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Journal Articles

Bosutinib is a Substrate of the ABC Efflux Transporter P-Glycoprotein.

Pietro Perini, MS, Sara Redaelli, PhD, Rocco Piazza, MD, Michela Viltadi, MS, Frank Boschelli, PhD, Carlo Gambacorti, MD
Journal: Blood
Blood (2009) 114 (22): 3763.
https://doi.org/10.1182/blood.V114.22.3763.3763
Published: 2009
Journal Articles

Determination of the Activity Profile of Bosutinib, Dasatinib and Nilotinib against 18 Imatinib Resistant Bcr/Abl Mutants

Sara Redaelli, MS, Rocco Piazza, MD, Roberta Rostagno, Marianna Sassone, MD, Vera Magistroni, PhD, Pietro Perini, MS, Manuela Marega, MS, Frank Boschelli, PhD, Carlo Gambacorti, MD
Journal: Blood
Blood (2008) 112 (11): 3220.
https://doi.org/10.1182/blood.V112.11.3220.3220
Published: 2008
Journal Articles

Synergistic Activity of the Novel Src/Abl Inhibitor Bosutinib in Combination with Imatinib.

Sara Redaelli, Frank Boschelli, Michela Viltadi, Iris Meneghetti, Carlo Gambacorti
Journal: Blood
Blood (2007) 110 (11): 2930.
https://doi.org/10.1182/blood.V110.11.2930.2930
Published: 2007
Journal Articles

The Dual Src/Abl Kinase Inhibitor SKI-606 Effectively Inhibits Bcr-Abl Kinase Activity and Reduces Proliferation of CML Primitive Progenitor Cells.

Heiko Konig, MD, Simran K. Sindhu, Frank Boschelli, PhD, Tessa L. Holyoake, MD, Stephen J. Forman, MD, Ravi Bhatia, MD
Journal: Blood
Blood (2006) 108 (11): 1370.
https://doi.org/10.1182/blood.V108.11.1370.1370
Published: 2006
Journal Articles

A Study of the Binding Mode and the In Vitro Activity of the Protein Tyrosine Kinase Inhibitor SKI-606 in the BCR-ABL Positive Cells.

Tiziana Grafone, Simona Soverini, Gianluca Tasco, Manuela Mancini, Frank Boschelli, Jennifer Golas, David Frauling, Sabrina Colarossi, Emanuela Ottaviani, Alessandra Gnani, Giannoulia Panagiota, Fausto Castagnetti, Rita Casadio, Gianantonio Rosti, Giovanni Martinelli, Michele Baccarani
Journal: Blood
Blood (2006) 108 (11): 2335.
https://doi.org/10.1182/blood.V108.11.2335.2335
Published: 2006
Journal Articles

In Vitro and In Vivo Activity of SKI-606, a Novel Abl/Src Inhibitor, Against Imatinib Resistant BCR-ABL+ Neoplastic Cells.

Miriam Puttini, Addolorata M.L. Coluccia, Frank Boschelli, Anna Franceschino, Lucia Tornaghi, Shaheen Ahmed, Sara Redaelli, Rocco Piazza, Vera Magistroni, Federica Andreoni, Leonardo Scapozza, Franca Formelli, Carlo Gambacorti
Journal: Blood
Blood (2006) 108 (11): 2176.
https://doi.org/10.1182/blood.V108.11.2176.2176
Published: 2006
Journal Articles

Gene Expression Profile in the CML Cell Line K562 Treated with SKI-606, a Dual Inhibitor of Src/Abl Kinase.

Matteo Renzulli, Tiziana Grafone, Cristian Taccioli, Carolina Terragna, Frank Boschelli, Manuela Mancini, Pasquale Creo, Emanuela Ottaviani, Sabrina Colarossi, Marilina Amabile, Simona Soverini, Angela Poerio, Ilaria Iacobucci, Michele Baccarani, Giovanni Martinelli
Journal: Blood
Blood (2005) 106 (11): 4870.
https://doi.org/10.1182/blood.V106.11.4870.4870
Published: 2005
Journal Articles

A Novel 4-anilino-3-quinolinecarbonitrile Dual Src and Abl Kinase Inhibitor (SKI-606) Has In Vitro Activity on CML Ph+Blast Cells Resistant to Imatinib.

Tiziana Grafone, Manuela Mancini, Emanuela Ottaviani, Matteo Renzulli, Frank Boschelli, Laura Ferraretti, Maria Alessandra Santucci, Marilina Amabile, Simona Soverini, Carolina Terragna, Angela Poerio, Gianantonio Rosti, Cristian Taccioli, Michele Baccarani, Giovanni Martinelli
Journal: Blood
Blood (2004) 104 (11): 1991.
https://doi.org/10.1182/blood.V104.11.1991.1991
Published: 2004