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Denise Toscani
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Journal Articles

Bovine Herpes Virus Type 1 Oncolytic Therapy Elicits Direct Cytotoxic Effects and Immune Microenvironment Reshaping in Multiple Myeloma

Vincenzo Raimondi, Paola Storti, Rosanna Vescovini, Valentina Franceschi, Giulia Pozzi, Denise Toscani, Nicolas Thomas Iannozzi, Oxana Lungu, Anna Benedetta Dalla Palma, Laura Pelagatti, Federica Librale, Mattia Dessena, Stefania Ricci, Prisco Mirandola, Gaetano Donofrio, Nicola Giuliani
Journal: Blood
Blood (2024) 144 (Supplement 1): 4660.
https://doi.org/10.1182/blood-2024-200024
Published: 2024
Journal Articles

Single Cell Transcriptomics on Bone Marrow Biopsies Unveils Peculiar Bone Microenvironment Cell Subtypes and Highlights Alterations Correlated with High-Risk Features in Precursor Monoclonal Gammopathies and Multiple Myeloma Patients

Mattia Dessena, Tommaso Torelli, Cristina Manferdini, Denise Toscani, Alessandro Guidi, Rosanna Vescovini, Nicolas Thomas Iannozzi, Anna Benedetta Dalla Palma, Vincenzo Raimondi, Oxana Lungu, Federica Librale, Matia Bernardi, Stefania Ricci, Laura Pelagatti, Giannalisa Todaro, Gabriella Sammarelli, Camilla Sitzia, Emanuela Aleo, Gina Lisignoli, Luca Agnelli, Nicola Giuliani, Paola Storti
Journal: Blood
Blood (2024) 144 (Supplement 1): 4656.
https://doi.org/10.1182/blood-2024-207574
Published: 2024
Journal Articles

PYGO2-MDR1 Axis in Multiple Myeloma Patients with 1q21 Amplification As Promising Target to Overcome Carfilzomib Resistance

Nicolas Thomas Iannozzi, Jessica Burroughs Garcia, Valentina Marchica, Valentina Franceschi, Denise Toscani, Rosanna Vescovini, Vincenzo Raimondi, Oxana Lungu, Giannalisa Todaro, Gabriella Sammarelli, Matteo Scita, Federica Librale, Anna Benedetta Dalla Palma, Gaetano Donofrio, Paola Storti, Luca Agnelli, Giancarlo Pruneri, Nicola Giuliani
Journal: Blood
Blood (2023) 142 (Supplement 1): 6575.
https://doi.org/10.1182/blood-2023-181685
Published: 2023
Journal Articles

Glutamine Addiction of Multiple Myeloma Cells Reprograms Mesenchymal Stromal Cell Enzymes and Transporters Towards a Pro-Tumor Phenotype

Martina Chiu, Erika Griffini, Denise Toscani, Giuseppe Taurino, Chiara Maccari, Roberta Andreoli, Giovanna D'Amico, Nicola Giuliani, Ovidio Bussolati
Journal: Blood
Blood (2023) 142 (Supplement 1): 4680.
https://doi.org/10.1182/blood-2023-186637
Published: 2023
Journal Articles

Glutamate Metabolism Shapes Osteoclast Differentiation: New Potential Therapeutic Target to Block Osteoclastic Bone Resorption in Multiple Myeloma Patients

Denise Toscani, Oxana Lungu, Vincenzo Raimondi, Martina Chiu, Nicolas Thomas Iannozzi, Jessica Burroughs Garcia, Anna Benedetta Dalla Palma, Matteo Scita, Matia Bernardi, Valentina Marchica, Paola Storti, Ovidio Bussolati, Nicola Giuliani
Journal: Blood
Blood (2022) 140 (Supplement 1): 4217–4218.
https://doi.org/10.1182/blood-2022-166654
Published: 2022
Journal Articles

Identification of the Proteasome Subunits PSMB4 and PSMD4 As Novel Targets in Multiple Myeloma Patients Carrying 1q21 Amplification

Jessica Burroughs Garcia, Paola Storti, Nicolas Thomas Iannozzi, Laura Notarfranchi, Denise Toscani, Valentina Marchica, Vincenzo Raimondi, Luca Agnelli, Valentina Franceschi, Giannalisa Todaro, Oxana Lungu, Matia Bernardi, Matteo Scita, Gabriella Sammarelli, Gaetano Donofrio, Anna Benedetta Dalla Palma, Nicola Giuliani
Journal: Blood
Blood (2022) 140 (Supplement 1): 6750–6751.
https://doi.org/10.1182/blood-2022-165974
Published: 2022
Journal Articles

PSMB4 and PSMD4 Are Correlated with 1q21 Amplification in CD138 + Plasma Cells: New Potential Druggable Targets in Myeloma Patients

Jessica Burroughs-Garcia, Paola Storti, Luca Agnelli, Denise Toscani, Valentina Marchica, Gabriella Sammarelli, Giannalisa Todaro, Vincenzo Raimondi, Valentina Franceschi, Naomi Soressi, Anna Benedetta Dalla Palma, Laura Notarfranchi, Gaetano Donofrio, Nicola Giuliani
Journal: Blood
Blood (2021) 138 (Supplement 1): 2657.
https://doi.org/10.1182/blood-2021-150198
Published: 2021
Journal Articles

Development and Validation of [ 18 f](2 S ,4 R )-4-Fluoroglutamine in Multiple Myeloma Mouse Models

Denise Toscani, Silvia Valtorta, Martina Chiu, Andrea Sartori, Angela Coliva, Arianna Brevi, Giuseppe Taurino, Matteo Grioni, Vincenzo Raimondi, Jessica Burroughs-Garcia, Paola Storti, Livia Ruffini, Federica Vacondio, Franca Zanardi, Matteo Bellone, Rosa Maria Moresco, Ovidio Bussolati, Nicola Giuliani
Journal: Blood
Blood (2021) 138 (Supplement 1): 2674.
https://doi.org/10.1182/blood-2021-147721
Published: 2021
Journal Articles

PD-L1/PD-1 Pattern of Distribution within Bone Marrow Microenvironment Cells in Patients with Smoldering Myeloma and Active Multiple Myeloma

Federica Costa, Rosanna Vescovini, PhD, Laura Notarfranchi, Paola Storti, PhD, Valentina Marchica, MS, Anna Benedetta Dalla Palma, MD, Cristina Manferdini, BS, Denise Toscani, PhD, Rosalba Eufemiese, MS, Jessica Burroughs, PhD, Gina Lisignoli, PhD, Nicola Giuliani
Journal: Blood
Blood (2020) 136 (Supplement 1): 49–50.
https://doi.org/10.1182/blood-2020-139275
Published: 2020
Journal Articles

[ 18 f]-( 2S , 4R )-4-Fluoroglutamine As a New Positron Emission Tomography Tracer in Multiple Myeloma

Nicola Giuliani, Silvia Valtorta, PhD, Martina Chiu, PhD, Denise Toscani, PhD, Andrea Sartori, PhD, Angela Coliva, PhD, Arianna Brevi, Stefania Battaglia, MS, Emanuela Vicario, PhD, Giuseppe Taurino, MS, Matteo Grioni, Francesca Ferlenghi, PhD, Livia Ruffini, MD, Federica Vacondio, PhD, Franca Zanardi, PhD, Matteo Bellone, MD, Rosa Maria Moresco, PhD, Ovidio Bussolati, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5542.
https://doi.org/10.1182/blood-2019-127935
Published: 2019
Journal Articles

Glutamine Depletion By Addicted Myeloma Cells Inhibits Osteoblastic Differentiation of Bone Marrow Mesenchymal Stromal Cells Limiting Asparagine Availability: A Possible New Mechanism for Myeloma Bone Disease

Martina Chiu, PhD, Denise Toscani, PhD, Emanuela Vicario, PhD, Roberta Andreoli, PhD, Giuseppe Taurino, MS, Valentina Marchica, MS, Paola Storti, PhD, Massimiliano Bianchi, PhD, Ovidio Bussolati, MD PhD, Nicola Giuliani
Journal: Blood
Blood (2019) 134 (Supplement_1): 4339.
https://doi.org/10.1182/blood-2019-128034
Published: 2019
Journal Articles

Short-Term Risk of Progression of Patients with Asymptomatic Monoclonal Gammopathies to Active Multiple Myeloma: The Critical Impact of the Tumoral Mass

Anna Benedetta Dalla Palma, MD, Laura Notarfranchi, MD, Jessica Crosara, MD, Mario Pedrazzoni, MD, Fabrizio Accardi, MD, Valentina Marchica, MS, Denise Toscani, PhD, Emanuela Vicario, PhD, Paola Storti, PhD, Nicola Giuliani
Journal: Blood
Blood (2019) 134 (Supplement_1): 1795.
https://doi.org/10.1182/blood-2019-128252
Published: 2019
Journal Articles

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

Denise Toscani, PhD, Martina Chiu, PhD, Giuseppe Taurino, MS, Emanuela Vicario, MS, Valentina Marchica, MS, Fabrizio Accardi, MD, Anna Benedetta Dalla Palma, MD, Paola Storti, PhD, Gaetano Donofrio, PhD, Franco Aversa, MD, Ovidio Bussolati, MD PhD, Nicola Giuliani, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4481.
https://doi.org/10.1182/blood-2018-99-111337
Published: 2018
Journal Articles

CD14 + CD16 + Monocyte Binding to Myeloma Cells Is Required for Daratumumab Dependent Killing in Multiple Myeloma Patients

Paola Storti, PhD, Rosanna Vescovini, PhD, Valentina Marchica, MS, Marina Bolzoni, PhD, Federica Costa, MS, Emanuela Vicario, MS, Denise Toscani, PhD, Anna Benedetta Dalla Palma, MD, Fabrizio Accardi, MD, Fabio Malavasi, MD, Franco Aversa, MD, Nicola Giuliani, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3200.
https://doi.org/10.1182/blood-2018-99-112873
Published: 2018
Journal Articles

Relationship between Bone Marrow PD-1 and PD-L1 Expression and the Presence of Osteolytic Bone Disease in Multiple Myeloma Patients

Federica Costa, MS, Marina Bolzoni, PhD, Rosanna Vescovini, PhD, Fabrizio Accardi, MD, Anna Benedetta Dalla Palma, MD, Federica De Luca, PhD, Valentina Marchica, MS, Denise Toscani, PhD, Emanuela Vicario, MS, Paola Storti, PhD, Franco Aversa, MD, Nicola Giuliani, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3183.
https://doi.org/10.1182/blood-2018-99-118200
Published: 2018
Journal Articles

Inhibition of p62-ZZ Domain-Mediated Signaling Overcomes Bortezomib Resistance in Multiple Myeloma Cells Independent of Their p53 Status

Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Rebecca Silberman, MD, Denise Toscani, PhD, Judith L Anderson, Nicola Giuliani, MD PhD, Xiang-Qun Xie, PhD, Noriyoshi Kurihara, DDS, PhD, G David Roodman, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4421.
https://doi.org/10.1182/blood.V130.Suppl_1.4421.4421
Published: 2017
Journal Articles

Soluble CX3CL1/Fractalkine Is a New Player in the Pro-Inflammatory Microenvironment of Multiple Myeloma Patients Related to Bone Marrow Plasma Cell Infiltration and Neo-Vascularization

Anna Corcione, Valentina Marchica, Elisa Ferretti, Denise Toscani, PhD, Marina Bolzoni, PhD, Federica Costa, PhD, Cristina Mancini, MD, Eugenia Martella, MD, Fabrizio Accardi, MD, Laura Notarfranchi, MD, Domenico Ribatti, MD, Angelo Vacca, MD PhD, Franco Aversa, MD, Vito Pistoia, MD, Nicola Giuliani, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3044.
https://doi.org/10.1182/blood.V130.Suppl_1.3044.3044
Published: 2017
Journal Articles

Gfi1 Transcription Factor Is a Pro-Survival Molecule in Multiple Myeloma Cells

Denise Toscani, PhD, Cheolkyu Park, PhD, Fengming Wang, DDS, PhD, Judith Anderson, Nicola Giuliani, MD, PhD, G. David Roodman, MD PhD, Daniela Nicoleta Petrusca, PhD
Journal: Blood
Blood (2016) 128 (22): 4422.
https://doi.org/10.1182/blood.V128.22.4422.4422
Published: 2016
Journal Articles

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Marina Bolzoni, Martina Chiu, Fabrizio Accardi, Rosanna Vescovini, Irma Airoldi, Paola Storti, Katia Todoerti, Luca Agnelli, Gabriele Missale, Roberta Andreoli, Massimiliano G. Bianchi, Manfredi Allegri, Amelia Barilli, Francesco Nicolini, Albertina Cavalli, Federica Costa, Valentina Marchica, Denise Toscani, Cristina Mancini, Eugenia Martella, Valeria Dall’Asta, Gaetano Donofrio, Franco Aversa, Ovidio Bussolati, Nicola Giuliani
Journal: Blood
Blood (2016) 128 (5): 667–679.
https://doi.org/10.1182/blood-2016-01-690743
Published: 2016
Includes: Supplemental data
Journal Articles

Generation and Characterization of Microvesicles after Daratumumab Interaction with Myeloma Cells

Antonella Chillemi, PhD, Valeria Quarona, Andrea Zito, Fabio Morandi, PhD, Danilo Marimpietri, Massimiliano Cuccioloni, PhD, Oldham J Robert, Cragg S Mark, PhD, Marina Bolzoni, PhD, Denise Toscani, PhD, Vito Pistoia, MD, Nicola Giuliani, MD PhD, Alberto L Horenstein, PhD, Kate Sasser, PhD, Fabio Malavasi, MD
Journal: Blood
Blood (2015) 126 (23): 1849.
https://doi.org/10.1182/blood.V126.23.1849.1849
Published: 2015