenib (AG-120) in Patients with IDH1 -Mutant Relapsed/Refractory Myelodysplastic Syndrome: Updated Enrollment of a Phase 1 Dose Escalation and Expansion Study

James M. Foran, MD, Courtney D. DiNardo, MDMSc, Justin M. Watts, MD, Eytan M. Stein, MD, Stephane De Botton, Amir T. Fathi, MD, Gabrielle T. Prince, MD, Anthony Stein, MD, Richard M. Stone, MD, Prapti A. Patel, MD, Martin S. Tallman, MD, Sung Choe, PhD, Hongfang Wang, PhD, Vickie Zhang, PhD, Bin Fan, PhD, Katharine E. Yen, PhD, Abdulafeez Oluyadi, PharmD, Thomas Winkler, MD, Denice Hickman, BSN, Samuel V. Agresta, MD, Hua Liu, PhD, Bin Wu, PhD, Eyal C. Attar, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4254.
https://doi.org/10.1182/blood-2019-123946
Published: 2019
Journal Articles

Population Pharmacokinetics of Ivosidenib (AG-120) in Patients with IDH1-Mutant Advanced Hematologic Malignancies

Kha Le, PhD, Russ Wada, PhD, David Dai, PhD, Bin Fan, PhD, Guowen Liu, PhD, Hua Liu, PhD, Eyal C. Attar, MD, Samuel V. Agresta, MD, Hua Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1394.
https://doi.org/10.1182/blood-2018-99-109863
Published: 2018
Journal Articles

Ivosidenib (AG-120) Induced Durable Remissions and Transfusion Independence in Patients with IDH1-Mutant Untreated AML: Results from a Phase 1 Dose Escalation and Expansion Study

Gail J. Roboz, MD, Courtney D. DiNardo, MDMSc, Eytan M. Stein, MD, Stephane de Botton, MD PhD, Alice S. Mims, MD, Gabrielle T. Prince, MD, Jessica K. Altman, MD, Martha L. Arellano, MD, William B. Donnellan, MD, Harry P. Erba, MD PhD, Gabriel N. Mannis, MD, Daniel A Pollyea, MD, Anthony S. Stein, MD, Geoffrey L. Uy, MD, Justin M. Watts, MD, Amir T. Fathi, MD, Hagop M. Kantarjian, MD, Martin S. Tallman, MD, Sung Choe, PhD, David Dai, PhD, Bin Fan, PhD, Hongfang Wang, PhD, Vickie Zhang, PhD, Katharine E. Yen, PhD, Stephanie M. Kapsalis, OTR, Denice Hickman, RN, Hua Liu, PhD, Samuel V. Agresta, MD, Bin Wu, PhD, Eyal C. Attar, MD, Richard M. Stone, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 561.
https://doi.org/10.1182/blood-2018-99-110595
Published: 2018
Journal Articles

Ivosidenib (AG-120) Induced Durable Remissions and Transfusion Independence in Patients with IDH1-Mutant Relapsed or Refractory Myelodysplastic Syndrome: Results from a Phase 1 Dose Escalation and Expansion Study

Courtney D. DiNardo, MDMSc, Justin M. Watts, MD, Eytan M. Stein, MD, Stephane de Botton, MD PhD, Amir T. Fathi, MD, Gabrielle T. Prince, MD, Anthony S. Stein, MD, James M. Foran, MD, Richard M. Stone, MD, Prapti A. Patel, MD, Martin S. Tallman, MD, Sung Choe, PhD, Hongfang Wang, PhD, Vickie Zhang, PhD, David Dai, PhD, Bin Fan, PhD, Katharine E. Yen, PhD, Stephanie M. Kapsalis, OTR, Denice Hickman, RN, Samuel V. Agresta, MD, Hua Liu, PhD, Bin Wu, PhD, Eyal C. Attar, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1812.
https://doi.org/10.1182/blood-2018-99-111264
Published: 2018
Journal Articles

Ivosidenib (AG-120) in Mutant IDH1 AML and Advanced Hematologic Malignancies: Results of a Phase 1 Dose Escalation and Expansion Study

Courtney D. DiNardo, MDMSc, Stephane De Botton, Eytan M. Stein, MD, Gail J. Roboz, MD, Alice S. Mims, MD MSCR, Daniel A. Pollyea, MD, Ronan T. Swords, MD PhD FRCPI, FRCPath, Jessica K. Altman, MD, Robert H. Collins, MD, Gabriel N. Mannis, MD, Geoffrey L. Uy, MD, Will Donnellan, MD, Arnaud Pigneux, MD PhD, Amir T. Fathi, MD MD BS, Anthony S. Stein, MD, Harry P. Erba, MD PhD, Gabrielle T. Prince, MD, James M. Foran, MD, Elie Traer, MD PhD, Robert K. Stuart, MD, Martha L. Arellano, MD, James L. Slack, MD, Mikkael A. Sekeres, MD MS, Katharine Yen, Stephanie M. Kapsalis, Hua Liu, Meredith Goldwasser, Sam Agresta, MD, Eyal C. Attar, MD, Martin S. Tallman, MD, Richard M. Stone, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 725.
https://doi.org/10.1182/blood.V130.Suppl_1.725.725
Published: 2017
Journal Articles

Determination of IDH1 Mutational Burden and Clearance Via Next-Generation Sequencing in Patients with IDH1 Mutation-Positive Hematologic Malignancies Receiving AG-120, a First-in-Class Inhibitor of Mutant IDH1

Courtney D DiNardo, MD, Stéphane de Botton, Eytan M Stein, Gail J. Roboz, Ronan T Swords, MD PhD FRCPI, FRCPath, Daniel A Pollyea, MD, Amir T. Fathi, MD, Robert Collins, Jessica K Altman, Ian W. Flinn, MD PhD, Gabriel N Mannis, Alice S. Mims, MD MSCR, James M. Foran, MD, Arnaud Pigneux, MD, Gabrielle T Prince, MD, Geoffrey L Uy, MD, Martin S. Tallman, MD, Hagop M. Kantarjian, MD, Hua Liu, Eyal C Attar, Jennifer Sacolick, Katharine Yen, Jonathan B Hurov, Sung Choe, Bin Wu, Richard M. Stone, MD
Journal: Blood
Blood (2016) 128 (22): 1070.
https://doi.org/10.1182/blood.V128.22.1070.1070
Published: 2016
Journal Articles

Longitudinal Pharmacokinetic/Pharmacodynamic Profile of AG-120, a Potent Inhibitor of the IDH1 Mutant Protein, in a Phase 1 Study of IDH1-Mutant Advanced Hematologic Malignancies

Bin Fan, PhD, Kha Le, PhD, Erika Manyak, BASc, Hua Liu, Malia Prahl, Chris J Bowden, Scott Biller, Sam Agresta, MD, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 1310.
https://doi.org/10.1182/blood.V126.23.1310.1310
Published: 2015
Journal Articles

First Multicenter, Randomized Phase 3 Study in Patients (Pts) with Relapsed/Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL): Alisertib (MLN8237) Versus Investigator's Choice (Lumiere trial; NCT01482962)

Owen A. O'Connor, MD PhD, Muhit Özcan, MD, Eric D. Jacobsen, MD, Josep Maria Roncero Vidal, MD, Judith Trotman, MBChB, Judit Demeter, MD PhD DsC, Tamás Masszi, MD, Juliana Pereira, MD PhD, Radhakrishnan Ramchandren, MD, Francesco A. d'Amore, MD PhD, Francine Foss, MD, Won-Seog Kim, MD PhD, John P. Leonard, MD, Carlos Sérgio Chiattone, MD PhD, Pier Luigi Zinzani, MD PhD, Hua Liu, PhD, JungAh Jung, PhD, Xiaofei Zhou, PhD, E. Jane Leonard, MSc, Claudio Dansky Ullmann, MD, Andrei R. Shustov, MD
Journal: Blood
Blood (2015) 126 (23): 341.
https://doi.org/10.1182/blood.V126.23.341.341
Published: 2015
Journal Articles

Exome Sequencing Identifies Somatic Mutations of DDX3X in Natural Killer/T-Cell Lymphoma

Lu Jiang, PhD, Zhao-Hui Gu, PhD, Zi-Xun Yan, PhD, Xia Zhao, MD, Yin-Yin Xie, PhD, Zi-Guan Zhang, B.S., Chun-Ming Pan, M.S., Yuan Hu, MD, Chang-Ping Cai, MD, Ying Dong, MD, Li Wang, MD, Yang Shen, MD, Guoyu Meng, PhD, Jian-Feng Zhou, MD, PhD, Jian-Da Hu, MD, PhD, Jin-Fen Wang, MD, Lin-Hua Yang, MD, Feng Zhang, MD, Jian-Min Wang, MD, Zhao Wang, MD, Zhi-Gang Peng, MD, Fang-Yuan Chen, MD, Zi-Min Sun, MD, Hao Ding, MD, Jin-Yan Huang, PhD, Yuan-Hua Liu, MD, Jumei Shi, MD, PhD, Jian Hou, MD, Jin-Song Yan, MD, PhD, Jing-Yi Shi, PhD, Lan Xu, PhD, Yang Li, MD, Jing Lu, B.S., Zhong Zheng, MD, Wen Xue, B.S., Wei-Li Zhao, MD, PhD, Zhu Chen, MD, PhD, Sai-Juan Chen, MD, PhD
Journal: Blood
Blood (2014) 124 (21): 1663.
https://doi.org/10.1182/blood.V124.21.1663.1663
Published: 2014
Journal Articles

Integrated Safety Analysis of Single-Agent MLN8237 (alisertib), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Hematologic Malignancies and Solid Tumors

Ely Benaim, MD, Xiaofei Zhou, PhD, Hua Liu, PhD, E. Jane Leonard, MSc, Eric Freedland, Liviu Niculescu
Journal: Blood
Blood (2012) 120 (21): 3683.
https://doi.org/10.1182/blood.V120.21.3683.3683
Published: 2012
Journal Articles

Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells

Brief Report
Su Mi Choi, Hua Liu, Pooja Chaudhari, Yonghak Kim, Linzhao Cheng, Jian Feng, Saul Sharkis, Zhaohui Ye, Yoon-Young Jang
Journal: Blood
Blood (2011) 118 (7): 1801–1805.
https://doi.org/10.1182/blood-2011-03-340620
Published: 2011
Includes: Supplemental data
Journal Articles

Phase I Study of An Investigational Aurora A Kinase Inhibitor MLN8237 In Patients with Advanced Hematologic Malignancies.

Swaminathan Padmanabhan, MBBS, MD, Thomas C. Shea, MD, Julie M. Vose, MD, Craig B. Reeder, MD, Jesus G Berdeja, MD, Kevin T. McDonagh, MD, Andre Goy, MD, Kevin R Kelly, MD, Xiaofei Zhou, PhD, Hua Liu, PhD, Howard Fingert, MD, Nathan Fowler, MD
Journal: Blood
Blood (2010) 116 (21): 2799.
https://doi.org/10.1182/blood.V116.21.2799.2799
Published: 2010
Journal Articles

The Development of Novel Hemostatic Bypassing Molecules.

Rodney M. Camire, PhD, Matthew Bunce, PhD, Lacramioara Ivanciu, PhD, Raffaella Toso, PhD, Harre D. Downey, Jian-Hua Liu, Valder R. Arruda, MD, PhD
Journal: Blood
Blood (2009) 114 (22): SCI-20.
https://doi.org/10.1182/blood.V114.22.SCI-20.SCI-20
Published: 2009