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Journal Articles

Bovine Herpes Virus Type 1 Oncolytic Therapy Elicits Direct Cytotoxic Effects and Immune Microenvironment Reshaping in Multiple Myeloma

Vincenzo Raimondi, Paola Storti, Rosanna Vescovini, Valentina Franceschi, Giulia Pozzi, Denise Toscani, Nicolas Thomas Iannozzi, Oxana Lungu, Anna Benedetta Dalla Palma, Laura Pelagatti, Federica Librale, Mattia Dessena, Stefania Ricci, Prisco Mirandola, Gaetano Donofrio, Nicola Giuliani

Blood (2024) 144 (Supplement 1): 4660.

https://doi.org/10.1182/blood-2024-200024

Published: 2024

Journal Articles

PYGO2-MDR1 Axis in Multiple Myeloma Patients with 1q21 Amplification As Promising Target to Overcome Carfilzomib Resistance

Nicolas Thomas Iannozzi, Jessica Burroughs Garcia, Valentina Marchica, Valentina Franceschi, Denise Toscani, Rosanna Vescovini, Vincenzo Raimondi, Oxana Lungu, Giannalisa Todaro, Gabriella Sammarelli, Matteo Scita, Federica Librale, Anna Benedetta Dalla Palma, Gaetano Donofrio, Paola Storti, Luca Agnelli, Giancarlo Pruneri, Nicola Giuliani

Blood (2023) 142 (Supplement 1): 6575.

https://doi.org/10.1182/blood-2023-181685

Published: 2023

Journal Articles

Identification of the Proteasome Subunits PSMB4 and PSMD4 As Novel Targets in Multiple Myeloma Patients Carrying 1q21 Amplification

Jessica Burroughs Garcia, Paola Storti, Nicolas Thomas Iannozzi, Laura Notarfranchi, Denise Toscani, Valentina Marchica, Vincenzo Raimondi, Luca Agnelli, Valentina Franceschi, Giannalisa Todaro, Oxana Lungu, Matia Bernardi, Matteo Scita, Gabriella Sammarelli, Gaetano Donofrio, Anna Benedetta Dalla Palma, Nicola Giuliani

Blood (2022) 140 (Supplement 1): 6750–6751.

https://doi.org/10.1182/blood-2022-165974

Published: 2022

Journal Articles

PSMB4 and PSMD4 Are Correlated with 1q21 Amplification in CD138 + Plasma Cells: New Potential Druggable Targets in Myeloma Patients

Jessica Burroughs-Garcia, Paola Storti, Luca Agnelli, Denise Toscani, Valentina Marchica, Gabriella Sammarelli, Giannalisa Todaro, Vincenzo Raimondi, Valentina Franceschi, Naomi Soressi, Anna Benedetta Dalla Palma, Laura Notarfranchi, Gaetano Donofrio, Nicola Giuliani

Blood (2021) 138 (Supplement 1): 2657.

https://doi.org/10.1182/blood-2021-150198

Published: 2021

Journal Articles

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

Denise Toscani, PhD, Martina Chiu, PhD, Giuseppe Taurino, MS, Emanuela Vicario, MS, Valentina Marchica, MS, Fabrizio Accardi, MD, Anna Benedetta Dalla Palma, MD, Paola Storti, PhD, Gaetano Donofrio, PhD, Franco Aversa, MD, Ovidio Bussolati, MD PhD, Nicola Giuliani, MD PhD

Blood (2018) 132 (Supplement 1): 4481.

https://doi.org/10.1182/blood-2018-99-111337

Published: 2018

Journal Articles

Oncolytic Virotherapy in Multiple Myeloma: A Possible Alternative Role of Bovine Viruses.

Valentina Marchica, Gaetano Donofrio, PhD, Rosanna Vescovini, PhD, Giulia Tebaldi, Alfonso Rosamilia, Daniela Guasco, Paola Storti, PhD, Marina Bolzoni, PhD, Federica Costa, Chiara Schifano, MSc, Sabrina Bonomini, MSc, Fabrizio Accardi, MD, Francesco Piazza, MD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2016) 128 (22): 2093.

https://doi.org/10.1182/blood.V128.22.2093.2093

Published: 2016

Journal Articles

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Blood (2016) 128 (5): 667–679.

https://doi.org/10.1182/blood-2016-01-690743

Published: 2016

Includes: Supplemental data

Journal Articles

Hypoxia-Inducible Factor (HIF)-1alpha Inhibitionin Myeloma Cells Significantly Increases the Anti-Myeloma Effect of Lenalidomide in Vivo

Paola Storti, PhD, Valentina Marchica, Denise Toscani, PhD, Irma Airoldi, PhD, Sophie Maiga, PhD, Marina Bolzoni, PhD, Nicoletta Campanini, Eugenia Martella, MD, Cristina Mancini, MD, Valentina Ferri, Gaetano Donofrio, PhD, Martine Amiot, PhD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2015) 126 (23): 3012.

https://doi.org/10.1182/blood.V126.23.3012.3012

Published: 2015

Journal Articles

Galectin-1 Is Highly Expressed By Myeloma Cells and the Bone Marrow Microenvironment and Its Suppression Delineates a New Therapeutic in Vitro and in Vivo Strategy in Multiple Myeloma

Paola Storti, PhD, Gaetano Donofrio, PhD, Valentina Marchica, Daniela Guasco, Katia Todoerti, PhD, Irma Airoldi, PhD, Judith Anderson, Marina Bolzoni, Valentina Ferri, Eugenia Martella, MD, Cristina Mancini, MD, Nicoletta Campanini, Antonino Neri, G. David Roodman, MD, PhD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2014) 124 (21): 3373.

https://doi.org/10.1182/blood.V124.21.3373.3373

Published: 2014

Journal Articles

Aurora and IKK kinases cooperatively interact to protect multiple myeloma cells from Apo2L/TRAIL

Laura Mazzera, Guerino Lombardi, Manuela Abeltino, Micaela Ricca, Gaetano Donofrio, Nicola Giuliani, Anna Maria Cantoni, Attilio Corradi, Antonio Bonati, Paolo Lunghi

Blood (2013) 122 (15): 2641–2653.

https://doi.org/10.1182/blood-2013-02-482356

Published: 2013

Includes: Supplemental data

Journal Articles

Hypoxia-Inducible Factor (HIF)-1a Is A Therapeutic Target in Myeloma-Induced Angiogenesis and Bone Destruction in Vivo .

Marina Bolzoni, Paola Storti, PhD, Gaetano Donofrio, PhD, Irma Airoldi, PhD, Daniela Guasco, Denise Toscani, Marco Peronaci, Eugenia Martella, MD, Mirca Lazzaretti, PhD, Luca Agnelli, PhD, Ken Patrene, Cristina Mancini, MD, Martine Amiot, PhD, Antonino Neri, Simona Colla, Judith Anderson, Franco Aversa, MD, G. David Roodman, MD, PhD, Nicola Giuliani

Blood (2012) 120 (21): 2947.

https://doi.org/10.1182/blood.V120.21.2947.2947

Published: 2012

Journal Articles

Hypoxia-Inducible Factor (HIF)-1α Is a Therapeutic Target in Myeloma-Induced Angiogenesis

Paola Storti, PhD, Irma Airoldi, PhD, Marina Bolzoni, Mirca Lazzaretti, PhD, Daniela Guasco, Luca Agnelli, PhD, Eugenia Martella, MD, Cristina Mancini, MD, Antonino Neri, MD, Gaetano Donofrio, PhD, Nicola Giuliani, M.D., Ph.D.

Blood (2011) 118 (21): 3927.

https://doi.org/10.1182/blood.V118.21.3927.3927

Published: 2011

Journal Articles

The Activation of Wnt5a-Mediated Non Canonical Wnt Signaling in Human Bone Marrow Osteoprogenitor Cells Increases Osteoblastogenesis and Counterbalances the Inhibitory Effect of Myeloma Cells on Ror2/FZD5 Expression,

Marina Bolzoni, Paola Storti, PhD, Daniela Guasco, Mirca Lazzaretti, PhD, Eugenia Martella, MD, Cristina Mancini, MD, Luca Agnelli, PhD, Sabrina Bonomini, Antonino Neri, MD, Gaetano Donofrio, PhD, Nicola Giuliani, M.D., Ph.D.

Blood (2011) 118 (21): 3928.

https://doi.org/10.1182/blood.V118.21.3928.3928

Published: 2011

Journal Articles

Myeloma Cells Inhibit the Non-Canonical Wnt Co-Receptor Ror2 in Human Mesenchymal/Osteoprogenitor Cells: Effect of Wnt5a/Ror2 Pathway Activation On MM-Induced Impairment of the Osteogenic Differentiation Process.

Marina Bolzoni, Simona Colla, Paola Storti, Gaetano Donofrio, Manuela Abeltino, Valentina Sgobba, Sabrina Bonomini, Vittorio Rizzoli, Nicola Giuliani

Blood (2009) 114 (22): 741.

https://doi.org/10.1182/blood.V114.22.741.741

Published: 2009

Journal Articles

Oxygen Tension in the Bone Marrow (BM) of Patients with Malignant and Indolent Monoclonal Gammopathy: Role of Hypoxia and Hypoxia-Inducible Factor (HIF)-1α in the Regulation of Gene Expression and Pro-Angiogenic Profiles of CD138 + Cells.

Nicola Giuliani, Simona Colla, Paola Storti, Valentina Sgobba, Katia Todoerti, Gaetano Donofrio, Marina Bolzoni, Manuela Abeltino, Mirca Lazzaretti, Sabrina Bonomini, Monica Crugnola, Antonino Neri, Vittorio Rizzoli

Blood (2009) 114 (22): 422.

https://doi.org/10.1182/blood.V114.22.422.422

Published: 2009

Journal Articles

HOXB7 Is Critically Involved in Multiple Myeloma-Induced Angiogenic Switch.

Paola Storti, Gaetano Donofrio, Marina Bolzoni, Simona Colla, Irma Airoldi, Valentina Sgobba, Manuela Abeltino, Katia Todoerti, Luca Agnelli, Mirca Lazzaretti, Cristina Mancini, Sabrina Bonomini, Domenico Ribatti, Vito Pistoia, Antonino Neri, Vittorio Rizzoli, Nicola Giuliani

Blood (2009) 114 (22): 125.

https://doi.org/10.1182/blood.V114.22.125.125

Published: 2009

Journal Articles

Hypoxia and Hypoxia Inducible Factor (HIF)-1α in Multiple Myeloma: Effect on the Pro-Angiogenic Signature of Myeloma Cells and the Bone Marrow Microenvironment.

Simona Colla, Paola Storti, Gaetano Donofrio, Mirca Lazzaretti, Sabrina Bonomini, Paolo Lunghi, Monica Crugnola, Marina Bolzoni, Luisa Galla, Luigi Ippolito, Eugenia Martella, Gabriella Sammarelli, Luisa Craviotto, Cecilia Caramatti, Marcellina Mangoni, Antonio Bonati, Vittorio Rizzoli, Nicola Giuliani

Blood (2008) 112 (11): 1687.

https://doi.org/10.1182/blood.V112.11.1687.1687

Published: 2008

Journal Articles

Activation of Non-Canonical Wnt Pathway in Human Mesenchymal Cells Affects Osteogenic Differentiation: A Potential Target in Multiple Myeloma Microenvironment

Nicola Giuliani, Simona Colla, Paola Storti, Gaetano Donofrio, Marina Bolzoni, Sabrina Bonomini, Luisa Galla, Gabriella Sammarelli, Marcellina Mangoni, Vittorio Rizzoli

Blood (2008) 112 (11): 2742.

https://doi.org/10.1182/blood.V112.11.2742.2742

Published: 2008

Journal Articles

The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 α (HIF-1α) activity: involvement in myeloma-induced angiogenesis

Blood (2007) 110 (13): 4464–4475.

https://doi.org/10.1182/blood-2007-02-074617

Published: 2007

NARROW

Bovine Herpes Virus Type 1 Oncolytic Therapy Elicits Direct Cytotoxic Effects and Immune Microenvironment Reshaping in Multiple Myeloma

PYGO2-MDR1 Axis in Multiple Myeloma Patients with 1q21 Amplification As Promising Target to Overcome Carfilzomib Resistance

Identification of the Proteasome Subunits PSMB4 and PSMD4 As Novel Targets in Multiple Myeloma Patients Carrying 1q21 Amplification

PSMB4 and PSMD4 Are Correlated with 1q21 Amplification in CD138 + Plasma Cells: New Potential Druggable Targets in Myeloma Patients

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

Oncolytic Virotherapy in Multiple Myeloma: A Possible Alternative Role of Bovine Viruses.

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Hypoxia-Inducible Factor (HIF)-1alpha Inhibitionin Myeloma Cells Significantly Increases the Anti-Myeloma Effect of Lenalidomide in Vivo

Galectin-1 Is Highly Expressed By Myeloma Cells and the Bone Marrow Microenvironment and Its Suppression Delineates a New Therapeutic in Vitro and in Vivo Strategy in Multiple Myeloma

Aurora and IKK kinases cooperatively interact to protect multiple myeloma cells from Apo2L/TRAIL

Hypoxia-Inducible Factor (HIF)-1a Is A Therapeutic Target in Myeloma-Induced Angiogenesis and Bone Destruction in Vivo .

Hypoxia-Inducible Factor (HIF)-1α Is a Therapeutic Target in Myeloma-Induced Angiogenesis

The Activation of Wnt5a-Mediated Non Canonical Wnt Signaling in Human Bone Marrow Osteoprogenitor Cells Increases Osteoblastogenesis and Counterbalances the Inhibitory Effect of Myeloma Cells on Ror2/FZD5 Expression,

Myeloma Cells Inhibit the Non-Canonical Wnt Co-Receptor Ror2 in Human Mesenchymal/Osteoprogenitor Cells: Effect of Wnt5a/Ror2 Pathway Activation On MM-Induced Impairment of the Osteogenic Differentiation Process.

Oxygen Tension in the Bone Marrow (BM) of Patients with Malignant and Indolent Monoclonal Gammopathy: Role of Hypoxia and Hypoxia-Inducible Factor (HIF)-1α in the Regulation of Gene Expression and Pro-Angiogenic Profiles of CD138 + Cells.

HOXB7 Is Critically Involved in Multiple Myeloma-Induced Angiogenic Switch.

Hypoxia and Hypoxia Inducible Factor (HIF)-1α in Multiple Myeloma: Effect on the Pro-Angiogenic Signature of Myeloma Cells and the Bone Marrow Microenvironment.

Activation of Non-Canonical Wnt Pathway in Human Mesenchymal Cells Affects Osteogenic Differentiation: A Potential Target in Multiple Myeloma Microenvironment

The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 α (HIF-1α) activity: involvement in myeloma-induced angiogenesis

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